41. MMSupport.Net Support resource for multiple myeloma includes information, links and a forum. http://www.mmsupport.net/

MMSupport.Net Home Main Menu Home FAQs Articles Forums ... Tell a Friend Hit Counter 2091 Visitors Who's Online We have 2 guests online Free Anti-Virus Keep your computer safe from viruses and worms. If you don't already have an anti-virus program installed on your computer, click here to download this free 90 day trial from ComputerAssociates. Login Username Password Remember me Forgotten your password No account yet? Create one Welcome Welcome to MMSupport! This web site has been created for those of us with Multiple Myeloma, our caregivers and friends and family to use as a resource. The content is 100% contributed by members. You're encouraged to contribute content about your experiences in order to help others learn by sharing your knowledge. You may use the "Contact Us" link to send your stories, news or comments. Thanks for visiting! Wednesday, 02 June 2004 Osteonecrosis Of The Jaws The International Myeloma Foundation released a special advisory related to the possibility of bisphosphonate-related osteonecrosis of the jaws. Please read the IMF advisory by clicking on the following link. Sodium bicarbonate may prevent radiocontrast-induced renal injury Substituting a sodium bicarbonate solution for saline infusion prior to administration of radiocontrast material seems to reduce the incidence of nephropathy, according to a report in the Journal for the American Medical Association for May 19.

42. Treating Refractory Multiple Myeloma With VAD Plus Valspodar Treatment of multiple myeloma With VAD Plus Valspodar. A review article by Mohamad Hussein, MD. Treating Refractory multiple myeloma With VAD Plus Valspodar http://www.cancernews.com/myeloma/therapies1999.htm

Click over the LOGO below to visit CancerNews.com This site is a service of CancerNews.com Treating Refractory Multiple Myeloma With VAD Plus Valspodar Published online November 1999 By Mohamad Hussein, M.D. Dr. Mohamad Hussein is a Board Certified Oncologist (specialist in the treatment of adult cancers), Staff at the Cleveland Clinic Cancer Center, and Director, Cleveland Clinic Multiple Myeloma Programs . He directs clinical trials and designs treatment programs for Chronic Leukemia's and Multiple Myeloma at the South West Oncology Group "SWOG", a national cooperative group devoted to the treatment of adult cancers. This article is provided for information purposes only. It is not intended to be used for medical advice. Please read Clinical trials have demonstrated the safety and efficacy of this novel MDR modulator in chemotherapy-refractory MM patients. Sonneveld et al reported the first phase I trial (a study evaluating the safety of the drug) of valspodar in 22 patients with VAD- or melphalan-refractory MM.(Sonneveld, Leukemia, 1996; 10:1741-1750) In this study, patients were treated with three cycles of VAD plus an escalating dose of valspodar (2.5 to 15 mg/kg). The dose-limiting toxicities were myelosuppression (bone marrow suppression) and neuropathy (nerve damage. Because valspodar inhibits the normal clearance of some chemotherapeutic agents (eg, doxorubicin) via the liver and kidneys, it increases the drug levels in patients. Consequently, dose reductions, depending on the specific agent, are required. This does not, however, compromise the therapeutic efficacy of the chemotherapy regimen.

43. ACS :: What Is Multiple Myeloma? Detailed Guide multiple myeloma. What is multiple myeloma? multiple myeloma is a type of cancer formed by malignant plasma cells. http://www.cancer.org/docroot/cri/content/cri_2_4_1x_what_is_multiple_myeloma_30

Home Community Get Involved Donate ... Search GetRandomImage("headerImage", "jpg", 121, 77, 30); My Planner Register Sign In Cancer Reference Information ... Treatment Decision Tools Detailed Guide: Multiple Myeloma What is Multiple Myeloma? Multiple myeloma is a type of cancer formed by malignant plasma cells. Normal plasma cells are an important part of the immune system. The immune system is composed of several types of cells that work together to fight infections and other diseases. Lymphocytes (lymph cells) are the main cell type of the immune system. There are two types of lymphocytes: T cells and B cells. When B cells respond to an infection, they mature and change into plasma cells. Plasma cells produce and release proteins called antibodies (or immunoglobulins) to attack and help kill disease-causing germs such as bacteria. When plasma cells grow out of control, they can produce a tumor. These tumors can grow in several sites, particularly in the soft middle parts of bone marrow When these tumors grow in multiple sites, they are referred to as multiple myeloma.

44. ACS :: Detailed Guide: Multiple Myeloma Detailed Guide multiple myeloma. Get complete information about each of the topics below. Get PrinterFriendly Document multiple myeloma Detailed Guide. http://www.cancer.org/docroot/CRI/CRI_2_3x.asp?dt=30

45. Multiple Myeloma multiple myeloma. This section of CancerHelp UK tells you about multiple myeloma. You services. Forward to About multiple myeloma. http://www.cancerhelp.org.uk/help/default.asp?page=4746

46. Treating Multiple Myeloma Treating multiple myeloma. This section tells you about the treatment for multiple myeloma. You can choose from the following menu The stages Which treatment? http://www.cancerhelp.org.uk/help/default.asp?page=4749

47. EMedicine - Multiple Myeloma : Article By Sara Grethlein, MD multiple myeloma multiple myeloma is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown http://www.emedicine.com/med/topic1521.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Hematology Multiple Myeloma Last Updated: October 20, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: plasma cell myeloma, Kahler's disease, Kahler disease, plasma cell dyscrasia, plasma cell leukemia, leukopenia, anemia, thrombocytopenia, bone pain, hypercalcemia, spinal cord compression, hyperviscosity, amyloidosis, renal failure, monoclonal gammopathy of unknown significance, MGUS AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Sara Grethlein, MD , Course Director, Practice of Medicine, Associate Professor, Department of Internal Medicine, Division of Hematology and Oncology, State University of New York at Upstate Sara Grethlein, MD, is a member of the following medical societies: American Society of Hematology Editor(s): Koyamangalath Krishnan, MD, FRCP

48. EMedicine - Multiple Myeloma : Article By Steven M Sorenson, MD multiple myeloma multiple myeloma is the most common primary neoplasm of the skeletal system. The disease is a malignancy of plasma cells. multiple myeloma. http://www.emedicine.com/radio/topic460.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Radiology Musculoskeletal Multiple Myeloma Last Updated: December 7, 2001 Rate this Article Email to a Colleague Synonyms and related keywords: plasma cell myeloma, myeloma AUTHOR INFORMATION Section 1 of 12 Author Information Introduction Differentials X-ray ... Bibliography Author: Steven M Sorenson, MD , Staff Physician, Department of Radiology, University of California at San Diego Medical Center Coauthor(s): Amilcare Gentili, MD , Consulting Staff, Clinical Professor of Radiology, Department of Radiology, University of California at San Diego -Thornton Hospital Sulabha Masih, MD , Associate Professor of Diagnostic Radiology, University of California at Los Angeles; Consulting Staff, Department of Radiology, Section of Musculoskeletal Radiology, West Los Angeles Veterans Affairs Medical Center Carol Andrews, MD , Director, Spinal Injection Service, Assistant Professor, Department of Radiology, Section of Musculoskeletal Radiology, University of California at Los Angeles School of Medicine Steven M Sorenson, MD, is a member of the following medical societies:

49. 140.251.160.91/ multiple myelomamultiple myeloma. most common primary malignant neoplasm of bone; 5070y; MF 21. symptoms vague bone pain of progressive severity http://140.251.160.91/

50. FDA Approves Velcade For Multiple Myeloma Treatment FDA Approves Velcade for multiple myeloma Treatment. Another trial in 54 patients with relapsed multiple myeloma showed similar responses. http://www.fda.gov/bbs/topics/NEWS/2003/NEW00905.html

FDA Home Search FDA Site A-Z Index Contact FDA FDA News FOR IMMEDIATE RELEASE May 13, 2003 Media Inquiries: 301-827-6242 Consumer Inquiries: 888-INFO-FDA FDA Approves Velcade for Multiple Myeloma Treatment The Food and Drug Administration (FDA) today announced the approval of Velcade (bortezomib) injection, a new treatment for multiple myeloma, a cancer of the bone marrow. FDA reviewed the application for this drug in less than four months. Velcade is the first in a new class of anticancer agents known as proteasome inhibitors. Velcade was approved under the accelerated approval program. The program helps make promising products for serious or life threatening diseases available earlier in the development process by allowing approval to be based on a promising effect of the drug, such as tumor shrinkage, before there is actual evidence of improved survival or other clinical benefit. The drug’s commercial sponsor worked closely with FDA to define the studies that would be conducted. "As a result of close collaboration among the company, The National Cancer Institute, and FDA in the development and review of the drug, FDA was able to make this novel therapy available sooner to help many thousands of patients suffering from multiple myeloma." said FDA Commissioner Mark B. McClellan, M.D., Ph.D. "The approval of Velcade illustrates FDA’s commitment to providing patients with access to safe and effective drugs as quickly as possible."

51. Hematopathology The skull demonstrates the characteristic rounded punched out lesions of multiple myeloma. http://medlib.med.utah.edu/WebPath/HEMEHTML/HEME039.html

The skull demonstrates the characteristic rounded "punched out" lesions of multiple myeloma.

52. Hematopathology At low power, the abnormal plasma cells of multiple myeloma fill the marrow. http://medlib.med.utah.edu/WebPath/HEMEHTML/HEME041.html

At low power, the abnormal plasma cells of multiple myeloma fill the marrow.

53. Cancer Care multiple myeloma Home. CancerCare Support. CancerCare Connect. CancerCare Inform. To get expert information on managing your cancer, click here. multiple myeloma. http://www.cancercare.org/MultipleMyeloma/MultipleMyelomamain.cfm

Multiple Myeloma Home CancerCare Support CancerCare Connect CancerCare Inform ... Medical Information Cancer affects not only your body, but your whole life: your job, your family, your hobbies and activities. To get expert information on managing your cancer, click here Multiple Myeloma Cancer Care Cancer Care offers free counseling for individuals and groups in three different ways: face-to-face , on the telephone , or online Cancer Care Our popular Telephone Education Workshops provide cancer patients and healthcare professionals with the opportunity to listen to and ask questions of top cancer experts from around the country. View our calendar of upcoming workshops or listen to a previously recorded workshop Cancer Care Cancer Care offers numerous educational workshops and fact sheets (briefs) to help people with cancer and their loved ones cope with the day-to-day problems associated with the disease. Topics range from managing side effects, to legal issues, to eating well during treatment. Cancer Care Our website is more than just an informational resource. Visitors can communicate with a social worker, join an online support group, and learn about topics ranging from managing careers to talking to your families during a time of crisis. Cancer Care When you or a loved one is struggling with the difficulties of a cancer diagnosis, paying bills related to medical treatment can sometimes be overwhelming. Cancer

54. Cancer Care : Multiple Myeloma multiple myeloma, multiple myeloma. multiple myeloma. American Cancer Society Get detailed information on liver cancer from the American Cancer Society. http://www.cancercare.org/InternetLinks/InternetLinks.cfm?ID=3640&c=123

55. Multiple Myeloma Education Network Home Learn more. Therapies Show Promise New research is encouraging for the treatment of relapsing or refractory multiple myeloma. Do http://www.healthtalk.com/multiplemyeloma/index.cfm

Select a Condition Breast Cancer CLL Colon Cancer Crohn's Disease Lymphoma Multiple Myeloma Multiple Sclerosis Psoriasis Rheumatoid Arthritis Other Conditions The Latest Treatment Updates Tuesday, June 15 at 8 p.m. Eastern (5 p.m. Pacific) In-person (Seattle), on the phone and on the Internet Therapies Show Promise : New research is encouraging for the treatment of relapsing or refractory multiple myeloma. Before you were diagnosed with multiple myeloma, did you consider yourself at risk for the disease? Welcome to the Multiple Myeloma Education Network Whether you're living with multiple myeloma or caring for someone with this disease, you'll find the latest information and resources right here. Submit questions and read our Ask the Doctor column , take our weekly interactive poll and subscribe to our newsletter to see poll results and stay up to date. Ask the Doctor We partner with national experts who can get your questions answered about multiple myeloma. Search our growing list of questions we've already answered. The Latest Clinical Trials Update Clinical trials look promising for the treatment and, hopefully, remission of multiple myeloma.

56. Relapsing And Refractory Multiple Myeloma: What's New In Research This is a HealthTalk program about what s new in research for relapsing and refractory multiple myeloma. http://www.healthtalk.com/multiplemyeloma/interviews/siegel/index.cfm

Select a Condition Breast Cancer CLL Colon Cancer Crohn's Disease Lymphoma Multiple Myeloma Multiple Sclerosis Psoriasis Rheumatoid Arthritis Other Conditions Relapsing and Refractory Multiple Myeloma: What's New in Research? If treatment for your multiple myeloma has either failed or is no longer effective, exploring your options is critical. New therapies in the research pipeline are providing hope for people living with relapsing/refractory multiple myeloma. In this informative program, top multiple myeloma experts discuss new clinical trials for relapsing/refractory multiple myeloma, and one women shares her experience participating in a clinical trial. Understanding Relapsing/Refractory Multiple Myeloma FDA-Approved Treatments for Multiple Myeloma Clinical Trials for Relapsing/Refractory Multiple Myeloma Clinical Trial: CC-5013 Combined with Dexamethasone ... Stay Informed of Your Treatment Options This program was produced by HealthTalk in partnership with the International Myeloma Foundation David Siegel, M.D., Ph.D. Gail Tonks, Patient Advocate Brian Durie, M.D., host

57. Discovery Health Multiple Myeloma multiple myeloma occurs when a specialized white cell, known as a plasma cell, becomes cancerous. multiple myeloma. By Miriam P. Rogers, EdD, RN, AOCN, CNS. http://health.discovery.com/diseasesandcond/encyclopedia/2555.html

58. Multiple Myeloma Resources Directory - CancerIndex multiple myeloma is most common in people aged over 60, and is rare before the age of 40. Menu multiple myeloma Resources Directory. http://www.cancerindex.org/clinks2v.htm

Home Site Map Cancer Types Treatments ... About Multiple Myeloma Resources Directory Home Cancer Types Hematological Multiple Myeloma Multiple myeloma (also known as myelomatosis or myeloma) is a cancer in which there is abnormal growth in the number of plasma cells in the bone-marrow and blood. This can suppress the normal production of blood cells, including those associated with the body's immune system. The plasma cells may collect in the bone to make small tumours known as plasmacytomas. Multiple myeloma is most common in people aged over 60, and is rare before the age of 40. Menu: Multiple Myeloma Resources Directory Myeloma Organisations Information for Patients and the Public Information for Health Professionals / Researchers Molecular Biology of Multiple Myeloma Haematological Malignancies Myeloma Organisations (10 links) Cancer and Leukemia Group B (CALGB) (USA) multidisciplinary cooperative cancer treatment group, NCI / NIH International Meyeloma Foundation - UK (UK) The IMF established an office in Edinburgh in April 1997. IMF-UK is a registered charity. This site provides details about the organisation, support groups, meetings, newsletters and other related information. International Myeloma Foundation This site contains details of the IMF, telephone hotline, and information packs. Online resources include a newsletter, email discussion group, and patient handbook. Also there is information for researchers: grant applications etc.

59. CTCA Multiple Myeloma Treatment Overview If you have been diagnosed with multiple myeloma, CTCA can provide you with treatment options designed to help give you every tool available to help you fight http://www.cancercenter.com/multiple-myeloma.cfm

About Us Patient Services Your Treatment Options After Care Services ... Advanced Search Multiple Myeloma Cancer Center Overview Conventional Treatments Radiation Therapy External Beam Radiation ... Detection Tools Quick Links Clinical Trials CTCA News Employment Seminars ... Cancer Treatment Multiple Myeloma Cancer Center Overview To Learn More About This Topic: Chat with Us Email Us Multiple myeloma is a type of cancer that affects the plasma type of white blood cells. Myeloma cells tend to collect in the bone marrow and in the hard, outer part of bones. Sometimes they collect in only one bone and form a single mass, or tumor, called a plasmacytoma. In most cases, however, the myeloma cells collect in many bones, often forming many tumors and causing other problems. When this happens, the disease is called multiple myeloma. Please note that cancer is classified by the type of cell, or the part of the body, in which the disease begins. Although plasmacytoma and multiple myeloma affect the bones, they begin in cells of the immune system. This type of cancer is different from bone cancer, which actually begins in cells that form the hard, outer part of the bone. You should know this because the diagnosis and treatment of plasmacytoma and multiple myeloma are different from the diagnosis and treatment of bone cancer. According to the International Myeloma Foundation, there are over 13,500 new cases of Myeloma in the U.S. each year, representing twenty percent of blood cancers, and one percent of all types of cancer. The incidence varies from country to country, with a low of 1 in 100,000 in China to approximately 1 in 400,000 in most Western industrialized countries. Myeloma is more common in blacks that whites, with the male/female ratio 3:2. The incidence rises with age. Better diagnostic techniques and the higher average age of the general population may explain the rising incidence of myeloma over the past several decades. More patients under age 55 are being diagnosed with myeloma; risk factors include exposure to atomic radiation, petroleum products, pesticides, solvents, heavy metals and and airborne particles.

60. Multiple Myeloma Cancer Treatment: Stem Cell Rescue The experts at Cancer Treatment Centers of America offer stem cell rescue as one of many treatment options for multiple myeloma. multiple myeloma Cancer Center. http://www.cancercenter.com/multiple-myeloma/autologous-stem-cell-rescue.cfm

About Us Patient Services Your Treatment Options After Care Services ... Advanced Search Multiple Myeloma Cancer Center Overview Conventional Treatments Radiation Therapy External Beam Radiation ... Detection Tools Quick Links Clinical Trials CTCA News Employment Seminars ... Multiple Myeloma Multiple Myeloma Cancer Center Autologous Stem Cell Rescue To Learn More About This Topic: Chat with Us Email Us The experts at Cancer Treatment Centers of America offer autologous (from the self) bone marrow transplant and stem cell rescue as one of many treatment options for Multiple Myeloma. This treatment uses your own bone marrow and peripheral stem cells to overcome the bone marrow destroying effects of high dose chemotherapy and radiation therapy. This program may be an appropriate treatment option for you if you have multiple myeloma. The bone marrow transplant procedure involves giving you high-dose chemotherapy, with or without radiation, to kill cancer cells. This is called conditioning. The conditioning regimen also destroys normal bone marrow cells (stem cells). Because of this, these normal cells need to be replaced. After the conditioning is completed, you will be "rescued" by the infusion of healthy stem cells, which have been collected from either you (prior to chemotherapy) or a donor. Stem cells can be collected from the circulating blood or from the bone marrow. The transplant occurs when these healthy stem cells are given back to you, in the case of autologous stem cell rescue, or to you from a donor.

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