61. Isaacs' Syndrome isaacs syndrome is a peripheral motor neuron disorder characterized by muscularstiffness and cramping, particularly in the limbs. isaacs syndrome. http://www.bchealthguide.org/kbase/nord/nord758.htm

document.write(''); var hwPrint=1; var hwDocHWID="nord758"; var hwDocTitle="Isaacs' Syndrome"; var hwRank="1"; var hwSectionHWID="nord758"; var hwSectionTitle=""; var hwSource="cn6.0"; var hwProdCfgSerNo="wsh_html_031_s"; var hwDocType="NORD"; National Organization for Rare Disorders, Inc. Isaacs' Syndrome Important It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Continuous Muscle Fiber Activity Syndrome Neuromyotonia Quantal Squander Isaacs-Merten Syndrome Disorder Subdivisions Neuromytonia, Generalized, Sporadic Neuromyotonia, Generalized, Familial Neuromyotonia, Focal Related Disorders List Information on the following diseases can be found in the Related Disorders section of this report: Hallervorden-Spatz Disease Paraplegia, Hereditary Spastic Stiff Man Syndrome General Discussion Isaacs' Syndrome is a peripheral motor neuron disorder characterized by muscular stiffness and cramping, particularly in the limbs. Continuous fine vibrating muscle movements (myokymia) can be seen. Muscle relaxation may be difficult especially after physical activity involving the particular muscle(s). These symptoms persist even during sleep. Symptoms In Isaacs' Syndrome, involuntary continuous muscle fiber activity may cause stiffness and delayed relaxation in the affected muscles. Continuous fine vibrating muscle movements (myokymia) may occur along with these symptoms. Affected individuals may have episodes of the inabilitiy to coordinate voluntary muscle movement and difficulty walking (ataxia). Other symptoms may include staggering and reeling (titubation), stiffness, and lack of balance in response to starle. There may be diminished spontaneous gross motors activity.

62. NORD - National Organization For Rare Disorders, Inc. A general discussion, the synonyms and further resources. http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Isaacs' Syndr

63. Patient 2 Selftest Patient 2 isaacs syndrome. 1. The following symptom/sign is commonlyseen in isaacs syndrome A. increased reflexes B. percussion http://www.bcm.tmc.edu/neurol/challeng/pat2/selftest.html

Isaacs' Syndrome 1. The following symptom/sign is commonly seen in Isaacs' syndrome A. increased reflexes B. percussion myotonia C. muscle cramping D. proximal muscle weakness 2. Characteristic EMG findings in a patient with Isaacs' syndrome may include A. doublets B. neuromyotonic discharges C. myokymic discharges D. all of the above 3. Therapy for Isaacs' syndrome may include all of the following except A. phenytoin B. tegretol C. benzodiazepines D. plasma exchange 4. The following is true about Stiffman's syndrome A. the muscle stiffness persists in sleep B. is associated with anti-GAD antibodies C. myokymia is seen on EMG D. phenytoin and carbamazepine are beneficial in the treatment of stiffness 5. The underlying cause of Isaacs' syndrome is thought to be A. altered myelination B. antibodies influencing the potassium channel C. vasculitis D. impaired axoplasmic transport Department of Neurology, Baylor College of Medicine Comments to: neurons URL:http://www.bcm.tmc.edu/neurol/index.html

64. Readers Digest Health A description of isaacs' syndrome, its alternate names and resources. http://www.readersdigesthealth.com/kbase/nord/nord758.htm

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65. Isaacs' Syndrome isaacs syndrome Important It is possible that the main title of thereport isaacs syndrome is not the name you expected. Please http://my.webmd.com/hw/health_guide_atoz/nord758.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Quizzes, Calculators Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report Isaacs' Syndrome Important It is possible that the main title of the report Isaacs' Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Continuous Muscle Fiber Activity Syndrome Neuromyotonia Quantal Squander Isaacs-Merten Syndrome Disorder Subdivisions Neuromytonia, Generalized, Sporadic Neuromyotonia, Generalized, Familial Neuromyotonia, Focal General Discussion Isaacs' Syndrome is a peripheral motor neuron disorder characterized by muscular stiffness and cramping, particularly in the limbs. Continuous fine vibrating muscle movements (myokymia) can be seen. Muscle relaxation may be difficult especially after physical activity involving the particular muscle(s). These symptoms persist even during sleep. Resources NIH/National Arthritis and Musculoskeletal and Skin Diseases Information Clearinghouse 1 AMS Circle Bethesda, MD 20892-3675

66. Isaacs' Syndrome,Continuous Muscle Fiber Activity Syndrome,Neuromyotonia Quantal isaacs syndrome,Continuous Muscle Fiber Activity syndrome,Neuromyotonia QuantalSquander,isaacsMerten syndrome,Generalized Sporadic Neuromytonia,Generalized http://www.icomm.ca/geneinfo/isaacs.htm

Isaacs' Syndrome,Continuous Muscle Fiber Activity Syndrome,Neuromyotonia Quantal Squander,Isaacs-Merten Syndrome,Generalized Sporadic Neuromytonia,Generalized Familial Neuromyotonia,Focal Neuromyotonia,Isaacs' Syndrome,Continuous Muscle Fiber Activity Syndrome,Neuromyotonia Quantal Squander,Isaacs-Merten Syndrome,Generalized Sporadic Neuromytonia,Generalized Familial Neuromyotonia,Focal Neuromyotonia For Information on Workshops and Seminars for Special Needs Children click here The GAPS INDEX to Information on the Internet about Genetic Disorders and Birth Defects Genetic Information and Patient Services, Inc. (GAPS) HOME DISORDERS GLOSSARY Isaac's Syndrome also known as: Continuous Muscle Fiber Activity Syndrome Neuromyotonia Quantal Squander Isaacs-Merten Syndrome Disorder Subdivisions Neuromytonia, Generalized, Sporadic Neuromyotonia, Generalized, Familial Neuromyotonia, Focal (as defined by the National Organization for Rare Disorders Isaacs' Syndrome is a peripheral motor neuron disorder characterized by muscular stiffness and cramping, particularly in the limbs. Continuous fine vibrating muscle movements (myokymia) can be seen.

67. Definitions Of Genetic Disorders-N. Familial isaacs.htm Neuromytonia, Generalized,Sporadic isaacs.htm Neuronal RetinitisPigmentosa mitoch.htm Neuropathy of Brachialpelxus syndrome parsturn.htm http://www.icomm.ca/geneinfo/def-n.htm

For Information on Workshops and Seminars for Special Needs Children click here The GAPS INDEX to Information on the Internet about Genetic Disorders and Birth Defects Genetic Information and Patient Services, Inc. (GAPS) HOME DISORDERS GLOSSARY Definitions of Genetic Disorders beginning with the letter N Click on the link next to the disorder to view its definition. N-Acetylglucosamine-1-Phosphotransferase Deficiency icell.htm N-Acetyl Glutamate Synthetase Deficiency nags.htm NADH-CoQ reductasedeficiency mitoch.htm Naegeli Ectodermal Dysplasias ed.htm Nager Syndrome nager.htm Nager Acrofacial Dysostosis Syndrome acrofac.htm Nager Acrofacial Dysostosis Syndrome nager.htm Nager Syndrome acrofac.htm NAGS Deficiency nags.htm Nail Dystrophy-Deafness Syndrome ed.htm Nail Dysgenesis and Hypodontia toothnail.htm Nail-Patella Syndrome nailpatella.htm Nance-Horan Syndrome catdent.htm Nanocephalic Dwarfism seckel.htm Nanocephaly seckel.htm Nanophthalmia anoph.htm

68. Health Library - isaacs syndrome. Important It is possible that the main title of thereport isaacs syndrome is not the name you expected. Please http://yalenewhavenhealth.org/library/healthguide/IllnessConditions/topic.asp?hw

69. Health Library Irritable Bowel syndrome (IBS). isaacs syndrome. Islet cell cancerTreatment Health Professional Information Cancer.gov. Islet http://yalenewhavenhealth.org/library/healthguide/IllnessConditions/_SearchResul

70. Isaacs-Mertens Syndrome Information Diseases Database isaacsMertens syndrome may cause or Medical information linksisaacs-Mertenssyndrome specific sites. Medical dictionary, library http://www.diseasesdatabase.com/ddb31529.htm

Diseases Database Index Sponsors Contact ... Previous Page Isaacs-Mertens syndrome Information Search Isaacs-Mertens syndrome may cause or feature (Follow link for list) belong(s) to the category of (Follow link for list) Isaacs-Mertens syndrome: Definition(s) via UMLS Code translations and terms via UMLS Isaacs-Mertens syndrome: specific sites Send Isaacs-Mertens syndrome to medical search engines (JavaScript enabled browsers only) If your browser has no JavaScript you can still use these: Search using Internet medical databases Search using Internet search engines (non-specialist) We subscribe to the HONcode principles of the Health On the Net Foundation i-medicine.info - the evidence based medicine, informatics and audit portal Valid XHTML 1.0 Served 2004-06-02 23:11:30 Metadata Updated 2004-05-22

71. Health, Conditions And Diseases, Neurological Disorders, Muscle Diseases: Isaacs Baylor Neurology Case of the Month A summary and general discussionabout isaacs syndrome. NORD isaacs syndrome - A general http://www.combose.com/Health/Conditions_and_Diseases/Neurological_Disorders/Mus

Top Health Conditions and Diseases Neurological Disorders ... Isaacs Syndrome Related links of interest: Health:Conditions and Diseases:Musculoskeletal Disorders Health:Conditions and Diseases:Neurological Disorders:Peripheral Nervous System Health:Conditions and Diseases:Rare Disorders Baylor Neurology Case of the Month - A summary and general discussion about Isaacs' syndrome. NORD: Isaacs' Syndrome - A general discussion, the synonyms and further resources. Readers Digest Health - A description of Isaacs' syndrome, its alternate names and resources. A rare neuromuscular disorder with onset usually in late childhood or early adulthood. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor The combose.com directory is based on the Open Directory and has been modified and enhanced using our own technology. About ComboSE Download Combose Toolbar

72. Health Library - isaacs syndrome. isaacs syndrome is a peripheral motor neuron disorder characterizedby muscular stiffness and cramping, particularly in the limbs. http://12.42.224.152/Library/HealthGuide/IllnessConditions/topic.asp?hwid=nord75

73. Birth Disorder Information Directory - I IronLoading Anemia Hereditary See Anemia, Hereditary Sideroblastic. isaacs (Mertens) syndrome (Continuous Muscle Fiber Activity, Hereditary) http://www.bdid.com/defecti.htm

HOME I I-Cell Disease (Mucolipidosis, Type II) List of Sites ICE Syndrome (Ichthyosis-Cheek-Eyebrow Syndrome, Sidransky Feinstein Goodman Syndrome) ICHTHYOSISCHEEKEYEBROW SYNDROME ICF Syndrome See Centromeric Instability Immunodeficiency Syndrome Ichthyosiform/Ichthyosis List of Sites -Alopecia-Eclabion-Ectropion-Mental Retardation Syndrome ICHTHYOSIS WITH ALOPECIA, ECLABION, ECTROPION, AND MENTAL RETARDATION -Camptodactyly Syndrome See Camptodactyly-Ichthyosis Syndrome -Cheek-Eyebrow Syndrome See ICE Syndrome -Hepatosplenomegaly-Cerebellar Degeneration Syndrome ICHTHYOSIS, HEPATOSPLENOMEGALY, AND CEREBELLAR DEGENERATION -Spastic Neurologic Disorder-Oligophrenia Syndrome See Sjogren-Larsson Syndrome with Large Keratohyalin Granules in the Skin ICHTHYOSIS-MENTAL RETARDATION SYNDROME WITH LARGE KERATOHYALIN GRANULES IN THE SKIN Erythroderma -Corneal Involvement-Deafness Syndrome See KID Syndrome Congenital (Brocq) Also see Netherton Syndrome Bullous Form (Epidermolytic Hyperkeratosis) Bullous ichtyosiform erythroderma congenita BULLOUS ERYTHRODERMA ICHTHYOSIFORMIS CONGENITA OF BROCQ Nonbullous Form Type 1 (Nonbullous Congenital Ichthyosiform Erythroderma, Type I)

74. Isaacs' Syndrome isaacs syndrome. isaacs syndrome is thought to be an autoimmune disorder andelevations of IgG synthesis may be seen in the CSF of these patients. http://neuro-www.mgh.harvard.edu/forum_2/ParkinsonsDiseaseF/Isaacssyndrome.html

This Web Forum is not moderated in any sense. Anyone on the Internet can post articles or reply to previously posted articles, and they may do so anonymously. Therefore, the opinions and statements made in all articles and replies do not represent the official opinions of MGH and MGH Neurology. Neither is MGH or MGH Neurology responsible for the content of any articles or replies. No messages are screened for content. Isaacs' syndrome This response submitted by P.F. Jennings on 9/2/99. Email Address: jennings@cyberport.com Patient #2 Summary and Discussion Amit Verma, M.B.B.S. Chief Resident, Department of Neurology (Baylor) Diagnosis: 1) Isaacs' Syndrome 2) Syncope Patient #2 is a 39 year old male who was referred to our Center with a history of difficulty gripping things with his hands, "jumping muscles", slurred speech, and weight loss. The referring physicians were concerned about the possibility of Amyotrophic Lateral Sclerosis and the patient had been referred to evaluate this possibility. On clinical examination, the patient had good proximal strength with slight distal weakness. He did not appear to have the characteristic random muscle twitches which jump from place to place which would be characteristic of fasciculations. The movements were undulating in character like "worms moving under the skin", which is characteristic of myokymia. The EMG confirmed the absence of fasciculations and showed the presence of doublets, widespread irregular grouped motor unit discharges, and complex repetitive discharges with mixed widespread myotonic discharges which was consistent also with a diagnosis of Isaacs' syndrome or neuromyotonia. The patient's father also had a history of cramps, but the patient probably did not have the familial form of the disease because of the good response he had to treatment with plasma exchange, as outlined later.

75. Isaacs, Syndrome : Arborescences MeSH Translate this page isaacs, syndrome arborescences MeSH. Menu général CISMeF. Vouspouvez aussi consulter toutes les arborescences des mots clés http://www.chu-rouen.fr/navimesh/I/naviisaacssyndrome.html

Isaacs, syndrome : arborescences MeSH Menu général CISMeF Vous pouvez aussi consulter toutes les arborescences des mots clés utilisés dans CISMeF appareil locomoteur, maladies muscle, maladies arthrogrypose cellulalgie ... tumeur système nerveux périphérique 07 janvier 2004 courriel Menu général CISMeF Haut de page © CHU de Rouen . Toute utilisation partielle ou totale de ce document doit mentionner la source.

76. Fatigue Chronique Post-virale, Syndrome : Arborescences MeSH Translate this page page PubMed du motclef fatigue chronique post-virale, syndrome C05.651.310 pagePubMed du motclef page CISMeF du motclef isaacs, syndrome C05.651.392 page http://www.chu-rouen.fr/navimesh/F/navifatiguechroniquepostviralesyndrome.html

Fatigue chronique post-virale, syndrome : arborescences MeSH Menu général CISMeF Vous pouvez aussi consulter toutes les arborescences des mots clés utilisés dans CISMeF viroses arbovirus, infection bronchiolite virale dermatoses virales ... troubles amyotrophiques 07 janvier 2004 courriel Menu général CISMeF Haut de page © CHU de Rouen . Toute utilisation partielle ou totale de ce document doit mentionner la source.

77. Health Library - isaacs syndrome. Important It is possible that the main title of thereport isaacs syndrome is not the name you expected. Please http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=

78. Healthwise Topic isaacs syndrome, Back to previous page. Synonyms. Continuous MuscleFiber Activity syndrome; Neuromyotonia; Quantal Squander; isaacsMerten syndrome. http://www.suttercoast.org/health/healthinfo/index.cfm?section=healthinfo&page=a

79. Mioti: Diseases + Conditions Diseases + Conditions isaacs Merten syndrome. Search Mioti http://www.mioti.com/cat/condition/condition.asp?Cat=IsaacsMertenSyn

80. Index - Trustworthy, Physician-Reviewed Information From WebMD IS isaacs syndrome isaacsMerten syndrome Ischemic Necrosis of Bone Islet cellcancer Treatment - Health Professional Information Cancer.gov Islet cell http://content.health.msn.com/hw/index/index-topics-I.asp

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