61. Nemours.org - Immunology - Frequently Asked Questions Not all immune deficiencies are acquired, however, and a child may be born with other conditions causing immune deficiency. Does she have an immune deficiency? http://www.nemours.org/no/faq/faq1798.html

Find a Doctor About Us Employment Alfred I. duPont Hospital ... Contact Us Frequently Asked Questions Immunology If my child has an immune deficiency, does that mean she has AIDS? AIDS is one very serious type of immune deficiency. It is an acquired immune deficiency, meaning that it develops after birth. Not all immune deficiencies are acquired, however, and a child may be born with other conditions causing immune deficiency. These other conditions are generally far less serious than AIDS. How serious is an immune deficiency? Immune deficiencies vary widely in their seriousness. Some will resolve in time, with or without intervention, leaving the child with a normal immune system. Others are more serious and may require ongoing treatment with intravenous immunoglobulin. A small group of extremely serious primary immune deficiencies require bone marrow transplantation from a parent or sibling. Why is my child sick all the time? Does she have an immune deficiency?

62. Las Inmunodeficiencias (Immune Deficiencies) Translate this page Alergias y el Asma. http://www.healthsystem.virginia.edu/UVAHealth/peds_allergy_sp/oidhub.cfm

@import url(/assets/UVAHealth/ssi/css/greystone_advance.css); Alergias y el Asma Anomalías Craneofaciales Artritis Bebé de Alto Riesgo Cirugía Ortopédica Crecimiento/Desarrollo Cuidado de Los Ojos Cuidado Quirúrgico Dermatología Diabetes Embarazo de Alto Riesgo Embarazo y Parto Enf. Cardiovasculares Enf. Digestivas Enf. Infecciosas Enfermedad Terminal Genética Médica Hematología Lesiones/Intoxicaciones Medicina del Adolescente Oncología Otorrinolaringología Quemaduras Recién Nacido Normal Salud Mental Salud Oral Seguridad y Prevención Sistema Nervioso Trasplantes Trastor. Respiratorio Urología FIND A DOCTOR MAKE AN APPOINTMENT CALENDAR OF EVENTS CLINICAL TRIALS Las Inmunodeficiencias La Inmunodeficiencia Combinada Severa (SCID) La Agammaglobulinemia Ligada al X Topics Página Principal (Home Page) Las Inmunodeficiencias (Immune Deficiencies) La Agamaglobulinemia Ligada a X (X-linked Agammaglobulinemia) La Inmunodeficiencia Combinada Severa (SCID) (Severe Combined Immunodeficiency [SCID]) Glosario Recursos en la Red UVa Health System PO Box 80229 Charlottesville , VA 22908 For comments and suggestions about this page: Health Topics Contact Last Modified: 2004/03/09 of the University of Virginia About This Site

63. Primary Immune Deficiencies - An Overview - SMi Publishing - Reports - Overview Primary immune deficiencies An Overview. A comprehensive analysis. Primary immune deficiencies are inborn genetic defects in the immune system. http://www.smi-online.co.uk/reports/overview.asp?isr=0401574

64. Children Iwth Immune Deficiencies A& Bioterroism Risk has somewhat different characteristics and symptoms, depending on the parts of the immune defense system that are compromised. Some deficiencies are deadly http://www.youngagain2000.com/children1.html

PRODUCT AND LIBRARY SEARCH Home Email Us General Information Affiliates ... take a wellness test CHOOSE YOUR LANGUAGE suggested links The Five Star TOP SERVICE award is Yahoo! Shopping's sign of superlative quality. Young Again participates in Yahoo's Merchant Rating System, and our customers have voted Young Again Yahoo's highest rating Read what our customers tell Yahoo! about our service and products. Click Here Powered by Web Host Station Subscribe to the Longevity News Email: Children With Immune Problems at Greater Bioterror Risk Doctors warn that even smallpox vaccine is risky TUESDAY, March 4 (HealthScoutNews) Smallpox, anthrax, plague, botulism. The words spark considerable anxiety among Americans amid all the warnings about possible bioterrorism attacks. For those with primary immunodeficiency (PI), a genetic immune system disorder that afflicts more children than leukemia and lymphoma combined, the potential danger looms much larger. "Regardless of the agent we're talking about, these kids are more vulnerable," says Dr. Allan Lock, director of the developmental immunology program at the National Institute of Child Health and Human Development. "We're talking about an at-risk population." PI afflicts at least 500,000 Americans, many of them children, but often goes undiagnosed or is diagnosed only after patients become extremely ill or chronically debilitated, sometimes with life-threatening conditions, experts say.

65. AAAAI - Patients & Consumers Center: Topic Of The Month: November 2001: Allergie Most primary immune deficiencies are inherited diseases that can occur at any age. There are a wide variety of primary immune deficiencies. http://www.aaaai.org/patients/topicofthemonth/1101/default.stm

Topic of the Month: November 2001: Allergies and the Immune System Click here for a larger view What is the immune system? When you get a cold, what helps you get better? It’s your immune system – a very complicated system of cells that exist in many organs throughout the body. The diagram at the right portrays the many areas of the body where these specialized cells exist. Working together, the cells that make up your immune system must recognize and react to foreign substances such as viruses, bacteria, parasites, and fungi. The major components of the immune system and the roles they play The major components of the immune system include: B-lymphocytes Major function is to produce antibodies Develop from bone marrow There are 5 major classes of antibodies: Immunoglobulin G (IgG) Immunoglobulin A (IgA) Immunoglobulin M (IgM) Immunoglobulin E (IgE) Immunoglobulin D (IgD) T-lymphocytes Directly attack foreign antigens such as viruses, fungi, or transplanted tissues Act as regulators of the immune system Develop from bone marrow Phagocytes Ingest and kill microorganisms Develop from bone marrow Prominent in the bloodstream, spleen, liver, lymph nodes and lungs

66. Allergy & Asthma Disease Management Center: Ask The Expert: Immune Deficiency Immune Deficiency -. As a group, antibody deficiencies represent the most common types of primary immune deficiencies in human subjects. http://www.aaaai.org/aadmc/ate/immunedeficiency.html

Immune Deficiency re: Treatment of CVID during pregnancy We look after patients with antibody deficiency and have recently been referred a pregnant lady with CVID. We do not have that much clinical experience with pregnant patients, as usually our patients present having already had their children. Do any of the immunologists have a protocol on how to manage pregnant ladies with CVID and ongoing monitoring of their immunoglobulin levels? To help respond to your questions, I consulted my colleague, Dr. Arnold Levinson, director of a large Adult Immunodeficiency Clinic and someone with extensive experience with CVID. His response is enclosed below. I have also enclosed below for your interest abstracts of two of the limited reports about CVID in pregnancy which I found in a Medline search. Dr. Levinson's response: We increase their IVIG dose in concern with their weight. My limited experience is that in addition to increased volume of distribution, I think there is increased catabolism and shortened half-life. So, don't be surprised if higher mg/kg (adjusted for weight) do not provide the desired trough levels. Particularly important considerations during last trimester when sufficient passive immunity needed to protect mom and fetus. J Clin Immunol. 2001 Mar;21(2):150-4.

67. Inborn Immune Deficiencies- The Anthony Nolan Bone Marrow Trust progressive disability. These may result form the deficiency of a single enzyme required for a specific metabolic process. Bone http://www.anthonynolan.org.uk/ndonors/diseases/inborn.html

The Anthony Nolan Trust where leukaemia meets its match INBORN ERRORS OF THE METABOLISM AND OTHER GENETIC DISORDERS Bone marrow transplant has been extensively used to treat a wide variety of haematological disorders. More recently, it has been used to treat a group of rare and ultimately lethal metabolic disorders and other genetic diseases, some of which are immediately life-threatening and other of which are associated with progressive disability. These may result form the deficiency of a single enzyme required for a specific metabolic process. Bone marrow transplant is used to provide a source of the deficient enzyme. Some examples are given below: Type of Illness Click for more information Hurlers / Hunters find out more Metachromatic Leucodystrophy find out more Adrenoleucodystrophy find out more Gauchers Disease find out more Osteopetrosis find out more Leukaemia Myelodyplastic and Myeloproliferative syndromes Bone Marrow Failure Syndromes ... Haemoglobinopathies Other Relevant Pages How patients and donors are matched.

68. New Science Sheds Light On Immune Deficiencies View text/printer form. New Science Sheds Light on immune deficiencies by Ginger Julian. What do 20/20, Oprah Winfrey, the Wall Street http://www.immunesupport.com/news/95fal003.htm

View text/printer form New Science Sheds Light on Immune Deficiencies by Ginger Julian What do 20/20, Oprah Winfrey, the Wall Street Journal, the Journal of the American Medical Association, Reader's Digest, and Prevention Magazine have in common? They are all reporting on the dramatic reduction of seasonal depression in people who have used full-spectmm light therapy. Interestingly, a small but high-tech Santa Barbara company on the cutting edge of the new science of light therapy has been producing products for SAD (Seasonal Affective Disorder) patients for seven years now. However, what is exciting today is new evidence about how light therapy is affecting people with immune deficiency diseases such as Chronic Fatigue Immune Deficiency Syndrome (CFIDS), AIDS, Gulf War syndrome, cancer and leukemia. Increasingly, studies are showing that the use of radiation-shielded full- spectrum light is contributing in many ways to the human healing process, both mentally and physically. How? Light has been discovered to be an important nutrient which feeds and replenishes the human nervous system (the body's electrical system). In addition, important facts overlooked until now by modern medicine have shown that not only is the body made up of tissue it's wired! And this wiring needs an energy source like cells need food. Pharmaceutical companies have attempted to respond to immune deficiencies with new research on drugs and special nutrients, but according to the leading pioneer of full-spectrum lights, Dr. John Ott, light is also a nutrient which nourishes and replenishes our bodies, thereby strengthening our immune system. People with immune-system deficiency diseases are finding that sitting in front of light boxes which contain

69. Children's Services: Press Release, Center For Primary Immunodeficiencies Rebecca Buckley, MD, a renowned immunologist in the treatment of primary immune deficiencies, will lead the IDF Center at Duke Children’s Hospital. http://dukehealth1.org/childrens_services/press_release_immune.asp

Immune Deficiency Foundation, Elizabeth Lee Director of Marketing, 410/321-6647 Fleishman-Hillard, Cynthia Coleman, 816/512-2387 IMMUNE DEFICIENCY FOUNDATION OPENS CENTER FOR PRIMARY IMMUNODEFICIENCIES Raleigh-Durham, N.C. In addition to consultative services, the Immune Deficiency Foundation Center at Duke will provide appropriate laboratory tests, access to therapy, and specialists, as well as providing public and professional education services. The IDF grant will also help to fund a clinical data coordinator at the center. The position will support research efforts on primary immune deficiencies at Duke and those sponsored by IDF. About Rebecca Buckley, M.D. Dr. Rebecca Buckley is the chief of the division of allergy and immunology and director of the Duke University Allergy and Immunology Training Program, a position she has held since 1974. Her research interests have included the fundamental causes and optimal treatment of genetically determined immunodeficiency diseases and in the regulation of IgE synthesis. She is the author of more than 245 published scientific articles and book chapters, a member of numerous medical organizations, and has held leadership positions in many of them.

70. Immune Deficiencies And Your Pet Norwich Bulletin 12/29/2001 immune deficiencies And Your Pet. I have a friend who is a medical doctor who has twenty-two cats and recently began chemotherapy. http://www.listnow.com/helpingpaws/articles/article_130.html

Articles Index Contact Us Home Norwich Bulletin - 12/29/2001 Immune Deficiencies And Your Pet I have a friend who is a medical doctor who has twenty-two cats and recently began chemotherapy. She never once considered giving up any of her cats and this column is dedicated to the many people with immune deficiencies whose doctors aren’t quite as understanding as to the importance of a pet. You see, there is one medicine that makes you feel better and calms your fears with no side effects; the problem is that many doctors tell people with immune deficiencies they can’t have it – and that medicine is your pet. The truth, as my friend explained to me, is that people with AIDS and other weakened immune systems can live happily and safely with their animals. Many people are advised to give up their pets because of diabetes, cirrhosis of the liver, chemotherapy, or other conditions that temporarily suppress immunity. This is really not necessary, especially when that beloved pet may be the most important source of pleasure and companionship that a person has. After all, research documents that illness progresses more rapidly in depressed patients and what could be more depressing than having to give up your eight year old cat or dog? Research also shows that immune deficient people with pets tend to be less depressed and less lonely and therefore, actually improve their health.

71. Immune Deficiencies Immune Deficiency Disorders,. including AIDS and cancer, as well as autoimmune diseases. Stem cell transplantation for chronic lymphocytic http://www.cell-transplantation.net/immune.html

Immune Deficiency Disorders, including AIDS and cancer, as well as autoimmune diseases. Stem cell transplantation for chronic lymphocytic leukemia: different outcome after autologous and allogeneic transplantation and correlation with minimal residual disease status Allogeneic stem cell transplantation reduces disease progression compared to autologous transplantation in patients with multiple myeloma Allogeneic peripheral blood stem cell transplantation Last modified: Wednesday, 29 May 2002

72. Pediatric Clinics Of North America PRIMARY immune deficiencies PRESENTATION, DIAGNOSIS, AND MANAGEMENT. TABLE 2 LABORATORY FEATURES OF SELECTED PRIMARY TCELL immune deficiencies. http://medicine.ucsd.edu/peds/Pediatric Links/Links/AllergyImmunology/T Cell Imm

Pediatric Clinics of North America Volume 47 • Number 6 • December 2000 PRIMARY IMMUNE DEFICIENCIES: PRESENTATION, DIAGNOSIS, AND MANAGEMENT T-CELL IMMUNODEFICIENCIES Melissa E. Elder MD, PhD Division of Pediatric Immunology/Allergy/Rheumatology, Department of Pediatrics, University of California at San Francisco, San Francisco, California Address reprint requests to Melissa E. Elder, MD, PhD Division of Pediatric Immunology/Allergy/Rheumatology Department of Pediatrics M679 505 Parnassus Avenue University of California at San Francisco San Francisco, CA 94143-0105 Primary T-cell immunodeficiencies are rare inherited disorders that affect T-cell development and function. These disorders usually present in infancy or early childhood; however, the age of symptom onset may vary depending on the underlying gene defect. Although T-cell immune responses may be selectively affected, abnormal B-cell function often is associated, in part because of concomitant intrinsic B-cell defects but also because production of most antibodies is dependent on T-cell help. SEVERE COMBINED IMMUNODEFICIENCY SYNDROMES ; normal range, 4000-13,500 cells/mm

73. Case Based Pediatrics Chapter However, some patients have immune deficiencies and these patients are frequently not diagnosed. Table 2 Conditions suggestive of immune deficiency . . . . . http://www.hawaii.edu/medicine/pediatrics/pedtext/s05c05.html

Case Based Pediatrics For Medical Students and Residents Department of Pediatrics, University of Hawaii John A. Burns School of Medicine Chapter V.5. Immune Deficiency Akaluck Thatayatikom, MD March 2003 Return to Table of Contents This is a 14 month old male infant who presents to the emergency department with a chief complaint of high fever and no response to antipyretic therapy. This illness started suddenly with the abrupt onset of fever early yesterday morning. He then developed a severe cough and increased work of breathing. No other symptoms are noted. The patient was born in a refugee camp and has lived in Florida and Texas before moving to Hawaii 3 months ago. The mother reports that he is frequently ill. No reports from Florida or Texas are available, but his mother reports he was also seen as an outpatient frequently and he was hospitalized at least once in Florida. He was hospitalized 2 months ago for pneumococcal pneumonia (right upper lobe consolidation and pneumococcal bacteremia). Exam: VS T 40.3, P 145, R 55, BP 100/60, oxygen saturation 98%, weight 7 kg (

74. Human Disease --  Encyclopædia Britannica The causes of disease. Diseases of immune origin. immune deficiencies. The immune system may fail to function for many reasons. Many http://www.britannica.com/eb/article?eu=119799&tocid=63235&query=allergy

75. Immune Deficiencies immune deficiencies. Severe Combined Immunodeficiency. total loss of acquired immunity; can be caused by mutations in genes required http://www.med.uiuc.edu/m1/genetics/tutorial11/DevErr/de6.htm

Immune Deficiencies Severe Combined Immunodeficiency total loss of acquired immunity can be caused by mutations in genes required for signaling among immune cells during development can be caused by loss of an enzyme required for degrading DNA byproducts following cell death (adenosine deaminase deficiency) can be caused by viruses (HIV) DiGeorge syndrome loss of cell mediated immunity cannot perform antibody class switch often caused by deletions of parts of chromosome 22 Bruton's hypogammaglobulinemia loss of Bruton's tyrosine kinase activity loss of B-cells and humoral immunity Hyper IgM syndrome can be caused by mutations in CD40 gene cannot perform class switch susceptible to bacterial infections NEXT BACK INDEX

76. KIDS Foundation - Education The following articles are here to help provide education on Primary immune deficiencies. Our Immune System. The 10 Warning Signs of Primary Immune Deficiency. http://www.pidsnz.co.nz/educate.htm

Education The following articles are here to help provide education on Primary Immune Deficiencies Our Immune System The 10 Warning Signs of Primary Immune Deficiency Primary Immune Deficiency Fact Sheet Recurrent Infections (PDF file, 1.41 Mb) Abstracts from ESID 2002 Conference We also have a library of books which members can borrow. Click on the Adobe graphic below if you don't have Adobe Acrobat Reader (it's free !). Note: If you are using Adobe Acrobat Reader 5.0 you may get the error message "error reading linearized hint data" when opening a PDF document. You can correct this error by doing the following: Open Acrobat Reader and open the menu Edit/Preferences/Options. Disable the entry: "Allow Fast Web View." Save the changes and reopen the web browser and try to view the document. Please send any suggestions and corrections to the webmaster Last updated 18 Sep 2003

77. Re:  Immune Deficiencies Re immune deficiencies. From Tammy some kind. Has anyone been tested postive for Toxoplasmosis or any immune deficiencies other than HIV? http://www.castlemans.org/_dialogue/000008c0.htm

Castleman's Dialogue Home Contents Search Post ... Previous Up Re: Immune Deficiencies From: Tammy Wright Email: dwright@woh.rr.com Remote Name: Date: 11 March 2004 Time: 12:27 PM Comments I have been told that I tested postive for toxoplasm antibodies. I have HV Castleman's. I still have many more test ahead of me to check my brain. I have an area on my brain that they are not sure what it is from. The doctors are doing a complete DNA breakdown on me. I do not have HIV and tested negitive for HHV-8. They mentioned a possible immune deficiency of some kind. Has anyone been tested postive for Toxoplasmosis or any immune deficiencies other than HIV? I feel that I am just going in constant circles. Last changed: March 11, 2004

78. AEGiS-MMWR: Current Trends Acquired Immune Deficiency Syndrome (AIDS): Precautio The etiology of the underlying immune deficiencies seen in AIDS cases is unknown. One hypothesis consistent with current observations http://www.aegis.com/pubs/mmwr/1982/MM3143.html

Important note: Information in this article was accurate in November 1982. The state of the art may have changed since the publication date. Current Trends Acquired Immune Deficiency Syndrome (AIDS): Precautions for Clinical and Laboratory Staffs MMWR Weekly, November 05, 1982 / 31(43);577-80 Centers for Disease Control and Prevention The etiology of the underlying immune deficiencies seen in AIDS cases is unknown. One hypothesis consistent with current observations is that a transmissible agent may be involved. If so, transmission of the agent would appear most commonly to require intimate, direct contact involving mucosal surfaces, such as sexual contact among homosexual males, or through parenteral spread, such as occurs among intravenous drug abusers and possibly hemophilia patients using Factor VIII products. Airborne spread and interpersonal spread through casual contact do not seem likely. These patterns resemble the distribution of disease and modes of spread of hepatitis B virus, and hepatitis B virus infections occur very frequently among AIDS cases. The following precautions are advised in providing care to AIDS patients: Extraordinary care must be taken to avoid accidental wounds from sharp instruments contaminated with potentially infectious material and to avoid contact of open skin lesions with material from AIDS patients.

79. Entrez PubMed Primary immune deficiencies unravel the molecular basis of immune response. Notarangelo LD, Giliani S, Mazzolari E, Gulino AV. Department http://www.biomedcentral.com/pubmed/14692236

Entrez PubMed Nucleotide Protein ... Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes 3D Domains Domains Gene GEO GEO DataSets HomoloGene Journals MeSH NCBI Web Site OMIM PMC PopSet SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: Sort Author Journal Pub Date Text File Clipboard E-mail Order Rev Clin Exp Hematol. 2003 Mar;7(1):84-111. Related Articles, Links Primary immune deficiencies unravel the molecular basis of immune response. Notarangelo LD, Giliani S, Mazzolari E, Gulino AV. Department of Pediatrics and Institute of Molecular Medicine Angelo Nocivelli, University of Brescia, Spedali Civili, 25123 Brescia, Italy. notarang@master.cci.unibs.it

80. BioMed Central | Full Text | Immune Deficiencies Due To Defects In Cytokine Sign To obtain access to Current Allergy and Asthma Reports through your institution use the options below. If you would like information http://www.biomedcentral.com/1529-7322/3/396

home journals A-Z journals by subject advanced search ... my BioMed Central To obtain access to Current Allergy and Asthma Reports through your institution use the options below. If you would like information about a personal subscription, please contact subs@phl.cursci.com Click here to view an abstract of this article Click here to login if you are already a subscriber to Current Allergy and Asthma Reports Subscribe to Current Allergy and Asthma Reports Register for a free online trial Ask your librarian to investigate institutional access Athens users please click here to gain access If you believe you are seeing this page in error, or cannot activate your subscription, e-mail us info@biomedcentral.com Terms and Conditions Privacy statement Information for advertisers ... Contact us

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