41. Entrez PubMed Abstract, CSF hypocretin1 levels in narcolepsy, kleine-levin syndrome, and other hypersomnias and neurological conditions. J Neurol Neurosurg Psychiatry. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=PureSearch&db=PubMed&details_t

42. Entrez PubMed Comment in Psychiatry. 2000 Spring;63(1)1013. The kleine-levin syndrome as a neuropsychiatric disorder a case report. Masi G http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

43. Disabilityexchange.org - Taxonomy kleinelevin syndrome. What is kleine-levin syndrome? Is there any treatment? There is no definitive treatment for kleine-levin syndrome. http://www.disabilityexchange.org/taxonomy/index.php?fid=3&path=3_771

44. Kleine-Levin Syndrome - General Practice Notebook kleinelevin syndrome. Medical search. kleine-levin syndrome is characterised by episodes of somnolence and increased appetite, often http://www.gpnotebook.co.uk/medwebpage.cfm?ID=-456130552

45. Mioti: Diseases + Conditions Diseases + Conditions kleinelevin syndrome. Search Mioti kleine-levin syndrome Foundation. The kleine-levin syndrome Foundation, Inc. http://www.mioti.com/cat/condition/condition.asp?Cat=KleineLevin

46. Free Online ICD9/ICD9CM Codes And Medical Dictionary kleinelevin syndrome Hypersomnia, Periodic Kleine-Levin-Critchley Syndrome Kleine Levin Critchley Syndrome Kleine Levin Syndrome Periodic Hypersomnia http://icd9cm.chrisendres.com/index.php?action=dictdtl&recordid=15153

47. Indian Journal Of Psychiatry kleinelevin syndrome a report of two cases. Two cases of kleine-levin syndrome with illness duration of three and four months respectively are presented. http://www.ijponline.org/July2001/indIJPCaseRep1.html

VOL. 43 NO.3 July 2001 Indian Journal of Psychiatry, 2001, Home Kleine-Levin syndrome : a report of two cases ABSTRACT Two cases of Kleine-Levin Syndrome with illness duration of three and four months respectively are presented. Both cases in their adolescence presented with typical features of the syndrome-onset after high grade fever, episodic course and spontaneous remission of each episode and normalcy in between the episodes. Characteristic features of each episode in both cases were hypersomnia, eating excessively, disinhibited behaviour, affective features like irritability social withdrawal and lack of personal care and cognitive disturbance. The second case had sexual disinhibition which is another important feature seen in Kleine-Levin Syndrome. Both patients responded well to lithium therapy. Key words : Kleine-Levin syndrome From India very few cases of Kleine-Levin syndrome have been reported (Prabhakaran et al.,1970; Shukla et al.,1982; Sagar et al.,1990; Malhotra et al.,1997). Here we present two cases of Kleine-Levin syndrome which were referred to the Child and Adolescent Psychiatry Clinic of G.B. Pant Hospital, New Delhi for management during last two years. Case 1 Case 2 Discussion Kleine-Levin syndrome is a peculiar disorder that primarily affects males but upto a quarter cases are now reported in females (Duffy et al.,1968). This disorder is conventionally considered as a neuro-psychiatric disordor and has been classified under the category of sleep disorder- recurrent hypersomnia or disorder of excessive somnolecence (Moore et al.,2000). The International Classification (ICD-10) has not included Kleine-Levin syndrome under the heading of behavioural syndromes associated with physiological disturbances and physical factors (F50-F59) or non-organic hypersomnia (WHO, 1992). It has been considered as a disorder of organic origin and has therefore, classified in chapter VI in Diseases of Nervous System (G47.8).

48. Penn State Faculty Research Expertise Database (FRED) Faculty Research Expertise Database. kleinelevin syndrome. Kleine Levin Critchley Syndrome, Kleine Levin Syndrome. Periodic Hypersomnia, Periodic Hypersomnias. http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D017593

49. NINDS Kleine-Levin Syndrome Information Page More about NINDS kleinelevin syndrome Information Page. Contact us Content for this page. NINDS kleine-levin syndrome Information Page. Reviewed 01-28-2003 http://accessible.ninds.nih.gov/health_and_medical/disorders/kleine_levin.htm

Disorders - National Institute of Neurological Disorders and Stroke (NINDS) Skip menus Main sections of the NINDS web site Home About NINDS Disorders-you are in this section ... Find People Disorders section pages and search Image Description Science For the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system. Select Topic Disorder Quick Links Alzheimer's Autism Cerebral Palsy Chronic Pain Epilepsy Headache Multiple Sclerosis Parkinson's Stroke Traumatic Brain Injury More about NINDS Kleine-Levin Syndrome Information Page Studies with patients Research literature Press release NINDS Search (search help) Contact us My privacy NINDS is part of the National Institutes of Health Contact us Content for this page NINDS Kleine-Levin Syndrome Information Page Reviewed 01-28-2003 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Kleine-Levin Syndrome? Is there any treatment? What is the prognosis? What research is being done? ... Related NINDS Publications and Information What is Kleine-Levin Syndrome? Kleine-Levin syndrome is a rare disorder that causes recurring periods of excessive drowsiness and sleep (up to 20 hours per day). Symptoms, which may last for days to weeks, include excessive food intake, irritability, disorientation, lack of energy, and hypersensitivity to noise. Some patients may also experience hallucinations and an abnormally uninhibited sex drive. Affected persons are normal between episodes, although depression and amnesia may be noted temporarily after an attack. It may be weeks or more before symptoms reappear. Onset is typically around adolescence to the late teens. The disorder is 4 times more common in males than in females. Symptoms may be related to malfunction of the hypothalamus, the part of the brain that governs appetite and sleep.

50. Kleine Levin Syndrome Kleine levin syndrome. kleinelevin syndrome/DI; kleine-levin syndrome/DT; Snoring/CO; Magnetic Resonance Imaging; Human; Male; Adolescents; Case Report. http://medind.nic.in/imvw/imvw2432.html

Extracted from IndMED Chakraborty PK; Katoch V; Sharma PK; Divinakumar KJ; Johri S. Dept-of psychiatry, SSQ. 402 Air Force Station, Kanpur Kleine levin syndrome Medical Journal Armed Forces India. 2001 Oct; 57(4): 335-6 KEYWORDS: Kleine-levin Syndrome/DI; Kleine-levin Syndrome/DT; Snoring/CO; Magnetic Resonance Imaging; Human; Male; Adolescents; Case Report References: 8 Record Identifier: NI205364

51. ORPHANET - Rare Diseases - Orphan Drugs Contact, Order the Orphanet book, Printing version, DISEASE kleinelevin syndrome, ICD G47.8, No description is available, MIM 148840, Other website(s)(3), http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=33543

52. Kleine Levins Syndrom and Managing the Adolescent with kleinelevin syndrome. Journal of Adolescent Health Care, 5; 139-141 (April 1984). Internetadresser http//www.kleinelevin.com http://www.hu.sll.se/frames/diagnos/medicin/kleinelevins.htm

Kleine-Levins syndrom Monica Björkman © 00 01 26 I min gamla lärobok i neurologi av Brain (1962) beskrivs syndromet så här: "...a rare disorder characterized by periodic attacks of excessive appetite followed by profound sleepiness which may last for days. During this phase the patient´s personality may be profoundly altered, but in the intervals between the attacks he is usually normal. The cause is unknown and in my experience no abnormality,clinical, biochemical, or electric can be discovered during the attack." Historik W. Kleine skrev en artikel på tyska 1925 om periodisk sömnsjuka och M. Levin skrev 1936 en i England som ungefär hette: Periodisk sömnighet och våldsam hunger, ett nytt syndrom.Det finns flera namn på syndromet: periodisk sömnsjuka, periodisk hypersomni, hypersomnia-bulimia syndromet och periodic somnolence and morbid hunger syndrome. Symtomlista från 1963 1. Drabbar unga människor och

53. FORMULAIRE INSCRIPTION RECHERCHE WWW.LACHAINETTE.COM Translate this page Contacts Rare disease selected kleine-levin syndrome Id, First name, Country, Web. 302, Bérangère, FRANCE, 660, Marie, FRANCE, 1112, guillaume, FRANCE, http://www.lachainette.com/US/ContactsPathologie.php?Action=contacter&Id=3449

54. Neurology -- Abstracts: Koerber Et Al. 34 (12): 1597 Neurology. ARTICLES. Increased cerebrospinal fluid 5hydroxytryptamine and 5- hydroxyindoleacetic acid in kleine-levin syndrome. RK http://www.neurology.org/cgi/content/abstract/34/12/1597

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: Email this article to a friend Correspondence: Submit a response to this article Similar articles found in: Neurology Online PubMed PubMed Citation This Article has been cited by: other online articles Search PubMed for articles by: Koerber, R. K. Case, M. Alert me when: new articles cite this article Download to Citation Manager ARTICLES Increased cerebrospinal fluid 5-hydroxytryptamine and 5- hydroxyindoleacetic acid in Kleine-Levin syndrome RK Koerber, R Torkelson, G Haven, J Donaldson, SM Cohen and M Case A 17-year-old man with the Kleine-Levin syndrome died unexpectedly of cardiopulmonary arrest during a period of autonomic instability that followed an episode of megaphagia. At autopsy, the only pertinent finding was mild depigmentation of the locus ceruleus and substantia nigra. Premortem CSF levels of 5-hydroxytryptamine (5-HT) and 5- hydroxyindoleacetic acid (5-HIAA) levels were elevated. These findings indicate that many symptoms of the Kleine-Levin syndrome are a result of a neurotransmitter imbalance in the serotonergic pathway of the brainstem.

55. Neurology -- Abstracts: Dauvilliers Et Al. 59 (11): 1739 kleinelevin syndrome. An autoimmune Background kleine-levin syndrome (KLS) is a rare disorder of unknown etiology. Pathophysiologic hypotheses http://www.neurology.org/cgi/content/abstract/59/11/1739

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: Full Text of this Article PDF Version of this Article Citation Map Email this article to a friend Correspondence: Submit a response to this article Similar articles found in: Neurology Online PubMed PubMed Citation This Article has been cited by: other online articles Search PubMed for articles by: Dauvilliers, Y. Tafti, M. Alert me when: new articles cite this article Download to Citation Manager Collections under which this article appears: Endocrine All Sleep Disorders Other hypersomnias Genetic linkage Neurology American Academy of Neurology Kleine-Levin syndrome An autoimmune hypothesis based on clinical and genetic analyses Y. Dauvilliers, MD G. Mayer, MD M. Lecendreux, MD E. Neidhart, BSc R. Peraita-Adrados, MD K. Sonka, MD M. Billiard, MD and M. Tafti, PhD Mehdi.Tafti@medecine.unige.ch Background: Kleine-Levin syndrome (KLS) is a rare disorder of unknown etiology. Pathophysiologic hypotheses include a hypothalamic dysfunction and abnormalities in the central serotonin and dopamine metabolism. Several clinical symptoms also suggest an underlying

56. Sleep Disorders Conditions And Diseases Support Groups Health Support Groups kleinelevin syndrome kleine-levin syndrome -KLS- is a rare sleep disorder that causes random episodes of excessive sleeping for indefinite periods of time http://support-groups.health.designerz.com/support-groups-conditions-and-disease

Map.Designerz.com Health.Designerz.com Support Groups News Support Groups Chat ... Mailing List document.write(' '); Health Support Groups Conditions and Diseases Sleep Disorders Support Groups ... Support Groups Chat Channels Visited Clear Featured Links Web Hosting Domain Names Designerz Portals Store Sign up for our mailing list ... Support Groups A comprehensive resource on Support Groups Conditions And Diseases Sleep Disorders Show Health support groups (Support Groups Conditions And Diseases Sleep Disorders) content on your web site Reach Health support groups (Support Groups Conditions And Diseases Sleep Disorders) Audience Save on Support Groups Conditions And Diseases Sleep Disorders books, magazines and software See which Support Groups Conditions And Diseases Sleep Disorders domain names are available Search Support Groups Conditions And Diseases Sleep Disorders on other search engines Press Releases, Stories and Articles on Support Groups Conditions And Diseases Sleep Disorders View all press releases Submit your press release View all articles Submit your article Featured Results (opens in a new window) Sleep Disorders Message Board Forum on the various sleep disorders.

57. Eating Disorders Specialist - Anorexia Bulimia Nervosa Pica And Obesity Includin with central nervous system (CNS) disorders including gangliocytoma of the third ventricle 99, hypothalmic astrocytoma 100, kleinelevin syndrome 101, 102 http://www.ltspeed.com/bjblinder/14.htm

Home Articles Papers Book Chapters ... About HYPERPHAGIA 14. HYPERPHAGIA Hyperphagia is defined as excessive ingestion of food beyond that needed for basic energy requirements. Ingestion may occupy unusual amounts of time. Eating may be obligatory and disrupt normal activity. In contrast, bulimia usually occurs surreptitiously in defined episodes and is terminated by abdominal pain, guilt or sleepiness. Hyperphagia Associated with Sleep Disorders Sasson [117] has noted that in patients with sleep apnea who are somnolent during the day, there is obligatory eating to induce alertness, thus reducing daytime drowsiness. This hyperphagia has produced markedly increased body weights in such patients. Binge eating behavior and morning anorexia have been described by Stunkard [118] in the context of a "night eating" syndrome, suggesting a component of sleep disturbance. In the Kleine-Levin Syndrome [101] hyperphagia is associated with hypersomia. Recent evidence evaluating episode hormone secretion dorms sleep in Kleine-Levin Syndrome reveals an abnormality in the hypothalamic regulation of pituitary hormones [119].

58. The Science Advisory Board kleinelevin syndrome dogbert.pitzer.edu/~dvaughan/ Rating kleine-levin syndrome is a rare disease with the sympotoms of the periodic sudden onset of http://www.scienceboard.net/resources/databases.asp?linkId=983

59. Monosemptomatik Kleine-Levin Sendromu: Bir Olgu Sunumu; Karadeniz Ve Ark. Translate this page Background.- kleine-levin syndrome is characterized by recurring episodes of hypersomnia, mental disturbances and abnormal behaviour including hyperphagia and http://ctf.istanbul.edu.tr/dergi/online/2000v31/s4/004o2.htm

MONOSEMPTOMATÝK KLEINE-LEVIN SENDROMU: Bir Olgu Sunumu* Derya KARADENÝZ, Enis ERDEM, Ayça GÜRDAL, Zerrin PELÝN, Levent ÖZTÜRK, Hakan KAYNAK Background.- Kleine-Levin syndrome is characterized by recurring episodes of hypersomnia, mental disturbances and abnormal behaviour including hyperphagia and hypersexuality. The episodes start suddenly generally after a mild viral infection, mild head injury or sometimes after a psychological stress. They last few days to several weeks and end abruptly. Between the episodes, there is no sleep disturbance and patients are physically and mentally normal. Patients sleep as long as 18 to 20 hours of the day during the episode. Hyperphagia and/or hypersexuality. are in compulsive manner. Mental disturbances include, irritability, feeling of unreality or confusion. Recently, monosymptomatic and atypic forms of the syndrome were reported. In monosymptomatic form, hypersomnia occurs without hyperphagia and hypersexuality. Atypical Kleine-Levin Syndrome includes the forms where one of the symptom is replaced by an opposite one. Observation.-

60. Arq. Neuro-Psiquiatr.  Vol.56 no.3B; Abstract: S0004-282X1998000400021 , Abstract. REIMAO, RUBENS and SHIMIZU, MARISA H. kleinelevin syndrome clinical course, polysomnography and multiple sleep latency test. Case report. Arq. http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-282X1998000400021&

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