61. Johns Hopkins Arthritis ACR 2003 Highlights On Myositis Johns Hopkins Arthritis Presents myositis Highlights from the American College of Rheumatology 2003 Annual Meeting. http://www.hopkins-arthritis.som.jhmi.edu/edu/acr2003/myositis.html

Lisa Christopher-Stine, M.D. Clinical Outcomes Abstract 720 Preliminary Definitions in Improvement for Adult Myositis Abstract 723 Organ Involvement and Long Term Survival Abstract 724 Consensus Criteria: Adult and Juvenile Idiopathic Myopathy Treatments Abstracts 730 Statin-Induced Myopathy Abstracts 1081 Tacrolimus for Antisynthetase Associated Interstitial Lung Disease Pathogenesis Abstract 1082 Histidyl-tRNA Synthetase and the Granzyme B Cleavage Site Abstract 1084 Role of Endothelial Cells and Dendritic Cells Clinical Aspects Abstract 720 Preliminary Definitions in Improvement for Adult Myositis L. Rider, E. Giannini, H. Brunner, N. Ruperto, A. Reed, L. James-Newton, T. Sanghvi, M. Cronin, I. Garcia-de la Torre, D. Isenberg, L. Kagen, T. Levine, I. Lundberg, C. Oddis, S. Rutkove, K. Sivakumar, Y. Song, I. Targoff, J. Vencovsky, R. Wortmann, S. Ytterberg, P. Lachenbruch, F. Miller, for the International Myositis Assessment and Clinic Studies (IMACS) Group Objective: Recently, a core set of outcome measures for adult myositis has been developed. The authors, therefore, sought to develop a responder index, which combines the core measures for use in clinical trials. Specifically, they wanted to determine a preliminary definition of improvement (DOI). Methods: Experts in the field of adult myositis rated 113 paper patient profiles, based on data from 4 NIH clinical trials, as "clinically improved" or "not improved." Nominal group technique was used to reach consensus - defined here as 70% or greater agreement. Consensus was achieved in 102 of the 113 cases. The six core set measures of disease status used were: Physician Global activity; Patient Global Activity; Muscle Strength; Physical Function; Muscle Enzymes, and Extra-muscular Activity. These consensus patient profiles were next used to test the DOIs for sensitivity, specificity, positive and negative predictive values, and rate of false positives and false negatives. Thirteen candidate DOI's that had greater than or equal to 80% sensitivity and specificity in the adult paper patient profile dataset were presented to a working group of 15 myositis experts then ranked their top choices for validity and ease of use.

62. HealthCentral - General Encyclopedia - Myositis General Health Encyclopedia, myositis. http://www.healthcentral.com/mhc/top/001245.cfm

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63. BioMed Central | Full Text | Myositis Opinion myositis Ivor Caro MD and Valencia D Thomas MD Dermatology Clinical Investigations Unit, Suite 402 Physicians Office Building 275 Cambridge Street http://www.biomedcentral.com/1523-3820/4/233

home journals A-Z journals by subject advanced search ... Issue 3 Viewing options Abstract Full text PDF Other links: E-mail to a friend Download references Search PubMed For Caro I Thomas VD Opinion Myositis Ivor Caro MD and Valencia D Thomas MD Dermatology Clinical Investigations Unit, Suite 402 Physicians Office Building 275 Cambridge Street, Massachusetts General Hospital, Boston, MA, 02114, USA Current Treatment Options in Infectious Diseases Outline Opinion statement Opinion statement Introduction Treatment References Outline Introduction Opinion statement Introduction Treatment References POLYMYOSITIS AND DERMATOMYOSITIS The pathogenesis of polymyositis (PM) and dermatomyositis (DM) has not been elucidated. The incidence of familial autoimmune disease, common environmental exposures, or elevated titers to Toxoplasma gondii , herpes simplex virus, or coxsackie B virus have not been found. A presumed association between PM/DM and the use of silicone breast implants and bovine collagen implants has not been proven Many infectious agents have been investigated as possible etiologic factors. It is unlikely that one specific agent could be responsible for all the cases. It has been postulated that such an agent could initiate a hypersensitivity reaction involving the skin and muscle of genetically susceptible patients. The phenomenon of molecular mimicry is when patients can develop abnormal immune responses when exposed to an antigen ( eg , a virus) that mimics a self-protein Approximately 35% to 40% patients with PM/DM have myositis-specific antibodies. However, the relationship between them and the pathogenesis is unclear. Twenty-five percent to 30% of patients have antiaminoacyl-tRNA synthetases, of which anti-Jo-1 (anti-histidyl-tRNA synthetase) is the most common. These patients may have myositis, arthritis, interstitial lung disease (ILD), Raynauds phenomenon, and 'mechanics hand' (the antisynthetase syndrome). The development of antibody appears to be antigen-driven and is influenced by human leukocyte antigen (HLA) subtypes. An initiating event, such as a viral infection, may be important. Antibodies to other cytoplasmic antigens, such as signal recognition particle (anti-SRP), may occur in a lower percentage of patients. These patients do not develop the antisynthetase syndrome, but may have more severe disease. The Mi-2 antigen appears to be most specific for DM and is found in 15% to 20% of patients

64. Caring Medical - Symptoms - Myositis CONDITION myositis. DESCRIPTION myositis refers to several different illnesses, including polymyositis, dermatomyositis, and inclusion body myositis. http://www.caringmedical.com/symptoms/condition.asp?condition_id=682

65. Medication Causes Of Myositis Medication Causes of myositis Toxic Myopathy. Drug induced myositis. Book, Home Page. http://www.fpnotebook.com/RHE91.htm

Home About Links Index ... Editor's Choice document.write(code); Advertisement Rheumatology Pharmacology Bone ... Diffuse Medication Causes of Myositis Intra-Articular Disorders Injectable Corticosteroid Allopurinol Colchicine ... Infliximab Medication Causes of Myositis Toxic Myopathy Drug induced Myositis Book Home Page Cardiovascular Medicine Dentistry Dermatology Emergency Medicine Endocrinology Gastroenterology General Medicine Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Rheumatology Index General Bone Cardiovascular Medicine Dermatology Diffuse Examination Infectious Disease Intra-Articular Disorders Laboratory Marfans Myofascial Neurology Osteoarthritis Pain Pediatrics Pharmacology Procedure Radiology RA Spondylitis Symptom Evaluation Page Pharmacology Index Bone Bisphosphonates Bone Calcitonin Bone Teriparatide Diffuse Myopathy Joint Corticosteroid Joint Gout Allopurinol Joint Gout Colchicine Joint Gout Probenacid RA Anti-interleukin Anakinra RA DMARD Gold RA DMARD Hydroxychloroquine RA DMARD Leflunomide RA DMARD Methotrexate RA DMARD Penicillamine RA TNF Adalimumab RA TNF Etanercept RA TNF Infliximab See Also Dermatomyositis Polymyositis Causes Alcohol Corticosteroid s D-Penicillamine Cimetidine Chloroquine Clofibrate Colchicine Emetine Hydroxyurea Ipecac NSAID s Nifluric acid Phenylbutazone Pravastatin References

66. Myositis Ossificans myositis Ossificans, Book, Home Page. http://www.fpnotebook.com/ORT211.htm

Home About Links Index ... Editor's Choice document.write(code); Advertisement Orthopedics Hip Fracture ... Iliopsoas Strain Myositis Ossificans Osteitis Pubis Quadriceps Contusion Assorted Pages Trochanteric Bursitis True Leg Length Discrepancy Functional Leg Length Discrepancy Examination ... Snapping Hip Myositis Ossificans Book Home Page Cardiovascular Medicine Dentistry Dermatology Emergency Medicine Endocrinology Gastroenterology General Medicine Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Orthopedics Index Ankle Brachial Cervical Spine Dermatology Elbow Examination Foot Forearm Fracture Hand Hematology and Oncology Hip Infectious Disease Knee General Pulmonology L-Spine Neurology Pediatrics Prevention Procedure Radiology Rheumatology Shoulder Sports Medicine Symptom Evaluation T-Spine Wrist Page Hip Index Bursa Trochanteric Fracture Fracture Femur Neck Fracture Femur Subtrochanteric Fracture Femur Intertrochanteric Fracture Femur Shaft Fracture Stress Avulsion Fracture Stress Neck Fracture Stress Pubic Ramus Stress Fracture Stress Shaft Leg Length Discrepancy Leg Length Discrepancy Functional Sports Adductor Sports Dislocation Sports Hamstring Strain Sports Iliopsoas Strain Sports Myositis Ossificans Sports Osteitis Pubis Sports Quad Contusion Pathophysiology Hematoma that ossifies Symptoms and Signs

67. Inclusion Body Myositis Information And Picture Inclusion body myositis. Inclusion body myositis. Inclusion body myositis (IBM) is a disease of muscle, which causes muscles to become thin and weak. http://health-pictures.com/inclusion-body-myositis.htm

Health Related Pictures and Definitions From the Consumer Health Information Network WWW http://www.health-pictures.com/ If you are not familiar with Cetyl Myristoleate for arthritis then you need ot visit this site. Home Pictures and Photos Inclusion body myositis Inclusion body myositis Inclusion body myositis (IBM) is a disease of muscle, which causes muscles to become thin and weak. It was recognised as a disease in its own right in the 1960's. It usually occurs in middle to late life and is more common in men than women. We don't know how many people in the UK are affected but it is the most common muscle disease diagnosed after the age of 50. Nevertheless, it is sufficiently rare that most general practitioners will not have looked after patients with IBM before, and many doctors will not have heard of the condition. Check out websites on cancer cystic fibrosis and arthritis This web site is intended for your own informational purposes only. No person or entity associated with this web site purports to be engaging in the practice of medicine through this medium. The information you receive is not intended as a substitute for the advice of a physician or other health care professional. If you have an illness or medical problem, contact your health care provider. var sc_project=247934;

68. AAEM - Patient Resources - Myositis Patient Resources myositis. myositis. myositis is a general term for inflammatory disorders of muscle. myositis Association of America - www.myositis.org. http://www.aaem.net/aaem/patientInfo/myositis.cfm

Patient Resources - Myositis Membership Directory Practice Issues / Advocacy Employment/Training Career Center Fellowship Listing EDX Courses Training Links ... List Rental Myositis Myositis is a general term for inflammatory disorders of muscle. The most common symptom is weakness and patients frequently complain of muscle pains. There are many causes of myositis, including but not limited to drugs, infections, and autoimmune disorders. Patients of all ages may be affected. The treatment depends on the cause. For More Information: American Chronic Pain Association - www.theacpa.org Myositis Association of America - www.myositis.org To Main Patient Resources Page 421 First Avenue SW, Suite 300 East Rochester, MN 55902 Telephone: (507) 288-0100 Fax: (507) 288-1225 E-mail: aaem@aaem.net

69. AAEM - Patient Resources - Inclusion Body Myositis Patient Resources Inclusion Body myositis. Inclusion Body myositis. Inclusion body myositis is a slowly progressive inflammatory disorder of muscle. http://www.aaem.net/aaem/patientInfo/inclusion_body_myositis.cfm

Patient Resources - Inclusion Body Myositis Membership Directory Practice Issues / Advocacy Employment/Training Career Center Fellowship Listing EDX Courses Training Links ... List Rental Inclusion Body Myositis Inclusion body myositis is a slowly progressive inflammatory disorder of muscle. Men over age 50 are most commonly affected. In some rare cases the disease may be inherited. Symptoms include muscle weakness in the arms and legs. The diagnosis can be made when characteristic changes are seen on a muscle biopsy specimen. Occasionally patients have been reported to improve with intravenous gamma globulin or steroids, but overall the response to treatment is poor. For More Information: Myositis Association of America - www.myositis.org National Organization for Rare Disorders (NORD) - www.rarediseases.org Muscular Dystrophy Association - www.mdausa.org To Main Patient Resources Page 421 First Avenue SW, Suite 300 East Rochester, MN 55902

70. Myositis - Medical Dictionary Definitions Of Popular Medical Terms Advanced Search. http://www.medterms.com/script/main/art.asp?articlekey=16419

71. Back Pain Treatment, Back Pain Relief, Tension Myositis Syndrome, Dr. Sarno back pain treatment, back pain relief, tension myositis syndrome, dr. sarno, dr. john sarno, herniated discs, ruptured discs, medical http://www.healingbackpain.com/

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72. Simple FactSheet: Myopathy, Cardiomyopathy, Myositis What is Myopathy, Cardiomyopathy, myositis? HIV drugs that can cause Myopathy, Cardiomyopathy, myositis, symptoms, risk of experiencing, diagnosis, treatment. http://www.aegis.com/factshts/network/simple/myop.html

Myopathy, Cardiomyopathy, Myositis a Simple FactSheet from the A IDS T reatment D ata N etwork Myopathy and cardiomyopathy: This side effect is thought to be caused by damage to the mitochondria in muscle cells. Symptoms: Symptoms are weakness and loss of muscle tissue in the arms, legs and buttocks. This type of toxicity can also affect the heart muscle, a problem called cardiomyopathy. Drugs responsible: This side effect is most often associated with zidovudine (AZT, Retrovir) , but has also been reported with stavudine (d4T, Zerit) Risk of experiencing this side effect: Diagnosis: A blood test for an enzyme called creatinine kinase (CK or CPK) is used to help diagnose myopathy. CK levels are often higher than normal in people with myopathy. Normal CK levels are generally 10-79 u./L for women and 17-148 u./L for men. Taking a small piece of muscle tissue (a muscle biopsy) and studying it under the microscope can show if the mitochondria in muscle cells are damaged. In the case of cardiomyopathy, a heart test called an echocardiogram can help look for problems with heart function. Studies are needed to work out if regular echocardiograms should be done in people taking anti-HIV drugs, particularly Retrovir or Zerit. Treatment: Because there is no known treatment for NRTI-related myopathy, the best approach may be to identify the drug that is causing it. If possible, an alternative anti-HIV drug can then be substituted. A study published in 1998 looked at muscle biopsies from people with Retrovir-related myopathy. The researchers found that mitochondrial damage in the muscle tissue improved rapidly after Retrovir was stopped.

73. Myositis Definition Of Myositis. What Is Myositis? Meaning Of Myositis. What Doe Definition of myositis in the Dictionary and Thesaurus. Provides examples from classic literature, search by definition of myositis. http://www.thefreedictionary.com/myositis

Dictionaries: General Computing Medical Legal Encyclopedia myositis Word: Word Starts with Ends with Definition Noun myositis - inflammation of muscle tissue dermatomyositis - myositis characterized by weakness of limb and neck muscles and much muscle pain and selling accompanied by skin rash affecting cheeks and eyelids and neck and chest and limbs; progression and severity vary among individuals polymyositis - myositis characterixed by weakness of limb and neck muscles and much muscle pain and swelling; progression and severity vary among individuals inclusion body myositis - myositis characterized by weakness of limb muscles (especially the thighs and wrists and fingers); sometimes involves swallowing muscles; onset after 50 and slowly progressive; seen more often in men than in women inflammation redness rubor - a response of body tissues to injury or irritation; characterized by pain and swelling and redness and heat myositis trichinosa trichiniasis trichinosis - infestation by trichina larvae that are transmitted by eating inadequately cooked meat (especially pork); larvae migrate from the intestinal tract to the muscles where they become encysted Legend: Synonyms Related Words Antonyms Some words with "myositis" in the definition:

74. Myositis Trichinosa Definition Of Myositis Trichinosa. What Is Myositis Trichino Definition of myositis trichinosa in the Dictionary and Thesaurus. Provides examples from classic literature, search by definition of myositis trichinosa. http://www.thefreedictionary.com/myositis trichinosa

Dictionaries: General Computing Medical Legal Encyclopedia myositis trichinosa Word: Word Starts with Ends with Definition Noun myositis trichinosa - infestation by trichina larvae that are transmitted by eating inadequately cooked meat (especially pork); larvae migrate from the intestinal tract to the muscles where they become encysted trichiniasis trichinosis myositis - inflammation of muscle tissue infestation - the state of being invaded or overrun by parasites Legend: Synonyms Related Words Antonyms Some words with "myositis trichinosa" in the definition: dermatomyositis inclusion body myositis infestation myositis ... trichinosis Previous General Dictionary Browser Next Myopic astigmatism Myops Myopsis ... Myotomic Full Dictionary Browser myopathy myope Myophan Myophonus (enc.) Myopia Myopia (enc.) myopic Myopic astigmatism Myoprocta (enc.) Myops Myopsis Myopus Myopy ... Myosin (enc.) MyosinUnrootedTree.jpg (enc.) myosis Myositic myositis Myosotis ... Myosotis (enc.) Myosotis scorpiodes Myosotis sylvatica Myost cheese (enc.) myotactic reflex myotic Myotis Myotis leucifugus ... Myotomy (enc.) Myotonia Myotonia (enc.)

75. Myositis Founded 1993. Dedicated to serving those with polymyositis, dermatomyositis, juvenile myositis, and inclusion body myositis. Self Help Clearinghouse. myositis. http://www.bchealthguide.org/kbase/shc/shc29mys.htm

document.write(''); var hwPrint=1; var hwDocHWID="shc29mys"; var hwDocTitle="Myositis"; var hwRank="1"; var hwSectionHWID="shc29mys"; var hwSectionTitle=""; var hwSource="cn6.0"; var hwProdCfgSerNo="wsh_html_031_s"; var hwDocType="SHC"; Self Help Clearinghouse Myositis Myositis Association of America National network. Founded 1993. Dedicated to serving those with polymyositis, dermatomyositis, juvenile myositis, and inclusion body myositis. Provides education and support. Also serves as a clearinghouse between patients and scientists. Newsletter, research reviews, literature and telephone support. Area meetings available as well as annual conference. Fund raising for research. Dues: $50. WRITE: Myositis Association of America c/o Betty Curry 755 Cantrell Ave., Suite C Harrisonburg, VA 22801 CALL: 540-433-7686 (day) FAX: 540-432-0206 E-MAIL: maa@myositis.org WEBSITE: http://www.myositis.org VERIFIED: 4/21/2003 The Myositis Association National network. Founded 1993. 50 groups. Dedicated to serving those with polymyositis, dermatomyositis, juvenile myositis, and inclusion body myositis. Provides education and support. Also serves as a clearinghouse between patients and scientists. Newsletter, research reviews, literature and phone support. Area meetings available as well as annual conference. Guidelines available for starting similar groups. Fund raising for research. Dues: $35.

76. Muscular Dystrophy Campaign Inclusion Body Myositis What is inclusion body myositis? Inclusion body myositis (IBM) is a disease of muscle, which causes muscles to become thin and weak. http://www.muscular-dystrophy.org/information/keyfacts/ibm.html

@import "../../css/cssstyle.css"; Receive copies of Target MD Get your message to over 30,000 readers by advertising in Target MD magazine. Call for details: David N Russell Inclusion Body Myositis February 2003 Written by Dr S Hammans (Consultant Neurologist) Wessex Neurological Centre, Southampton for the Muscular Dystrophy Campaign. What is inclusion body myositis? Inclusion body myositis (IBM) is a disease of muscle, which causes muscles to become thin and weak. It was recognised as a disease in its own right in the 1960's. It usually occurs in middle to late life and is more common in men than women. We don't know how many people in the UK are affected but it is the most common muscle disease diagnosed after the age of 50. Nevertheless, it is sufficiently rare that most general practitioners will not have looked after patients with IBM before, and many doctors will not have heard of the condition. How will it affect me? IBM is a slowly progressive condition causing a gradual deterioration in muscle strength over the years. Most limb muscles can be affected. In particular the quadriceps (the thigh muscles which extend the knee joint), and forearm muscles that flex the wrists and fingers are commonly weak. Accordingly, patients often notice difficulty with stairs, getting out of a chair and a poor grip. Swallowing muscles are affected in some patients, but most do not encounter severe swallowing problems. The disease typically does not affect muscles of the heart, eye, gut or bladder. It does not affect the function of the brain or sensation, and speech is rarely affected. In general patients do not die of the disease, but most meet with some degree of disability as the disease progresses.

77. Muscular Dystrophy Campaign Myositis Ossifcans Progressiva myositis ossificans progressiva, also known as Fibrodysplasia ossificans progressiva or FOP, is a disabling condition which is caused by the formation of bony http://www.muscular-dystrophy.org/information/keyfacts/mo1.html

@import "../../css/cssstyle.css"; Receive copies of Target MD Get your message to over 30,000 readers by advertising in Target MD magazine. Call for details: David N Russell Myositis Ossifcans Progressiva January 2000 Written by Professor J M Connor MD, FRCP for the Muscular Dystrophy Campaign. Myositis ossificans progressiva, also known as Fibrodysplasia ossificans progressiva or FOP, is a disabling condition which is caused by the formation of bony bars within the muscles of the body. This bone formation is usually first noticed in early childhood as a series of hard lumps in the neck or along the spine. These lumps, which may be tender, gradually shrink in size as the affected muscles are replaced by bone. The appearance of bony lumps in muscles is usually spontaneous but can also be provoked by any injury to the muscles. Disability in MOP is physical and very variable in extent; intelligence in unaffected. How does the condition progress? MOP is progressive in that more muscles become involved with increasing age, but the rate of progression is very variable from one person to another. Furthermore, the condition tends to show long periods of inactivity (of up to several years in length). Can any muscles be affected?

78. Myositis --  Encyclopædia Britannica myositis Encyclopædia Britannica Article. To cite this page MLA style myositis. Encyclopædia Britannica. 2004. Encyclopædia Britannica Premium Service. http://www.britannica.com/eb/article?eu=55919

79. Myositis Ossificans --  Encyclopædia Britannica myositis ossificans Encyclopædia Britannica Article. To cite this page MLA style myositis Ossificans. Encyclopædia Britannica. 2004. http://www.britannica.com/eb/article?eu=55920

80. Myositis / Family Village Library Library M N. myositis. The mission of The myositis Association is to improve the lives of those affected by inflammatory myopathies. http://www.familyvillage.wisc.edu/lib_Myositis.htm

Myositis Who to Contact Where to Go to Chat with Others Learn More About It Web Sites ... Search Google for "Myositis" Who to Contact Myositis Association of America 755 Cantrell Ave., Suite C Harrisonburg, Virginia, 22801 540-433-7686 (phone) 540-432-0206 (fax) E-mail: tma@myositis.org Web: http://www.myositis.org/ The mission of The Myositis Association is to improve the lives of those affected by inflammatory myopathies. We will seek out persons with inflammatory myopathies, provide a support network, act as a resource for patients and the medical community, advocate for patients, and promote research into the cause and treatment of the diseases. Where to Go to Chat with Others Our Myositis Welcome, this is a list for all those who suffer with inflammatory myopathies (myositis). If you have been diagnosed with Polymyositis (PM)Dermatomyositis (DM) Inclusion Body Myositis (IBM) Juvenile Myositis (JM) then this is the place for you to make new friends, enjoy new topics, share stores and try to make a difference in the way you feel. Learn More About It What is Myositis?

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