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         Hepatic Encephalopathy:     more books (47)
  1. Hepatic Encephalopathy: Syndromes and Therapies by Harold O. Conn, 1994-01
  2. Hepatic Encephalopathy by Alan H. Lockwood, 1992-11
  3. Cirrhosis, Hepatic Encephalopathy and Ammonium Toxicity (Advances in Experimental Medicine and Biology)
  4. Hepatic Encephalopathy in Chronic Liver Failure
  5. Hepatic Encephalopathy - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by ICON Health Publications, 2004-10-04
  6. Cirrhosis, Hyperammonemia, and Hepatic Encephalopathy (Advances in Experimental Medicine and Biology)
  7. Advances in Hepatic Encephalopathy and Metabolic Nitrogen Exchange by Livio Capocaccia, Manuela Merli, et all 1994-12-27
  8. Advances in Cirrhosis, Hyperammonemia, and Hepatic Encephalopathy (Advances in Experimental Medicine and Biology)
  9. Hepatic Encephalopathy: Management With Lactulose and Related Carbohydrates by Harold O. Conn, 1988-10
  10. Hepatic Encephalopathy and Nitrogen Metabolism
  11. Hepatic Encephalopathy, Hyperammonemia and Toxicity (Advances in Experimental Medicine and Biology)
  12. Hepatic Encephalopathy: Pathophysiology and Treatment (Experimental Biology and Medicine) by Roger F. Butterworth, Gilles Pomier Layrargues, 1989-10-01
  13. Progress in Hepatic Encephalo & Metabolic Nitrogen by Bengt Jeppsson, Finn Bengtsson, 1991-04-24
  14. Encephalopathy and Nitrogen Metabolism in Liver Failure

1. EMedicine - Encephalopathy, Hepatic : Article By David C Wolf, MD, FACP, FACG
Encephalopathy, Hepatic hepatic encephalopathy is a syndrome observed inpatients with cirrhosis of the liver. Ferenci P hepatic encephalopathy.
http://www.emedicine.com/med/topic3185.htm
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Encephalopathy, Hepatic
Last Updated: April 12, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: portosystemic encephalopathy, PSE, hepatic coma, cirrhosis of the liver, hepatic cirrhosis, portosystemic collateral vessels, portocaval shunt surgery, portal hypertension, end-stage liver disease, ESLD, coma, dysfunction of hepatic synthetic activity, fulminant hepatic failure, FHF, liver failure AUTHOR INFORMATION Section 1 of 9 Author Information Definition Pathogenesis Clinical Features Of Hepatic Encephalopathy ... Bibliography
Author: David C Wolf, MD, FACP, FACG , Medical Director of Liver Transplantation, Associate Professor, Department of Internal Medicine, Division of Gastroenterology and Hepatobiliary Diseases, New York Medical College and Westchester Medical Center Editor(s): John Gunn Lee, MD

2. HEPATIC ENCEPHALOPATHY
hepatic encephalopathy A condition which is used to describe the deleterious effects of liver failure on support may also be required. See encephalopathy for additional details.
http://www.medhelp.org/glossary/new/gls_2197.htm
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HEPATIC ENCEPHALOPATHY - A condition which is used to describe the deleterious effects of liver failure on the central nervous system. Features include confusion ranging to unresponsiveness ( coma ). A common cause is alcoholic cirrhosis . Treatment includes the binding and elimination of ammonia in the intestinal tract . General life support including respiratory support and cardiovascular support may also be required. See encephalopathy for additional details.
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3. MedlinePlus Medical Encyclopedia: Hepatic Encephalopathy
hepatic encephalopathy. Definition Return to top. hepatic encephalopathy is brainand nervous system damage that occurs as a complication of liver disorders.
http://www.nlm.nih.gov/medlineplus/ency/article/000302.htm
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Hepatic encephalopathy
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Illustrations
Digestive system organs Alternative names Return to top Hepatic coma; Encephalopathy - hepatic Definition Return to top Hepatic encephalopathy is brain and nervous system damage that occurs as a complication of liver disorders. It is characterized by various neurologic symptoms including changes in reflexes, changes in consciousness , and behavior changes that can range from mild to severe. Causes, incidence, and risk factors Return to top Hepatic encephalopathy is caused by disorders affecting the liver. These include disorders that reduce liver function (such as cirrhosis or hepatitis ) and conditions where blood circulation bypasses the liver. The exact cause of the disorder is unknown.
However, when the liver cannot properly metabolize and detoxify substances in the body, toxic substances build up in the bloodstream. One substance believed to be particularly toxic to the central nervous system is

4. Postgraduate Medicine: Hepatic Encephalopathy
hepatic encephalopathy. Metabolic consequence of cirrhosis often is reversible. Hepaticencephalopathy metabolic consequence of cirrhosis often is reversible.
http://www.postgradmed.com/issues/2001/02_01/assi.htm
Hepatic encephalopathy
Metabolic consequence of cirrhosis often is reversible
Souheil Abou-Assi, MD; Z. Reno Vlahcevic, MD* VOL 109 / NO 2 / FEBRUARY 2001 / POSTGRADUATE MEDICINE CME learning objectives
  • To understand the pathogenesis of hepatic encephalopathy in chronic liver disease
  • To recognize the clinical manifestations and diagnostic tools used to detect hepatic encephalopathy
  • To be aware of the precipitating factors for hepatic encephalopathy and to try to avoid them in patients with cirrhosis
The authors disclose no financial interests in this article. Supported by a grant from the National Institutes of Health and a grant from the Department of Veterans Affairs. *Deceased. This is the first of three articles on cirrhosis This page is best viewed with a browser that supports tables. Preview : Hepatic encephalopathy is characterized by neuropsychiatric manifestations ranging from a slightly altered mental status to coma, and neuromuscular symptoms may be present. This complication of chronic or acute liver disease is a result of the failure of the liver to detoxify toxins originating in the intestine. The pathogenesis probably is multifactorial, although the predominant causative agent appears to be ammonia. In this article, Drs Abou-Assi and Vlahcevic discuss the timely recognition and correction of factors contributing to this often reversible condition.
Abou-Assi S, Vlahcevic ZR. Hepatic encephalopathy: metabolic consequence of cirrhosis often is reversible. Postgrad Med 2001;109(2):52-70

5. Hepatic Encephalopathy
More Medical Pages. hepatic encephalopathy. Pancreatic Cancer . Acute Pancreatitis . Chronic Pancreatitis . Liver Transplantation . Anal Incontinence . hepatic encephalopathy. DEFINITION hepatic encephalopathy is a syndrome seen in patients with cirrhosis of the liver systemic collateral vessels. Indeed, hepatic encephalopathy may develop in noncirrhotic patients
http://www.geocities.com/twisted_artist/Medecine/hepatic_encephalopathy.htm
More Medical Pages Hepatic Encephalopathy Pancreatic Cancer Acute Pancreatitis Chronic Pancreatitis ... Anal Incontinence Hepatic Encephalopathy
DEFINITION: Hepatic encephalopathy is a syndrome seen in patients with cirrhosis of the liver. It is characterized by personality changes, intellectual impairment, and a depressed level of consciousness , fluctuating neurologic signs, asterixis or "flapping tremor," and distinctive electroencephalographic changes. An important prerequisite for the syndrome is diversion of portal blood into the systemic circulation through porto-systemic collateral vessels. Indeed, hepatic encephalopathy may develop in non-cirrhotic patients who have undergone portocaval shunt surgery. The development of hepatic encephalopathy is explained to some extent by the effect of neurotoxic substances, which occurs in the setting of cirrhosis and portal hypertension. Subtle signs of hepatic encephalopathy are seen in nearly 70% of patients with cirrhosis. Symptoms may be debilitating in a significant number of patients and are seen in 24-53% of patients who undergo portosystemic shunt surgery. About 30% patients dying of end-stage liver disease will experience significant encephalopathy, approaching coma. Encephalopathy may be acute and reversible or chronic and progressive . In severe cases, irreversible coma and death may occur. Acute episodes may recur with variable frequency

6. Gastrin Level
Offers participating factors, pathophysiology, symptoms and signs, diagnosis and management.
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7. Volume 96, Number 7, July 2001
July 2001 Volume 96 , Number 7 Pages 1968 1976. hepatic encephalopathy Citethis article as Blei AT and Córdoba J. hepatic encephalopathy.
http://www-east.elsevier.com/ajg/issues/9607/ajg3964fla.htm
Practice Guidelines
July 2001
Volume , Number
Pages Hepatic Encephalopathy Andres T. Blei a rdoba b and The Practice Parameters Committee of the American College of Gastroenterology Cite this article as:
a Department of Medicine, Lakeside VA Medical Center and Northwestern University, Chicago, Illinois b Unidad de Hepatologia, Hospital Vall d'Hebron and Autonomous University of Barcelona, Barcelona, Spain
Preamble
Introduction
Hepatic encephalopathy (HE) may be defined as a disturbance in central nervous system function because of hepatic insufficiency. This broad definition reflects the existence of a spectrum of neuropsychiatric manifestations related to a range of pathophysiological mechanisms. Present in both acute and chronic liver failure, these neuropsychiatric manifestations are potentially reversible.
Clinical Considerations Pathophysiology The main tenet of all theories of the pathogenesis of HE is firmly accepted: nitrogenous substances derived from the gut adversely affect brain function. These compounds gain access to the systemic circulation as a result of decreased hepatic function or portal-systemic shunts. Once in brain tissue, they produce alterations of neurotransmission that affect consciousness and behavior. Abnormalities in glutamatergic, serotoninergic, -aminobutyric acid-ergic (GABA-ergic), and catecholamine pathways, among others, have been described in experimental HE (

8. HealthCentral - General Encyclopedia - Hepatic Encephalopathy
and risk factors hepatic encephalopathy is caused by disorders affecting the liver with otherwise stable liver disorders, hepatic encephalopathy may be triggered by episodes
http://www.healthcentral.com/mhc/top/000302.cfm
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9. Hepatic Encephalopathy
hepatic encephalopathy. DESCRIPTION Altered mental and neuromotor functioning associated with acute or chronic liver disease and/or portal systemic shunting of blood. Treatment of hepatic encephalopathy. Am J Gastroenter 1997;9214291439
http://www.5mcc.com/Assets/SUMMARY/TP0411.html
Hepatic encephalopathy
DESCRIPTION: Altered mental and neuromotor functioning associated with acute or chronic liver disease and/or portal systemic shunting of blood. The prominent features are mild to marked forgetfulness, impaired arousability, and a "flapping tremor" (asterixis).
System(s) affected: Gastrointestinal, Nervous
Genetics: Unknown
Incidence/Prevalence in USA:
  • Occurs in 1/3 cases of cirrhosis
  • Occurs in all cases of fulminant hepatic failure
  • Present in nearly half of patients who reach the stage of liver disease requiring transplantation

Predominant age: Parallels that of fulminant liver disease with peak in the 40's, and cirrhosis with peak in late 50's. May occur at any age.
Predominant sex: Male = Female (reflecting the underlying liver disease)
CAUSES:
  • Shunting of intestinal blood through the severely diseased liver without the intervention of viable liver cells. TIPS (transjugular intrahepatic portacaval shunt), a widely used radiologically inserted shunt to lower portal pressure, produces liver encephalopathy.
  • Shunting of such blood through collateral circulation or surgically constructed portacaval shunts
  • Most common in long standing cirrhosis of the liver with spontaneous shunting of intestinal blood through collaterals.

10. WebMD/Lycos Hepatic Encephalopathy
An in depth look at this disorder, from alternative names to a description, causes, incidence and risk factors, symptoms, diagnosis, treatment, prognosis, complications and prevention.
http://webmd.lycos.com/content/asset/adam_disease_hepatic_coma
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11. Medical Encyclopedia: Hepatic Encephalopathy (Print Version)
Medical Encyclopedia hepatic encephalopathy. hepatic encephalopathy is brain andnervous system damage that occurs as a complication of liver disorders.
http://www.nlm.nih.gov/medlineplus/print/ency/article/000302.htm
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Medical Encyclopedia: Hepatic encephalopathy
URL of this page: http://www.nlm.nih.gov/medlineplus/ency/article/000302.htm Alternative names Hepatic coma; Encephalopathy - hepatic Definition Hepatic encephalopathy is brain and nervous system damage that occurs as a complication of liver disorders. It is characterized by various neurologic symptoms including changes in reflexes, changes in consciousness, and behavior changes that can range from mild to severe. Causes, incidence, and risk factors Hepatic encephalopathy is caused by disorders affecting the liver. These include disorders that reduce liver function (such as cirrhosis or hepatitis) and conditions where blood circulation bypasses the liver. The exact cause of the disorder is unknown.
However, when the liver cannot properly metabolize and detoxify substances in the body, toxic substances build up in the bloodstream. One substance believed to be particularly toxic to the central nervous system is ammonia, which is produced by the body when proteins are digested, but is normally detoxified by the liver. Many other substances may also accumulate in the body and contribute to damage to the nervous system.
In people with otherwise stable liver disorders, hepatic encephalopathy may be triggered by episodes of gastrointestinal bleeding, excessive intake of dietary protein, electrolyte abnormalities (especially decrease in potassium, which may result from vomiting or treatments such as diuretics or paracentesis), infections, renal disease, and procedures that shunt blood past the liver.

12. THE MERCK MANUAL, Sec. 4, Ch. 38, Clinical Features Of Liver Disease
PortalSystemic Encephalopathy ( hepatic encephalopathy; Hepatic Coma) term of the pathophysiology than "hepatic encephalopathy" or "hepatic coma " but clinically all three are
http://www.merck.com/pubs/mmanual/section4/chapter38/38f.htm
This Publication Is Searchable The Merck Manual of Diagnosis and Therapy Section 4. Hepatic And Biliary Disorders Chapter 38. Clinical Features Of Liver Disease Topics [General] Jaundice Hepatomegaly Portal Hypertension ... Other Symptoms And Signs Of Liver Disease
Portal-Systemic Encephalopathy
(Hepatic Encephalopathy; Hepatic Coma)
A neuropsychiatric syndrome caused by liver disease and usually associated with portal-systemic shunting of venous blood. "Portal-systemic encephalopathy" is a more descriptive term of the pathophysiology than "hepatic encephalopathy" or "hepatic coma," but clinically all three are used interchangeably.
Etiology
Portal-systemic encephalopathy may occur in fulminant hepatitis caused by viruses, drugs, or toxins, but it more commonly occurs in cirrhosis or other chronic disorders when extensive portal-systemic collaterals have developed as a result of portal hypertension. The syndrome also follows portacaval shunt or similar portal-systemic anastomoses. In patients with chronic liver disease, encephalopathy is usually precipitated by specific, potentially reversible causes (eg, GI bleeding; infection; electrolyte imbalance, especially hypokalemia; alcoholic debauches) or iatrogenic causes (tranquilizers, sedatives, analgesics, diuretics).

13. Hepatic Encephalopathy
Subject hepatic encephalopathy Topic Area Hepatitis C Forum The HepatitisForum Question Posted By Fred on Thursday, April 06, 2000
http://www.medhelp.org/forums/hepatitis/messages/30218a.html
Questions in The Hepatitis Forum have been answered by
doctors from Henry Ford Health System. Subject: hepatic encephalopathy
Topic Area: Hepatitis C
Forum: The Hepatitis Forum
Question Posted By: Fred on Thursday, April 06, 2000
I have a friend who has hepatitis, she has been living with this disease for the past 16yrs. I think it has already advanced to very severe form. Recently she was hospitalized again and was diagnosed to have hepatic encephalopathy. She is insisting that she is dying. She is a very dear friend and i just want to know more about the disease. Can you please guide me on what course would this disease take. Is there a real possibility that she would leave us. Thank you for your help. Answer Posted By: HFHSM.D.-D.M. on Sunday, April 16, 2000
Dear Fred:
I appreciate your letter and I can imagine your concern towards your 16 year old friend. There are all kinds of liver disease and it is hard for me to tell you anything specific about her without knowing a fair bit more. I will try to make some general comments.
One of the jobs of the liver is to remove toxic or waste chemicals from the blood. When a liver becomes diseased, it can lose its ability to “cleanse” the blood and bad chemicals can build up. Some of these chemicals can cause a certain lethargy or confusion that we call hepatic encephalopathy. As a general rule, anytime a patient with liver disease has hepatic encephalopathy, it usually means they have advanced liver disease. Their prognosis depends upon the underlying cause of the liver disease and whether it can be treated. If some one has a treatable form of liver disease, they can potentially do well for a long time. Some times, we can treat the hepatic encephalopathy effectively with medications and individuals can do well for years. However, hepatic encephalopathy is usually a very serious symptom. If some one does not have a treatable form of liver disease of if they clearly are not going to do well, we might want to think about options like liver transplant.

14. Tulane Center For Abdominal Transplant: Liver
hepatic encephalopathy. Definition A brain dysfunction caused by theaccumulation of toxic chemicals in the blood stream. The normal
http://www.tulanetransplant.com/li_enceph.htm
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Hepatic Encephalopathy Definition:
A brain dysfunction caused by the accumulation of toxic chemicals in the blood stream. The normal liver acts as a filter removing harmful substances from the blood. With cirrhosis the liver is not able to remove a variety of toxic chemicals. These chemical remain in the blood and eventually enter the brain, causing a variety of disturbances with brain function. The toxin most easily identified is ammonia.
Symptoms:
Fatigue, sleepiness, confusion, depression, irritability, personality changes, forgetfulness, slurred speech, tremors (shakes), and problems with balance may occur. As the condition worsens, patients become more sleepy and eventually lapse into a coma. Some patients with encephalopathy develop a peculiar odor on their breath (fetor hepaticus) from the toxins.
Treatment:
The toxins are produced in the intestine by bacterial metabolism of protein. The following therapies help reduce the levels of ammonia and other toxins.

15. Hepatic Encephalopathy
hepatic encephalopathy is an acute medical condition that may become a medical emergency known or suspected liver disorder. hepatic encephalopathy can rapidly progress to become an
http://www.drkoop.com/ency/article/000302trt.htm
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Hepatic encephalopathy
Alternative Names: Hepatic coma; Encephalopathy - hepatic
Treatment: Hepatic encephalopathy is an acute medical condition that may become a medical emergency. Hospitalization is required.
The goals of treatment include life support, elimination or treatment of precipitating factors, and removal or neutralization of ammonia and other toxins . Life support may be required, including support of breathing or circulation, particularly if coma develops. The brain may develop swelling, which can be life-threatening.
Precipitating factors must be identified and treated. Gastrointestinal bleeding must be stopped. The intestines must be emptied of blood. Blood breaks down into protein components that are converted to ammonia. Treatment of infections, renal failure, and electrolyte abnormalities (especially potassium) is important.
In patients with severe, repeated cases of encephalopathy, the patient may be advised to reduce

16. Liver Facts-Hepatic Encephalopathy
hepatic encephalopathy is theresult of biochemical abnormalities associated with liver failure....... H. hepatic encephalopathy.
http://www.liverfacts.com/ms/ency/368/main.html
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Hepatic Encephalopathy
Related Stories Lung Transplants Buy Time for Those With Cystic Fibrosis Nitric Oxide Improves Liver Transplant Odds Deciphering Immune Response to Transplants Related Videos Kinder Kidney Transplant Hepatitis C: A Race Issue Cleaning The Liver Related Slides Hepatitis Liver Cirrhosis Liver Transplant Related Encyclopedia Hepatic Encephalopathy Hepatitis Hepatitis A Definition
This is a condition that usually occurs secondary to advanced liver disease and is marked by a disturbance of mental functioning. Hepatic means "of the liver" and Encephalopathy means "a disorder of the brain." Description
Hepatic encephalopathy is the result of biochemical abnormalities associated with liver failure. Although disturbed ammonia metabolism is one component of hepatic encephalopathy, it is clear that ammonia is not solely responsible for the disturbed mental status. Encephalopathy is the mandatory clinical feature for diagnosis of acute liver failure. Difficulties in the recognition of the early stages of encephalopathy and distinction from drug-induced and renal (kidney)-induced alterations of mental state do not detract from the value of this sign as the most powerful clinical indicator of the severity of liver disease.

17. Hepatic Encephalophaty
The typical symptoms of hepatic encephalopathy include. · impaired consciousness(drowsiness),. The typical symptoms of hepatic encephalopathy include.
http://home3.inet.tele.dk/omni/encephalopathy.htm
The Danish Hepatitis C website Hepatic encephalopathy (for patients and relatives): The typical symptoms of hepatic encephalopathy include The typical symptoms of hepatic encephalopathy include ... Ascites Hepatic encephalopathy (for patients and relatives): Hepatic encephalopathy refers to the changes in the brain that occur in patients with advanced acute or chronic liver disease. If liver cells are damaged, certain substances that are normally cleansed from the blood by the healthy liver are not removed (ammonia mainly, and other toxins). A patient with chronic hepatic encephalopathy may develop progressive loss of memory, disorientation, untidiness, and muscular tremors, leading to a form of chronic dementia. The ingestion of protein invariably aggravates these symptoms. The treatment of hepatic encephalopathy involves, first, the removal of all drugs that require detoxification in the liver and, second, the reduction of the intake of protein. Restricting the amount of protein in the diet will generally lower the levels of amino acids and ammonia in the bloodstream and brain. Most physicians advise their patients with this condition to eat only about 40 grams of protein a day, and will prescribe lactulose or neomycin to lower amino acid production. Non-meat proteins, such as those found in vegetables and milk, are preferred. Certain amino acids are used in treatment, since they are considered less likely to cause mental impairment. A dietary supplement rich in these amino acids is used at many liver treatment centers.

18. Cirrhosis And Its Effect Hepatic Encephalopaty
The typical symptoms of hepatic encephalopathy include. · impaired consciousness(drowsiness),. · monotonous speech,. Treatment of hepatic encephalopathy.
http://home3.inet.tele.dk/omni/cirrhosis2.htm
The Danish Hepatitis C website Cirrhosis of the liver and its effect (No. 2) – Hepatic encephalopathy The following explains why you should avoid protein in your diet and why you should avoid drugs which causes the liver to filter them out: Contents: 1. Cirrhosis of the liver and its effects 1a. Ascites 1b. Oesophagael Varices 1b.1. Sclerotherapy Versus Banding for Variceal Bleeding ... 1c. Hepatic encephalopaty Cirrhosis of the liver and its effects Chronic Hepatitis C (CHC) is one of the diseases that may lead to cirrhosis of the liver (the normal liver cells are irreversibly replaced by scar tissue). The loss of normal liver tissue increasingly slows the processing of nutrients, hormones, drugs, and toxins by the liver, as well as the production of proteins and other substances made by the liver. The scar tissue that forms in cirrhosis damages the structure of the liver, progressively making the flow of blood through the liver more difficult. People with liver cirrhosis may develop other complications:
  • When the liver is heavily scarred, the blood cannot get through the liver at the normal pace because of the obstruction presented by the scar tissue, thus creating a higher than normal pressure in the portal vein - the main vein feeding the liver (portal hypertension).

19. AllRefer Health - Hepatic Encephalopathy (Encephalopathy - Hepatic, Hepatic Coma
hepatic encephalopathy (Encephalopathy Hepatic, Hepatic Coma) information centercovers causes, prevention, symptoms, diagnosis, treatment, incidence, risk
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You are here : AllRefer.com Health Hepatic Encephalopathy
Hepatic Encephalopathy
Definition Prevention
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Alternate Names : Encephalopathy - Hepatic, Hepatic Coma Definition Hepatic encephalopathy is brain and nervous system damage that occurs as a complication of liver disorders. It is characterized by various neurologic symptoms including changes in reflexes, changes in consciousness , and behavior changes that can range from mild to severe.
Digestive System Organs Hepatic encephalopathy is caused by disorders affecting the liver. These include disorders that reduce liver function (such as cirrhosis or hepatitis ) and conditions where blood circulation bypasses the liver. The exact cause of the disorder is unknown.

20. AllRefer Health - Hepatic Encephalopathy Treatment (Encephalopathy - Hepatic, He
hepatic encephalopathy (Encephalopathy Hepatic, Hepatic Coma) informationcenter covers Treatment. Encephalopathy. hepatic encephalopathy.
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Hepatic Encephalopathy
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Alternate Names : Encephalopathy - Hepatic, Hepatic Coma Treatment Hepatic encephalopathy is an acute medical condition that may become a medical emergency. Hospitalization is required.
The goals of treatment include life support, elimination or treatment of precipitating factors, and removal or neutralization of ammonia and other toxins . Life support may be required, including support of breathing or circulation, particularly if

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