81. I Have Been Diagnosed With IgA Nephropathy, What Does This Mean? Q. I have been diagnosed with iga nephropathy, what does this mean? Greaterthan 90 percent of iga nephropathy is not familial. http://www.aakp.org/Iga_nephropathy.htm

Home Membership Education AAKP News ... Useful Links Q. I have been diagnosed with IgA nephropathy, what does this mean? A IgA nephropathy (IgAN or Berger’s Disease, pronounced “burr-jay” not “bur-ger” as in hamburger) results from a still not understood defect or overactivity of the immune system on which an antibody called immunoglobulin A (IgA) is deposited in glomeruli causing inflammation (called glomerulonephritis), and eventual scarring of glomeruli (called glomerulosclerosis). IgAN accounts for about 10 percent of end-stage renal disease (ESRD). Usually slowly progressive, IgAN may be relatively stable for years (basically the common IgAN that adults usually have). Approximately 30 percent of patients progress to ESRD in 10 to 25 years. Rarely, ESRD develops in under five years. IgA nephropathy has a familial (no other family members with the disease) attack rate in about 10 percent of cases in Kentucky and parts of the Southeast. Familial clustering of IgAN has also been reported in

82. Loyola Univ. Health Sys. - Urology - Immunoglobulin A (IgA) Nephropathy Immunoglobulin A (IgA) Nephropathy What is iga nephropathy? What Causes iga nephropathy?The IgA protein is a normal part of the body s immune system. http://www.luhs.org/health/topics/urology/iganeph.htm

You are here: Home Health Information Health Topics Urology Immunoglobulin A (IgA) Nephropathy What is IgA Nephropathy? IgA nephropathy is a chronic kidney disease that may progress over a period of 10 to 20 years, and can lead to end-stage renal disease. It is caused by deposits of the protein immunoglobulin A (IgA) inside the glomeruli (filters) within the kidney. These glomeruli normally filter waste and excess water from the blood and send them to the bladder as urine. However, the IgA protein prevents this filtering process. This may lead to the following: blood and protein in the urine swelling in the hands and feet What Causes IgA Nephropathy?

83. Update - IgA Nephropathy And CD89 An update on recent devleopments in the study of human iga nephropathy learndoctor.com. IgAnephropathy - Launay et al J Exp Med 2000 191(11)1999-2009. http://www.learndoctor.com/updates/iganephropathy.htm

IgA nephropathy - Launay et al J Exp Med 2000 191(11):1999-2009 Medline abstract - in new window Full text article - in new window - a subscription to the journal may be required This disease is a glomerulonephritis and is the commonest primary glomerulonephritis worldwide. Kidney biopsies typically show deposition of IgA in the mesangium of the glomerulus and the proliferation of mesangial cells and increased amounts of mesangial matrix. There are often increases in the amount of circulating IgA in the plasma of patients. The cause of the disease is not fully understood. Several groups now suggest that the molecule CD89 may play a role. This is a receptor for the Fc portion of IgA antibodies. The Fc portion of the molecule is the part that is not normally involved in binding to the foreign antigen. The receptors are involved in binding IgA and transporting it across cells. CD89 is also termed an FcalphaR. A group from the famous Necker hospital in Paris now report in the Journal of Experimental Medicine, that in patients with IgA nephropathy there are high levels of soluble CD89 bound to IgA which circulate in the blood as a complex. They then put the gene for human CD89 into mice and showed that these transgenic mice developed a disease like IgA nephropathy. When serum from these affected mice was administered to unaffected mice, the serum transmitted the disease. Furthermore, if the CD89-IgA complexes were removed from this serum it was unable to transmit the disease. These finding suggest that the presence of high plasma levels of the complex formed between CD89 and IgA can cause a disease in mice similar to human IgA nephropathy. As such high levels are found in patients, but not in normal controls, these complexes may contribute to the pathology of human IgA nephropathy.

84. Blackwell Synergy - Cookie Absent Treatment of iga nephropathy in children. Norishige Yoshikawa. This communicationfocuses on the treatment of iga nephropathy in children. http://www.blackwell-synergy.com/links/doi/10.1046/j.1440-1797.7.s3.13.x/full/

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85. Blackwell Synergy - Cookie Absent Treatment of primary iga nephropathy. Principal discussant Efstathios Alexopoulos. 1.Van Es LA Nephrology Forum Pathogenesis of iga nephropathy. http://www.blackwell-synergy.com/links/doi/10.1111/j.1523-1755.2004.00437.x/enha

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86. Medical Encyclopedia Disease iga nephropathy (Berger´s disease). Causes And Risk iga nephropathy(Berger´s disease) is a form of mesangial proliferative nephritis. http://www.georgetownuniversityhospital.org/body.cfm?id=18&action=display&articl

87. Medical Encyclopedia Disease iga nephropathy (Berger´s disease). Causes And Risk iga nephropathy(Berger´s disease) is a form of mesangial proliferative nephritis. http://www.medstarhealth.org/body.cfm?id=124&action=display&articlenum=466

88. Applied Genetics News: GENOMICS: IgA Nephropathy Is Inherited Print friendly Tell a friend Find subscription deals GENOMICS iga nephropathyIs Inherited Applied Genetics News, Nov, 2000. Richard http://articles.findarticles.com/p/articles/mi_m0DED/is_4_21/ai_67541347

@import url(/css/us/style.css); @import url(/css/us/searchResult1.css); @import url(/css/us/articles.css); Advanced Search Home Help IN all publications this publication Reference Automotive Business Computing Entertainment Health News Reference Sports YOU ARE HERE Articles Applied Genetics News Nov, 2000 Content provided in partnership with Print friendly Tell a friend Find subscription deals GENOMICS: IgA Nephropathy Is Inherited Applied Genetics News Nov, 2000 Richard P. Lifton, a Howard Hughes Medical Institute investigator, and his colleagues at Yale University School of Medicine report that genetic analyses of 30 families in the United States and Italy indicate that IgA nephropathy is caused by a gene located on chromosome-6. Their findings are published in the November 2000 issue of Nature Genetics. "Prior to this finding, IgA nephropathy was recognized as the most common form of glomerulonephritis worldwide, but its causes were unknown and were believed to be diverse," says Lifton. IgA nephropathy is thought to affect up to 1% of the population worldwide. IgA nephropathy makes itself known by the presence of blood in the urine following an upper respiratory infection. Deposits of IgA appear in the kidney, leading to scarring and eventual dysfunction. A substantial fraction of patients end up on dialysis or require kidney transplants. There is wide variation in the prevalence of the disease. It is common in Southeast Asia but rare among African-Americans, for instance.

89. Building The Case For Biopsy In IgA Nephropathy - College Of American Pathologis Building the case for biopsy in iga nephropathy. Firstline treatmentfor newly diagnosed iga nephropathy is ACE inhibitors (ACEI). http://www.cap.org/apps/docs/cap_today/feature_stories/feat2_1101.html

College of American Pathologists Home Request Account Contact Us Terms and Conditions ... Feedback Search Building the case for biopsy in IgA nephropathy Using biopsy to track disease activity November 2001 Feature Story William Check, PhD Advances in understanding IgA nephropathy , like the disease itself, come in two classes: the slowly progressive type, which is more common, and the less common aggressive form. Consequently, recent reports on this disease contain many preliminary or "promising" findings but fewer firm conclusions. Summarizing a clinical conference on IgA nephropathy that he co-chaired at the 2000 annual meeting of the American Society of Nephrology, J. Charles Jennette, MD, says, "The conference emphasized that there are still a lot of unresolved issues in clinical management, etiology and pathogenesis, and pathological evaluation of IgA nephropathy." Pathogenesis is "one of the most exciting issues," says Dr. Jennette, Brinkhous Distinguished Professor and chair of pathology and laboratory medicine at the University of North Carolina at Chapel Hill. "A potentially very important observation is that there may be abnormalities in the molecular structure of circulating IgA in patients with IgA nephropathy and the closely related disease Henoch-Sch¶nlein purpura, particularly abnormalities in galactosylation in the hinge region of IgA molecules," he adds. Adds Dr. Jennette: "The renal pathologist and nephrologist must interact in making the diagnosis of IgA nephropathy, in coming to a consensus on prognosis, and in trying to decide on appropriate treatment. Person-to-person or phone consultation is probably as frequent or more frequent in renal pathology practice than in any other area of pathology."

90. IgA Nephropathy Foundation iga nephropathy Foundation httphttp//www.igan.org/ The IgAN Foundation s missionis to provide vital and the latest information on the diagnosis and http://www.pslgroup.com/dg/dd246.htm

91. Karger Publishers Vol. 126. iga nephropathy. From Molecules to Men. Since the pathogenesis ofiga nephropathy is still obscure, specific treatment is not yet available. http://content.karger.com/ProdukteDB/produkte.asp?Aktion=showproducts&ProduktNr=

92. Karger Publishers Vol. 111. iga nephropathy. 6th International Symposium, Adelaide, February/March1994. iga nephropathy. 6th International Symposium, Adelaide, February/March 1994. http://content.karger.com/ProdukteDB/produkte.asp?Aktion=showproducts&ProduktNr=

93. Re: What Is IGA Nephropathy? kidney disorders message board. Re What is iga nephropathy? In Reply toRe What is iga nephropathy? posted by Linda on July 02, 2000 at 004238 http://www.healthboards.com/kidney-disorders/447.html

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94. What Is IGA Nephropathy? kidney disorders message board. What is iga nephropathy? Could someone pleasetell me what that is ? Thanks. Follow Ups. Re What is iga nephropathy? http://www.healthboards.com/kidney-disorders/441.html

**** Menu **** Home Acne ADD Addiction Addison's Disease Aging Issues AIDS Allergies ALS Alternative Medicine Alzheimer's Anemia Arthritis Asthma Autism Back Problems Bowel Disorders Cancer Caregivers Carpal Tunnel Syndrome Cerebral Palsy Children's Health Chronic Fatigue Common Cold Cosmetic Surgery Cystic Fibrosis Dental Problems Depression Diabetes Digestive Disorders Disabilities Down Syndrome Eating Disorders Epilepsy Fibromyalgia Foot Problems General Health Gulf War Syndrome Headaches Hearing Disorders Heart Disorders Hepatitis Herpes High Blood Pressure High Cholesterol HIV/AIDS Immune Disorders Infectious Diseases Infertility Inner Ear Disorders Irritable Bowel Kidney Disorders Leukemia Lupus Lyme Disease Menopause Men's Health Mental Health Multiple Sclerosis Muscular Dystrophy Myositis Neuromuscular Diseases Neuropathy Osteoporosis Pain Management Parkinson's Polio Pregnancy Rare Disorders Reflex Sympathetic Dystrophy Restless Leg Syndrome Sexual Health Sexually Transmitted Diseaases SIDS Sleep Disorders Smoking Cessation Spinal Cord Disorders Stroke Thyroid Disorders TMJ Disorder Tuberculosis Viagra Weight Loss Women's Health Message Boards on Health Related Topics kidney disorders message board What is IGA Nephropathy?

95. IgA Nephropathy - Causes, Symptoms & Treatment iga nephropathy Facts plus the Latest News on iga nephropathy Treatments HealthNewsflash. HealthNewsflash. iga nephropathy Fact Book. http://www.healthnewsflash.com/conditions/iga_nephropathy.php

Search our Archive for the Latest News on IgA Nephropathy Browse By Category Browse Alphabetically Search Health Conditions IgA Nephropathy Fact Book IgA nephropathy is a kidney disorder caused by deposits of the protein immunoglobulin A (IgA) inside the glomeruli (filters) within the kidney. These glomeruli (the singular form is glomerulus ) normally filter wastes and excess water from the blood and send them to the bladder as urine. The IgA protein prevents this filtering process, leading to blood and protein in the urine and swelling in the hands and feet. This chronic kidney disease may progress over a period of 10 to 20 years. If this disorder leads to end-stage renal disease, the patient must go on dialysis or receive a kidney transplant. The IgA protein is a normal part of the body's system to protect against disease (the immune system). We do not know what causes IgA deposits in the glomeruli. But, since IgA nephropathy may run in families, genetic factors probably contribute to the disease. Kidney disease usually cannot be cured. Once the tiny filtering units are damaged, they cannot be repaired. Treatment focuses on slowing the progression of the disease and preventing complications. One complication is high blood pressure, which further damages glomeruli.

96. Living Kidney Donor With IgA Nephropathy? Response to reader´s question Was a predonation donor kidney biopsy absolutelyindicated in this donor who was found to have iga nephropathy after the fact? http://www.medscape.com/viewarticle/443809

97. Clinical Trials Detail Drug Therapy for the Treatment of iga nephropathy. Trial Status Active.Why is this study being done? What is iga nephropathy? http://mayoresearch.mayo.edu/mayo/research/trials/clinicaltrialdetails.cfm?trial

98. Re: IGA NEPHROPATHY Foundation Enterprises Dialysis Recruiters Re iga nephropathy. In Reply to Reiga nephropathy posted by sue on February 06, 2004 at 152552 Message Sir, http://www.he.net/~brumley/renal/doctormessages/2891.html

Re: IGA NEPHROPATHY Follow Ups Post Followup Nephrologists Forum FAQ Posted by Satish Munoli on May 10, 2004 at 07:58:03: In Reply to: Re: IGA NEPHROPATHY posted by sue on February 06, 2004 at 15:25:52: Message: Sir, I have been diagnosed as Iga - nephropathy - with mild messengial proliferation by Biopsy. Biopsy also says mild deposits in messangium, clear messengium seen, No tubulointerstitial changes. The matrix shows Masangium : deposits of IGA and 3Cs which Mesangial defuse granular, no fbronogin Tubules : no deposits of any kind no fibrosis Arteries: no deposits of any kind no fibrosis My BP at the time of diagnose was 130/90 and 24 hr protin in urin was 318 mg. After one month of medication my first followup report says My BP is continuously 130/80 SIMPLE UNINE ANALYSIS RBC - NIL ALBUMIN - TRACE AND BLOOD REPORT SAYS S. CREATNINE - 0.9 BLOOD UREA - 24 RANGE 10-40 BUN - 5.3 RANGE 2.3 -7.8 How ever for last 1 month ther is frothing in my urine. WHITE in colour.( May be I have been observing regularly now than before) I would like to know is recurring frothing indicates significant raise in Protine? If yes then why my urine report says Just ALBUMIN 'Trace'. Before biopsy it was ALBUMIN '+'.

99. To ÌìÔÃ About IgA Nephropathy To about iga nephropathy. renal failure. All patients with IgAnephropathy should be followed closely by their nephrologists. http://www.omnitalk.net/health/messages/2284.html

To ÌìÔ about IgA nephropathy Ëͽ»Õß: Dr.Doctor ÓÚ September 24, 2003 02:05:14: ³¤ÆÚ·þÓ¶¬³æÏIJݶÔIGAÉöÑ×ÓаïÖúÂ𣿠I have no any idea about the effectivenes of this treatment. As matter of fact, I am not aware of this treatment at all. ¾µÏµ°°×Äò? I do not believe there is such a term called ¾µÏµ°°×Äò. Please recheck on this. It must be a wrong description because U can not see protein under microscope. It must be either proteinuria or microscopic hematuria. Either way, some patients, but not all patients, with proteinuria or persistent microscopic hematuria can progress to renal failure. All patients with IgA nephropathy should be followed closely by their nephrologists. Generally speaking, majority patients follow a benign course, i.e., do not progress to renal failure. Many patients are at risk for at least slow progression. Some patients (15-20%) can even progress to end stage renal disease which requires renal replacement therapy (renal transplantation or dialysis). There are some risk factors (persistent proteinuria above 1 gm/day, hypertension, persistent microscopic hematuria, elevated serum creatinine, and some histologic findings) that can predict the likelihood of developing progressive disease. Äܹý·òÆÞÉú»îÂ𣿠why not?!

100. Project: O-glycosylation Of IgA1 In IgA Nephropathy (NIWI) from Project Oglycosylation . entire NIWI site (en), Help. ProjectO-glycosylation of IgA1 in iga nephropathy. switch to nl. mutation. http://www.niwi.knaw.nl/en/oi/nod/onderzoek/OND1282119/toon

Login NIWI (en) Research Information NOD - Dutch Research Database ... Powered by from "Project: O-glycosylation..." entire NIWI site (en) Project: O-glycosylation of IgA1 in IgA nephropathy Titel O-glycosylering van IgA1 bij IgA nefropathie Abstract IgA nephropathy (IgAN) is the most common form of glomerulonephritis and is characterized by hematuria and deposition of immunoglobulin A1 (IgA1) in the mesangium. In IgAN patients part of the serum IgA1 in the hinge region appears to contain O-glycans with a deviating structure. Changes in the O-glycosylation of the hinge region possibly have important consequences because the quaternary structure of the molecule is influenced, which may lead to changes in molecular function. It has indeed been demonstrated that the IgA1 from IgAN patients differs from the normal IgA1, e.g. in its interaction with FcaR1/CD89. Our hypothesis is that the deviating O-glycosylation of IgA1 contributes to the pathogenesis of IgAN. The main aim of this study is to assess the role of the deviating O-glycosylation of IgA1 in IgAN. For sensitive detection and analysis of the deviating O-glycans of IgA1 it is essential to dispose of specific monoclonal antibodies (MAbs). Concrete research aims of this project are:

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