41. Chemical Leukodystrophy chemical leukodystrophy. This article submitted by Cindy Daubenmire on 9/12/95. Does anybody know what chemical leukodystrophy is? http://neuro-www.mgh.harvard.edu/neurowebforum/generalfeedbackarticles/chemicall

chemical leukodystrophy This article submitted by Cindy Daubenmire on 9/12/95. Does anybody know what chemical leukodystrophy is? Could it manifest itself similarly to MS? Where can I get information about it? Next Article Previous Article Return to Topic Menu Here is a list of responses that have been posted to this article... SLEEP (7/14/96) 12:40 AM chemical leukodystrophy (1/5/96) 22:30 You now have TWO OPTIONS: Post a new Article or post a Response to this Article Click here to post a new Article! If you would like to post a Response to this article, fill out this form completely... Do not use slashes ("/") or colons (":") in your Article title! Response Title: Author: Response Text: Original Article: (Don't change this field!) Forum: (Don't change this field either!) Article complete. Click HERE to return to the Neurology Web-Forum Menu.

42. Leukodystrophy Articles, Support Groups, And Resources leukodystrophy articles, support groups, and resources for patients from Med Help International (www.medhelp.org). leukodystrophy. http://www.medhelp.org/HealthTopics/Leukodystrophy.html

[Health Topics A-Z] A B C D ... Z Leukodystrophy Support Groups: United Leukodystrophy Foundation, Inc. [Med Help Home] [Library Search] [Medical Forums] ... [Patient Network] Revised: 6/2/2004

43. Health Library - leukodystrophy. Synonyms. None. Disorder Subdivisions. Refsum s Disease; Cerebrotendinous Xanthomatosis; Metachromatic leukodystrophy; Globoid leukodystrophy; http://yalenewhavenhealth.org/library/healthguide/IllnessConditions/topic.asp?hw

44. Health Library - prevention. leukodystrophy, Metachromatic. blindness. Metachromatic leukodystrophy is inherited as an autosomal recessive trait. http://yalenewhavenhealth.org/library/healthguide/IllnessConditions/topic.asp?hw

45. Leukodystrophy leukodystrophy. What is leukodystrophy? What is the prognosis? The prognosis for the leukodystrophies varies according to the specific type of leukodystrophy. http://www.clevelandclinic.org/health/health-info/docs/1200/1298.asp?index=6034&

46. Leukodystrophy, Metachromatic leukodystrophy, Metachromatic Important It is possible that the main title of the report leukodystrophy, Metachromatic is not the name you expected. http://my.webmd.com/hw/health_guide_atoz/nord212.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Quizzes, Calculators Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report Leukodystrophy, Metachromatic Important It is possible that the main title of the report Leukodystrophy, Metachromatic is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Late-Onset Metachromatic Leukodystrophy ARSA Arylsulfatase A Deficiency Cerebroside Sulfatase Deficiency Diffuse Cerebral Sclerosis Greenfield Disease Metachromatic Form of Diffuse Cerebral Metachromatic Leukoencephalopathy MLD Sulfatide Lipidosis Sulfatidosis Disorder Subdivisions Late Infantile Metachromatic Leukodystrophy Juvenile Metachromatic Leukodystrophy Adult Metachromatic Leukodystrophy General Discussion Metachromatic leukodystrophy, the most common form of leukodystrophy, is a rare inherited neurometabolic disorder affecting the white matter of the brain (leukoencephalopathy). It is characterized by the accumulation of a fatty substance known as sulfatide (a sphingolipid) in the brain and other areas of the body (i.e., liver, gall bladder, kidneys, and/or spleen). The fatty protective covering on the nerve fibers (myelin) is lost from areas of the central nervous system (CNS) due to the buildup of sulfatide. Symptoms of metachromatic leukodystrophy may include convulsions, seizures, personality changes, spasticity, progressive dementia, motor disturbances progressing to paralysis, and/or visual impairment leading to blindness.

47. Leukodystrophy United leukodystrophy Foundation, Inc. leukodystrophy United leukodystrophy Foundation, Inc. National network. Founded 1982. Provides http://my.webmd.com/hw/health_guide_atoz/shc29leu.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Quizzes, Calculators Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... United Leukodystrophy Foundation, Inc. Leukodystrophy United Leukodystrophy Foundation, Inc. National network. Founded 1982. Provides information and resources for leukodystrophy patients and their families. Communication network among families. Promotes research, public and professional awareness. Quarterly newsletter. National conference. Dues $25/family; $50/professional. WRITE: United Leukodystrophy Fdn. 2304 Highland Dr. Sycamore, IL 90178 CALL: 815-895-3211 FAX: 815-895-2432 E-MAIL: ulfoff@tbcnet.com WEBSITE: http://www.ulf.org VERIFIED: 4/30/2003 The above information is based upon information available through the "verified" date at the end of each listing. Since American Self-Help Group Clearinghouse's resources are limited; it is not possible to keep every entry in American Self-Help Group Clearinghouse database completely current and accurate. Please check with the organizations listed for the most current information. For additional information and assistance about self-help groups, please contact the American Self-Help Group Clearinghouse in Cedar Knolls, New Jersey, by email at: info@selfhelpgroups.org

48. Australian Leukodystrophy Support Group Inc http://avoca.vicnet.net.au/~leuko/

49. Whtleuko What is leukodystrophy? leukodystrophy is a progressive disorder that affects the brain, spinalcord, and the peripheral nerves witin the brain. http://www.miramar.sdccd.cc.ca.us/faculty/fgarces/ChemProj/Ch100_F2K/Chem100Page

What is Leukodystrophy? brain is affected with the dyemilation of the myelin sheath. A group of equipped researchers called the Myelin Project , who's aim was to try and repair the myelin sheath and decrease the dyemilation through oriented experiments. The group work included researchers from Yale University, Mount Sinai Medical Group, and the College in France, just to name a few. Myelin sheath- Myelin sheaths are hundreds of concentric layers of a white, fatty material that encase somenervefibers in vertebrate animals. In the neuron cell, they are formed by specialized cells (Schwann cells) the and help insulate and protect the axon. They also increase the impulse of nerve transmission. Axon-Axons are the long threadlike extensions of a nerve cell that are located at the core of a nerve fiber. They generally conducts electrochemical impulses away from the cell body towards other nerve cells or an effector organ (such as a muscle) . These axons terminate in synapses, and junctions with other nerve cells, muscles, or glands. In the neuron cell, the axon is the longest process that extends from a cell body. Some of these axons reach a length of more then three feet (one meter) . When they have a thick diameter the nerve impulses are conducted very quickly.

50. Leukodystrophy Search Books. Keywords Find it Here. leukodystrophy. leukodystrophy CHORUS document on the different types of leukodystrophy. http://www.health-nexus.com/leukodystrophy1.htm

Health-Nexus.Net Health-Nexus.Org The #1 Health information site Home ... Up Search Health-Nexus for: Match ALL words Match ANY word Email this page to a friend ! Post a question or comment on our Message Board Home Page Health Specialties Health News ... Alternative Health Options Substance Abuse Animal Health Search: Books Magazines Video Keywords: Find it Here Leukodystrophy The Family Village / Library / Leukodystrophy - Types of Leukodystophy: Adrenoleukodystrophy, Alexander Disease, Canavan Disease, Krabbes Disease, Metachromatic Leukodystrophy, and Refsum's Disease. United Leukodystrophy Foundation - UNITED LEUKODYSTROPHY FOUNDATION 2304 Highland Drive * Sycamore, Illinois USA 60178 * Phone: (800) 728-5483 * FAX: (815) 895-2432 The United Leukodystrophy Foundation (ULF), incorporated in 1982, is a nonprofit, voluntary health organization. Leukodystrophy - CHORUS document on the different types of Leukodystrophy.

51. V. Leukodystrophy-like Changes Slide Vol. 1, Article 4, Palasis, et al. V. leukodystrophylike Changes. A leukodystrophy or demyelinating disorder can have a similar appearance. A. B. A. B. http://www.neurographics.org/Palasis/7.shtml

Vol. 1, Article 4 Palasis, et al. V. Leukodystrophy-like Changes Fig 8. 4 yr old girl with hearing loss and lactic aciduria. A, Axial IR and, B, axial T2 FSE images reveal abnormal signal within the white matter of the occipital horns. No significant white matter volume loss is present. A leukodystrophy or demyelinating disorder can have a similar appearance. A. B. A. B. Fig 9. 5 yr old girl with bilateral hearing loss, growth delay, and lactic aciduria. A. Sagittal T1 weighted and B, axial FLAIR images demonstrate abnormal confluent periventricular white matter signal. Small areas of cystic change within the abnormal white matter can also be seen. This appearance is suggestive of a leukodystrophy, but can be seen with mitochondrial disorders as well. A. B. Fig 10. 12 yr old girl with decreased muscle mass, poor growth and retinitis pigmentosa. A, Axial FLAIR sequence shows abnormal signal involving cerebellar and perirolandic white matter. B. Axial T2 FSE demonstrates perirolandic white matter signal abnormality (arrow). No basal ganglia lesions were present. The patient was diagnosed with possible Kearns-Sayre syndrome. It should be kept in mind that there is considerable overlap between the appearance of various mitochondrial OXPHOS disorders. A.

52. Disease Directory : Neurological Disorders : Demyelinating Diseases : Leukodystr AicardiGoutieres Syndrome - News, descriptions, contacts, and other information concerning this leukodystrophy. AshleysAngels.org What is leukodystrophy? http://www.diseasedirectory.net/Neurological_Disorders/Demyelinating_Diseases/Le

Wednesday, June 02, 2004 Neurological Disorders Demyelinating Diseases Guillain-Barre Syndrome Leukodystrophy ... Demyelinating Diseases : Leukodystrophy Adrenoleukodystrophy Krabbe Disease Canavan Metachromatic Leukodystrophy ... Aicardi-Goutieres Syndrome - News, descriptions, contacts, and other information concerning this leukodystrophy. Alexander Disease - Information sheet compiled by NINDS, the National Institute of Neurological Disorders and Stroke. AllRefer Health - Metachromatic Leukodystrophy (Arylsulfatase A ... - Metachromatic Leukodystrophy (Arylsulfatase A Deficiency, MLD) information center covers causes, prevention, symptoms, diagnosis, treatment, incidence, risk - What is Leukodystrophy? Answer: Leukodystrophy, also referred to How does Leukodystrophy occur? Answer: Generally speaking, in Leukodystrophy Call Again Soon - Directed at making life better for people affected by Leukodystrophy and those who know and love them. Campath 1-h for MS - Provides details of personal experience of Campath 1-h as a treatment for multiple sclerosis. chemical leukodystrophy - chemical leukodystrophy. This article submitted by Cindy Daubenmire on 9/12/95. Does anybody know what chemical leukodystrophy is?

53. Bethanys Hope Foundation - What Is MLD? Metachromatic leukodystrophy (MLD), Metachromatic blindness. Metachromatic leukodystrophy is inherited as an autosomal recessive trait. http://www.bethanyshope.org/whatismld.html

Bethany's Story What is MLD? Research Family Area ... Help Metachromatic Leukodystrophy (MLD) Metachromatic Leukodystrophy (MLD), the most common form of Leukodystrophy, is a rare inherited neurometabolic disorder affecting the white matter of the brain (Leukoencephalopathy). It is characterized by the accumulation of a fatty substance known as sulfatide (a sphingolipid) in the brain and other areas of the body (i.e., liver, gall bladder, kidneys, and/or spleen). The fatty protective covering on the nerve fibers (myelin) is lost from areas of the central nervous system (CNS) due to the buildup of sulfatide. Symptoms of Metachromatic Leukodystrophy may include convulsions, seizures, personality changes, spasticity, progressive dementia, motor disturbances progressing to paralysis, and/or visual impairment leading to blindness. Metachromatic Leukodystrophy is inherited as an autosomal recessive trait. There are three types of the disease that have similar symptoms.

54. Metachromatic Leukodystrophy: Research Into Developing Therapies UNIVERSITY of PITTSBURGH DEPARTMENT of HUMAN GENETICS Molecular Genetics Laboratory. Metachromatic leukodystrophy Research Into Developing Therapies. http://www.pitt.edu/~geneorb/metachromatic_leukodystrophy__new_approaches_to_tre

U NIVERSITY of P ITTSBURGH D EPARTMENT of H UMAN G ENETICS Molecular Genetics Laboratory Metachromatic Leukodystrophy: Research Into Developing Therapies Metachromatic leukodystrophy (MLD) is an inherited disease in which fatty substances build up in the brain and spinal cord. This buildup happens in the part of the brain and spinal cord called the white matter, affecting a person's mental development and ability to move in a coordinated way. Most forms of MLD appear in early childhood, but the disease may also occur in adults. It usually leads to progressive paralysis and, in children, early death. MLD is a rare disease, affecting about one in 50,000 people. Traditional forms of treatment have not been very successful at combating MLD. However, promising new approaches from the fields of gene therapy and cell transplantation provide hope for the future. What causes MLD? MLD is caused by an inability to break down sulfatide a fatty substance normally present in the brain. Scientists have traced the development of MLD to a defect in the gene that tells the body how to make an enzyme called arylsulfatase A (ASA). ASA is the enzyme responsible for breaking down sulfatide into smaller, harmless chemicals that can be eliminated or reused by the body. In MLD, the lack of proper ASA enzyme leads to a buildup of sulfatide, which causes a process called demyelination. Demyelination causes the symptoms of MLD affecting communication between nerves in the brain.

55. MedFriendly.com: Metachromatic Leukodystrophy provides an easy to understand definition for the medical term, metachromatic leukodystrophy. TM, Metachromatic leukodystrophy MedFriendly.com TM TM http://www.medfriendly.com/metachromaticleukodystrophy.html

TM Metachromatic leukodystrophy MedFriendly.com TM TM A B C D ... What is the origin of the term, "metachromatic leukodystrophy"? The Official Parent's SourceBook on Metachromatic Leukodystrophy (Official Parents Guide) WHAT IS IT? Metachromatic leukodystrophy is a type of metabolic disorder that leads to a deadly build up of fats (known as lipids) in the body and the destruction of myelin . Myelin is a fatty nerve covering that sends impulses quickly. A metabolic disorder means that there is some type of impairment in metabolism. Metabolism is a term for the chemical actions in cells that release energy from nutrients or that use energy to create other substances. A cell is the smallest, most basic unit of life, that is capable of existing by itself. Metachromatic leukodystrophy is an inherited disorder, meaning that it is passed on to the child from the parents' genes. Genes are units of material contained in a person's cells that contain coded instructions as for how certain bodily characteristics (such as eye color) will develop. All of a person's genes come from his/her parents. Genes are contained in structures called chromosomes. Each person has 23 pairs of chromosomes. In metachromatic leukodystrophy, chromosome 22 is dysfunctional because it is missing an enzyme known as arylsulfatase. An enzyme is a type of protein that helps produce chemical reactions in the body. Without the enzyme, arylsulfatase, a build up of metachromatic lipids occurs in the body. Metachromatic lipids are fatty substances that have changed colors. The technical name for the type of metachromatic lipids that build up in this condition is called galactosyl sulfatidates.

56. Globoid Cell Leukodystrophy related terms Krabbe s disease, galactocerebrosidosis. What is globoid cell leukodystrophy? How is globoid cell leukodystrophy inherited? http://www.upei.ca/~cidd/Diseases/nervous system disorders/globoid cell leukodys

related terms: Krabbe's disease, galactocerebrosidosis What is globoid cell leukodystrophy? This is a storage disease, one of a relatively rare group of disorders in which there is a deficiency of a particular enzyme necessary for normal metabolic processes within the body. The result is an accumulation in cells ("storage") of whatever product the enzyme normally acts upon. Typically, animals with a storage disease are normal at birth, fail to grow as rapidly as littermates, and at a consistent age, develop progressive signs of a disorder of the nervous system which will ultimately be fatal. In globoid cell leukodystrophy (GCL), the lack of the enzyme ß-galactocerebrosidase results in an accumulation of galactocerebroside, a component of myelin. This disrupts the cells that normally produce myelin, a fatty substance that coats nerve cells, serves as an electrical insulator and is crucial to the normal conduction of nerve impulses. The progressive loss of myelin in the white matter tracts of the nervous system (brain, spinal cord and/or peripheral nerves) causes a variety of clinical signs such as lack of coordination, tremors, and weakness. Krabbe's disease is a similar condition in people.

57. Metachromatic Leukodystrophy Metachromatic leukodystrophy is a genetic disorder caused by a deficiency of the enzyme arylsulfatase A. Subscribe now . Metachromatic leukodystrophy. http://healthlink.mcw.edu/article/921440824.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Neurology By keywords: Receive Health Link via email! Subscribe now >> Metachromatic Leukodystrophy Metachromatic leukodystrophy (MLD) is a genetic disorder caused by a deficiency of the enzyme arylsulfatase A. It is one of a group of genetic disorders called the leukodystrophies that affect growth of the myelin sheath, the fatty coveringwhich acts as an insulatoron nerve fibers in the brain. There are three forms of MLD: late infantile, juvenile, and adult. In the late infantile form, which is the most common, onset of symptoms begins between ages 6 months and 2 years. The infant is usually normal at birth, but eventually loses previously gained abilities. Symptoms include hypotonia (low muscle tone), speech abnormalities, loss of mental abilities, blindness, rigidity (uncontrolled muscle tightness), convulsions, impaired swallowing, paralysis, and dementia. Symptoms of the juvenile form begin between ages 4 and 14, and include impaired school performance, mental deterioration, ataxia, seizures, and dementia.

58. Leukodystrophy leukodystrophy refers to a group of genetic disorders that are characterized by the imperfect growth or development of the white matter or myelin sheath http://healthlink.mcw.edu/article/921774741.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: By keywords: Receive Health Link via email! Subscribe now >> Leukodystrophy Leukodystrophy, also called "the leukodystrophies," refers to a group of genetic disorders that are characterized by the imperfect growth or development of the white matter or myelin sheath covering nerve fibers in the brain. The myelin sheath is an extremely complex fatty substance made of many components. Each of the leukodystrophies affects one of these components. Specific leukodystrophies include metachromatic leukodystrophy, Krabbe leukodystrophy, adrenoleukodystrophy, Pelizaeus-Merzbacher disease, Canavan disease, Alexander disease, Zellweger syndrome, Refsum disease, and cerebrotendinous xanthomatosis. Scientists say there may be other leukodystrophies that have not yet been identified. The most common signs seen in most leukodystrophies include gradual changes in an infant or child who previously appeared well. Changes may appear in body tone, movements, gait, speech, ability to eat, vision, hearing, behavior, memory, or thought processes. The symptoms, which vary according to the specific type of leukodystrophy, may be difficult to recognize in the early stages of the disease. Treatment of the leukodystrophies is symptomatic and supportive, and may include medications, physical, occupational and speech therapies, and nutritional, educational, and recreational programs.

59. Krabbe's Leukodystrophy Krabbe s leukodystrophy,. Print this article, (Knud Krabbe s leukodystrophy, Fig. 1. a, b. CT scan without contrast. Periventricular http://www.amershamhealth.com/medcyclopaedia/medical/Volume VI 1/KRABBES LEUKODY

Amershamhealth.com Search for: Type a word or a phrase. All forms of the word are searchable. Browse entry words starting with: A B C D ... Other characters Krabbe's leukodystrophy, (Knud H. Krabbe, 18851961, Danish neurologist), (also known as globoid cell leukodystrophy), lysosomal disorder of myelin metabolism ( lysosomal diseases ), with autosomal recessive inheritance, characterized by a deficiency of galactosylceramidase, also called galactocerebroside beta-galactosidase. Galactocerebroside accumulates in the brain and peripheral nerves. Clinically three different phases are recognized: spasticity and irritability by six months of age; followed by rapid deterioration of motor function, chronic opisthotonus and myoclonic jerking, hyperpyrexia and hypersalivation; and finally decerebration followed by death, which is usually within the first year of life. The abnormalities found on CT and MR are related to the stage of the disease ( Fig.1 ). CT hyperdensities may be noted in the basal ganglia due to calcific deposits; these are not as clear on MR. White matter T2 hyperintensity is observed in the posterior limb of the internal capsule, fibres of the corona radiata and brain stem. No enhancement has been reported. GS The Encyclopaedia of Medical Imaging Volume VI:1 Krabbe's leukodystrophy, Fig. 1

60. Leukodystrophy Other characters, leukodystrophy,. Print this article, see Krabbes leukodystrophy, metachromatic leukodystrophy, lysosomal diseases and adrenoleukodystrophy. http://www.amershamhealth.com/medcyclopaedia/medical/Volume VI 1/LEUKODYSTROPHY.

Amershamhealth.com Search for: Type a word or a phrase. All forms of the word are searchable. Browse entry words starting with: A B C D ... Other characters Leukodystrophy, see Krabbes leukodystrophy metachromatic leukodystrophy lysosomal diseases and adrenoleukodystrophy GS The Encyclopaedia of Medical Imaging Volume VI:1 Contacts GE Healthcare Making Waves

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