1. MedlinePlus Medical Encyclopedia: Megaloblastic Anemia megaloblastic anemia. top. Deficiencies of vitamin B12 and folic acid are the most common causes of megaloblastic anemia. Other causes http://www.nlm.nih.gov/medlineplus/ency/article/000567.htm

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Megaloblastic anemia Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Megaloblastic anemia - view of red blood cells Hypersegmented PMN (Close-up) Blood cells Alternative names Return to top Anemia - megaloblastic Definition Return to top Megaloblastic anemia is a blood disorder characterized by anemia, with red blood cells that are larger than normal, usually resulting from a deficiency of folic acid or of vitamin B-12 Causes, incidence, and risk factors Return to top Deficiencies of vitamin B-12 and folic acid are the most common causes of megaloblastic anemia. Other causes are leukemia, myelofibrosis multiple myeloma , certain hereditary disorders, drugs that affect DNA synthesis such as chemotherapy agents (methotrexate), alcohol, and other causes. Risk factors relate to the causes. (See also pernicious anemia Symptoms Return to top Loss of appetite Diarrhea Tingling and numbness of hands and feet Pale skin color Tiredness Headaches Sore mouth and tongue Change in skin color Signs and tests Return to top Examination of neurological signs may show abnormal reflexes, decreased position sense, and decreased vibration sense if related to vitamin B-12 deficiency.

2. EMedicine - Megaloblastic Anemia : Article By Paul Schick, MD megaloblastic anemia megaloblastic anemias are a heterogeneous group of disorders that share common morphologic characteristics. Erythrocytes are larger and have higher nuclear-to-cytoplasmic http://www.emedicine.com/med/topic1420.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Hematology Megaloblastic Anemia Last Updated: November 14, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: blood disorder, megaloblastosis, cobalamin deficiency, vitamin B-12 deficiency, folate deficiency, pernicious anemia, PA, cobalamin neuropathy, ineffective erythropoiesis, food-cobalamin malabsorption, gastrectomy, Zollinger-Ellison syndrome, ZES, ileal resection, regional ileitis, intestinal lymphoma, Diphyllobothrium latum, D latum, fish tapeworm, blind loop syndrome, nitrous oxide exposure, NO exposure, surgical intestinal resection, amyloidosis, Whipple disease, scleroderma, psoriasis, exfoliative dermatitis, pregnancy, drug reactions, chemotherapy AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Paul Schick, MD

3. Hematology And Medical Oncology At Oregon Health & Science University An article by Thomas G. DeLoughery, Associate Professor of Medicine discussing all aspects of this disorder. http://www.ohsu.edu/som-hemonc/handouts/deloughery/megalobl.shtml

General About the Division In the News Lance Armstrong Foundation For Patients General Information Helpful Links Clinical Trials Clinics Hem Onc BMT/Leukemia Prostate Heinrich/Corless Laboratories For Health Professionals Conferences Faculty Information Career Opportunities Fellowship Program Current Internal Pages Medical Oncology "The disease of cancer will be banished from life by calm, unhurrying, persistent men and women, working with every shiver of feeling controlled and suppressed in hospitals and laboratories, and the motive that will conquer cancer will not be pity or horror; it will be curiosity to know how and why." H.G. Wells, 1901 is dedicated to the study and treatment of cancer and disorders of the blood in adults. About the Division Clinics Hematological Malignancies Hematology / Oncology Hem Onc in the News Conferences / Grand Rounds Physician Career Opportunities Heinrich and Corless Laboratories Physician Resource Page - (Hem Onc faculty and staff only) Clinical Trials Helpful Links for Patients and Physi cians Faculty Information Internal pages (intranet access only) Lance Armstrong Foundation

4. Megaloblastic Anemia megaloblastic anemia is a blood disorder characterized by anemia, with red blood cells that are larger are the most common causes of megaloblastic anemia. Other causes are leukemia http://www.healthscout.com/ency/article/000567.htm

Advertisement Search HealthScout Web MEDLINE Special Offers TV Specials Top Features Schizophrenia Hair Loss Liver Disease Allergies ... Impotence Resources Healthscout News 3D Interactive Human Atlas Health Videos Health Encyclopedia ... Drug Library Channels Home Today Women Men ... Drug Checker Advertisement Disease Injury Nutrition Poison ... Prevention Megaloblastic anemia Definition: Megaloblastic anemia is a blood disorder characterized by anemia, with red blood cells that are larger than normal, usually resulting from a deficiency of folic acid or of vitamin B-12 Alternative Names: Anemia - megaloblastic Causes, incidence, and risk factors: Deficiencies of vitamin B-12 and folic acid are the most common causes of megaloblastic anemia. Other causes are leukemia, myelofibrosis multiple myeloma , certain hereditary disorders, drugs that affect DNA synthesis such as chemotherapy agents (methotrexate), alcohol, and other causes. Risk factors relate to the causes. (See also pernicious anemia Review Date: 5/2/2003 Reviewed By: Ezra E. W. Cohen, M.D., Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL. Review provided by VeriMed Healthcare Network.

5. Megaloblastic (Pernicious) Anemia -Blood Diseases & Disorders nbsp nbsp. megaloblastic anemia nbsp What is megaloblastic (pernicious) anemia? Megaloblastic (pernicious) anemia is a rare disorder in which the body does http://www.umm.edu/blood/aneper.htm

Donations / Banking Blood Diseases Blood Disorders... Anemias ... Site Map Related Resources Within UMM Hematology Pediatric Oncology Blood Diseases Megaloblastic (Pernicious) Anemia What is megaloblastic (pernicious) anemia? Megaloblastic (pernicious) anemia is a rare disorder in which the body does not absorb enough vitamin B12 from the digestive tract, resulting in an inadequate amount of red blood cells (RBCs) produced. What causes megaloblastic (pernicious) anemia? Megaloblastic (pernicious) anemia is more common in individuals of northern European descent. Megaloblastic (pernicious) anemia results from a lack of intrinsic factor in gastric secretions (a substance needed to absorb vitamin B12 from the gastrointestinal tract). Vitamin B12 deficiency results. The inability to make intrinsic factor may be the result of chronic gastritis, or the result of a gastrectomy (removal of all or part of the stomach). Megaloblastic (pernicious) anemia may also be associated with type 1 diabetes, thyroid disease, and a family history of the disease. What are the symptoms of megaloblastic (pernicious) anemia?

6. Megaloblastic (Pernicious) Anemia - Lucile Packard Children's Hospital What is megaloblastic (pernicious) anemia? megaloblastic anemia, also called pernicious anemia, is a type of There are many causes of megaloblastic anemia, but the most common http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/hematology/megalob.html

Bone Marrow Transplantation Hematology Hematopoietic Stem Cell Transplantation Oncology ... Oncology Megaloblastic (Pernicious) Anemia What is megaloblastic (pernicious) anemia? Megaloblastic anemia, also called pernicious anemia, is a type of anemia characterized by very large red blood cells. In addition to the cells being large, the inner contents of each cell are not completely developed. This malformation causes the bone marrow to produce fewer cells, and sometimes the cells die earlier than the 120-day life expectancy. Instead of being round or disc-shaped, the red blood cells can be oval. What causes megaloblastic (pernicious) anemia? There are many causes of megaloblastic anemia, but the most common source in children occurs from a vitamin deficiency of folic acid. Other sources of megaloblastic anemia include the following: digestive diseases Certain diseases of the lower digestive tract can lead to megaloblastic anemia. These include celiac disease, chronic infectious enteritis, and enteroenteric fistulas. malabsorption Inherited congenital folate malabsorption, a genetic problem in which infants cannot absorb folic acid in their intestines, can lead to megaloblastic anemia. This requires early intensive treatment to prevent long term problems such as mental retardation.

7. NORD - National Organization For Rare Disorders, Inc. Folate Deficiency Anemia. Folic Acid Deficiency Anemia. Hypovitaminosis B12. megaloblastic anemia of Pregnancy antitumor or immunosuppressive drugs may also cause megaloblastic anemia. http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Anemia, Megal

8. MedlinePlus Medical Encyclopedia: Megaloblastic Anemia - View Of Red Blood Cells megaloblastic anemia view of red blood cells. This picture shows large, dense, oversized, red blood cells (RBCs) that are seen in megaloblastic anemia. http://www.nlm.nih.gov/medlineplus/ency/imagepages/1214.htm

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Megaloblastic anemia - view of red blood cells This picture shows large, dense, oversized, red blood cells (RBCs) that are seen in megaloblastic anemia. Megaloblastic anemia can occur when there is a deficiency of vitamin B-12. Update Date: 3/1/2004 Updated by: Michael C. Milone, M.D., Ph.D., Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA. Health Topics Drug Information Encyclopedia Dictionary ... National Institutes of Health Page last updated: 11 May 2004

9. Genetic Mutations Linked To Rare Metabolic Disease Columbus, Ohio Researchers have identified two mutations in a single gene as the cause of a rare disease, megaloblastic anemia. http://www.osu.edu/units/research/archive/cubn.htm

OSU Research News Service (physical and natural sciences) OSU Newsfeatures Service (social and behavioral sciences) OSU Cancer Report (cancer research and treatment) OSU News Research Archive (an archive of past stories) Coverage of OSU Research Reports on national news stories Frontiers (a magazine about cancer research and treatment) Synergy (a magazine produced by the College of Biological Sciences) Reporting on Cancer (a reporter's guide to the disease) Ralf Krahe GENETIC MUTATIONS LINKED TO RARE METABOLIC DISEASE COLUMBUS, Ohio Researchers have identified two mutations in a single gene as the cause of a very rare metabolic disease that affects people in Finland, Norway and Saudi Arabia. It has taken nearly 40 years since the identification of the disease for researchers to trace its cause back to a faulty gene. An international team of a dozen scientists, including those from Ohio State University, reported their discovery in the latest issue of the journal Nature Genetics Called megaloblastic anemia 1, or Imerslund-Grasbeck syndrome after the two researchers who first described it, the defects prevent the normal absorption of vitamin B-12. If left untreated, the disease can be fatal. While serious, the syndrome is exceedingly rare only one person in a million may develop this disease. The disease has also been identified in patients from Israel, Turkey, Kuwait and the United States as well.

10. EMedicine - Megaloblastic Anemia : Article Excerpt By: Paul Schick, MD megaloblastic anemia megaloblastic anemias are a heterogeneous group of disorders that share common morphologic characteristics. http://www.emedicine.com/med/byname/megaloblastic-anemia.htm

(advertisement) Excerpt from Megaloblastic Anemia Synonyms, Key Words, and Related Terms: blood disorder, megaloblastosis, cobalamin deficiency, vitamin B-12 deficiency, folate deficiency, pernicious anemia, PA, cobalamin neuropathy, ineffective erythropoiesis, food-cobalamin malabsorption, gastrectomy, Zollinger-Ellison syndrome, ZES, ileal resection, regional ileitis, intestinal lymphoma, Diphyllobothrium latum, D latum, fish tapeworm, blind loop syndrome, nitrous oxide exposure, NO exposure, surgical intestinal resection, amyloidosis, Whipple disease, scleroderma, psoriasis, exfoliative dermatitis, pregnancy, drug reactions, chemotherapy Please click here to view the full topic text: Megaloblastic Anemia Background: Megaloblastic anemias are a heterogeneous group of disorders that share common morphologic characteristics. Erythrocytes are larger and have higher nuclear-to-cytoplasmic ratios compared to normoblastic cells. Neutrophils can be hypersegmented, and megakaryocytes are abnormal. On the molecular level in megaloblastic cells, the maturation of nuclei is delayed, while cytoplasmic development is normal. Megaloblastosis is a generalized disorder because nonhematopoietic cells such as GI and uterine cervical mucosal cells can also have megaloblastic features. The etiology of megaloblastic anemias is diverse, but a common basis is impaired DNA synthesis. The most common causes of megaloblastosis are cobalamin (vitamin B-12) and folate deficiencies. The usual causes of cobalamin deficiency are pernicious anemia (PA) (see

11. Megaloblastic Anaemia Haematological profile, diagnosis and treatment of megaloblastic anemia. Vitamin B12 deficiency and frolic acid deficiency. http://www.uq.edu.au/vdu/HDUAnaemiaMegaloblastic.htm

Megaloblastic Anaemia Diagnosis Many cases are seen that have a decreased serum B12 with a normal haematological profile and possibly normal clinical findings Test for methylmalonic acid in the serum as an indicator of vitB12 deficiency Test for homocysteine to check folate levels Haematological Profile Hb/RCC/Hct - Dec (due to Dec. DNA production) MCV/MCH - Inc. (As precursors are megaloblastic) MCHC - Normal RDW - Inc. (Anisocytosis due to microcytes, normocytes and oval macrocytes) Plt./WCC - Dec Pancytopaenia with a normochromic, macrocytic anaemia Intramedullary haemolysis due to ineffective erythropoiesis (reason for hypercellular BM) Poikilocytosis - ++ (tear drops and schistocytes) Anisocytosis - +++ (oval macrocytes) A "Shift-to-the-Left" indicates an Inc. in band form WBCs Hypercellular bone marrow (M:E at 1:1 or reversed) Erythron Large cells with fine chromatin (Megaloblasts) Nuclear(N)/Cytoplasmic(C) dissociation with N lagging C - normal cytoplasmic maturation Multiple Howell-Jolly bodies (diagnostic if observed) Leucon Giant myelocytes and metamyelocytes Thrombon Often not obvious The peripheral blood (PB) and bone marrow (BM) findings do not distinguish between a vitamin B12/cobalamin deficiency and a folic acid (folate) deficiency

12. ► Megaloblastic Anemia megaloblastic anemia. Causes, incidence, and risk factors Deficiencies of Vitamin B12 and folic acid are the most common causes of megaloblastic anemia. http://www.umm.edu/ency/article/000567.htm

Disease Nutrition Surgery Symptoms Injury ... Encyclopedia (English) Toggle English Spanish Megaloblastic anemia Overview Symptoms Treatment Prevention Definition: Megaloblastic anemia is a blood disorder characterized by anemia, with red blood cells that are larger than normal, usually resulting from a deficiency of folic acid or Vitamin B-12 Alternative Names: Anemia - megaloblastic Causes, incidence, and risk factors: Deficiencies of Vitamin B-12 and folic acid are the most common causes of megaloblastic anemia. Other causes are leukemia myelofibrosis multiple myeloma , certain hereditary disorders, drugs that affect DNA synthesis such as chemotherapy agents (methotrexate), alcohol, and other causes. Risk factors relate to the causes. (See also pernicious anemia Megaloblastic anemia - view of red blood cells Hypersegmented PMN (Close-up) Blood cells Review Date: 10/8/2001 Reviewed By: Rebecca Elstrom, M.D., University of Pennsylvania Medical Center, Philadelphia, PA. Review provided by VeriMed Healthcare Network. Home Health Info Our Physicians Our Services ... Make Appt.

13. Megaloblastic Anemia (vitamin B12 Deficiency) next up previous Next Case 1 Up Atlas of Hematology Previous Iron deficiency anemia. megaloblastic anemia (vitamin B12 deficiency). http://pathy.med.nagoya-u.ac.jp/atlas/doc/node106.html

Next: Case 1 Up: Atlas of Hematology Previous: Iron deficiency anemia Megaloblastic anemia (vitamin B12 deficiency) Case 1 Case 2 Case 3 Case 4¡¤5 ... [content] Nagoya University School of Medicine Department of Medicine The Branch Hospital Takuji Ichihashi, Tomoki Naoe Nagasaki University School of Medicine Department of Hematology Kazutaka Kuriyama Kyoto University College of Medical Technology Masataka Sasada Hamamatsu University School of Medicine Department of Medicine Three Ryuzo Ohno

14. Hematopathology The CBC here shows a markedly increased MCV, typical for megaloblastic anemia. The MCV can be mildly increased in persons recovering http://medlib.med.utah.edu/WebPath/HEMEHTML/HEME025.html

The CBC here shows a markedly increased MCV, typical for megaloblastic anemia. The MCV can be mildly increased in persons recovering from blood loss or hemolytic anemia, because the newly released RBC's, the reticulocytes, are increased in size over normal RBC's, which decrease in size slightly with aging.

15. Pernicious Anemia Vitamin B12, in turn, is necessary for the formation of red blood cells. Pernicious anemia is a type of megaloblastic anemia. Alternative Names http://www.healthscout.com/ency/article/000569.htm

Advertisement Search HealthScout Web MEDLINE Special Offers TV Specials Top Features Schizophrenia Hair Loss Liver Disease Allergies ... Impotence Resources Healthscout News 3D Interactive Human Atlas Health Videos Health Encyclopedia ... Drug Library Channels Home Today Women Men ... Drug Checker Advertisement Disease Injury Nutrition Poison ... Prevention Pernicious anemia Definition: Anemia is a condition where red blood cells are not providing adequate oxygen to body tissues. There are many types and causes of anemia. (See the general article - anemia .) Pernicious anemia is caused by a lack of intrinsic factor, a substance needed to absorb vitamin B12 from the gastrointestinal tract. Vitamin B12, in turn, is necessary for the formation of red blood cells. Pernicious anemia is a type of megaloblastic anemia Alternative Names: Macrocytic achylic anemia; Congenital pernicious anemia; Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption) Causes, incidence, and risk factors: Intrinsic factor is a protein the body uses to absorb vitamin B12. When gastric secretions do not have enough intrinsic factor, vitamin B12 is not adequately absorbed, resulting in pernicious anemia. Because vitamin B12 is needed by nerve cells and blood cells for them to function properly, pernicious anemia causes a wide variety of symptoms, including fatigue, shortness of breath, tingling sensations, difficulty walking, and diarrhea.

16. AllRefer Health - Megaloblastic Anemia (Anemia - Megaloblastic) megaloblastic anemia (Anemia Megaloblastic) information center covers causes, prevention, symptoms, diagnosis, treatment, incidence, risk factors, signs http://health.allrefer.com/health/megaloblastic-anemia-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia You are here : AllRefer.com Health Megaloblastic Anemia Megaloblastic Anemia Definition Prevention Treatment Expectations or Prognosis ... Go To Main Page Alternate Names : Anemia - Megaloblastic Definition Megaloblastic anemia is a blood disorder characterized by anemia, with red blood cells that are larger than normal, usually resulting from a deficiency of folic acid or of vitamin B-12 Megaloblastic Anemia - View of Red Blood Cells Hypersegmented PMN (Close-Up) Blood Cells Deficiencies of vitamin B-12 and folic acid are the most common causes of megaloblastic anemia. Other causes are leukemia, myelofibrosis multiple myeloma , certain hereditary disorders, drugs that affect DNA synthesis such as chemotherapy agents (methotrexate), alcohol, and other causes. Risk factors relate to the causes. (See also

17. AllRefer Health - Megaloblastic Anemia - View Of Red Blood Cells - Pernicious An megaloblastic anemia View of Red Blood Cells - Pernicious Anemia (Congenital Pernicious Anemia, Juvenile Pernicious Anemia, Macrocytic Achylic Anemia http://health.allrefer.com/health/pernicious-anemia-megaloblastic-anemia-view-of

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia You are here : AllRefer.com Health Pernicious Anemia : Megaloblastic Anemia - View of Red Blood Cells Pernicious Anemia Alternate Names : Congenital Pernicious Anemia, Juvenile Pernicious Anemia, Macrocytic Achylic Anemia, Vitamin B12 Deficiency (Malabsorption) Megaloblastic Anemia - View of Red Blood Cells This picture shows large, dense, oversized, red blood cells (RBCs) that are seen in megaloblastic anemia. Megaloblastic anemia can occur when there is a deficiency of vitamin B-12. Other images that might be of interest to you Basophil (Close-Up) Blood Cells Formed Elements of Blood Hypersegmented PMN (Close-Up) ... Red Blood Cells, Tear-Drop Shape Jump to another section Definition Pernicious Anemia Prevention Pernicious Anemia Treatment Pernicious Anemia Prognosis ... Calling Your Health Care Provider Topics that might be of interest to you Addison's Disease Anemia Celiac Disease - Sprue Chronic Thyroiditis (Hashimoto's Disease) ... WBC Count Other Topics Appetite - Decreased Babinski's Reflex Balanced Diet Bleeding Gums ... Main Page of Pernicious Anemia From Our Sponsors:

18. HealthCentral - General Encyclopedia - Megaloblastic Anemia megaloblastic anemia. Causes, incidence, and risk factors Deficiencies of vitamin B12 and folic acid are the most common causes of megaloblastic anemia. http://www.healthcentral.com/mhc/top/000567.cfm

WELCOME! Receive Free Newsletters Join a Community SEARCH FOR: CONSUMER HEALTH INFORMATION TOPIC CENTERS Choose a topic Acne Alcohol Allergies Alternative Medicine Alzheimer's Anemia Arthritis Asthma Baby and Toddler Health Back Care Bipolar Disorder Birth Control Bodywork and Mind/Body Bowel Breast Cancer Cancer Overview Caregiving Chemotherapy Children's Health Cholesterol Circumcision Colds and Flus Colon Cancer Cosmetic Surgery Crohn's Disease Dental Depression Diabetes Diet Drugs Digestion Disabilities Drugs and Medications Eating Disorders Eczema Erectile Dysfunction Eye and Vision Fitness Foot Care GERD/Heartburn Hair Loss Hearing Heart and Circulation Hepatitis Herbs Herpes High Blood Pressure HIV and AIDS Home Remedies Hyperactivity and ADD Immunizations/Vaccines Impotence Incontinence/Bladder Infertility Leukemia Lung Cancer Medical Breakthroughs Medical Expenses Medical Marijuana Men's Health Menopause Mental Health Migraines and Headaches Multiple Sclerosis Nutraceuticals Nutrition and Healthy Eating Osteoporosis Pain Management Parenting Parkinson's Pregnancy and Childbirth Prostate Cancer Prostate Disorders Psoriasis Rheumatoid Arthritis Safety and First Aid Schizophrenia Senior Health Sex and Relationships Sexual Health Skin and Hair Sleep Disorders Smoking Stress Reduction Stroke Substance Abuse and Addiction Teen Health Thyroid Disorders Travel Health Vitamins and Supplements Weight Loss Women's Health Women's Reproductive Cancers Yeast Infection Yoga Search Tips Advertisement Advertisement Main Consumer Health Information Home News Dr. Dean Edell

19. HealthCentral.com megaloblastic anemia view of red blood cells. This picture shows large, dense, oversized, red blood cells (RBCs) that are seen in megaloblastic anemia. http://www.healthcentral.com/mhc/img/img1214.cfm

WELCOME! Receive Free Newsletters Join a Community SEARCH FOR: CONSUMER HEALTH INFORMATION TOPIC CENTERS Choose a topic Acne Alcohol Allergies Alternative Medicine Alzheimer's Anemia Arthritis Asthma Baby and Toddler Health Back Care Bipolar Disorder Birth Control Bodywork and Mind/Body Bowel Breast Cancer Cancer Overview Caregiving Chemotherapy Children's Health Cholesterol Circumcision Colds and Flus Colon Cancer Cosmetic Surgery Crohn's Disease Dental Depression Diabetes Diet Drugs Digestion Disabilities Drugs and Medications Eating Disorders Eczema Erectile Dysfunction Eye and Vision Fitness Foot Care GERD/Heartburn Hair Loss Hearing Heart and Circulation Hepatitis Herbs Herpes High Blood Pressure HIV and AIDS Home Remedies Hyperactivity and ADD Immunizations/Vaccines Impotence Incontinence/Bladder Infertility Leukemia Lung Cancer Medical Breakthroughs Medical Expenses Medical Marijuana Men's Health Menopause Mental Health Migraines and Headaches Multiple Sclerosis Nutraceuticals Nutrition and Healthy Eating Osteoporosis Pain Management Parenting Parkinson's Pregnancy and Childbirth Prostate Cancer Prostate Disorders Psoriasis Rheumatoid Arthritis Safety and First Aid Schizophrenia Senior Health Sex and Relationships Sexual Health Skin and Hair Sleep Disorders Smoking Stress Reduction Stroke Substance Abuse and Addiction Teen Health Thyroid Disorders Travel Health Vitamins and Supplements Weight Loss Women's Health Women's Reproductive Cancers Yeast Infection Yoga Search Tips Advertisement Advertisement Main Consumer Health Information Home News Dr. Dean Edell

20. Diagnose-Me: Conditions: Megaloblastic Anemia / Pernicious Anemia 06, 2004. megaloblastic anemia / Pernicious Anemia, hypovitaminosis B12. Signs, symptoms indicators of megaloblastic anemia / Pernicious Anemia http://www.diagnose-me.com/cond/C364379.html

Home FAQ Start The Analyst Last updated: May 06, 2004 Megaloblastic Anemia / Pernicious Anemia Signs, symptoms and indicators Conditions that suggest it Contributing risk factors Other conditions that may be present ... anemias are somewhat rare blood disorders characterized by the presence of large, structurally and visually abnormal, immature red blood cells megaloblasts ). Decreased numbers and immaturity of white blood cells leukocytes ) and blood platelets (thrombocytes) may also occur. Megaloblastic anemias are usually caused by a deficiency or defective absorption of either vitamin B12 cobalamin ) or folic acid . As a result, they are also known as the vitamin deficiency anemias. Folic acid was discovered in 1931 as a "cure" for the anemia of pregnancy. Eating extra yeast also seemed to relieve the symptoms of pernicious anemia , but the neurological symptoms of this disease either were not resolved or appeared later on, confirming some doctors’ feelings that there were two different problems involved. In 1945, folic acid was isolated from spinach; we now know that

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