1. NINDS Mobius Syndrome Information Page mobius syndrome (Congenital Facial Diplegia) information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS). http://www.ninds.nih.gov/health_and_medical/disorders/mobius.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about Mobius Syndrome Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health NINDS Mobius Syndrome Information Page Synonym(s): Congenital Facial Diplegia Reviewed 9-10-2003 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Mobius Syndrome? Is there any treatment? What is the prognosis? What research is being done? ... Organizations What is Mobius Syndrome? Mobius syndrome is a rare birth defect caused by the absence or underdevelopment of the 6th and 7th cranial nerves, which control eye movements and facial expression. The first symptom, present at birth, is an inability to suck. Other symptoms can include: feeding, swallowing, and choking problems; excessive drooling; crossed eyes; lack of facial expression; inability to smile; eye sensitivity; motor delays; high or cleft palate; hearing problems; and speech difficulties. Small or absent brain stem nuclei that control the cranial nerves, as well as decreased numbers of muscle fibers, have been reported. Deformities of the tongue, jaw, and limbs, such as clubfoot and missing or webbed fingers, may also occur. As children get older, lack of facial expression and inability to smile become the dominant visible symptoms. The prognosis for otherwise normal development is excellent in most cases.

2. Mobius Syndrome mobius syndrome, a rare genetic disorder characterized by facial paralysis, is caused by the absence or underdevelopment of the 6th and 7th cranial nerves. http://healthlink.mcw.edu/article/921441372.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Neurology By keywords: Receive Health Link via email! Subscribe now >> Mobius Syndrome Mobius syndrome, a rare genetic disorder characterized by facial paralysis, is caused by the absence or underdevelopment of the 6th and 7th cranial nerves. These nerves control eye movements and facial expression. In newborns, the first symptom is an inability to suck. Excessive drooling and strabismus (crossed eyes) may occur. Other symptoms may include lack of facial expression; inability to smile; feeding, swallowing, and choking problems; eye sensitivity; motor delays; high or cleft palate; hearing problems; and speech difficulties. Deformities of the tongue, jaw, and limbs, such as club foot and missing or webbed fingers, may also occur. Most patients have low muscle tone, especially in the upper body. Mental retardation may also occur. As children get older, lack of facial expression and inability to smile become the dominant visible symptoms. Mobius syndrome may be accompanied by Pierre Robin syndrome, a disease in which there is an abnormally small jaw, downward displacement of the tongue, and a soft, cleft palate. It may also be accompanied by Poland's anomaly, a disease characterized by abnormal development of one side of the chest and limb deformities.

3. Mobius Syndrome mobius syndrome. This article submitted by Shawn K. Centers, DO on 4/14/95. mobius syndrome is a conginital disorder involving (1)complete or partial VIIth nerve palsy (2 http://neuro-www.mgh.harvard.edu/neurowebforum/ChildNeurologyArticles/MobiusSynd

Mobius Syndrome This article submitted by Shawn K. Centers, DO on 4/14/95. Mobius syndrome is a conginital disorder involving (1)complete or partial VIIth nerve palsy (2)abducens palsy (3) limb malformations especially talipes (3) less commonly there may be palsies of the Vth, IXth, and XXIIth CN's. There have been less than 80 reported cases in the literature. I am interested in the pathogenesis of this disorder and any additional known cases. Next Article Previous Article Return to Topic Menu Here is a list of responses that have been posted to this article... Rea Respiratory Palsy (1/14/97) 8:35 PM Nerve Transplant IN Moebius (12/21/96) 2:30 PM Nerve Transplanted (12/21/96) 12:31 PM Leslie (12/19/96) 2:16 PM ... Mobius Syndrome (5/16/95) 2:10 PM You now have TWO OPTIONS: Post a new Article or post a Response to this Article Click here to post a new Article! If you would like to post a Response to this article, fill out this form completely... Do not use slashes ("/") or colons (":") in your Article title! Response Title: Author: Response Text: Original Article: (Don't change this field!)

4. HONselect - Mobius Syndrome Accepted terms English mobius syndrome Congenital Oculofacial Paralysis, Moebius Syndrome, Mobius. Français MOBIUS, SYNDROME. Deutsch Moebius-Syndrom http://www.hon.ch/HONselect/RareDiseases/C10.292.300.825.html

List of rare diseases: English Deutsch Language: MeSH term: Accepted terms: English: Mobius Syndrome - Congenital Oculofacial Paralysis, Moebius - Moebius Congenital Oculofacial Paralysis - Moebius Syndrome - Mobius Syndromes - Moebius Syndromes - Syndrome, Mobius Français: MOBIUS, SYNDROME Deutsch: Moebius-Syndrom - Gesichtslähmung Español: SINDROME DE MOBIUS Português: SINDROME DE MOBIUS HONselect ressources Definition: Yes Articles: Yes Images: No News: No Conferences: No Clinical trials: No Web sites: English Yes Français No Deutsch No Español No Português No Home About us Site map Feedback ... HONewsletter http://www.hon.ch/HONselect/RareDiseases/C10.292.300.825.html Last modified: Wed Apr 28 2004

5. Introduction: Mobius Syndrome - WrongDiagnosis.com Introduction to mobius syndrome as a medical condition including symptoms, diagnosis, misdiagnosis, treatment, prevention, and prognosis. http://www.wrongdiagnosis.com/m/mobius_syndrome/intro.htm

Diseases IMPORTANT! Use of this site is subject to our and Home Symptoms Diseases Risks Search: We show you all these ads in order to provide this free site; give your feedback WrongDiagnosis TM Premium Report: Diabetes Diagnosis and Misdiagnosis Available Now! Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Mobius syndrome Next sections Basic Summary for Mobius syndrome Prevalence and Incidence of Mobius syndrome Prognosis of Mobius syndrome Symptoms of Mobius syndrome ... Associated Conditions of Mobius syndrome Next chapters: Neuronal Migration Disorders Holoprosencephaly Muscular Dystrophy Duchenne Muscular Dystrophy ... Feedback Introduction: Mobius syndrome Mobius syndrome: Type of facial paralysis. Mobius syndrome: Mobius syndrome, a rare genetic disorder characterized by facial paralysis, is caused by the absence or underdevelopment of the 6th and 7th cranial nerves. These nerves control eye movements and facial expression. Contents for Mobius syndrome: Basic Summary for Mobius syndrome Prevalence and Incidence of Mobius syndrome Prognosis of Mobius syndrome Symptoms of Mobius syndrome ... Statistics about Mobius syndrome Footnotes: 1. excerpt from

6. About.com With Laura L. Jelliffe, Ph.D. Symptoms, diagnosis, and treatment of mobius syndrome. Information on research, community outreach and support. http://genetics.about.com/science/genetics/library/blmob.htm

7. IRSC - Rare Disorders, Mobius Syndrome The Internet Resources for Special Children (IRSC) Global disABILITY resource is dedicated to communicating information relating to the needs of children with disABILITIES on a global basis MCW http://www.irsc.org:8080/irsc/irscmain.nsf/sub?readform&cat=Rare Disorders&a

8. Readers Digest Health A list of alternate names for mobius syndrome, along with a general discussion and resources. http://www.rd.com/common/nav/index.jhtml?articleId=8612437

9. MOBIUS SYNDROME mobius syndrome. mobius syndrome is a rare congenital disturbance consisting of varying Clinical Manifestations mobius syndrome is characterized by unilateral or bilateral inability http://members.aol.com/scottolitsky/mobius.htm

MOBIUS SYNDROME Mobius syndrome is a rare congenital disturbance consisting of varying involvement of facial and lateral gaze paresis. Mobius first suggested that congenital bilateral abducens-facial paralysis might be an independent pathologic entity, thus gaining eponymic distinction. Clinical Manifestations Mobius syndrome is characterized by unilateral or bilateral inability to abduct the eyes. Although horizontal movements are usually lacking, vertical movements and convergence are intact. Pupillary constriction, vision, and the retina are generally normal. Congenital esotropia is common in children with Mobius syndrome. In a retrospective study of 61 patients with this syndrome, 38 per cent had early-onset esotropia. The unilateral or bilateral complete or incomplete facial palsy is usually observed during the first few weeks of life because of difficulty with sucking and feeding, and incomplete closure of the eyelids during sleep. These patients typically have masklike faces with an inability to grin and wrinkle the forehead. Mobius syndrome is frequently associated with paresis of other muscles supplies by the cranial nerves. Often, there is partial atrophy of the tongue with inability to protrude the tongue beyond the lips. Paralysis of the soft palate and muscles of mastication may also occur. Various skeletal and muscle defects are common, including absence or hypoplasia of the pectoral muscles, syndactyly, club feet, and congenital limb amputations.

10. Mobius Syndrome mobius syndrome. As I understand it, current thinking suggests that mobius syndrome may result from a vascular field defect (ie. http://neuro-www.mgh.harvard.edu/neurowebforum/ChildNeurologyArticles/MobiusSynd

Mobius Syndrome This response submitted by Barry Kosofsky- MGH Child Neuro on 5/16/95. Dr. Centers, Sorry for the delay, but we are just coming on-line. As I understand it, current thinking suggests that Mobius Syndrome may result from a vascular field defect (ie. failure of perfusion of a specific vessel during fetal life, with maldevelopment of the neural, muscular, and other tissue structures normally perfused by that vessel). There was an article that you should be able to pull from a literature search of "Mobius Syndrome" that was published (? in Peds or J Peds, or Teratology) about 2 years ago that dicusses this theory (and other field defects such as POLAND Syndrome). Good Luck, Barry E. Kosofsky, M.D., Ph.D. Next Article Return to Main Article Article complete. Click HERE to return to the Neurology Web-Forum Menu.

11. Mobius Syndrome Information Diseases Database mobius syndrome Moebius congenital oculofacial paralysis, Disease Database Information http://www.diseasesdatabase.com/sieve/item1.asp?glngUserChoice=31978

12. Mobius Syndrome - Information / Diagnosis / Treatment / Prevention home genetic disorders mobius syndrome mobius syndrome. About.com with Laura L. Jelliffe, Ph.D. Symptoms, diagnosis, and treatment of mobius syndrome. http://www.healthcyclopedia.com/genetic-disorders/mobius-syndrome.html

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... genetic disorders > mobius syndrome Mobius Syndrome Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Medical Definition Health News Web Directory: Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "Mobius' syndrome" Health News: Search millions of published articles for news on Mobius Syndrome Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: About.com with Laura L. Jelliffe, Ph.D. Symptoms, diagnosis, and treatment of mobius syndrome. Information on research, community outreach and support. MCW Healthlink: Mobius Syndrome Details about this disease, including what it is, the causes, symptoms and treatment options. Mobius Syndrome Also known as congenital facial diplegia, an information sheet compiled by NINDS.

13. Mobius Syndrome mobius syndrome. Synonym(s) Congenital Facial Diplegia. What is mobius syndrome? mobius syndrome, a rare genetic disorder http://www.clevelandclinic.org/health/health-info/docs/1300/1307.asp?index=6064&

14. Show-documents.asp What s New. The Cleveland Clinic, mobius syndrome Written Information. Care Treatment. mobius syndrome. New Search1. The Cleveland http://www.clevelandclinic.org/health/search/do-query.asp?TopicId=1329

15. Search: - Info.co.uk Results for mobius syndrome from Info.co.uk metasearch. Find better search results from the Web, Yellow Pages and White Pages quickly and easily! http://dpxml.infospace.com/infocom.uk/results?otmpl=dog/webresults.htm&qkw=M

16. Mobius Syndrome - Condition, Disease, Or Disorder Article mobius syndrome Article relating to particular medical disease, condition, or disorder. mobius syndrome. What is mobius syndrome? http://www.stopgettingsick.com/Conditions/condition_template.cfm/2569/303/1

Beta Glucan,beta 1,3/1,6 glucan,beta 1,3 glucan,Beta 1,6 Glucan,immune system/a> Guest search My Health Focus Immunity Alternative and Complementary Therapies Diseases and Conditions ... Healing Stories Forums General Health Home Remedies The Water Cooler Feedback ... My Profile Last updated 06/02/04 12:24 PST Mobius Syndrome What is Mobius Syndrome? Is there any treatment? There is no specific course of treatment for Mobius syndrome. Treatment is supportive and symptomatic. Infants may require feeding tubes or special bottles to maintain sufficient nutrition. Surgery may correct strabismus and improve limb and jaw deformities. Physical and speech therapy may improve motor skills and coordination, and help to better control speaking and eating abilities. Plastic reconstructive surgery may be beneficial in some individuals. Also, in a few cases, nerve and muscle transfers (microvascular muscle transplant) to the corners of the mouth have been performed to provide some ability to smile. What is the prognosis?

17. MOBIUS SYNDROME mobius syndrome. mobius syndrome is a rare congenital disturbance consisting of varying involvement of facial and lateral gaze paresis. http://www.members.aol.com/scottolitsky/mobius.htm

MOBIUS SYNDROME Mobius syndrome is a rare congenital disturbance consisting of varying involvement of facial and lateral gaze paresis. Mobius first suggested that congenital bilateral abducens-facial paralysis might be an independent pathologic entity, thus gaining eponymic distinction. Clinical Manifestations Mobius syndrome is characterized by unilateral or bilateral inability to abduct the eyes. Although horizontal movements are usually lacking, vertical movements and convergence are intact. Pupillary constriction, vision, and the retina are generally normal. Congenital esotropia is common in children with Mobius syndrome. In a retrospective study of 61 patients with this syndrome, 38 per cent had early-onset esotropia. The unilateral or bilateral complete or incomplete facial palsy is usually observed during the first few weeks of life because of difficulty with sucking and feeding, and incomplete closure of the eyelids during sleep. These patients typically have masklike faces with an inability to grin and wrinkle the forehead. Mobius syndrome is frequently associated with paresis of other muscles supplies by the cranial nerves. Often, there is partial atrophy of the tongue with inability to protrude the tongue beyond the lips. Paralysis of the soft palate and muscles of mastication may also occur. Various skeletal and muscle defects are common, including absence or hypoplasia of the pectoral muscles, syndactyly, club feet, and congenital limb amputations.

18. Conditions And Diseases - Mobius Syndrome Top Links mobius syndrome Web Site Links. mobius syndrome Also known as congenital facial diplegia, an information sheet compiled by NINDS. http://www.disease-resources.com/Top_Health_Conditions_and_Diseases_Genetic_Diso

Sub Categories Related Healthcare Subjects Disabilities Environmental Health Fitness Health Insurance ... Men's Health Mobius Syndrome Web Site Links Moebius Syndrome Foundation Bringing together information from and links to medical and lay support for those affected by Moebius syndrome. Mobius Syndrome Also known as congenital facial diplegia, an information sheet compiled by NINDS. MCW Healthlink: Mobius Syndrome Details about this disease, including what it is, the causes, symptoms and treatment options. About.com with Laura L. Jelliffe, Ph.D. Symptoms, diagnosis, and treatment of mobius syndrome. Information on research, community outreach and support. Readers Digest Health A list of alternate names for mobius syndrome, along with a general discussion and resources. Other Useful Health Web Links National Institutes of Health (NIH) US Government department in charge of medical research. AHRQ: Clinical Information Clinical information on evidence-based practice, clinical guidelines, medical effectiveness, pharmaceutical therapy, new technology, screening and preventive services, outcomes research, and the National Guideline Clearinghouse. The UK Health Technology Assessment Programme Site contains details of program's many projects and publications; an NHS national research and development initiative.

19. Genetic Disorders, Mobius Syndrome Submit Your Site to the mobius syndrome category. Sponsored mobius syndrome Sites. Submit Your Site to the mobius syndrome category. Sponsored Results. http://www.iseekhealth.com/mobius_syndrome-1602.php

Home About Us Contact Submit Your Site Search : Home Health Conditions and Diseases Genetic Disorders ... Mobius Syndrome More Mobius Syndrome Categories: Submit Your Site to the Mobius Syndrome category Sponsored Mobius Syndrome Sites Cystic Fibrosis Book Store At WellnessBooks.com Comprehensive source to books on Cystic Fibrosis. Includes community boards and chat, book reviews and online ordering. Buy Genetic Disorders Products We link to merchants which offer Genetic Disorders products for sale. Online Doctors - Ask Us Now! Kasamba's variety of health experts- including Doctors, Specialists, Herbalists, Nurses and more- offer real help for affordable consultation fees- live via chat or e-mail! Buy Genetics Books At Amazon.com and Save! Would you like to save on Genetics Books at Amazon and other stores? Compare prices at BookSellersNow.com! Our site continually proves that online shopping can be fun! About.com with Laura L. Jelliffe, Ph.D. - Symptoms, diagnosis, and treatment of mobius syndrome. Information on research, community outreach and support. MCW Healthlink: Mobius Syndrome - Details about this disease, including what it is, the causes, symptoms and treatment options.

20. Genetic Disorders, Mobius Syndrome Category Home Health Conditions and Diseases Genetic Disorders mobius syndrome. * Site Title · The name of the site. (eg http://www.iseekhealth.com/directory/index.php?method=show_link_exchange&directo

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