1. MedlinePlus Medical Encyclopedia: Hypopituitarism hypopituitarism. Pituitary insufficiency Definition Return to top. hypopituitarism is a condition caused by low levels of pituitary hormones. http://www.nlm.nih.gov/medlineplus/ency/article/000343.htm

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Hypopituitarism Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Endocrine glands The pituitary gland Pituitary hormones Pituitary and TSH Alternative names Return to top Pituitary insufficiency Definition Return to top Hypopituitarism is a condition caused by low levels of pituitary hormones. Causes, incidence, and risk factors Return to top The pituitary gland is a small structure that is located just below the brain. It is attached by a stalk to the hypothalamus , the area of the brain that controls its function. The hormones secreted by the pituitary and their functions are: growth hormone (GH), which stimulates growth of tissues and bone thyroid stimulating hormone (TSH), which stimulates the thyroid gland to secrete hormones that affect body metabolism adrenocorticotropic hormone (ACTH), which stimulates the adrenal gland to secrete cortisol which helps to maintain blood pressure prolactin , which stimulates female breast development and milk production luteinizing hormone (LH), which controls sexual function in males and females

2. What Is Hypopituitarism? - Endocrinology Health Guide The diagnosis, causes, treatment and symptoms are discussed as well as what this disorder is. http://www.umm.edu/endocrin/hypopit.htm

Endocrinology Health Guide... Pituitary Gland Disorders... Pituitary Tumors Acromegaly ... Glossary Related Resources Within UMM Endocrinology Joslin Diabetes Center School of Medicine Endocrinology Site Endocrinology Health Guide Hypopituitarism What is hypopituitarism? Hypopituitarism, also called an underactive pituitary gland, is a condition that affects the anterior lobe of the pituitary gland usually resulting in a partial or complete loss of functioning of that lobe. The resulting symptoms depend on which hormones are no longer being produced by the gland. Because the pituitary gland affects the other endocrine organs, effects of hypopituitarism may be gradual or sudden and dramatic. What are the symptoms of hypopituitarism? Symptoms vary depending on what hormones are insufficiently produced by the pituitary gland. The following are common symptoms associated with reduced production of certain hormones: insufficient gonadotropins production (luteinizing hormone and follicle-stimulating hormone) In premenopausal women, this leads to absent menstrual cycles, infertility, vaginal dryness, and loss of some female characteristics. In men, this deficiency leads to impotence, shriveling of testes, decreased sperm production, infertility, and loss of some male characteristics.

3. Pituitary Network Association - Disorders - Hypopituitarism Pituitary Network Association Pituitary Network Association - Disorders - hypopituitarism hypopituitarism. hypopituitarism is a general term that refers to any under function of the Causes http://www.pituitary.com/disorders/hypopituitarism.php

Hypopituitarism Hypopituitarism is a general term that refers to any under function of the pituitary gland. This is a clinical definition used by endocrinologists and is interpreted to mean that one or more functions of the pituitary are deficient. The term may refer to both anterior and posterior pituitary gland failure. Causes of hypopituitarism Deficiency of ACTH and cortisol Deficiency of ACTH resulting in cortisol deficiency is the most dangerous and life threatening of the hormonal deficiency syndromes. With gradual onset of deficiency over days or weeks, symptoms are often vague and may include weight loss, fatigue, weakness, depression, apathy, nausea, vomiting, anorexia and hyperpigmentation. As the deficiency becomes more serious or has a more rapid onset, (Addisonian crisis) symptoms may include confusion, stupor, psychosis, abnormal electrolytes (low serum sodium, elevated serum potassium), and vascular collapse (low blood pressure and shock) which can be fatal. Treatment consists of cortisol administration or another similar steroid (like prednisone). For patients with acute adrenal insufficiency (Addisonian crisis), rapid intravenous administration of high dose steroids is essential to reverse the crisis. Deficiency of TSH and thyroid hormone Deficiency of thyroid hormone causes a syndrome consisting of decreased energy, increased need to sleep, intolerance of cold (inability to stay warm), dry skin, constipation, muscle aching and decreased mental functions. This constellation of symptoms is very uncomfortable and is often the symptom complex that drives patients with pituitary disease to seek medical attention. Replacement therapy consists of a daily pill called thyroxine (Synthroid, Levothyroxine etc). The correct dose is determined through blood tests.

4. HealthSouth: Healthcare In Surgery, Ambulatory, Diagnostic And Rehab A look at the treatment, prognosis and complications of this disease. http://www.healthsouth.com/medinfo/home/app/frame?2=/medlib/medLibDispatcher&

5. EMedicine - Hypopituitarism : Article By Stuart A Brilliant, MD hypopituitarism ED physicians have the opportunity to see patients who have been diagnosed with, or are being worked up for, hypopituitarism. While ED physicians rarely diagnose hypopituitarism http://www.emedicine.com/emerg/topic277.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Emergency Medicine Endocrine And Metabolic Hypopituitarism Last Updated: June 29, 2001 Rate this Article Email to a Colleague AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography Author: Stuart A Brilliant, MD , Staff Physician, Department of Emergency Medicine, University of Connecticut Editor(s): Robin R Hemphill, MD , Associate Program Director, Assistant Professor, Department of Emergency Medicine, Vanderbilt University; Francisco Talavera, PharmD, PhD , Senior Pharmacy Editor, Pharmacy, eMedicine; Howard A Bessen, MD , Program Director, Professor of Medicine, Department of Emergency Medicine, Harbor-UCLA Medical Center; John Halamka, MD , Chief Information Officer, CareGroup Healthcare System, Assistant Professor of Medicine, Department of Emergency Medicine, Beth Israel Deaconess Medical Center; Assistant Professor of Medicine, Harvard Medical School; and Craig Feied, MD, FACEP, FAAEM

6. Discovery Health Hypopituitarism hypopituitarismBy Adam Brochert, MD. Images When this gland becomes less active than normal for any reason, hypopituitarism is said to occur http://health.discovery.com/diseasesandcond/encyclopedia/1570.html

7. Hypopituitarism hypopituitarism. DESCRIPTION Generalized condition caused by partial or total failure of the pituitary gland's vital Sheehan H, Summers VK The syndrome of hypopituitarism. Q.J http://www.5mcc.com/Assets/SUMMARY/TP0465.html

Hypopituitarism DESCRIPTION: Generalized condition caused by partial or total failure of the pituitary gland's vital hormones - ACTH, TSH, LH, FSH, GH, prolactin (PRL) System(s) affected: Endocrine/Metabolic, Reproductive, Skin/Exocrine, Nervous, Gastrointestinal, Musculoskeletal Genetics: Some pituitary defects are congenital Incidence/Prevalence in USA: Relatively rare Predominant age: Occurs in adults and children. In children it causes dwarfism and pubertal delay. Predominant sex: Male = Female CAUSES: Lesions or tumors of the anterior pituitary gland (intrasellar or extrasellar) Congenital defects Pituitary apoplexy Hypophysectomy Infiltrative diseases (e.g., sarcoidosis, histiocytosis X) Sometimes idiopathic Lymphocytic hypophysitis Irradiation Accidental or surgical trauma Hypothalamic disease Synonyms: Pituitary cachexia Hypopituitarism syndrome Simmonds syndrome Panhypopituitarism ICD-9-CM: 253.2 panhypopituitarism REFERENCES: Sheehan H, Summers VK: The syndrome of hypopituitarism. Q.J. Med 1949;42:319 Vance M: Hypopituitarism. N Eng J Med 1994;330:1651

8. Medical Encyclopedia: Hypopituitarism (Print Version) Medical Encyclopedia hypopituitarism. Definition. hypopituitarism is a condition caused by low levels of pituitary hormones. Causes, incidence, and risk factors. http://www.nlm.nih.gov/medlineplus/print/ency/article/000343.htm

To print this page, use the print option from your browser. To close this window, click on the "x" in the upper right hand corner of the window. Medical Encyclopedia: Hypopituitarism URL of this page: http://www.nlm.nih.gov/medlineplus/ency/article/000343.htm Alternative names Pituitary insufficiency Definition Hypopituitarism is a condition caused by low levels of pituitary hormones. Causes, incidence, and risk factors The pituitary gland is a small structure that is located just below the brain. It is attached by a stalk to the hypothalamus, the area of the brain that controls its function. The hormones secreted by the pituitary and their functions are: growth hormone (GH), which stimulates growth of tissues and bone thyroid stimulating hormone (TSH), which stimulates the thyroid gland to secrete hormones that affect body metabolism adrenocorticotropic hormone (ACTH), which stimulates the adrenal gland to secrete cortisol which helps to maintain blood pressure prolactin, which stimulates female breast development and milk production luteinizing hormone (LH), which controls sexual function in males and females

9. The Methodist Hospital - Data Not Available A look at this disorder and its causes, symptoms, diagnosis and treatment by Methodist Health Care System. http://methodisthealth.com/endocrin/hypopit.htm

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10. Pituitary Network Association - Disorders - Hypopituitarism A brief description of this disorder. http://www.pituitary.org/disorders/hypopituitarism.php

Hypopituitarism Hypopituitarism is a general term that refers to any under function of the pituitary gland. This is a clinical definition used by endocrinologists and is interpreted to mean that one or more functions of the pituitary are deficient. The term may refer to both anterior and posterior pituitary gland failure. Causes of hypopituitarism Deficiency of ACTH and cortisol Deficiency of ACTH resulting in cortisol deficiency is the most dangerous and life threatening of the hormonal deficiency syndromes. With gradual onset of deficiency over days or weeks, symptoms are often vague and may include weight loss, fatigue, weakness, depression, apathy, nausea, vomiting, anorexia and hyperpigmentation. As the deficiency becomes more serious or has a more rapid onset, (Addisonian crisis) symptoms may include confusion, stupor, psychosis, abnormal electrolytes (low serum sodium, elevated serum potassium), and vascular collapse (low blood pressure and shock) which can be fatal. Treatment consists of cortisol administration or another similar steroid (like prednisone). For patients with acute adrenal insufficiency (Addisonian crisis), rapid intravenous administration of high dose steroids is essential to reverse the crisis. Deficiency of TSH and thyroid hormone Deficiency of thyroid hormone causes a syndrome consisting of decreased energy, increased need to sleep, intolerance of cold (inability to stay warm), dry skin, constipation, muscle aching and decreased mental functions. This constellation of symptoms is very uncomfortable and is often the symptom complex that drives patients with pituitary disease to seek medical attention. Replacement therapy consists of a daily pill called thyroxine (Synthroid, Levothyroxine etc). The correct dose is determined through blood tests.

11. Postgraduate Medicine: Endocrine Problems Symposium: How To Diagnose Hypopituita How to diagnose hypopituitarism. Preview Various abnormalities of or trauma to the pituitary gland or hypothalamus can cause hypopituitarism. http://www.postgradmed.com/issues/1998/07_98/schmidt.htm

How to diagnose hypopituitarism Learning the features of secondary hormonal deficiencies Diane N. Schmidt, MD; Kathleen Wallace, MD VOL 104 / NO 7 / JULY 1998 / POSTGRADUATE MEDICINE This page is best viewed with a browser that supports tables This is the third of three articles on endocrine disorders Preview : Various abnormalities of or trauma to the pituitary gland or hypothalamus can cause hypopituitarism. Resultant hormonal deficiencies may be partial and may take years to develop fully. Therefore, the clinical picture is often subtle and may include numerous manifestations, depending on the hormones involved and the patient's age at onset. In addition to discussing the causes of hypopituitarism, the authors of this article describe how to recognize and treat resulting hypothyroidism, adrenal insufficiency, hypogonadism, and growth-hormone deficiency. H ypopituitarism is deficiency of one or more anterior pituitary hormones, which results in insufficient stimulation and therefore insufficient hormonal output of the respective target glands. The target-gland dysfunction is referred to as secondary deficiency, indicating that the pituitary gland is the source of the problem. Unexpected laboratory results may be the first clue to hypopituitarism. Illustrative case report A 59-year-old woman was admitted because of an asthma exacerbation and was noted to have fatigue, generalized weakness, hoarseness, constipation, cold intolerance, facial and infraorbital puffiness, and dry, cool skin. She was obese, having had weight gain over the course of many years. On questioning, she reported experiencing excessive hemorrhaging during many of her 10 pregnancies, being unable to breast-feed any of her children, and having amenorrhea since the age of 28. On admission, she was taking only high-dose corticosteroids that had recently been prescribed for asthma. Her pulse was 88 beats per minute and her reflexes showed a delayed relaxation phase. There was no evidence of thyroid enlargement.

12. EMedicine - Hypopituitarism (Panhypopituitarism) : Article By James R Mulinda, M hypopituitarism (Panhypopituitarism) hypopituitarism is a clinical syndrome of deficiency in pituitary hormone production. This http://www.emedicine.com/MED/topic1137.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Endocrinology Hypopituitarism (Panhypopituitarism) Last Updated: December 2, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: pituitary gland, hypothalamus, panhypopituitarism, pituitary insufficiency, adrenocorticotropic hormone, ACTH, corticotropin, follicle-stimulating hormone, FSH, luteinizing hormone, LH, growth hormone, GH, prolactin, thyroid-stimulating hormone, TSH, thyrotropin, antidiuretic hormone, ADH AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: James R Mulinda, MD, FACP, FACE , Consulting Staff, Department of Internal Medicine, Division of Endocrinology, Pennsylvania Hospital, University of Pennsylvania Editor(s): David S Schade, MD

13. EMedicine - Hypopituitarism : Article By Lawrence Wetterau, MD hypopituitarism hypopituitarism is a partial or complete insufficiency of pituitary hormone secretion, which may derive from pituitary or hypothalamic disease. Onset can occur in children or The focus of this article is childhood-onset hypopituitarism. A brief review http://www.emedicine.com/ped/topic1130.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Pediatrics Endocrinology Hypopituitarism Last Updated: December 6, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: growth hormone deficiency, GHD, multiple pituitary hormone deficiency, MPHD, pituitary hypothalamus, hypoglycemia, short stature AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Lawrence Wetterau, MD , Assistant Professor of Pediatrics, Division of Pediatric Endocrinology, Columbus Children's Hospital Coauthor(s): Pinchas Cohen, MD , Director of Research and Training, Professor, Department of Pediatrics, Division of Endocrinology, Mattel Children's Hospital, University of California at Los Angeles Lawrence Wetterau, MD, is a member of the following medical societies: American Academy of Pediatrics , and Endocrine Society Editor(s): Phyllis Speiser, MD

14. THE MERCK MANUALSECOND HOME EDITION, Hypopituitarism In Ch. 162 hypopituitarism. hypopituitarism is an underactive pituitary gland that results in deficiency of one or more pituitary hormones. http://www.merck.com/mrkshared/mmanual_home2/sec13/ch162/ch162c.jsp

15. THE MERCK MANUAL, Sec. 19, Ch. 269, Endocrine And Metabolic Hyperthyroidism. Short Stature Due To hypopituitarism. Short Stature Due To Miscellaneous Causes. Short Stature Due To hypopituitarism (Pituitary Dwarfism). http://www.merck.com/mrkshared/mmanual/section19/chapter269/269d.jsp

16. Hypopituitarism Information Diseases Database hypopituitarism Pituitary failure Adenohypophyseal hyposecretion, Disease Database Information http://www.diseasesdatabase.com/sieve/item1.asp?glngUserChoice=6522

17. Hypopituitarism Note All links within content go to MayoClinic.com. Diseases and Conditions. hypopituitarism. hypopituitarism is rare, affecting about 1 in 10,000 Americans. http://www.cnn.com/HEALTH/library/DS/00479.html

International Edition MEMBER SERVICES The Web CNN.com Home Page World U.S. Weather ... Special Reports SERVICES Video E-mail Services CNNtoGO Contact Us SEARCH Web CNN.com In association with: DIABETES AND ENDOCRINE SYSTEM Endocrine System Graves' disease Goiter Male hypogonadism Hyperthyroidism ... Prolactinoma INFORMATION CENTERS: Pick a category Health Centers Family Health Men's Health Women's Health Children's Health Seniors' Health Working Life Pain Management Condition Centers Immune System Allergy Alzheimer's Arthritis Respiratory System Cancer Endocrine System Digestive System Heart and Blood Infectious Disease Mental Health Note: All links within content go to MayoClinic.com Diseases and Conditions Hypopituitarism From MayoClinic.com Special to CNN.com Overview Hypopituitarism is a disorder in which your pituitary gland fails to produce one or more of its hormones, or doesn't produce enough of them. A short supply of one or more of these pituitary hormones can affect any number of your body's routine functions. The pituitary is a small bean-shaped gland located at the base of your brain, somewhat behind your nose and between your ears. It's part of your endocrine system, which consists of glands that produce hormones that regulate processes throughout your body. Besides the pituitary gland, the endocrine system includes the thyroid gland, parathyroid glands, adrenal glands, pancreas, ovaries (in females) and testicles (in men).

18. The Pituitary Foundation | Disorders | Hypopituitarism If the pituitary is not producing one or more of these hormones, or not producing enough, then this condition is known as hypopituitarism. hypopituitarism. http://www.pituitary.org.uk/disorders/hypopit.htm

Text version Home News Contact Us ... Skip search box SEARCH THIS SITE Advanced search Skip section links DISORDERS Acromegaly Adult GH Deficiency ... Disorders Index LINKS Skip main links The Endocrine System Pituitary Disorders Resources ... About The Pituitary Foundation Hypopituitarism The pituitary gland produces a number of hormones or chemicals which are released into the blood to control other glands in the body. If the pituitary is not producing one or more of these hormones, or not producing enough, then this condition is known as hypopituitarism. The term Multiple Pituitary Hormone Deficiency (MPHD) is sometimes used to describe the condition when the pituitary is not producing two or more of these hormones. If all the hormones produced by the pituitary are affected this condition is known as panhypopituitarism. Hypopituitarism is most often caused by a benign (i.e. not cancerous) tumour of the pituitary gland, or of the brain in the region of the hypothalamus. Pituitary underactivity may be caused by the direct pressure of the tumour mass on the normal pituitary or by the effects of surgery or radiotherapy used to treat the tumour. Less frequently, hypopituitarism can be caused by infections (such as meningitus) in or around the brain or by severe blood loss, by head injury, or by various rare diseases such as sarcoidosis (an illness which resembles tuberculosis).

19. The Pituitary Foundation | GP Fact File | 6. Hypopituitarism Pituitary Foundation Fact Sheet. hypopituitarism. hypopituitarism may also develop after several years of treatment of a pituitary tumour by radiotherapy. http://www.pituitary.org.uk/gp-factfile/6-hypopit.htm

Text version Home News Contact Us ... Skip search box SEARCH THIS SITE Advanced search Skip section links GP FACT SHEETS 1. Introduction 2. Non-Functioning Tumour 3. Acromegaly 5. Hyperprolactinaemia ... GP Fact File Index LINKS Skip main links The Endocrine System Pituitary Disorders Resources ... About The Pituitary Foundation Pituitary Foundation Fact Sheet Hypopituitarism Hormone deficiency caused by the inadequate secretion of one or more of the hormones normally secreted by the pituitary, is known as hypopituitarism. It may be caused by compression of the normal tissue by a developing tumour, surgery, or radiotherapy. If hypopituitarism is caused by tumour compression, function may be partially or fully recovered after surgery or medical therapy to reduce the size of the tumour. Surgically-induced hypopituitarism may occur in some cases, particularly if the tumour is large, but this can be transitory and some or all of the function may recover. Hypopituitarism may also develop after several years of treatment of a pituitary tumour by radiotherapy. Presenting symptoms Symptoms of Hormone Deficiency Symptoms Deficient Hormone Growth retardation in children, excessive tiredness, muscle weakness

20. Introduction: Hypopituitarism - WrongDiagnosis.com Introduction to hypopituitarism as a medical condition including symptoms, diagnosis, misdiagnosis, treatment, prevention, and prognosis. http://www.wrongdiagnosis.com/h/hypopituitarism/intro.htm

Diseases IMPORTANT! Use of this site is subject to our and Home Symptoms Diseases Risks Search: We show you all these ads in order to provide this free site; give your feedback WrongDiagnosis TM Premium Report: Diabetes Diagnosis and Misdiagnosis Available Now! Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Hypopituitarism Next sections Basic Summary for Hypopituitarism Next chapters: Hyperpituitarism Cough Lesch-Nyhan syndrome Cyclosporiasis ... Feedback Introduction: Hypopituitarism Hypopituitarism: Under-active pituitary gland Contents for Hypopituitarism: Basic Summary for Hypopituitarism Diseases Did we miss something? Please tell your story or provide feedback or suggestions By using this site you agree to our and . Information provided on this site is for informational purposes only; it is not intended as a substitute for advice from your own medical team. The information on this site is not to be used for diagnosing or treating any health concerns you may have - please contact your physician or health care professional for all your medical needs. Please see our and Book Lists WrongDiagnosis.com

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