101. Multiple Myeloma - James P. Wilmot Cancer Center - Rochester, NY Louis Constine MD. multiple myeloma. What is multiple myeloma? If you are experiencing any of these symptoms, see your doctor. Diagnosing multiple myeloma. http://www.stronghealth.com/services/cancer/aboutcancer/multiplemyeloma.cfm

@import "/css/Strongw3c.css"; Search: Search Help Cancer Center Home Patient Care Home Our Team ... Request an Appointment More Information Cancer Center News Cancer Center Clinical Trials Dialogue Newsletter Patient Care Find out about our clinical trials for: Multiple Myeloma National cancer clinical trials Our Specialists Camille Abboud M.D. Steven Bernstein M.D. Jainulabdeen J. Ifthikharuddin M.D. Jeffrey Lancet M.D. ... Louis Constine M.D. Multiple Myeloma What is Multiple Myeloma? Risk Factors At this time, doctors and scientists do not know exactly what causes multiple myeloma, or how to prevent it. Although there do not appear to be any clear risk factors, current research suggests the following: Age.

102. Multiple Myeloma Clinical Trials multiple myeloma Research Treatment. The Resources What is multiple myeloma? multiple myeloma is a cancer of the body s plasma cells. http://www.fhcrc.org/cancer_info/diseases/myeloma/

@import "/wrapper/fhcrc.css"; HOME Multiple Myeloma Multiple Myeloma Treatment Options Clinical Trials Treatment Team Other Resources The purpose of these web pages is to inform patients, their families, and the wider community about the Fred Hutchinson Cancer Research Center's clinical trials (protocols) for treatment of multiple myeloma. Researchers at the Hutchinson Center develop experimental protocols based on their research, and also participate in experimental protocols developed by other cancer researchers. At this site you will find: Treatment Options List and Description of Open Clinical Trials Research and Treatment Team Links to Other Resources What is multiple myeloma? Multiple myeloma is a cancer of the body's plasma cells. Plasma cells are normally present in the bone marrow (making up less than 5% of the bone marrow) and are responsible for the production of antibodies when the body is dealing with infection. Cancerous plasma cells (myeloma cells) build up in the bone marrow, interfering with normal immune response and bone marrow production of normal blood cells. These myeloma cells invade and damage the bone, causing tumors (myelomas) to form. Myeloma cells then travel to other sites in the body, causing further tumors (hence the name "multiple myeloma"). Common features or symptoms of multiple myeloma are bone pain (especially with movement), anemia, fatigue, hypercalcemia, and increased incidence of infections (such as bladder or kidney infections, skin infections, pneumonia, or sinusitis).

103. CancerConsultants - Patient Resource Center: Cancer News multiple myeloma. November 2002, VAD with Pegylated Liposomal Doxorubicin (Doxil®) Represent New Option for Treatment of multiple myeloma Treatment. http://www.cancerconsultants.com/patient/news_intro.php?article=myeloma_news_int

104. The Cancer Council Victoria - Multiple Myeloma multiple myeloma. Contained in this section are the following http://www.accv.org.au/cancer1/patients/myeloma/myeloma.htm

Home Cancer patients Cancer information Multiple myeloma Multiple myeloma Contained in this section are the following: What is cancer? Tell me more about multiple myeloma How is multiple myeloma diagnosed? What treatments are available? ... What help is available? Last updated: December 2002 Top of page Select a topic Asbestos and cancer Bladder cancer Bowel cancer Brain cancer Breast cancer Cervical cancer Kidney cancer Leukaemia Lung cancer Lymphoma Melanoma Mouth, nose and throat cancer Multiple myeloma Ovarian cancer Pancreatic cancer Prostate cancer Stomach cancer Uterine cancer Advanced cancer - carers Advanced cancer - patients Chemotherapy Radiotherapy Eating well Fatigue Relaxation Cancer dictionary Clinical trials Hair loss Jump to another patient information topic About us Cancer patients Health professionals Preventing cancer ... What's new

105. Virtual Hospital: ElectricPE: The Diagnosis Of Pulmonary Embolism: Multiple Myel multiple myeloma. This case is a 51 year old male with known multiple myeloma who returned for his third course of chemotherapy. http://www.vh.org/adult/provider/radiology/ElectricPE/Patients/Case13.html

For Providers ElectricPE: The Diagnosis of Pulmonary Embolism: Case Study 13 Multiple Myeloma Jeffrey R. Galvin, M.D. and James J. Choi, B.S. Peer Review Status: Externally Peer Reviewed by the AMA This case is a 51 year old male with known multiple myeloma who returned for his third course of chemotherapy. During the admissions history and physical the patient reported a one week history of left posterior pleuritic chest pain that felt better when he rubbed the area with his hand. He had dyspnea on exertion but not at rest. He denied cough, fever, or hemoptysis. He also reported an episode of left lower extremity pain that began 3 weeks ago. The pain has decreased but the swelling has persisted. His arterial blood gases on admission were PH 7.45 Pco2 33 Po2 64 He had a low grade temperature 37.9 The chest x-ray showed a pleural based density in the left costophrenic angle and a linear density in the posterior aspect of the left lower lobe. The perfusion scan showed an area of decreased perfusion in the posterior aspect of the left lower lobe that matched the area of infiltrate in the left lower lobe on the chest radiograph. The ventilation scan showed decreased ventilation in the posterior aspect of the left lower lobe.

106. FORCES - SMOKING DOES NOT CAUSE MULTIPLE MYELOMA Back to The evidence. SMOKING DOES NOT CAUSE multiple myeloma. Is cigarette smoking a risk factor for nonHodgkin s lymphoma or multiple myeloma? http://www.forces.org/evidence/carol/carol31.htm

Forces International Back to The evidence SMOKING DOES NOT CAUSE MULTIPLE MYELOMA Back to main page When the Mills study of multiple myeloma among Seventh-Day Adventists claimed in 1990 that smokers had over three times the risk of non-smokers, the national media eagerly trumpeted it as yet another new danger of smoking. This was despite the fact that previous studies actually found a slightly reduced overall risk among smokers, and that Mills' 21 cases represented not even 3% of the multiple myeloma cases studied to that date. It's a classic "little tiny study with a great big headline." Just as important is the basic epidemiological principle that cases and controls should be as ALIKE as possible except in the condition or protocol being studies. Seventh-Day Adventists are not representative of the general population. Their drinking, smoking, dietary and exercise habits are well outside the parameters of the population at large. In effect, using them as a "control group" is not only scientifically unsound; it borders on the absurd.. What is more, even Mills et al. later admitted that

107. UM CCC - Information Guide - Multiple Myeloma multiple myeloma Information Guide. The Leukemia Lymphoma Society. Myeloma multiple myeloma Research Foundation. multiple myeloma A Disease Overview. http://www.cancer.med.umich.edu/learn/pwmyeloma.htm

U-M Health System U-M Medical School U-M Gateway Information Guides PERC Search our Catalogue Ask a Question Information Guides ... Staff and Contact Information See Also: Clinic and Treatment Areas Clinical Trials Community Events Cancer Nutrition Services Multiple Myeloma Information Guide The purpose of this information guide is to help patients newly diagnosed with Multiple Myeloma find sources of information and support. This list is not meant to be comprehensive, but rather to provide starting points for information seeking. The materials can be found at the Patient Education Resource Center of the University of Michigan Comprehensive Cancer Center, in room B1-361. Print-friendly version of this guide Pamphlets Available free at the Patient Education Resource Center on Level B-1 Myeloma Multiple Myeloma Research Foundation.

108. Multiple Myeloma multiple myeloma is a cancer of plasma cells. In multiple myeloma, abnormal plasma cells grow rapidly and uncontrollably to form tumors in bone. http://www.cancer.med.umich.edu/learn/myeloma.htm

U-M Health System U-M Medical School U-M Gateway Multiple Myeloma Education: Disease and Treatment Information Adult Hematology Clinic main page Hematology Oncology Information main page ... Support Groups Questions and Answers What is multiple myeloma? How does it occur? What are the symptoms? How is it diagnosed? ... How can I take care of myself? What is multiple myeloma? Multiple myeloma is a cancer of plasma cells. Plasma cells are white blood cells made in the bone marrow, which is the spongy tissue inside bones. Normal plasma cells make antibodies to fight infection. In multiple myeloma, abnormal plasma cells grow rapidly and uncontrollably to form tumors in bone. They make abnormal antibodies, which are not useful, and the tumors interfere with the growth and function of normal cells made by the bone marrow. This results in anemia and lowered resistance to infection. Fewer blood platelets are produced, so your blood clots more slowly than normal. The uncontrolled production of plasma cells in the bone marrow also causes pain in the bones. Bone tissue may be destroyed, and the bones may break more easily. Calcium from destroyed bone tissue can accumulate in the blood and damage the kidneys. Collapsed bones in the spine may compress nerves, causing numbness or paralysis. If it is not treated, multiple myeloma can spread throughout your body and be fatal.

109. Sloan-Kettering - Multiple Myeloma multiple myeloma is a cancer of the bone marrow that arises when plasma cells white blood cells that produce infectionfighting antibodies become http://www.mskcc.org/mskcc/html/3371.cfm

var tab = tabs[tabs.length] = []; tab.id = 12; var TAB_WWWROOT = "/mskcc/"; var tabDarkColor = "#336699"; var tabMediumColor = "#99BBCC"; createHeaderImageCache(44,512,5626,1072,5664,638,8228); formatTabs(tabs); Cancer Information Types of Cancer Multiple Myeloma Multiple Myeloma Select a Multiple Myeloma Topic - Overview - Risk Factors - Symptoms - Diagnosis - Staging - Treatment - Pain Management - After Treatment Multiple myeloma is a cancer of the bone marrow that arises when plasma cells white blood cells that produce infection-fighting antibodies become malignant and invade the marrow. In this section you can find up-to-date information about multiple myeloma, and learn about Memorial Sloan-Kettering's expertise in caring for patients with this disease. Overview In 2001, about 14,400 people in the United States will be diagnosed with multiple myeloma. The number of new cases diagnosed each year has increased over the past decades, for reasons not well understood. Risk Factors In most cases, patients with multiple myeloma have no known risk factors. Symptoms The symptoms of multiple myeloma most commonly include one or more of the following: bone pain and skeletal fractures; infections; weight loss; hypercalcemia; loss of kidney function; hyperviscosity.

110. Multiple Myeloma - St. Luke's Episcopal Health System multiple myeloma is a cancer that arises from a proliferation of a particular type of white blood cells, namely, the plasma cell. http://www.sleh.com/sleh/Section004/index.cfm?pagename=Multiple Myeloma&PageMD=M

111. Multiple Myeloma Information Cancersource.com offers a wealth of multiple myeloma information including, treatment, symptoms and prevention. multiple myeloma Information. http://www.cancersource.com/20.cfm

Advertisement Multiple Myeloma Information CancerSource.com offers a wealth of multiple myeloma information and resources. Click here to access all the multiple myeloma information features on our site, including disease-specific multiple myeloma information, live chats, news, events, and more. CancerSource.com offers the multiple myeloma information you need to help with early detection and to manage your situation if you have already been diagnosed. Although being diagnosed with multiple myeloma is never easy, patients will find more multiple myeloma information and more treatment choices than ever before. On CancerSource.com, you will find the multiple myeloma information you need to make informed decisions about your health. Below is a list of general multiple myeloma information as well as more specific multiple myeloma information offered by Cancersource.com. General multiple myeloma information includes: Information on support groups News about multiple myeloma Features, events, and resources all related to multiple myeloma information Managing challenges of multiple myeloma Specific information on multiple myeloma includes: Disease-specific multiple myeloma information Multiple myeloma treatment options and possible side effects Information on multiple myeloma symptoms Information on multiple myeloma prevention For more information on multiple myeloma

112. Cancer Control Journal: Table Of Contents Developing a Model for multiple myelomaNational Institutes of Health (NIH) National Cancer Institute Developing a Model for multiple myeloma. RO CITY STATE 54.40.01.B2329, Bethesda, MD 20892. http://www.moffitt.usf.edu/pubs/ccj/v5n3/toc.html

May / June 1998 Biology of the Transition of Monoclonal Gammopathy of Undetermined Significance (MGUS) to Multiple Myeloma John A. Lust, MD, PhD, and Kathleen A. Donovan, PhD Management of Myeloma: Current and Future Approaches Martin M. Oken, MD Interferon in the Treatment of Multiple Myeloma Chaim Shustik, MD, FRCP(C) Hematopoietic Cell Transplantation for Multiple Myeloma William I. Bensinger, MD Guest Editorial: Overview of the Advances in the Treatment of Multiple Myeloma William S. Dalton, PhD, MD Cancer Economics: Contracting With a Medicare HMO Albert B. Einstein, Jr, MD, Patricia J. Goldsmith, and David W. Maberry, MHA Imaging in Oncology: Thallium Imaging of the Brain Claudia G. Berman, MD Ten Best Readings on Multiple Myeloma and Plasma Cell Dyscrasias William S. Dalton, PhD, MD Infections in Oncology: Sternoclavicular Joint Septic Arthritis Ines I. Mbaga, MD, John N. Greene, MD, and Ramon L. Sandin, MD Information for Cancer Patients Special Report: The Generalist Finds a Niche in a Comprehensive Cancer Center A Decade of Growth at the University of Texas M.D. Anderson Cancer Center Carmen P. Escalante, MD; Ellen F. Manzullo, MD; Mary Ann Weiser, MD, PhD; and Edward B Rubenstein, MD Clinical Research Protocols for Multiple Myeloma Calendar of Events In the Next Issue CME Instructions ... Pretest Posttest expired Back to the Cancer Journal Index For comments mail to: ccjournal@moffitt.usf.edu

113. NEJM -- Antitumor Activity Of Thalidomide In Refractory Multiple Myeloma Original Article from The New England Journal of Medicine Antitumor Activity of Thalidomide in Refractory multiple myeloma. Treatment of multiple myeloma. http://content.nejm.org/cgi/content/short/341/21/1565

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 341:1565-1571 November 18, 1999 Number 21 Next A correction has been published: N Engl J Med 2000;342(5):364 Antitumor Activity of Thalidomide in Refractory Multiple Myeloma Seema Singhal, M.D., Jayesh Mehta, M.D., Raman Desikan, M.D., Dan Ayers, M.S., Paula Roberson, Ph.D., Paul Eddlemon, B.S., Nikhil Munshi, M.D., Elias Anaissie, M.D., Carla Wilson, M.D., Ph.D., Madhav Dhodapkar, M.D., Jerome Zeldis, M.D., Bart Barlogie, M.D., Ph.D., David Siegel, M.D., Ph.D., and John Crowley, Ph.D. Full Text PDF Editorial by Raje, N. ... Chapters at Harrison's ABSTRACT Background Patients with myeloma who relapse after high-dose chemotherapy have few therapeutic options. Since increased bone marrow vascularity imparts a poor prognosis in myeloma, we evaluated the efficacy of thalidomide, which has antiangiogenic properties, in patients with refractory disease. Methods Eighty-four previously treated patients with refractory myeloma (76 with a relapse after high-dose chemotherapy) received oral thalidomide as a single agent for a median of 80 days (range

114. BioSpace News: Multiple Myeloma BioSpace News multiple myeloma. multiple myeloma is the second most common blood cancer in the United States affecting approximately 50,000 people. http://www.biospace.com/news_rxtarget.cfm?RxTargetID=230

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