81. Penn State Faculty Research Expertise Database (FRED) , Related Terms, multiple system atrophy Syndrome, Multisystem Atrophy. Multisystemic......Faculty Research Expertise Database. multiple system atrophy. http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D019578

82. Charmayne's Multiple System Atrophy/Shy-Drager Pages - General Information multiple system atrophy (MSA), ShyDrager (SDS), Olivopontocerebellar Atrophy (OPCA), Striatonigral Degeneration, ParkinsonPlus. http://www.bischel.com/general.html

WELCOME! 01/01/03 - PLEASE NOTE!: Due to changes in the direction of my own personal life, I am no longer actively watching for additions/changes/corrections/updates to these pages. Should you desire an addition or update to these pages, please do contact me via email at charmayn@aracnet.com General MSA Information These links generally mirror the Shy-Drager mail-list at http://groups.yahoo.com/group/shydrager/links/ ~ by Pam Bower *** NEW *** MSA Diagnostic Criteria ~ October 2001 report co-authored by Andre Diedrich and Dr. David Robertson, Vanderbilt University *** NEW *** Cellular and Molecular Pathology of Multiple System Atrophy: A Review and Recent Developments ~ Keynote Lecture by P L Lantos *** NEW *** Darlene Turner's Shy-Drager Tribute Page *** NEW *** Multi System Atrophy and My Story ~ by Tim Foley from Trumbull, Connecticut, USA *** NEW *** Multiple System Atrophy ~ June 2001 article by H U Rehman *** NEW *** Shy-Drager Syndrome ~ by Carol A Turkington *** NEW *** Sporadic Cerebellar Degeneration ~ March 2001 presentation by Dr. Sid Gilman. Also see: http://accesswave.ca/~pbower/msa_gilman.htm

83. 2nd International Meeting On Multiple System Atrophy (MSA) 2nd International Meeting on multiple system atrophy (MSA). neurology, motoric system, movement disorders, atrophy, multiple system atrophy, MSA. http://mediconf.de/recstitl/22658504.HTM

MediConf World Calendar of Medical Events 2nd International Meeting on Multiple System Atrophy (MSA) neurology, motoric system, movement disorders, atrophy, multiple system atrophy, MSA For details on this meeting and more meetings in the same field visit our Medical Specialty Calendar MediConf lists over 10000 future events including conferences, workshops, seminars, symposia and exhibitions in the fields of medicine, healthcare, pharmacology, and biotechnology. Every medical specialty is included, from allergy to zoonoses. MediConf is an excellent source of information for healthcare professionals and the pharmaceutical industry worldwide. Tel: +49-511-443330, Fax: +49-511-442770, E-mail: mediconf@aol.com

84. Multiple System Atrophy multiple system atrophy (MSA). A consensus conference on the diagnosis of multiple system atrophy set out diagnostic criteria (Gilman et al, 1999). http://www.dizziness-and-balance.com/disorders/central/movement/msa.html

Multiple System Atrophy (MSA) Timothy C. Hain, MD Chicago IL, USA. Please read our Return to Index Search this site Page last modified: March 8, 2004 Multiple system atrophy is a rare neurological disorder characterized by a combination of parkinsonism, cerebellar and pyramidal signs, and autonomic dysfunction. The term "Multiple System Atrophy" is synonymous with striatonigral degeneration (SND) when Parkinsonism predominates, olivopontocerebellar atrophy (OPCA) when cerebellar signs predominate, and Shy-Drager syndrome when autonomic failure is dominant. The incidence (new case per 100,000 person years) for ages 50 to 99 years is 3.0 (Bower et al, 1997), or about half as frequent as it's close relative, progressive supranuclear palsy (PSP) . The mean age of onset is 54. The Parkinsonism of MSA is generally an akinetic rigid syndrome, similar to that of PSP . Rest tremor may occur but is not a predominant feature. Postural instability is common. Parkinsonism is generally the most common initial sign and eventually develops in about 90% of all patients. The cerebellar signs inlude finger-to-nose or heel-shin dysmetria, gait ataxia, intention tremor and nystagmus. Cerebellar signs are the first feature on only about 5% of patients. Cerebellar signs are observed in 50% of cases (Ben-Shlomo et al, 1997). Sporadic OPCA evolves into MSA in roughly 25% of cases within 5 years.

85. Entrez PubMed Click here to read Orthostatic Hypotension in multiple system atrophy. Riley DE. Department of Neurology, Case Western Reserve University http://www.biomedcentral.com/pubmed/11096750

Entrez PubMed Nucleotide Protein ... Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes 3D Domains Domains Gene GEO GEO DataSets HomoloGene Journals MeSH NCBI Web Site OMIM PMC PopSet SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: Sort Author Journal Pub Date Text File Clipboard E-mail Order Curr Treat Options Neurol. 2000 May;2(3):225-230. Related Articles, Links Orthostatic Hypotension in Multiple System Atrophy. Riley DE. Department of Neurology, Case Western Reserve University School of Medicine, 1000 Euclid Avenue, Lakeside 3200, Cleveland, OH 44106, USA. David.Riley@uhhs.com PMID: 11096750 [PubMed - as supplied by publisher] Summary Brief Abstract Citation ASN.1

86. BioMed Central | Abstract | Orthostatic Hypotension In Multiple System Atrophy Opinion Orthostatic Hypotension in multiple system atrophy David E Riley MD Department of Neurology, 1000 Euclid Avenue Lakeside 3200, Case Western Reserve http://www.biomedcentral.com/1092-8480/2/225/abstract

home journals A-Z journals by subject advanced search ... Issue 3 Viewing options Abstract Full text PDF Other links: E-mail to a friend Download references PubMed record Related articles in PubMed Search PubMed For Riley DE Opinion Orthostatic Hypotension in Multiple System Atrophy David E Riley MD Department of Neurology, 1000 Euclid Avenue Lakeside 3200, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA Current Treatment Options in Neurology Abstract There is no known way to cure multiple system atrophy or even to slow its insidious progression, but there are opportunities to treat many of its symptoms and complications. Of all the autonomic disturbances it causes, orthostatic hypotension is asso-ciated with one of the better chances for successful intervention. Milder symptoms may be treated by nonpharmacologic means ( eg , changes in diet and activities and compressive maneuvers and devices). Syncopal patients will require treatment with medications. Midodrine is the most effective drug. It is more physiologic and better tolerated, but much more expensive, than fludrocortisone. The latter is often beneficial but frequently causes lower limb edema. Low-dose propranolol is occasionally useful. Other drugs worth trying are indomethacin and intranasal desmopressin. The variety of measures available to treat orthostatic hypotension in multiple system atrophy affords physicians some prospect of easing the suffering of many patients with this otherwise disabling and discouraging disorder.

87. Arquivos De Neuro-Psiquiatria - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2002000400019&l

88. MDVU Library - Multiple System Atrophy multiple system atrophy or MSA is a neurodegenerative disease marked by a combination of symptoms affecting movement, blood pressure, and other body functions. http://www.mdvu.org/library/disease/msa/

WE MOVE 204 West 84th Street New York, NY 10024 E-mail: wemove@wemove.org Library Movement Disorders Description Symptoms and Complications of Multiple System Atrophy ... Additional Resources Latest Multiple System Atrophy News from E-MOVE Announcement: Movement Disorders Virtual University Is Open Tremor-Ataxia Syndrome From Fragile X Premutation (AAN 2003) Riluzole Is Ineffective in PD and MSA (Movement Disorders Congress 2002) Transcranial Ultrasound for Differential Diagnosis of Parkinsonism (Movement Disorders Congress 2002 ... MSA: Progression, Hypoxia Response Library Search the E-MOVE Archives Multiple System Atrophy Support Organizations Our Mission Professional Services ... Contact Us Multiple System Atrophy Description Multiple system atrophy (MSA) is a neurodegenerative disease marked by a combination of symptoms affecting movement, blood pressure, and other body functions; hence the label "multiple system" atrophy. The cause of MSA is unknown. Various Forms of MSA Symptoms of MSA vary in distribution, onset and severity from person to person. Because of this, three different diseases were initially described to encompass this range of symptoms: Shy-Drager syndrome, striatonigral degeneration, and olivopontocerebellar atrophy. In Shy-Drager syndrome, the most prominent symptoms are those involving the autonomic system, the body system that regulates blood pressure, urinary function, and other functions not involving conscious control. Striatonigral degeneration causes parkinsonian symptoms such as slowed movements and rigidity, while olivopontocerebellar atrophy principally affects balance, coordination, and speech.

89. MDVU Library - Multiple System Atrophy - Treatment Of Multiple System Atrophy multiple system atrophy. Treatment of multiple system atrophy. A number of drugs can be used to treat the various symptoms of MSA, although http://www.mdvu.org/library/disease/msa/msa_tre.html

WE MOVE 204 West 84th Street New York, NY 10024 E-mail: wemove@wemove.org Library Movement Disorders Description Symptoms and Complications of Multiple System Atrophy ... Additional Resources Library Research News Multiple System Atrophy Support Organizations Our Mission Professional Services ... Contact Us Multiple System Atrophy Treatment of Multiple System Atrophy A number of drugs can be used to treat the various symptoms of MSA, although they become less effective as the disease progresses. Levodopa and dopamine agonists used to treat Parkinson's disease are sometimes effective for the slowness and rigidity of MSA. Orthostatic hypotension can be improved with fludrocortisone, midodrine, or other drugs that raise blood pressure. Male impotence may be treated with penile implants or drugs. Incontinence may be treated with medications or catheterization. Constipation may improve with increased dietary fiber or laxatives. A speech-language pathologist may be able to offer strategies for improving swallowing and speaking. Use of softer foods may improve the ability to swallow. A gastrostomy tube, which delivers foods directly to the stomach, is occasionally needed later in the disease course. WE MOVE

90. PillSupplier.com - Conditions And Diseases/Neurological Disorders/Neurodegenerat Category multiple system atrophy. Conditions and Diseases/Neurological Disorders/Neurodegenerative Diseases/multiple system atrophy. Links http://www.pillsupplier.com/dir/248/

Category: Multiple System Atrophy HOME ABOUT US ORDER STATUS BMI CALCULATOR ... CONTACT US Prescription Drugs Diet Pills Adipex Bontril Didrex ... Login Conditions and Diseases/Neurological Disorders/Neurodegenerative Diseases/Multiple System Atrophy Links: EMSA-SG [rate it] [review it] Study group for Multiple System Atrophy. MRI imaging of Multiple System Atrophy by E. Kraft [rate it] [review it] The Combination of Hypointense and Hyperintense Signal Changes on T2-Weighted Magnetic Resonance Imaging Sequences: A Specific Marker of Multiple System Atrophy? Multiple System Atrophy [rate it] [review it] Articel by Timothy C. Hain, MD Northwestern University Medical School, Chicago. Multiple System Atrophy [rate it] [review it] Good Article on MSA by the National Parkinson Foundation. Multiple System Atrophy [rate it] [review it] A short article and a nice .pdf document on MSA by the department of neurology of Mount Sinai School of Medicine (MSSM). Multiple System Atrophy - NeurologyChannel [rate it] [review it] Good article on MSA including MSA anatomy. Multiple System Atrophy: Article by Horacio Kaufmann [rate it] [review it] PDF article about MSA including MRI imaging.

91. NINDS Multiple System Atrophy Information Page More about NINDS multiple system atrophy Information Page. Contact us Content for this page. NINDS multiple system atrophy Information Page. Reviewed 923-2003 http://accessible.ninds.nih.gov/health_and_medical/disorders/msa.htm

Disorders - National Institute of Neurological Disorders and Stroke (NINDS) Skip menus Main sections of the NINDS web site Home About NINDS Disorders-you are in this section ... Find People Disorders section pages and search Image Description Science For the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system. Select Topic Disorder Quick Links Alzheimer's Autism Cerebral Palsy Chronic Pain Epilepsy Headache Multiple Sclerosis Parkinson's Stroke Traumatic Brain Injury More about NINDS Multiple System Atrophy Information Page Studies with patients Research literature Press release NINDS Search (search help) Contact us My privacy NINDS is part of the National Institutes of Health Contact us Content for this page NINDS Multiple System Atrophy Information Page Reviewed 9-23-2003 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Multiple System Atrophy? Is there any treatment? What is the prognosis? What research is being done? ... Related NINDS Publications and Information What is Multiple System Atrophy? Multiple system atrophy (MSA) refers to three slowly progressive related disorders that affect the central and autonomic nervous systems. The disorders are characterized by their foremost symptoms:

92. Disease - Multiple System Atrophy, North Carolina Disease multiple system atrophy, Online Medical Encyclopedia courtesy of University Health Systems of Eastern Carolina serving 29 counties in eastern North http://www.uhseast.com/18575.cfm

Back Email Us Search Centers of Excellence ... Disease Management Disease - Multiple system atrophy Central nervous system Definition: Multiple system atrophy is a degenerative disorder characterized by the following: Progressive damage to the autonomic nervous system (the portion of the nervous system that controls involuntary functions such as blood pressure, heart rate, digestion, and sexual function) Muscle tremor and rigidity Slow movement Alternative Names: Causes And Risk: Multiple system atrophy (MSA) is a rare degenerative condition. Its symptoms are similar to those of in that patients may move slowly, be tremulous, and have a shuffling gait. However, in MSA there is more widespread neurologic damage and damage to the autonomic nervous system (the portion of the nervous system that controls involuntary functions). There is progressive degeneration of the nervous system, with damage to all parts of the nervous system, including the brain. The cause is unknown. MSA develops gradually and is most often diagnosed in men older than 60. Symptoms: Dizziness or fainting when arising or after standing still Impotence Loss of sweating of any part of the body Loss of control of bowels or bladder Vision changes, decreased or

93. THE MERCK MANUAL, Sec. 14, Ch. 179, Disorders Of Movement Information about cerebellar and spinocerebellar disorders. Includes a short discussion about friedreich's ataxia, cerebellar ataxias and multiple systems atrophy. http://www.merck.com/pubs/mmanual/section14/chapter179/179g.htm

This Publication Is Searchable The Merck Manual of Diagnosis and Therapy Section 14. Neurologic Disorders Chapter 179. Disorders Of Movement Topics [General] Tremor Dyskinesias Drug-Induced Movement Disorders ... Idiopathic Orthostatic Hypotension And Shy-Drager Syndrome Cerebellar And Spinocerebellar Disorders Disorders of the cerebellum and its inflow or outflow pathways produce deficits in the rate, range, and force of movement. Anatomically, the cerebellum has three subdivisions. The archicerebellum (vestibulocerebellum) comprises the flocculonodular lobe, helps maintain equilibrium and coordinate eye-head-neck movements, and is closely interconnected with the vestibular nuclei. The midline vermis (paleocerebellum) helps coordinate movement of the trunk and legs. Vermis lesions result in abnormalities of stance and gait. The lateral hemispheres, which make up the neocerebellum, control ballistic and finely coordinated limb movements, predominantly of the arms. Signs of cerebellar disease are listed in Table 179-3.

94. Multisystem Atrophy - Neurologychannel Multisystem atrophy has three cardinal features Parkinsonism (see Parkinson’s); most patients do in fact have some sort of frontal system impairment and may http://www.neurologychannel.com/msa/

Home Search SiteMap Ask the Dr. ... Medical Store advertisement MULTISYSTEM ATROPHY Overview Anatomy of MSA Diagnosis Treatment CONDITIONS ADHD ALS Alzheimer's Disease Autism ... Carpal Tunnel Syndrome Cephalic Disorders Cerebral Palsy Charcot-Marie-Tooth Disease Chronic Pain Dementia Encephalitis Epilepsy ... Guillain-Barre Syndrome Headache Huntington's Disease Hydrocephalus Lou Gehrig's Disease ... Traumatic Brain Injury Vertigo TREATMENT OPTIONS Botulinum Toxin Therapy Epidural Injection Trigger Point Injection Vagus Nerve Stimulation RESOURCES neurologychannelMD Clinical Trials Links MDLocator ... What Is a Neurologist? Videos ABOUT US Healthcommunities.com Pressroom Testimonials Overview Multisystem atrophy (MSA) is a group of rare, multisystem degenerative diseases that have several clinical features of Parkinson’s and are sometimes referred to as the "Parkinsonism-plus syndromes." When MSA was first identified in 1960 it was named "Shy-Drager Syndrome" after the two physicians who first described its symptoms. Now, Shy-Drager Syndrome is recognized as only one of three manifestations of multisystem atrophy. The other two are Striatonigral Degeneration and Olivopontocerebellar Atrophy (OPCA) . The three are lumped together as MSA because of their clinical overlap and neuroanatomical similiarities. Multisystem atrophy has three cardinal features: Parkinsonism (see Parkinson’s Autonomic failure (including orthostatic hypotension

95. SDS/MSA Support Group Welcome to our Web Site. Our Sponsor since 1992. www.shire.com. Last Updated May 14, 2004. http://www.shy-drager.org/

Welcome to our Web Si te Our Sponsor since 1992 www.shire.com Last Updated May 14, 2004 ADDRESS CHANGE The National Headquarters for the SDS/MSA Support Group has changed to: SDS/MSA Support Group P.O. Box 279 Coupland, TX. 78615 The old address: 2004 Howard Lane, Austin. TX. 78728 will be forwarded to the new address: The MSA FAQ page has been updated. It is a 22 page by Robert Shu. We thank him for all this information and his hard work putting it together.. TOLL FREE TELEPHONE NUMBER 1-866-SDS-4999 (866-737-4999) The SDS/MSA Support Group has another web site www.shy-drager-syndrome.org to enhance the knowledge and accessibility of knowledge for our family of internet users. http://www.shy-drager-syndrome.org/charity-mall.html is a location you can shop online and these stores will donate a percentage of your purchases to SDS/MSA Support Group YOU ARE OUR VISITOR! Webmaster: Sylvia Summers

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