61. Marfan Syndrome - Information / Diagnosis / Treatment / Prevention home musculoskeletal disorders connective tissue marfan syndrome MarfanSyndrome. Children s Heart Institute What is marfan syndrome? http://www.healthcyclopedia.com/musculoskeletal-disorders/connective-tissue/marf

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... connective tissue > marfan syndrome Marfan Syndrome Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Related Topics Medical Definition Message Boards Health News ... Web Directory: Related Topics: Musculoskeletal Disorders/Connective Tissue/Ehlers-Danlos Syndrome Musculoskeletal Disorders/Connective Tissue/Hypermobility Syndrome Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "marfan syndrome" Message Boards: Google Groups: alt.support.marfan Health News: Search millions of published articles for news on Marfan Syndrome Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: Marfan Syndrome Comprehensive guide to this connective tissue disease.

62. ► Marfan Syndrome Home Medical Reference Encyclopedia (English) Toggle English / Spanish Marfansyndrome. marfan syndrome is inherited as an autosomal dominant trait. http://www.umm.edu/ency/article/000418.htm

Disease Nutrition Surgery Symptoms Injury ... Z Maryland Medical Center Programs Maryland Heart Center Home Medical Reference Encyclopedia (English) Toggle English Spanish Marfan syndrome Overview Symptoms Treatment Prevention Definition: Marfan syndrome is an inheritable disorder of connective tissue (which adds strength to the bodies structures) that affects the skeletal system, cardiovascular system, eyes, and skin. Causes, incidence, and risk factors: Marfan syndrome is inherited as an autosomal dominant trait. However, up to 30% of cases have no family history and are so called 'sporadic' cases. In sporadic cases, Marfan syndrome is believed to result from a spontaneous new mutation. The incidence is approximately 2 out of 10,000 people in all ethnic groups. Marfan syndrome causes skeletal defects typically recognized in a tall, lanky person with long limbs and spider-like fingers (arachnodactyly), chest abnormalities (pectus excavatum or pectus carinatum), curvature of the spine and a particular set of facial features including a highly arched palate, and crowded teeth. Common eye problems are nearsightedness myopia ), and dislocation of the lens of the eye.

63. The Physician And Sportsmedicine: Sports And Marfan Syndrome Sports and marfan syndrome. Awareness In Brief marfan syndrome isan autosomal dominant disorder of the connective tissues. Its http://www.physsportsmed.com/issues/2001/05_01/salim.htm

Sports and Marfan Syndrome Awareness and Early Diagnosis Can Prevent Sudden Death Mubadda A. Salim, MD; Bruce S. Alpert, MD THE PHYSICIAN AND SPORTSMEDICINE - VOL 29 - NO.5 - MAY 2001 In Brief: Marfan syndrome is an autosomal dominant disorder of the connective tissues. Its major manifestations are in the cardiovascular, musculoskeletal, and ocular systems. Recognizing the phenotypic presentation of tall stature, long limbs and fingers, chest deformity, myopia, midsystolic click, and systolic or diastolic murmur can lead to early diagnosis. Morbidity and mortality are primarily caused by cardiovascular involvement. The goal of medical therapy is to retard the aortic root dilation that leads to sudden death from dissection or rupture. Surgical interventions for mitral valve regurgitation and resection of aortic aneurysms are highly effective. In addition, individuals with Marfan syndrome should be restricted from participation in certain sports. I n 1986, the sudden death of former Olympic volleyball player Flo Hyman from a ruptured aortic aneurysm highlighted the need for better detection of Marfan syndrome (MFS) in athletes who may be at risk (1). MFS, a genetic disorder of the connective tissues, has an autosomal dominant inheritance caused by mutations in the gene for the fibrillin-1 protein (2). MFS represents one phenotypic end of the connective-tissue-disorder spectrum, but many of its features are shared with unaffected individuals (table 1). There is no universal molecular screening tool to identify different mutations or combinations of mutations. The prevalence of MFS in the general population is estimated at 2 to 3 per 10,000 (3).

64. DrRecommend: Marfan Syndrome Medical doctors review marfan syndrome electronic medical information resourcesavailable in any of the following media browsable WWW sites, or downloadable http://www.drrecommend.com/it/dir/Health/Conditions_and_Diseases/M/Marfan_Syndro

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65. Tall Persons Club GB & Ireland · Medical Information · Marfan Syndrome marfan syndrome, back to Medical Information. Written by Phil Marfansyndrome was first described in 1896 by one Dr Marfan. It is no http://www.tallclub.co.uk/medical/marfan.asp

Home Bulletin Board (BBS) Chat Room Events ... Member Login Marfan Syndrome back to Medical Information Marfan syndrome was first described in 1896 by one Dr Marfan. It is no respecter of age, sex, race, or ethnic background; anyone might be affected. Although usually described as an inherited disorder of the connective tissue, i.e. muscles and tendons, about 25% of cases occur by spontaneous mutation. The abnormal gene appears in an egg or sperm and goes on to produce an affected child of two unaffected parents. Because Marfan syndrome is an 'autosomal dominant' condition, someone with Marfan syndrome has a 50% chance of passing on the condition to their offspring. Of affected children, one in ten is likely to be seriously affected. The single abnormal gene responsible for the condition is found on chromosome 15. It reduces the production of fibrillin, a very fine fibre in connective tissue. There is currently no simple blood test available which could aid diagnosis of the condition. There follows a brief outline of the principal features of Marfan syndrome. As these details get a little technical in places, they have been translated into simpler English at the end of each paragraph.

66. Marfan Syndrome, Cincinnati Children's Hospital Medical Center marfan syndrome manifestations, causes, diagnosis, treatment, and prognosis informationfrom the Heart Encyclopedia by Cincinnati Children s Hospital Medical http://www.cincinnatichildrens.org/health/heart-encyclopedia/disease/syndrome/ma

Home Contact Us Site Map Go to Advanced Search ... Down Syndrome Marfan Syndrome Velo-Cardio-Facial Syndrome VACTERL (VATER) Association Signs and Symptoms Cardiac-Related Diagnostic Methods ... Contact Us Heart-Related Syndromes Marfan Syndrome Manifestations, Causes, Diagnosis, Treatment, Prognosis Explanation Manifestations Causes Diagnosis ... Prognosis What is Marfan syndrome? The Marfan syndrome is a genetic disorder that affects the body's connective tissues, or the tissues in between the main cells of each organ of the body. All organs contain connective tissue and, hence, the manifestations of Marfan syndrome appear in many parts of the body, especially the skeletal system, the eyes, the heart and blood vessels and the lungs. The term "syndrome" refers to the collection of physical findings that occur together often enough to provide a recognizable pattern that allows the diagnosis to be made. It was first described in a six year old girl by the French pediatrician, Antoine Marfan, in 1896. Return to Top Manifestations of Marfan syndrome The heart is affected in nearly 80 percent of patients with this syndrome. The most important finding is enlargement or dilation of the aorta, the main blood vessel that carries blood to the body. This abnormality in connective tissue of the first few inches of the aorta allows the aorta to stretch sufficiently to cause tearing or rupture.

67. President Lincoln And Marfan Syndrome Feature article about marfan syndrome, and the debate about whether US PresidentAbraham Lincoln had the disorder. President Lincoln and marfan syndrome. http://rarediseases.about.com/cs/marfansyndrome/a/092402.htm

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') About Rare / Orphan Diseases Home Essentials ... Rare cancers zau(256,152,145,'gob','http://z.about.com/5/ad/go.htm?gs='+gs,''); Is it a Rare Disease? Rare Diseases A - B Rare Diseases C - D Rare Diseases E - H ... Help zau(256,138,125,'el','http://z.about.com/0/ip/417/0.htm','');w(xb+xb); Stay Current Subscribe to the About Rare / Orphan Diseases newsletter. zau(256,152,100,'hs','http://z.about.com/5/ad/hs.htm?zIhsid=00',''); Search Rare / Orphan Diseases Email to a friend Print this page Stay Current Subscribe to the About Rare / Orphan Diseases newsletter. Suggested Reading Internet links on Marfan syndrome Internet links about Abraham Lincoln Most Popular ALD and Lorenzo's Oil The Elephant Man's Bones Reveal Mystery Prune Belly (Eagle-Barrett) Syndrome Progeria Syndromes ... Mad Cow Disease and Humans What's Hot Autoimmune Kidney Disease Tourette Syndrome Christmas Disease Bugs, PANDAS, and Tics ... Dystonia and Botox Injections President Lincoln and Marfan Syndrome From Mary Kugler Your Guide to Rare / Orphan Diseases Sign up for my Newsletter Would he be diagnosed with it today?

68. Marfan Syndrome - Medical Dictionary Definitions Of Popular Medical Terms MedicineNet Home MedTerms medical dictionary AZ List marfan syndrome. Advanced Search. marfan syndrome Index. http://www.medterms.com/script/main/art.asp?articlekey=4282

69. Marfan Syndrome. The American Heritage® Dictionary Of The English Language: Fou marfan syndrome. The American Heritage® Dictionary of the English Language FourthEdition. 2000. 2000. marfan syndrome. SYLLABICATION Mar·fan syndrome. http://www.bartleby.com/61/50/M0105050.html

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70. Continuing Education - Marfan Syndrome marfan syndrome. Objectives. Upon completion of this article the future. Physicalmanifestations of marfan syndrome. Skeletal system arachnodactyly http://www.nurseweek.com/ce/ce1102a.html

Marfan Syndrome Objectives Upon completion of this article, you will be able to: explain how Marfan syndrome is transmitted, list four components of the evaluation for possible Marfan effect in a patient, describe common cardiovascular manifestations of Marfan syndrome, discuss two considerations involving pregnancy in women with Marfan, and list four nursing interventions appropriate for patients with Marfan syndrome. Obtain 1 continuing education hour for this course #1102A by completing the exam. By Marilyn Fuller Delong, RN Do you know what Marfan syndrome is? If you saw it on a patient’s medical record, would you know how it was affecting his or her condition and what you should look for? Although Marfan syndrome remains a fairly obscure disorder, more than 50,000 people in the United States currently are aware that they have the condition. This means that one in every 3,000 to 5,000 people has Marfan syndrome, making it more common than cystic fibrosis and hemophilia and about as common in the United States as sickle cell anemia. It is one of about 100 inheritable disorders of the connective tissue. Connective tissue, including extracellular matrix, is composed of collagen fibers and elastic fibers. When the components are disrupted, there can be a cascade effect, causing functional changes in all connective tissue.

71. Marfan Syndrome marfan syndrome. As a result, many of the structures of the body lack thestiffness and strength they should have. What is marfan syndrome? http://www.stayinginshape.com/4union/libv/i51.shtml

PlaceMenu("GenInfo") PlaceMenu("Affinity") PlaceMenu("Prog") PlaceMenu("Physician") PlaceMenu("Contact") PlaceMenu("Career") PlaceMenu("Education") PlaceMenu("Newsletter") Search All Health Topics Heart Cancer Women ... En Espanol Marfan Syndrome Connective tissue is found throughout the body, supporting tendons, ligaments, blood vessel walls, heart valves and cartilage. (Read about " Vascular System " " The Heart and Its Valves ") Marfan syndrome is a condition where the chemical makeup of the connective tissue isn’t right, according to the American Heart Association. As a result, many of the structures of the body lack the stiffness and strength they should have. What is Marfan syndrome? Marfan syndrome is inherited, and can affect many of the body's systems, including the skeleton, lungs, eyes (Read about " The Eye "), skin, heart and blood vessels. According to the National Marfan Foundation (NMF), the syndrome affects both men and women of any ethnic group. The estimates on the number of people affected ranges from 25,000 according to National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) to the March of Dimes’ (MOD) estimate of about twice that. What causes Marfan syndrome?

72. Marfan Syndrome marfan syndrome. What Are the Symptoms? marfan syndrome can cause one ormore of these symptoms Heart problems an enlarged blood vessel. http://www.arthritis.org/conditions/DiseaseCenter/marfan_syndrome.asp

Welcome! Log In Create Profile advanced search Español ... 51 Ways to Be Good to Your Joints Marfan Syndrome If your question is not answered here, please contact one of our information specialists. What Is It? What Are the Symptoms? What Causes It? How Is It Diagnosed? ... Resources and Suggestions What Is It? Marfan syndrome is a rare inherited disorder which causes weakening of the body's connective tissue, a vital component of all body organs that supports and protects other body tissues. A mutant gene causes the body to produce defective fibrillin a protein in connective tissue. What Are the Symptoms? Marfan Syndrome can cause one or more of these symptoms: Heart problems an enlarged blood vessel. Tall stature unusually tall and slender, with particularly long arms, legs and fingers. Eye problems Nearsightedness (myopia) is a common problem with lens becoming "dislocated." Spine problems curvature of the spine (scoliosis). Breast bone may become indented.

73. Marfan Syndrome SECTION X marfan syndrome. Part I - Background Information. Definition. Tothis point, the diagnosis of marfan syndrome is made on clinical grounds. http://www.rbh.nthames.nhs.uk/Cardiology/Consensus/marfan.htm

Home Introduction General Recommendations Atrial Septal Defect ... Management of Cyanotic Patients Appendices Appendix I - Patient who can be cared for in the Community Appendix II - Patients who should be seen at /National or Regional ACHD Centres ... Adult Congenital Heart Unit SECTION X - MARFAN SYNDROME Part I - Background Information Definition Marfan syndrome is an autosomal dominantly inherited disorder of connective tissue in which cardiovascular, skeletal, ocular, and other abnormalities may be present to a highly variable degree. Prevalence has been estimated to be 1 in 3000-5000. Part II - Prevalence and Genetics New mutations account for 25-30% of cases. The clinical features are the result of a weakening of the supporting tissues, due to defects in fibrillin-1, a glycoprotein and a principal component of the extracellular matrix microfibril. The gene for fibrillin-1 (FBN1) is located on chromosome 15. More than 200 mutations in FBN1 have been described. The phenotype presents to a highly variable degree due to varying genotype expression (136-138). Part III - History and Management of Unoperated Patients Prognosis of patients with Marfan syndrome is mainly determined by aortic root abnormalities, which predispose to progressive dilation and dissection, and lead to aortic regurgitation. The mean survival of untreated patients is 40 years, but the variance is large. Not only the aortic root, but also other parts of the aorta and "elastic" arteries may be dilated and may dissect or rupture, but much less commonly. Patients with a dilated aorta are usually asymptomatic. The presence of aortic regurgitation or mitral valve prolapse with regurgitation may lead to signs or symptoms of left ventricular volume overload.

74. Marfan Syndrome - Lucile Packard Children's Hospital Cardiovascular Diseases. marfan syndrome What is marfan syndrome? Itoccurs in one in 20,000 livebirths. What causes marfan syndrome? http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/cardiac/marfan.html

Arrhythmia Service/Electrocardiography (ECG) Laboratory Cardiac Catheterization / Angiography Cardiology Cardiothoracic Surgery ... Packard Heart Surgeon Performs Operation on Smallest Infant Cardiovascular Diseases Marfan Syndrome What is Marfan syndrome? Marfan syndrome is a disorder involving the body's connective tissue. Connective tissue has many important functions, including the following: assisting with growth and development of the body's cells, both before and after birth supporting tissues in the body acting as an adhesive to hold certain tissues together protecting joints facilitating the passage of light through the eye A defective (FBN1) gene associated with Marfan syndrome affects the formation of a protein in connective tissue called fibrillin, which impacts the integrity of many organs and structures in the body. Organs and body systems that can be impacted include, but are not limited to, the following: heart and major blood vessels lungs skeletal system spinal cord eyes skin An estimated 50,000 people in the United States have Marfan syndrome (or three out of every 5,000 people). Marfan syndrome occurs in equal numbers in males and females, and also appears equally in all races and ethnic groups. It occurs in one in 20,000 livebirths.

75. Center For Marfan Syndrome And Related Connective Tissue Disorders - Lucile Pack Center for marfan syndrome and Related Connective Tissue Disorders.Location Lucile Packard Children s Hospital 725 Welch Road Palo http://www.lpch.org/clinicalSpecialtiesServices/ClinicalSpecialties/MarfanSyndro

Cardiologists Cardiothoracic Surgeons Medical Geneticists Ophthalmologists ... Orthopaedic Surgeons Center for Marfan Syndrome and Related Connective Tissue Disorders Location: Lucile Packard Children's Hospital 725 Welch Road Palo Alto, CA 94304 Click here for map Clinic/Suite: Clinic C Mailing Address: 725 Welch Road Palo Alto, CA 94304 Contact Phone: Fax Number: Email Address: spellone@stanfordmed.org Email is not secure. Do not send private medical information. Days and Hours: Monday 8:00 am - 5:00 pm Lucile Packard Children's Hospital hosts one of the premier centers for the study and treatment of Marfan Syndrome in the nation. At Packard, treatment of this genetic disease involves a coordinated multidisciplinary effort. Stanford hosts the most extensive program for Marfan-related thoracic aneurysm in California and one of the largest in the country. Marfan syndrome is an inherited disorder of connective tissue that strikes at least one in 5,000 individuals. The genetic defect that causes the Marfan syndrome involves the connective tissues within several organs such as the heart, aorta, eyes, and musculoskeletal system. Marfan syndrome affects both men and women, children and adults, and all races and ethnic groups. Without appropriate diagnosis and treatment, many Marfan patients die prematurely of cardiovascular complications. Marfan-related disorders include: Ehlers-Danlos Syndrome Annuoloaortic ectasia Homocystinuria Familial aortic aneurysms

76. Echocardiography marfan syndrome. disease. 2. marfan syndrome and retroperitoneal fibrosis.Phillips S; Evans C. Am J Roentgenol, 167(6)15967 1996 Dec. http://www2.umdnj.edu/~shindler/marfan_jump.html

Marfan Syndrome E-chocardiography Journal: Alphabetical List Chronological List Images Home Page ... Marfan syndrome at the Online Mendelian Inheritance in Man database. Images. Fibrillin. Pneumothorax mimicking dissection. Radiology case presentation from the University of Hawaii. Description in lay terms. CT scan of the descending aorta with mural thrombus surrounded by soft tissue attenuation encasing the aorta indicating the presence of retroperitoneal fibrosis. References: Delay in diagnosis is common in retroperitoneal fibrosis because of the non-specific clinical presentation. Ultrasonography combined with color Doppler imaging is a rapid and practical method in the early diagnosis and during follow-up. The authors describe 3 cases with retroperitoneal fibrosis, emphasizing the ultrasonographic and color Doppler features of the disease. 2. Marfan syndrome and retroperitoneal fibrosis. Phillips S; Evans C. Am J Roentgenol, 167(6):1596-7 1996 Dec Back to E-chocardiography Home Page. e-mail: shindler@umdnj.edu

77. The DNA Files - Interact - Marfan Syndrome INTERACT. marfan syndrome Scenario. Both were initially diagnosed with heartfailure, but further analysis uncovered the real killer marfan syndrome. http://www.dnafiles.org/interact/marfan/

INTERACT Marfan Syndrome Scenario In the U.S., few pursuits provide potential for fame and fortune as much as professional sports. Over recent decades, that fact has brought to light a troubling scenario: young athletes in peak condition dying suddenly, without warning. Flo Hyman, one of the women who brought volleyball to prominence in the U.S., collapsed and died in a matter of moments during a match. At least two highly-touted collegiate basketball stars also succumbed suddenly and unexpectedly, before ever having a chance to play a professional game. Both were initially diagnosed with heart failure, but further analysis uncovered the real killer: Marfan syndrome. Marfan is a genetic disorder that affects connective tissue and sometimes weakens the aorta (a blood vessel attached to the heart) so severely that it can rupture during physical exertion. About 1 in 10,000 people is affected by Marfan, and the condition is not limited to any race, gender, or ethnicity. What would you do if you thought that you - or a family member - had characteristics associated with Marfan? Explore your choices in our

78. Marfan Syndrome marfan syndrome. marfan syndrome. Marfan Association UK. marfan syndrome/ genetics. GeneReviews congenital contractural arachnodactyly. http://omni.ac.uk/browse/mesh/C0024796L0024796.html

low graphics Marfan Syndrome Marfan Syndrome Marfan Syndrome / genetics broader: Abnormalities, Multiple Connective Tissue Diseases Genetic Diseases, Inborn Heart Defects, Congenital other: Achondroplasia Adrenal Hyperplasia, Congenital Alagille Syndrome Angelman Syndrome ... Scleroderma, Circumscribed Marfan Syndrome Marfan Association UK The Web site for the Marfan Association in the UK, providing a fact sheet for patients about the syndrome, news, events, a contact list of support groups, and a list of publications. Organizations, Nonprofit Marfan Syndrome Great Britain Charities ... Questions and answers about Marfan syndrome This fact sheet on Marfan Syndrome is produced by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). It describes what Marfan Syndrome is, Marfan Syndrome characteristics, causes, diagnosis, and available treatments. Produced in October 2001, there is additional information on Marfan Syndrome research and sources of help and support. Patient Education Handout [Publication Type] Marfan Syndrome Marfan Syndrome / genetics GeneReviews : congenital contractural arachnodactyly Notes for physicians on congenital contractural arachnodactyly (CCA, Beals Syndrome). This document includes diagnosis, a clinical description, differential diagnosis, management, genetic counselling, and molecular genetics. Posted in January 2001, this resource forms part of GeneReviews (formerly GeneClinics profile), a peer-reviewed clinical genetic information resource that is funded by the US National Institutes of Health (NIH) and produced by the University of Washington, Seattle. This resource contains a summary and bibliographical references of the review. Free access to the full-text version of the review requires brief registration.

79. Salon :: :: People :: Feature :: Does Bin Laden Have Marfan Syndrome?, By Mark F Does bin Laden have marfan syndrome? It s certainly conceivable thathe has the marfan syndrome and could be evaluated for it. . http://www.salon.com/people/feature/2001/11/09/marfan/

Search All of Salon.com Directory Hot Topics Iraq Joe Conason's Journal The Sopranos Osama bin Laden ... World Trade Center and Pentagon Attacks Articles by date All of Salon.com By department Get a free Allstate quote Search our Personals ... Corrections Does bin Laden have Marfan syndrome? Is Osama suffering from a rare disease that can cause sudden death? By Mark Francis Cohen If what some medical experts say is true, it may not require a military strike to kill Osama bin Laden. For several years now, reports have been circulating that claim the 45-year-old is quite ill, sees doctors regularly and may have a heart problem. The evidence is sketchy, but some see signs that bin Laden could die suddenly. Marfan syndrome is a potentially fatal disorder of connective tissue, and some believe it's jeopardizing the life of al-Qaida's elusive leader. Bin Laden would be in good company: Some say Marfan would have killed Abraham Lincoln if John Wilkes Booth had missed his mark in 1865. It also appears to have claimed the lives of Jonathan Larson, author of the musical "Rent," who died on the eve of the production's 1996 Broadway debut; Chris Patton, a University of Maryland basketball star who died during a pickup game; and Flo Hyman, an Olympic volleyball player who died at 31 in 1986. The aortas of all three ripped in a manner consistent with the disorder. Charles de Gaulle and composer Sergei Rachmaninoff are also believed to have had Marfan. Although Marfan syndrome, like sickle cell anemia, is often the product of an inherited genetic mutation, determining whether someone has the disease is tricky. Experts say one in 10,000 people have it, but that thousands are unaware that they are affected. The

80. Barnes-Jewish Hospital - Marfan Syndrome marfan syndrome. Some experts suspect Abe Lincoln may have had marfan syndrome.marfan syndrome leads to aortic enlargement (aneurysm formation). http://www.barnesjewish.org/groups/default.asp?NavID=895

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