61. ALS Treatment: Amyotrophic Lateral Sclerosis Lou Gehrigs Disease Home About Us Products Disorders FAQ Message Board Resources Your AccountShopping Cart, hereditary spastic paraplegia (HSP). Hereditary http://www.enhancedlifesciences.com/hspinfo.php

path = "http://www.enhancedlifesciences.com/"; Home About Us Products Disorders ... Shopping Cart Hereditary Spastic Paraplegia (HSP) Hereditary Spastic Paraplegia (HSP) is a term used to describe a group of rare, inherited neurological disorders along the motor neuron disease continuum whose primary symptom is progressive spasticity (stiffness) and weakness of the leg and hip muscles. There are at least twenty different types of HSP; however, genetic causes are known for only eleven of them. It is estimated that approximately 20,000 individuals are affected by HSP in the U.S. Other names for this disorder include Familial Spastic Paraparesis (or Paraplegia), Strümpell-Lorrain Disease, Spastic Paraplegia, Hereditary Charcot-Disease, Spastic Spinal Paralysis, Diplegia Spinalis Progressiva, French Settlement Disease, Troyer syndrome and Silver syndrome. In the late 1800's, a neurologist in Heidelberg, Germany named A. Strümpell first described HSP. He observed two brothers and their father, who had gait disorders and spasticity in their legs. After the death of the two brothers, Strümpell was able to show, through autopsy, the degeneration of the nerve fibers leading through the spinal cord. HSP was originally named after Strümpell. HSP is caused by degeneration of the upper motor neurons in the brain and spinal cord. These neurons control voluntary movement; and the cell bodies of these neurons are located in the motor cortex area of the brain. They have long, hair-like processes called axons that travel to the brainstem and down the spinal cord. The axons relay messages to lower motor neurons that are located all along the brainstem and spinal cord. Lower motor neurons then carry the messages out to the muscles. This results in a progressive increase in muscle spasticity and weakness. The upper body may be minimally affected is some cases, resulting in problems with arm or speech and swallowing muscles.

62. Entrez PubMed Click here to read Spastin, the protein mutated in autosomal dominanthereditary spastic paraplegia, is involved in microtubule dynamics. http://www.biomedcentral.com/pubmed/11809724

Entrez PubMed Nucleotide Protein ... Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes 3D Domains Domains Gene GEO GEO DataSets HomoloGene Journals MeSH NCBI Web Site OMIM PMC PopSet SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: Sort Author Journal Pub Date Text File Clipboard E-mail Order Hum Mol Genet. 2002 Jan 15;11(2):153-63. Related Articles, Links Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics. Errico A, Ballabio A, Rugarli EI.

63. Arquivos De Neuro-Psiquiatria - hereditary spastic paraplegia ASSOCIATED WITH THIN CORPUS CALLOSUM. KEYWORDS hereditary spastic paraplegia, corpus callosum, MRI. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000500025&l

64. Arq. Neuro-Psiquiatr.  Vol.59 no.3B; Abstract: S0004-282X2001000500030 MachadoJoseph disease versus hereditary spastic paraplegia case report. Arq.Neuro-Psiquiatr., Sept. 2001, vol.59, no.3B, p.809-811. ISSN 0004-282X. http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-282X2001000500030&

65. Hereditary Spastic Paraplegia Medical Wisdom Information hereditary spastic paraplegia Information Page. Table of Contents (click to jumpto sections). What is hereditary spastic paraplegia? Is there any treatment? http://medicalwisdom.com/health/disorders/hereditarysp.htm

Join our Message Board Forum Health Concerns Women's Health ... Dental Health Concerns Hereditary Spastic Paraplegia Information Page Table of Contents (click to jump to sections) What is Hereditary Spastic Paraplegia? Is there any treatment? What is the prognosis? What research is being done? What is Hereditary Spastic Paraplegia? Hereditary spastic paraplegia (HSP), also called familial spastic paraparesis (FSP), refers to a group of inherited disorders that are characterized by progressive weakness and stiffness of the legs. Though the primary feature of HSP is severe, progressive, lower extremity spasticity, in more complicated forms it can be accompanied by other neurological symptoms. These include optic neuropathy, retinopathy (diseases of the retina), dementia, ataxia (lack of muscle control), icthyosis (a skin disorder resulting in dry, rough, scaly skin), mental retardation, peripheral neuropathy, and deafness. Diagnosis is primarily by neurological examination and testing to exclude other disorders. Specialized genetic testing and diagnosis are available at some medical centers. Is there any treatment?

66. Specialty Laboratories ::: We Help Doctors Help Patients Print View. hereditary spastic paraplegia E. Robert Wassman, MD Hereditary spasticparaplegia (HSP) can be divided into pure and complex forms with associated http://www.specialtylabs.com/books/display.asp?id=937

67. PillSupplier.com - Conditions And Diseases/Genetic Disorders/Hereditary Spastic Category hereditary spastic paraplegia. HOME Login . Conditions andDiseases/Genetic Disorders/hereditary spastic paraplegia. Links http://www.pillsupplier.com/dir/862/

Category: Hereditary Spastic Paraplegia HOME ABOUT US ORDER STATUS BMI CALCULATOR ... CONTACT US Prescription Drugs Diet Pills Adipex Bontril Didrex ... Login Conditions and Diseases/Genetic Disorders/Hereditary Spastic Paraplegia Links: GeneClinics: An Overview [rate it] [review it] In depth details about hereditary spastic paraplegia. Includes a summary, definition, categories, diagnosis, genetic counseling and resources. Hereditary Spastic Paraplegia [rate it] [review it] In depth look at this disease by John K. Fink, M.D., including genetic analysis, clinical features and FAQs. Hereditary Spastic Paraplegia [rate it] [review it] HSP information sheet compiled by the National Institute of Neurological Disorders and Stroke. HSPinfo.org [rate it] [review it] Information about hereditary spastic paraplegia, and disability resources. Includes newsletters, news, announcements, research and support. MCW Healthlink: HSP [rate it] [review it] An article about hereditary spastic paraplegia, also called familial spastic paralysis. The FSP Support Group [rate it] [review it] For people suffering from Familial Spastic Paraplegia. Includes a newsletter, discussion forum, links, and contact details.

68. Genetics Of Hereditary Spastic Paraplegia Genetics of hereditary spastic paraplegia. Wednesday, September 04, 2002.hereditary spastic paraplegia with identified gene loci or mutations. http://www.angelfire.com/retro/michaelpoon168/genetics_of_hereditary_spastic_par

var cm_role = "live" var cm_host = "angelfire.lycos.com" var cm_taxid = "/memberembedded" Michael Poon's Shrine of Neurology HOME CONTENTS CONTACT US HOME ... CONTACT US Genetics of hereditary spastic paraplegia Wednesday, September 04, 2002 Hereditary spastic paraplegia with identified gene loci or mutations Notation Inheritance Gene location Gene identified XR XR Proteolipid protein AD AD Spastin AR AD AR Paraplegin AD AD AD AR AD AD AR AD = autosomal dominant; AR = autosomal recessive; XR = X-linked recessive.

69. Startplane /Health/Conditions_and_Diseases/Genetic_Disorders/Hereditary_Spastic_ hereditary spastic paraplegia. See also Links. GeneClinics An Overview In depth details about hereditary spastic paraplegia. Includes http://www.startplane.com/Health/Conditions_and_Diseases/Genetic_Disorders/Hered

Start Plane About Us Free Webpages Top Health Hereditary Spastic Paraplegia Top Hereditary Spastic Paraplegia Sites Your Site Here! - Get your site listed on StartPlane! The #1 performance based directory online! See also: Top/Health/Conditions and Diseases/F Top/Health/Conditions and Diseases/Neurological Disorders/Muscle Diseases Links GeneClinics: An Overview - In depth details about hereditary spastic paraplegia. Includes a summary, definition, categories, diagnosis, genetic counseling and resources. Hereditary Spastic Paraplegia - HSP information sheet compiled by the National Institute of Neurological Disorders and Stroke. MCW Healthlink: HSP - An article about hereditary spastic paraplegia, also called familial spastic paralysis. Spastic Paraplegia Foundation - Supports on the upper motor neuron disorders hereditary spastic paraplegia and primary lateral sclerosis. Information about these conditions, disability resources, newsletters, news, announcements, research and support. The FSP Support Group - For people suffering from Familial Spastic Paraplegia. Includes a newsletter, discussion forum, links, and contact details. This category needs an editor Last Updated: 2003-12-02 04:35:05 Search: search the entire directory search this category only Help build the largest human-edited directory on the web.

70. Mental Retardation, Directory Human Genome Organisation. hereditary spastic paraplegia. NINDS HereditarySpastic Paraplegia Information Page SPF Spastic Paraplegia http://www.saunalahti.fi/kup/engl/webs_h.html

Finnish Information Center on Mental Retardation English links A B C D ... Z Hair defect photosensitivity mental retardation HAIR DEFECT WITH PHOTOSENSITIVITY AND MENTAL RETARDATION, OMIM, Victor A. McKusick Hair defect photosensitivity mental retardation, Orphanet Hajdu-Cheney syndrome ACROOSTEOLYSIS WITH OSTEOPOROSIS AND CHANGES IN SKULL AND MANDIBLE, OMIM Hajdu-Cheney syndrome (HCS), U.S. National Library of Medicine HAJDU-CHENEY SYNDROME, University Hospital Gent, Gent, Belgium. Hajdu Cheney Syndrome, NORD ... Hajdu Cheney Syndrome, Health Library Hall Syndrome Hall syndrome 1, U.S. National Library of Medicine Pallister-Hall syndrome, U.S. National Library of Medicine PALLISTER-HALL SYNDROME; PHS (OMIM Database) Hall-Riggs Syndrome Hall-Riggs Mental Retardation Syndrome, OMIM Hall-Riggs syndrome, Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes Hallermann-Streiff syndrome Hallermann-Streiff syndrome (HSS), Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes HALLERMANN-STREIFF SYNDROME; HSS, OMIM Hallermann Streiff syndrome, National Organization for Rare Disorders, Inc. Hallermann-Streiff syndrome, Selected medical images, Geneva Foundation for Medical Education and Research ... Hallermann-Streiff-François syndrome, Whonamedit Halpern Syndrome DYSEQUILIBRIUM SYNDROME; DES, OMIM

71. MDVU Library - Hereditary Spastic Paraplegia hereditary spastic paraplegia (HSP) is a group of genetic, degenerative disordersof the spinal cord characterized by progressive paraplegia and spasticity of http://www.mdvu.org/library/disease/hsp/

WE MOVE 204 West 84th Street New York, NY 10024 E-mail: wemove@wemove.org Library Movement Disorders Description Symptoms/Findings/ ... References Latest Hereditary Spastic Paraplegia News from E-MOVE Announcement: Movement Disorders Virtual University Is Open Announcement: New HD, HSP Pages on the WE MOVE Site Library Search the E-MOVE Archives Our Mission Professional Services Make a Donation ... Contact Us Hereditary Spastic Paraplegia Description Hereditary spastic paraplegia (HSP) is a group of genetic, degenerative disorders of the spinal cord characterized by progressive weakness (paraplegia) and stiffness (i.e., spasticity) of the legs. Spasticity refers to excessive muscle tone (hypertonicity) or muscle overactivity with increased velocity-dependent resistance to stretch. This group of disorders is also sometimes referred to as... Familial spastic paraparesis (FSP) Familial spastic paraplegia (FSP) Hereditary spastic paraparesis Strumpell-Lorraine syndrome Strumpell's disease HSP is often classified based upon whether progressive spasticity occurs as an isolated finding (i.e., uncomplicated or "pure" HSP) or with other neurologic abnormalities (i.e., complicated HSP). In families (kindreds) affected by complicated HSP, associated neurologic features have included mental retardation; deafness; degenerative changes of the retinas or the nerve-rich, innermost membranes of the eyes (retinopathy); impaired coordination of voluntary movements (ataxia); or progressive deterioration of thought processing and acquired intellectual abilities (dementia).

72. MDVU Library - Hereditary Spastic Paraplegia - Additional References hereditary spastic paraplegia. References. Boustany RMN, Fleischnick E, Alper CA,et al. Fink JK. Advances in hereditary spastic paraplegia. Curr Opin Neurol. http://www.mdvu.org/library/disease/hsp/hsp_ref.html

WE MOVE 204 West 84th Street New York, NY 10024 E-mail: wemove@wemove.org Library Movement Disorders Description Symptoms/Findings/ ... References Library Research News Our Mission Professional Services Make a Donation ... Contact Us Hereditary Spastic Paraplegia References Boustany RMN, Fleischnick E, Alper CA, et al. The autosomal dominant form of 'pure' familial spastic paraplegia: clinical findings and linkage analysis of a large pedigree. Neurology. Byrne, PC, Webb S, McSweeney F, Burke T, Hutchinson M, Parfrey NA. Linkage of AD HSP and cognitive impairment to chromosome 2p: haplotype and phenotype analysis indicates variable expression and low or delayed penetrance. Europ J Hum Genet. Cooley WC, Rawnsley E, Melkonian G, et al. Autosomal dominant familial spastic paraplegia: report of a large New England family. Clin Genet. Durr A, Davoine CS, Paternotte C, et al. Phenotype of autosomal dominant spastic paraplegia linked to chromosome 2. Brain. Fink JK. Advances in hereditary spastic paraplegia. Curr Opin Neurol.

73. ORPHANET - Rare Diseases - Orphan Drugs Included disease(s) hereditary spastic paraplegia, Xlinked complex Hereditaryspastic paraplegia, autosomal dominant complex hereditary spastic paraplegia http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=685

74. ParapleginFƒqƒgˆâ“`«Ž¾Š³ihereditary Spastic Paraplegia (HSP)j� The summary for this Japanese page contains characters that cannot be correctly displayed in this language/character set. http://mukb.medic.kumamoto-u.ac.jp/AAA/minirev/nakairev.html

ParapleginFƒqƒgˆâ“`«Ž¾Š³ihereditary spastic paraplegia (HSP)j‚ðˆø‚«‹N‚±‚·ƒ~ƒgƒRƒ“ƒhƒŠƒAAAAƒtƒ@ƒ~ƒŠ[ƒƒ^ƒƒvƒƒeƒA[ƒ[‚̕ψ٠’†ˆä rŽ÷i‰¡•lŽs‘åEˆãERIŒ¤‹†ƒZƒ“ƒ^[j

75. Wauu.DE: Health: Conditions And Diseases: Genetic Disorders: Hereditary Spastic Wauu.DE Health Conditions and Diseases GeneticDisorders hereditary spastic paraplegia. http://www.wauu.de/Health/Conditions_and_Diseases/Genetic_Disorders/Hereditary_S

Home Health Conditions and Diseases Genetic Disorders : Hereditary Spastic Paraplegia Search DMOZ-Verzeichnis: All Categories Categories Onlye Links: GeneClinics: An Overview In depth details about hereditary spastic paraplegia. Includes a summary, definition, categories, diagnosis, genetic counseling and resources. http://www.geneclinics.org/profiles/hsp/ Hereditary Spastic Paraplegia In depth look at this disease by John K. Fink, M.D., including genetic analysis, clinical features and FAQs. http://www.med.umich.edu/hsp/ Hereditary Spastic Paraplegia HSP information sheet compiled by the National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/health_and_medical/disorders/hereditarysp.htm HSPinfo.org Information about hereditary spastic paraplegia, and disability resources. Includes newsletters, news, announcements, research and support. http://hspinfo.org/ MCW Healthlink: HSP An article about hereditary spastic paraplegia, also called familial spastic paralysis. http://healthlink.mcw.edu/article/921730935.html The FSP Support Group For people suffering from Familial Spastic Paraplegia. Includes a newsletter, discussion forum, links, and contact details.

76. Orthoguide.com Hereditary Spastic ParaplegiaNeuromuscular Home Page E Toxin Axon Search results for hereditary spastic paraplegia . Orthoguide Matches 1 1 of 1. Search AltaVista for more on hereditary spastic paraplegia . http://www.mymedline.com/ortho/Hereditary_Spastic_Paraplegia.php3

Search results for "Hereditary Spastic Paraplegia" Orthoguide Matches 1 - 1 of 1 Disorders: Neuromuscular: Neuromuscular Home Page [http://www.neuro.wustl.edu/neuromuscular/] Search AltaVista for more on 'Hereditary Spastic Paraplegia' Global Search Add Url Free Medline ... Search Enter Keywords to Search and Your Choice of Search Arguments Or And Match entire phrase Orthoguide.com

77. The Association Of Hereditary Spastic Paraplegia And Hereditary Motor And Sensor The association of hereditary spastic paraplegia and hereditary motor andsensory neuropathy in the same family Münife Müftüoðlu 1 , MD, Ý. http://medicine.inonu.edu.tr/dergi/Contents/Volume2/Issue2/Abstract/193-195.html

The association of hereditary spastic paraplegia and hereditary motor and sensory neuropathy in the same family Münife Müftüoðlu , M.D., Ý. Özcan Ertürk , M.D., Cemal Özcan , M.D., Hakan Ekmekçi , M.D. The association of hereditary spastic paraplegia (HSP) and sensory neuropathies have been reported in a number of cases. But it is rare to detect both entities seperately in different members of the same family. In the present study, we report clinical and electrophysiological findings of three members of a family. In two of the siblings the clinical picture was indistinguishable from "pure" hereditary spastic paraplegia, but electrophysiological studies revealed a predominantly sensory polyneuropathy. In the third case (the mother of the siblings), the clinical diagnosis was consistent with hereditary motor sensory neuropathy type 2, which was also confirmed by electrophysiological studies. We believe that, with the further genetic reevaluations, the hereditary spastic paraplegia with sensory abnormalities may take a new place in the classification of hereditary motor and sensory polyneuropathies, as a distinct entity.[Journal of Turgut Özal Medical Center 2(2):193-195,1995] Key Words : Hereditary spastic paraplegia, hereditary motor and sensory neuropathy

78. Disabilityexchange.org - Taxonomy hereditary spastic paraplegia. Synonym(s) Familial Spastic Paralysis Whatis hereditary spastic paraplegia? hereditary spastic paraplegia http://www.disabilityexchange.org/taxonomy/index.php?fid=3&path=3_251

79. GeneTests: Search Results hereditary spastic paraplegia GeneReview hsp 49579 Resources 53830 Hereditary SpasticParaplegia, Dominant Research Tests 2631 hereditary spastic paraplegia http://www.genetests.org/query?mim=601162

80. »»Reviews For Hereditary Spastic Paraplegia«« hereditary spastic paraplegia Reviews. Related Subjects Genetic_Disorders. Bookreviews for hereditary spastic paraplegia sorted by average review score http://www.booksunderreview.com/Health/Conditions_and_Diseases/Genetic_Disorders

Hereditary Spastic Paraplegia Reviews Related Subjects: Book reviews for "Hereditary Spastic Paraplegia" sorted by average review score: The Hereditary Ataxias and Related Disorders (Clinical Neurology and Neurosurgery Monographs, Volume 6) Published in Hardcover by Churchill Livingstone (December, 1984) Author: A.E. Harding Amazon base price: Average review score: No reviews found. Related Subjects: Search site for a Book Review Sort by: Rank Last Modified Date Title Path Reverse Sort

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