81. 2nd Annual World Congress On The Insulin Resistance Syndrome The program will focus on atherosclerotic cardiovascular disease and will look into the emerging field of insulin resistance in liver disease and the http://www.allconferences.com/conferences/20031125172841/

2nd Annual World Congress on the Insulin Resistance Syndrome AllConferences.com Health Advanced Search Submit a Conference ... About Us See Also: AIDS Alternative Beauty Child ... Veterinary Event 2nd Annual World Congress on the Insulin Resistance Syndrome Begins November 18, 2004 Ends November 20, 2004 Papers Ab. 2nd Annual World Con Country USA State California City Los Angeles Email insulinresistance@pacbell.net Category Health Category 2 Health: Child Category 3 Health: Nutrition Exhibits Y Organization Contact 18372 Clark st #212 Tarzana, CA 91356 URL http://www.insulinresistance.us Description The meeting will be devoted primarily to the clinical aspects of the Syndrome and potential treatments. The conference will focus on the world wide epidemic of the Syndrome, it's prevalence in special population groups, women and children. The program will focus on atherosclerotic cardiovascular disease and will look into the emerging field of Insulin Resistance in liver disease and the development of certain cancers. Upon completion of this meeting, participants should be able to:

82. SHS - Insulin Resistance & Diabetes insulin resistance Diabetes. What is insulin, insulin resistance, diabetes? Insulin is What causes insulin resistance? It is http://www.studenthealth.ucla.edu/handoutsold/insulin.htm

Insulin is a hormone that carries glucose (sugar) from your blood into your cells so that it can be burned for energy. The pancreas produces insulin. Insulin resistance is a state in which your cells are not responding to insulin appropriately, so the sugar in your blood cannot get into your cells. To compensate, your pancreas pumps out more insulin to try to get the sugar out of your blood and into your cells. The hyperinsulinimia (high blood insulin) that results is able to maintain normal blood sugar levels and delay the onset of diabetes. Diabetes is diagnosed when your fasting blood sugar level is >/= 126 mg/dL. Type 1 diabetes is usually diagnosed in childhood and occurs when the pancreas stops producing insulin. Insulin injections are required for life. Type 2 diabetes is usually diagnosed in adulthood. It occurs when the cells stop responding to insulin (often due to insulin resistance), and the pancreas is unable to keep compensating by producing more and more insulin to maintain normal blood sugar levels. Is it bad to have high blood insulin levels?

83. Extreme Insulin Resistance Mayer Davidson writes several pages about insulin resistance in his book _Diabetes Mellitus Diagnosis and Treatment_. Except for http://www.faqs.org/faqs/diabetes/faq/part3/section-24.html

Single Page Top Document: diabetes FAQ: treatment (part 3 of 5) Previous Document: Gastroparesis Next Document: What is pycnogenol? Where and how is it sold? Usenet FAQs Search Web FAQs ... RFC Index Extreme insulin resistance Top Document: diabetes FAQ: treatment (part 3 of 5) Previous Document: Gastroparesis Next Document: What is pycnogenol? Where and how is it sold? Single Page Usenet FAQs Search Web FAQs ... RFC Index Send corrections/additions to the FAQ Maintainer: edward@paleo.org Last Update June 02 2004 @ 00:19 AM

84. Sorting Out The Facts On Insulin Resistance Sorting Out the Facts on insulin resistance. April 6, 2004. Some popular weightloss diets base their recommendations on the concept of insulin resistance. http://www.eatright.org/Public/NutritionInformation/index_19274.cfm

Shopping Cart About ADA ADA Journal Position Papers ... International (Enter a ZIP) Sorting Out the Facts on Insulin Resistance April 6, 2004 Some popular weight-loss diets base their recommendations on the concept of insulin resistance. What is the story on insulin resistance, and does it really play a part in weight management? Insulin resistance refers to the body’s inability to respond properly to the action of insulin, the hormone that helps the body use blood sugar, also known as blood glucose. Insulin resistance causes blood sugar levels to stay elevated by preventing glucose from entering the body’s cells to be used as a source of energy. Insulin resistance must be diagnosed by a physician using appropriate tests. Some people have a genetic predisposition to developing insulin resistance. Other factors include physical inactivity and obesity. The best way to help lower your risk for insulin resistance is a healthy lifestyle that includes regular exercise, a low-fat eating plan and a healthy weight. Produced by ADA's Public Relations Team To view previous Daily Tips, click here

85. Insulin Resistance - Encyclopedia Article About Insulin Resistance. Free Access, encyclopedia article about insulin resistance. insulin resistance in Free online English dictionary, thesaurus and encyclopedia. insulin resistance. http://encyclopedia.thefreedictionary.com/Insulin resistance

Dictionaries: General Computing Medical Legal Encyclopedia Insulin resistance Word: Word Starts with Ends with Definition In medicine This article is about medical science and practice. For substances that treat patients, see drugs, medication and pharmacology Note to contributors: This article is about medicine in general. Please add contributions to medical topics to their individual articles. Medicine is a branch of health science concerned with restoring and maintaining health and wellness. Broadly, it is the practical science of preventing and curing diseases. However, Medicine often refers more specifically to matters dealt with by physicians and surgeons. Click the link for more information. insulin Insulin (Latin insula Click the link for more information. resistance denotes a decompensation of glucose Glucose , a simple monosaccharide sugar, is one of the most important carbohydrates and is used as a source of energy in animals and plants. Glucose is one of the main products of photosynthesis and starts respiration. The natural form (D-glucose) is also referred to as dextrose , especially in the food industry.

86. A Gene Linked To Insulin Resistance Is Identified --- HealthandAge A gene linked to insulin resistance is identified. A gene linked to insulin resistance is identified. Reported by Susan Aldridge, PhD, medical journalist. http://www.healthandage.com/Home/gid1=5347

June 3, 2004 Home Health Centers HealthandAge Network Caregivers' Center ... Primer on Aging Choose Font Size Normal Large Extra Large A gene linked to insulin resistance is identified A gene linked to insulin resistance is identified Reported by Susan Aldridge, PhD, medical journalist New research shows that specific gene variants are linked to insulin resistance in a population of Mexican Americans. It's already known that insulin resistance is a high risk factor for diabetes and heart disease. Previously, the gene for lipoprotein lipase (LPL) has been identified as a risk factor for high blood pressure, obesity and atherosclerosis, although studies have been only on small groups. Now researchers at Cedars-Sinai Medical Center report on a new study of LPL, in Mexican Americans - a group at very high risk of insulin resistance. Almost 300 adult offspring of patients with known heart disease had DNA tests for the variants of LPL gene they carried, together with sensitive diagnostic tests for insulin resistance. This showed that specific LPL gene variants were linked with high levels of insulin resistance. At the same time, other variants were associated with low insulin resistance. The study therefore underlines the importance of this gene in the level of insulin resistance. Further work is now needed to define exactly what role LPL plays in the way the body regulates blood sugar level. Maybe future therapies for diabetes and heart disease can work by targeting LPL.

87. Scientists Close In On Trigger Of Insulin Resistance Scientists Close In On Trigger Of insulin resistance Extra sugar can cause insulin resistance in cells. Now scientists have an explanation. http://www.hopkinsmedicine.org/press/2002/APRIL/020415.htm

April 15, 2002 MEDIA CONTACT: Joanna Downer PHONE: E-MAIL: jdowner1@jhmi.edu Scientists Close In On Trigger Of Insulin Resistance Extra sugar can cause insulin resistance in cells. Now scientists have an explanation. In experiments with fat cells, Johns Hopkins scientists have discovered direct evidence that a build-up of sugar on proteins triggers insulin resistance, a key feature of most cases of diabetes. Proceedings of the National Academy of Sciences . The scientists found that at least two proteins involved in passing along insulin's message were unlikely to work properly when coated in extra sugar. Type 2 diabetes, the most common form in adults, occurs when muscle, fat and other tissues stop responding to insulin's signals to mop up sugar from the blood. The resulting high blood sugar, if uncontrolled, can lead to blindness, amputation and death. Understanding sugar's precise influence on insulin's activity may help improve treatment and prevention, scientists hope. "Cells don't respond to insulin itself. Instead, a whole cascade of events, set in motion by insulin, eventually causes cells to take in sugar," explains Gerald Hart, Ph.D., professor and director of biological chemistry in the school's Institute for Basic Biomedical Sciences. "We now have an explanation of how sugar can affect these signals, and even a hypothesis for how high blood sugar could cause tissue damage in diabetes by improperly modifying proteins."

88. Scientists Close In On Trigger Of Insulin Resistance April 15, 2002 Contact Emilio Williams Telephone 1410-502-3216 E-mail emilio@jhmi.edu Scientists Close In On Trigger Of insulin resistance Extra sugar can http://www.jhintl.net/English/Media/PRTrigger of Insulin Resistance.asp

Latest News Other Languages Find an Expert Media Contacts ... Contact Us Press Release April 15, 2002 Contact: Emilio Williams Telephone: 1-410-502-3216 E-mail: emilio@jhmi.edu Scientists Close In On Trigger Of Insulin Resistance Extra sugar can cause insulin resistance in cells. Now scientists have an explanation. In experiments with fat cells, Johns Hopkins scientists have discovered direct evidence that a build-up of sugar on proteins triggers insulin resistance, a key feature of most cases of diabetes. The results underscore the importance of glycosylation - attachment of a sugar to a protein as a way cells control proteins' activities, the scientists report in the April 16 issue of the Proceedings of the National Academy of Sciences. The scientists found that at least two proteins involved in passing along insulin's message were unlikely to work properly when coated in extra sugar. Type 2 diabetes, the most common form in adults, occurs when muscle, fat and other tissues stop responding to insulin's signals to mop up sugar from the blood. The resulting high blood sugar, if uncontrolled, can lead to blindness, amputation and death. Understanding sugar's precise influence on insulin's activity may help improve treatment and prevention, scientists hope. "Cells don't respond to insulin itself. Instead, a whole cascade of events, set in motion by insulin, eventually causes cells to take in sugar," explains Gerald Hart, Ph.D., professor and director of biological chemistry in the school's Institute for Basic Biomedical Sciences. "We now have an explanation of how sugar can affect these signals, and even a hypothesis for how high blood sugar could cause tissue damage in diabetes by improperly modifying proteins."

89. National Diabetes Education Initiative - Slides, Articles, CME Online, Events, L Diabetes Discrimination Between Obesity and insulin resistance in the Relationship With Adiponectin . http://www.ndei.org/website/index.cfm?a=litalerts.showArticle&Article_ID=826

90. Insulin Resistance - Humana Press insulin resistance The Metabolic Syndrome X. Reaven, Gerald M. (Stanford University School of Medicine, Stanford, CA) Laws, Ami (Stanford http://www.humanapress.com/Product.pasp?txtCatalog=HumanaBooks&txtProductID=0-89

91. HealthScout-Diabetes/Endo-Identifying Insulin Resistance Identifying insulin resistance. insulin resistance is a major medical problem often leading to diabetes and cardiovascular disease. http://www.healthscout.com/template.asp?page=newsdetail&id=8007484&ap=1

92. HIV Infection (Insulin Resistance) HIV Infection (insulin resistance). Clinical Clinical Trial Title Dyslipidemia as a Marker of insulin resistance in HIVInfected Persons. Clinical http://www.rush.edu/rumc/page-R10681.html

Infectious Disease Infectious Diseases Infectious Diseases HIV Infection (Initial Therapy) HIV Infection (Vaccine Prime Boost Regimen) HIV Infection (1) HIV Infection (Insulin Resistance) Clinical Trial Protocol ID Clinical Trial Investigator Name Barbara Swanson, DNSc, RN, ACRN Clinical Trial Title Dyslipidemia as a Marker of Insulin Resistance in HIV-Infected Persons Clinical Trial Protocol Description Insulin resistance can be a metabolic complication in people infected with human immunodeficiency virus (HIV). Insulin resistance often goes undetected because insulin levels are not routinely measured in people with HIV and it is clinically silent (no outward symptoms). Because untreated insulin resistance can lead to diabetes, there is a need to identify people with this condition and start appropriate management. We are conducting a case-control study to explore whether serum lipids, something that is routinely measured in people with HIV/AIDS, can be used to help identify insulin resistance in people with HIV. Serum lipids were chosen because among people who are not HIV-infected, insulin resistance has been associated with dyslipidemic profiles. Clinical Trial Eligibility Criteria HIV seropositive Between 18 and 60 years of age Has been maintained on a PI-containing antiretroviral therapy regimen for at least three months No known active, opportunistic infections or malignancies at the start of the study

93. Insulin Resistance Phenotypes Significance of insulin resistance Phenotypes. The association of elevated fasting and stimulated insulin levels with hypertension http://www.sph.uth.tmc.edu/hgc/fbpp/techSigInsulin.htm

Home General Info Who What ... Insulin Resistance Significance of Insulin Resistance Phenotypes The association of elevated fasting and stimulated insulin levels with hypertension and blood pressure levels has been confirmed in several large population-based studies [ ]. Although insulin sensitivity per se was not directly measured, the results of such studies have been widely interpreted as demonstrating a relationship between insulin sensitivity and blood pressure in the general population. In the FBPP, fasting insulin and glucose levels will be available in all subjects. While full characterization of insulin deficiency and resistance requires detailed testing, such as frequently sampled intravenous glucose tolerance testing or euglycemic clamps, one can obtain estimates of these important parameters in population studies based on homeostatic functions of fasting insulin and glucose [

94. Diabetes Mellitus: Insulin Resistance insulin resistance. insulin resistance describes the condition in which the pancreas is capable of producing insulin, but the cells are insensitive to it. http://www.vetmed.auburn.edu/sac/mededu/diabetes/insres.html

Insulin Resistance Insulin resistance describes the condition in which the pancreas is capable of producing insulin, but the cells are insensitive to it. If insulin is the “key” which unlocks the “gate” through which glucose must pass to enter cells, then insulin resistance results when there are too few “gates” or the ‘locks’ on the gates are “rusted shut” and are difficult to open despite the presence of insulin. There are many conditions which may predispose to the development of insulin-resistant diabetes or which may unmask a mild, subclinical, or transient diabetes that already exists. These include pregnancy, overproduction or over-administration of steroids like cortisone or prednisone, overproduction of growth hormone (acromegaly), infections, prolonged or severe stress, and many others. Alternatively, these conditions may increase the dose of insulin required to properly regulate a diabetic already undergoing therapy. A diabetic patient which requires an insulin dose higher than 1-2 units per pound of body weight per injection to maintain normal blood sugar levels is considered to be “insulin-resistant”; every effort should be made to identify possible conditions which may be increasing the insulin requirement. Sometimes, just a prolonged untreated bladder infection may be enough to dysregulate an otherwise well controlled diabetic. If your dog has recently required a significantly increased dose adjustment to re-regulate blood sugar levels, or is difficult to regulate despite high insulin doses, have your pet re-evaluated by your veterinarian. Although there are many reasons why a diabetic may be difficult to regulate, the possibility of insulin resistance must be considered once other potential causes have been investigated and ruled out.

95. PDR Vol. 51 - Insulin Resistance, Impaired Glucose Tolerance And Non-insulin-dep insulin resistance, impaired glucose tolerance and noninsulin-dependent diabetes, pathologic mechanisms and treatment Current status and therapeutic http://www.birkhauser.ch/books/biosc/pdr/pdr51_2.html

Home Highlights BioSciences Search ... Show shopping cart PDR Progress in Drug Research Ernst Jucker (Ed.) PDR Home PDR Vol 51 Index Authors Index Titles ... Guidelines Progress in Drug Research, Vol. 51 (E. Jucker, Ed.) Insulin resistance, impaired glucose tolerance and non-insulin-dependent diabetes, pathologic mechanisms and treatment: Current status and therapeutic possibilities By Nicholas C. Turner and John C. Clapham SmithKline Beecham Pharmaceuticals, New Frontiers Science Park (N), Harlow, Essex, UK CM19 5AW Summary Contents Introduction The natural history of insulin resistance, impaired glucose tolerance and non-insulin-dependent diabetes The site of insulin resistance in NIDDM Liver Skeletal muscle Adipocytes The b-cell Mechanisms of insulin resistance Obesity Obesity and insulin resistance Lipotoxicity Glucotoxicity Glucocorticoids The inheritance of insulin resistance and NIDDM Insulin resistance and NIDDM the unmet medical need Treatment and future therapeutic possibilities Thiazolidinediones Metformin Dehydroepiandrosterone analogues Antiglucocorticoids TNFa inhibitors Anti-obesity agents Current therapies Appetite suppressants Thermogenic agents Other approaches Newer anti-obesity agents Sibutramine Orlistat b3-adrenoreceptor agonists Leptin Uncoupling proteins Other approaches Summary References Keywords Insulin restistance, hyperinsulinaemia, non-insulin-dependent diabetes, pathological mechanisms, obesity, liptoxicity, glucotoxicity, glucocorticoids, inheritance and candidate genes, thiazolidinediones, PPARg agonists, metformin, dehydroepiandrosterone, TNFa, thermogenesis, sibutramine, orlistat, leptin, uncoupling proteins.

96. Insulin Resistance Project The presence of insulin resistance is strongly correlated with the development of the metabolic syndrome. In fact, some investigators http://www8.utsouthwestern.edu/utsw/cda/dept27717/files/148934.html

Advanced Search document.write(hashTable['Home'].parentMenu) Home Research Center for Human Nutrition Insulin Resistance Project Home About the Center Facilities Research ... CHN Newsletters The cellular action of insulin is initiated by its binding to the insulin receptor. This binding elicits a series of changes in signaling proteins within the cell that set off a cascade of metabolic actions. Insulin resistance can occur either because of a defect in insulin binding to its receptor or to "post-receptor" defects; with the latter, the spread of insulin-stimulated signals throughout the cell is deranged. The major site of glucose utilization is muscle, although other tissues use glucose. Insulin facilitates tissue uptake of glucose in all organs except the brain, which can use glucose without insulin. From the viewpoint of glucose metabolism, however, skeletal muscle accounts for most of insulin resistance. Nonetheless, insulin resistance can extend to other tissues, notably the liver, causing a generalized derangement of metabolism. The connection between insulin resistance and the metabolic syndrome is not fully understood. Most patients with insulin resistance have the metabolic syndrome. However it does not necessarily follow that all persons with insulin resistance have the metabolic syndrome. Besides insulin resistance, other factors apparently are needed for the development of the risk factors of the metabolic syndrome. Among these genetic factors may predominate. In other words, genetic factors may elicit the components of the metabolic syndrome in the presence of insulin resistance: atherogenic dyslipidemia, hypertension, elevated plasma glucose, a prothrombotic state, and a proinflammatory state.

97. CBS News | Hope For The Insulin Resistant | August 29, 2002 00:13:51 Hope For The Insulin Resistant August 28, 2002 (Photo AP / CBS) The majority of people with insulin resistance are still at http://www.cbsnews.com/stories/2002/08/28/scitech/pcanswer/main520050.shtml

Home U.S. Iraq World ... FREE CBS News Video August 29, 2002 00:13:51 The Early Show CBS Evening News 48 Hours 60 Minutes ... Section Front E-mail This Story Printable Version Hope For The Insulin Resistant August 28, 2002 (Photo: AP / CBS) The majority of people "with insulin resistance ... are still at significantly increased risk for heart attack, stroke and other diseases." American Association of Clinical Endocrinologists CBS Radio News Technical Analyst Larry Magid (Photo: CBS) (CBS) One-third of Americans are insulin resistant and most people don't even know it. If you're overweight, have high cholesterol and high blood pressure, there's a very good chance that you're one of them. The good news is that there is something you can do about it. That was the conclusion of a panel of experts who met this week in Washington, D.C. The conference was sponsored jointly by the American College of Endocrinology (ACE) and the American Association of Clinical Endocrinologists (AACE) with participation from the American Medical Association and other organizations. The condition, which is known as metabolic syndrome or "Syndrome X," was first identified by Stanford medical professor Gerald Reaven. It is associated with an increased risk of diabetes, heart problems and strokes.

98. EVMS/WHRV Radio Rounds: Insulin Resistance Wednesday, November 1, 2000, insulin resistance. Aaron I. Vinik, MBB.CH. Department This concept is now known as insulin resistance. With http://www.evms.edu/about/evms_rr/nov2000/11-01_vinik.html

Suggest this page to a friend Archives Introduction April 2001 ... May 1999 For further information, please contact: EVMS Office of Institutional Advancement Wednesday, November 1, 2000 Insulin Resistance Aaron I. Vinik, M.B.B.CH. Department of Internal Medicine Research Director of the Strelitz Diabetes Institutes Eastern Virginia Medical School I am Dr. Aaron Vinik, professor of internal medicine and director of the Strelitz Diabetes Research Institute at Eastern Virginia Medical School. I am here to tell you about the concept of insulin resistance and what this means to you, your health, your risk for macrovascular disease, and what you can do about it. With the ability to measure insulin in the blood, discovered by Yalow and Berson in 1961 for which they were awarded the Nobel prize, we first learned that most patients with Type 2 diabetes have too much insulin in their blood rather than too little as occurs in Type 1 diabetes. What appears to be wrong is the body's ability to recognize the insulin, like having a key that is unable to fit the lock, which represents the receptor, which is defective. This concept is now known as insulin resistance. With the availability of the insulin assay, we soon learned that insulin resistance is part of a much larger picture. It is found in people with high blood fat levels, hypertension, and obesity, particularly a high waist to hip ratio (the apple as opposed to pear shape); it is also found in women with polycystic ovaries who do not menstruate regularly, have an excess of male hormone (testosterone), and have too much hair on their face and forearms. In addition, they may have gout and abnormalities in the skin such as black velvety spots on the neck and jaw area. These features are not all cosmetic because they confer an increased susceptibility to heart attacks, strokes and gangrene.

99. Diabetes: Free Fatty Acids Induce Peripheral Insulin Resistance Without Increasi Diabetes Feb, 2001 Article. Free Fatty Acids Induce Peripheral insulin resistance Without Increasing Muscle Hexosamine Pathway Product Levels in Rats. http://www.findarticles.com/cf_0/m0922/2_50/71185831/p1/article.jhtml?term=gluco

100. LookSmart - Article Search For " Insulin Resistance Physiological Aspects" insulin resistance and associated compensatory responses in AfricanAmerican and Hispanic children. Effect of plasma leptin on insulin resistance. (Leptin). http://www.findarticles.com/cf_0/PI/search.jhtml?isp=FA&cat=health&key=+Insulin

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