61. Medifocus: Myelodysplastic Syndromes Guidebook MediFocus Guides Help Answer Key Questions about myelodysplastic syndromes What myelodysplastic syndromes. Trustworthy Information, Medifocus http://www.medifocus.com/myelodysplastic-syndromes.php

Select by Specialty Cardiology Endocrinology Gastroenterology Hematology Nephrology Neurology Oncology Orthopedics Otolaryngology Psychiatry Rheumatology Or Condition Abdominal Aortic Aneurysm Acoustic Neuromas Acute Myelogenous Leukemia Ankylosing Spondylitis Atrial Fibrillation Bipolar Disorder Bladder Cancer Carcinoid Tumors Chronic Lymphocytic Leukemia Chronic Pancreatitis Cluster Headaches Ductal Carcinoma in Situ (DCIS) Glioblastoma Graves' Disease Hereditary Hemochromatosis Lymphedema Meniere's Disease Multiple Myeloma Myelodysplastic Syndromes Non-Small Cell Lung Cancer Ovarian Cancer Parkinson's Disease Peripheral Neuropathy Polycystic Kidney Disease Polycystic Ovary Syndrome Reflex Sympathetic Dystrophy Renal Cell Carcinoma Restless Legs Syndrome Scleroderma (Systemic Sclerosis) Sjogren's Syndrome Small Cell Lung Cancer Spondylolisthesis Stroke Rehabilitation Thoracic Outlet Syndrome Tongue Cancer Trigeminal Neuralgia (tic douloureux) Vertigo MediFocus Guides Help Answer Key Questions about Myelodysplastic Syndromes: What are the standard treatments for Myelodysplastic Syndromes? What are your treatment options?

62. Clinical Trial: Arsenic Trioxide In Treating Patients With Myelodysplastic Syndr Arsenic Trioxide in Treating Patients With myelodysplastic syndromes. This study is currently recruiting patients. Sponsored by. Cell http://www.clinicaltrials.gov/ct/show/NCT00020969?order=41

63. Clinical Trial: Calcitriol And Dexamethasone In Patients With Myelodysplastic Sy Calcitriol and Dexamethasone in Patients With myelodysplastic syndromes. myelodysplastic syndromes, Drug Calcitriol Drug Dexamethasone, Phase II. http://www.clinicaltrials.gov/ct/show/NCT00030069?order=23

64. CCHS Clinical Digital Library INFO ) Chapter 85 The myelodysplastic syndromes Access document INFO ) Chapter 85 - The myelodysplastic syndromes Access document http://cchs-dl.slis.ua.edu/clinical/hematology/anemias/myelodysplasia.html

Clinical Resources by Topic: Hematology Myelodysplastic Syndrome Clinical Resources Pediatrics Geriatrics Pathology Clinical Guidelines ... Miscellaneous Resources See also: General Hematology Clinical Resources Myelodysplastic Syndrome Patient/Family Resources Harrison's Principles of Internal Medicine 15th Ed.-2001: Table of contents Health Sciences Library subscription INFO Chapter 61: Anemia and Polycythemia: Table of contents Hematopoiesis and the Physiologic Basis of Red Cell Production: Access document Anemia: Access document Clinical Presentation of Anemia: Access document Signs and Symptoms: Access document Approach to the Patient: Access document Definition and Classification of Anemia: Access document Treatment: Access document Chapter 109: Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes: Table of contents Introduction: Access document Myelodysplasia: Access document Definition: Access document Epidemiology: Access document Etiology and Pathophysiology: Access document Clinical Features: Access document Laboratory Studies: Access document Differential Diagnosis: Access document Prognosis: Access document Treatment: Access document Myelophthisic Anemias: Access document Hoffman: Hematology: Basic Principles and Practice 3rd Ed.-2000 (MD Consult):

65. CCHS Clinical Digital Library Myelodysplastic Syndrome Patient/Family Resources. myelodysplastic syndromes Table of contents myelodysplastic syndromes Treatment Access document. http://cchs-dl.slis.ua.edu/patientinfo/hematology/anemias/myelodysplastic.htm

Patient/Family Resources by Topic: Oncology Myelodysplastic Syndrome Patient/Family Resources Miscellaneous See also: General Oncology Patient/Family Resources Myelodysplastic Syndrome Clinical Resources MD Consult: Homepage Health Sciences Library subscription INFO Patient Handouts Table of content Myelodysplastic Syndromes (MDS): Access document Homepage Diseases Booklets: Table of contents Myelodysplastic Syndrome: HTML PDF Cancer.gov (National Cancer Institute): Homepage Myelodysplastic Syndromes Table of contents Myelodysplastic Syndromes Treatment: Access document Miscellaneous Myelodysplastic Syndrome Patient/Family Resources YAHOO - Health:Diseases and Conditions:Cancers Additional Cancers Resources ( These sites have not been reviewed. YAHOO - Health:Medicine:Hematology Additional Hematology resources ( These sites have not been reviewed. YAHOO - Health:Medicine:Oncology Additional Oncology Resources ( These sites have not been reviewed. Health Sciences Library College of Community Health Sciences The University of Alabama Service provided by the Clinical Digital Libraries Project of the UA and UNT Schools of Library and Information Studies Powered by UA Digital Libraries Navigation Lab technology

66. Myelodysplastic Syndromes (MDS) myelodysplastic syndromes (MDS). myelodysplastic syndromes affect the production and behavior of blood cell production and behavior. http://www.cedars-sinai.edu/5693.html

Home Medical Dictionary Contact Us About Us ... Myelodysplastic Syndromes (MDS) Myelodysplastic Syndromes (MDS) Myelodysplastic syndromes affect blood cell production and behavior. Blood carries oxygen, chemicals and hormones to the cells in the body and helps remove toxins and waste. Bone marrow (the spongy middle part of the large bones) produces the three main types of blood cells: Red blood cells carry oxygen to the tissues (muscles, bones, nerves and organs). Low red blood counts or malfunctioning red blood cells can cause anemia. Symptoms are paleness, feeling tired, fast-beating or pounding heart, dizziness, shortness of breath or headaches. White blood cells fight infection. Symptoms of infection caused by low white blood counts may include temperature rising to 38.0 C or 100.4 F, coughing, stiff neck, pain or burning with urination, sore throat, mouth or lip sores and sores that do not heal. Platelets help to prevent bleeding. Signs of inadequate platelets include bleeding or bruising too easily. Patients may experience bleeding of the gums when brushing their teeth, blood in the urine or stool, severe headache or visual changes or a stiff neck. The five categories of MDS are: Refractory anemia Refractory anemia with ringed sideroblasts Refractory anemia with excess blasts Refractory anemia in transformation to acute leukemia Chronic myelomonocytic leukemia The disease categories on the lower end of this list are more serious and have a worse prognosis than those at the top. Refractory anemia and refractory anemia with ringed sideroblasts primarily affect the red blood cells and are the most common forms of MDS. Refractory anemia with excess blasts is present when immature white blood cells are found in the bone marrow in abnormally large numbers (five to 20% bone marrow blasts, compared to normal blasts of less than one percent). Refractory anemia with excess blasts in transformation occurs when blasts become markedly increased (more than 20%) and may indicate that MDS will change to an acute form of leukemia.

67. Myelodysplastic Syndrome Center myelodysplastic syndromes (MDS), also known as preleukemias, tend to occur in patients who have low blood counts, despite the presence of normal or higher-than http://www.rush.edu/rumc/page-R11837.html

Bone Marrow Transplant Gynecologic Oncology Hematology Oncology (Pediatrics) Cancer Center Myelodysplastic Syndrome Center Program Description Myelodysplastic syndromes (MDS), also known as pre-leukemias, tend to occur in patients who have low blood counts, despite the presence of normal or higher-than-normal numbers of blood-forming cells in their bone marrow. Approximately 10,000 cases are diagnosed in the United States each year, usually among people over age 60. Rush doctors have been able to turn laboratory advances into improved therapies for patients. One such treatment, developed at Rush, involves the use of a combination of nontoxic drugs to regulate the abnormal blood-cell death observed in MDS patients. This therapy helps many patients with MDS, and causes few side effects. Clinical Team Azra Raza, MD, is medical director of the Myelodysplastic Syndrome Center at Rush. Contact Name Myelodysplastic Syndrome Center Contact Phone Contact E-mail contact_rush@rush.edu Location Hours of Operation Rush Professional Office Building

68. UPMC Cancer Centers - Cancer Information . What are myelodysplastic syndromes? myelodysplastic syndromes, also......myelodysplastic syndromes. PrinterFriendly Version. http://www.upmccancercenters.com/pdq_xml/cancer.cfm?id=94

69. Myelodysplastic Syndromes Cancer Overview - UMM Greenebaum Cancer Center What is myelodysplastic syndromes, a Cancer Overview presented by the University of Maryland Greenebaum Cancer Center. myelodysplastic syndromes (MDS) http://www.umm.edu/cancer/overview/mds.html

UM Greenebaum Cancer Center Request An Appointment About UMGCC... Clinical Trials... ... UMGCC News UM Greenebaum Cancer Center - Cancer Overviews Myelodysplastic Syndromes (MDS): What are Myelodysplastic Syndromes? Myelodysplastic syndromes (MDS) are a group of diseases in which the bone marrow does not function normally and not enough normal blood cells are made. These abnormal bone marrow cells do not form blood cells effectively and most of the blood cells produced by these abnormal marrow cells are defective. These abnormal blood cells are usually destroyed before they leave the bone marrow or shortly after entering the bloodstream. IN THIS OVERVIEW... What are MDS? Types of MDS Risk Factors Symptoms of MDS ... Greenebaum Cancer Center As a result, patients have shortages of blood cells, which are reflected in their low blood counts. In about 30 percent of cases of MDS, the bone marrow cells continue to become more abnormal, and eventually develop into acute leukemia, a rapidly growing cancer of bone marrow cells. According to the American Cancer Society, in about 30 percent of MDS cases, the abnormal bone marrow cells eventually progress into acute leukemia. Although some doctors believe MDS is an early form of leukemia, many MDS patients never develop leukemia.

70. NCI: Myelodysplastic Syndromes . Back to top What are myelodysplastic syndromes?......AZ Listing of Types of Cancer. myelodysplastic syndromes. Back to top http://www.jamesline.com/patientsandpublic/cancertypes/listing/index.cfm?action=

71. National Cancer Institute - Myeloproliferative Disorders: Treatment Expertreviewed information summary about the treatment of childhood acute myeloid leukemia, myelodysplastic syndromes, and other myeloproliferative disorders. http://www.cancer.gov/cancerinfo/treatment/myeloproliferative

var bSearchBoxBool=false; window.onload+="MM_preloadImages('/images/nav_home_over.gif','/images/nav_cancer_topics_over.gif','/images/nav_clinical_trials_over.gif','/images/nav_cancer_statistics_over.gif','/images/nav_research_funding_over.gif','/images/nav_news_over.gif','/images/nav_about_over.gif');" Myeloproliferative Disorders: Treatment Quick Links Dictionary Funding Opportunities NCI Publications NCI Calendar NCI Highlights Some Men with Low PSAs Have Prostate Cancer Energy Balance Trans-HHS Cancer Health Disparities Report Past Highlights Treatment [ patient ] [ health professional ] Expert-reviewed information summary about the treatment of adult acute myeloid leukemia. [ patient ] [ health professional ] Expert-reviewed information summary about the treatment of childhood acute myeloid leukemia, myelodysplastic syndromes, and other myeloproliferative disorders. [ patient ] [ health professional ] Expert-reviewed information summary about the treatment of chronic myelogenous leukemia. [ patient ] [ health professional ] Expert-reviewed information summary about the treatment of chronic myeloproliferative disorders, including polycythemia vera, chronic idiopathic myelofibrosis, essential thrombocythemia, and chronic neutrophilic/eosinophilic leukemia. [ patient ] [ health professional ] Expert-reviewed information summary about the treatment of myelodysplastic syndromes, including refractory anemias.

72. MedlinePlus: Bone Marrow Diseases myelodysplastic syndromes (PDQ) Treatment (National Cancer Institute) Also available in Spanish. Diagnosis/Symptoms; How Is Myelodysplastic Syndrome Diagnosed? http://www.nlm.nih.gov/medlineplus/bonemarrowdiseases.html

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Other health topics: A B C D ... List of All Topics Bone Marrow Diseases Contents of this page: News From the NIH General/Overviews Diagnosis/Symptoms ... Statistics Search MEDLINE for recent research articles on Bone Marrow Diseases You may also be interested in these MedlinePlus related pages: Anemia Bone Marrow Transplantation Leukemia, Adult Chronic Multiple Myeloma ... Blood/Lymphatic System Latest News FDA Approves New Drug for Bone Marrow Disease (05/19/2004, Food and Drug Administration) From the National Institutes of Health Chronic Myeloproliferative Disorders (PDQ): Treatment (National Cancer Institute) Also available in: Spanish Myelodysplastic Syndromes (PDQ): Treatment (National Cancer Institute) Also available in: Spanish General/Overviews Myelodysplastic Syndrome Myelodysplastic Syndromes: Basic Explanations Also available in: Spanish Clinical Trials ClinicalTrials.gov: Bone Marrow Diseases (National Institutes of Health) ClinicalTrials.gov: Myelodysplastic Syndromes

73. Myelodysplastic Syndrome Lewis S, Wainscoat JS, Moore NR, Golding SJ. Magnetic resonance imaging in myelodysplastic syndromes. Br J Radiol 1995 Feb;68(806)1217 UI95253709. http://home.earthlink.net/~radiologist/tf/031300.htm

This 77 y/o female presented with left hip pain and anemia after a fall. Plain films demonstrated some degenerative osteoarthritic changes but were otherwise unremarkable. An MRI with coronal T1 and fat saturated inversion recovery and axial proton density and fat saturated T2 weighted sequences was performed. Selected images from the MRI scan shown above demonstrate diffuse abnormal marrow signal and abnormal signal in the obturator internus. The abnormal signal in the obturator was felt to be due to muscle strain and was likely the cause of the acute left hip symptoms. Bone marrow biopsy and subsequent consultation with the Hematopathology Department at City of Hope National Medical Center with immunostains and expert morphologic review of peripheral blood and marrow led to the diagnosis of myelodysplastic syndrome. Lewis S, Wainscoat JS, Moore NR, Golding SJ. Magnetic resonance imaging in myelodysplastic syndromes. Br J Radiol 1995 Feb;68(806):121-7 UI:95253709 Takagi S, Tanaka O, Origasa H, Miura Y. Prognostic significance of magnetic resonance imaging of femoral marrow in patients with myelodysplastic syndromes. J Clin Oncol 1999 Jan;17(1):277-83 UI:99385425 Kusumoto S, Jinnai I, Matsuda A, Murohashi I, Bessho M, Saito M, Hirashima K, Heshiki A, Minamihisamatsu M. Bone marrow patterns in patients with aplastic anaemia and myelodysplastic syndrome: observations with magnetic resonance imaging. Eur J Haematol 1997 Sep;59(3):155-61 UI:97455911

74. BioMed Central | Full Text | Pediatric Myelodysplastic Syndromes To obtain access to Current Hematology Reports through your institution use the options below. If you would like information about http://www.biomedcentral.com/1540-3408/3/173

home journals A-Z journals by subject advanced search ... my BioMed Central To obtain access to Current Hematology Reports through your institution use the options below. If you would like information about a personal subscription, please contact subs@phl.cursci.com Click here to view an abstract of this article Click here to login if you are already a subscriber to Current Hematology Reports Subscribe to Current Hematology Reports Register for a free online trial Ask your librarian to investigate institutional access Athens users please click here to gain access If you believe you are seeing this page in error, or cannot activate your subscription, e-mail us info@biomedcentral.com Terms and Conditions Privacy statement Information for advertisers ... Contact us

75. Compassionate Use Of Subcutaneous 5-Azacytadine In Myelodysplastic Syndromes Title Compassionate Use of Subcutaneous 5Azacytadine in myelodysplastic syndromes. Disease Site myelodysplastic syndromes. Protocol Number U9103. http://www.cancer.dartmouth.edu/clinicaltrials/trials/U9103.shtml

In Affiliation with: Dartmouth Medical School Dartmouth-Hitchcock Medical Center The National Cancer Institute Welcome to Norris Cotton Cancer Center Contact About Directions Media You are: Home Clinical Trials Quick Links Clinical Services Patient Support Services Clinical Trials Research ... Giving and Volunteering Mailing List Enter your email address to receive periodic updates from the Cancer Center. Email Address A Norris Cotton Cancer Center (DHMC) Clinical Trial Title : Compassionate Use of Subcutaneous 5-Azacytadine in Myelodysplastic Syndromes Disease Site : Myelodysplastic Syndromes Protocol Number Trial Category Miscellaneous Primary Investigator(s) : Dr(s). Lowrey CRA : Fitzmaurice Contact Email Thomas.F.Fitzmaurice@Dartmouth.EDU Contact Phone Study Group : COMP Sponsor : COMPASSIONATE Related Website Eligibility Criteria Complete Protocol link (password protected): Openings in Study (if data is available): Date this study opened Notes In Affiliation with: Dartmouth Medical School Dartmouth-Hitchcock Medical Center The National Cancer Institute Norris Cotton Cancer Center One Medical Center Drive Lebanon, New Hampshire (NH) 03756

76. Cancer Care : Medical Update On Myelodysplastic Syndromes (MDS) their time of greatest need. Click here to learn how to make a secure donation. Medical Update on myelodysplastic syndromes (MDS), http://www.cancercare.org/TelephoneEducationWorkshopArchive/TelephoneEducationWo

77. Myelodysplastic Syndromes Institute. Information from PDQ for Patients. DESCRIPTION. What are myelodysplastic syndromes?......myelodysplastic syndromes. 208/02495. http://cancerweb.ncl.ac.uk/cancernet/202495.html

Myelodysplastic syndromes Description Stage Explanation Treatment Option Overview De Novo Myelodysplastic Syndrome ... Overview Of PDQ CancerMail from the National Cancer Institute Information from PDQ for Patients DESCRIPTION What are myelodysplastic syndromes? Myelodysplastic syndromes, also called pre-leukemia or "smoldering" leukemia, are diseases in which the bone marrow does not function normally and not enough normal blood cells are made. The bone marrow is the spongy tissue inside the large bones in the body. The bone marrow makes red blood cells (which carry oxygen and other materials to all tissues of the body), white blood cells (which fight infection), and platelets (which make the blood clot). Normally, bone marrow cells called blasts develop (mature) into several different types of blood cells that have specific jobs in the body. Myelodysplastic syndromes occur most often in older people, but they can occur in younger people. The most common sign is anemia, which means there are too few mature red blood cells to carry oxygen. There may also be too few white blood cells in the blood to fight infections. If the number of platelets in the blood is lower than normal, this may cause people to bleed or bruise more easily. A doctor should be seen if a person bleeds without any reason, bruises more easily than normal, has an infection that won't go away, or feels tired all the time. If there are symptoms, a doctor may order blood tests to count the number of each kind of blood cell. If the results of the blood test are not normal, the doctor may do a bone marrow biopsy. During this test, a needle is inserted into a bone and a small amount of bone marrow is taken out and looked at under the microscope. The doctor can then determine the kind of disease and plan the best treatment.

78. Myelodysplastic Syndrome Definition and Classification The myelodysplastic syndromes (MDS) are a group of disorders which are characterized by abnormal stem cell differentiation http://home.uchicago.edu/~adamcifu/MDS.htm

Myelodysplastic Syndrome Definition and Classification The myelodysplastic syndromes (MDS) are a group of disorders which are characterized by abnormal stem cell differentiation resulting primarily in peripheral cytopenias. They are fatal disorders which lead to death either through bone marrow failure or by transformation to leukemia. Life expectancy and likelihood of leukemic transformation varies with subtype of disease. MDS was initially referred to as refractory anemia because it was refractory to vitamin supplimentation. It has also been called preleukemia because of the presence of blasts in the marrows of some of these patients and smoldering leukemia because despite the presence of blasts the disease course is more protracted than AML. The most recent FAB classification goes a long way towards helping to organize MDS as each of the 5 subtypes has a somewhat different histology and prognosis. They are as follows: Refractory anemia without ringed sideroblasts (RA) usually presents clinically with anemia, thrombocytopenia, and neutropenia. There are no blasts on the peripheral smear and the bone marrow shows less 15% ringed sideroblasts and less than 5% blasts. Refractory anemia with ringed sideroblasts (RARS) is similar to RA but the abnormalities both in the periphery and in the marrow are more confined to the erythroid line. >15% of the erythrocytes are ringed sideroblasts. The ring is formed by iron deposits resulting from derangements in erythropoiesis

79. City Of Hope :: Comprehensive Cancer Center . What are myelodysplastic syndromes? myelodysplastic syndromes, also called preleukemia......About myelodysplastic syndromes http://www.cityofhope.org/ccc/db/cancer.asp?c=CDR0000062723

80. Myelodysplastic Syndromes Foundation toprated.gif myelodysplastic syndromes Foundation. http//www.mdsfoundation.org/. sm_cjpLogo.gifCopyright 1995-2003 - Carden Jennings Publishing Co., Ltd. http://www.bloodline.net/stories/storyReader$3266

Bloodline Home About Call for Papers Free Membership ... Search Educational Features Image Atlas Case Studies Private Lectures Conference Reviews ... Glossary Resources Conference Calendar Hematology Links Full Text Journals Classifieds Specialties BMT/Stem Cell Cord Blood Thrombosis Hemostasis ... Veterinary News Hematology News Blood News Update Discussion Today's Discussion Create New Topic List by Topic Members Join Now Login Myelodysplastic Syndromes Foundation http://www.mds-foundation.org/ Carden Jennings Publishing Co., Ltd. Featured Resources Optimizing Outcomes with IGIV Therapy Bloodline Reviews Volume 3, Issue 2 Immuno-fine-tuning: Focus on Intravenous Immune Globulin Selection Blood and Marrow Transplantation Reviews: The Impact of CMV in Stem Cell Transplantation Frontiers in HematOncology Volume 2, Issue 1 Bloodline Reviews Volume 3, Issue 1 Advances in Intravenous Immunoglobulin Therapy BloodLine Image Atlas

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