61. Urology - Hemolytic Uremic Syndrome hemolytic uremic syndrome What is hemolytic uremic syndrome (HUS)? hemolytic uremic syndrome is a rare condition that mostly affects http://www.muschealth.com/urology_GS/hemolyt.htm

Hemolytic Uremic Syndrome What is hemolytic uremic syndrome (HUS)? Hemolytic uremic syndrome is a rare condition that mostly affects children under the age of 10. It is often characterized by: damage to the lining of blood vessel walls destruction of red blood cells kidney failure What causes HUS? Most cases of HUS occur after an infection in the digestive tract caused by the E. coli bacterium. E. coli may be found in contaminated food, such as dairy products and meat. How might HUS progress? The first stage of HUS frequently lasts from 1 to 15 days and may include gastrointestinal symptoms such as: abdominal pain bloody diarrhea vomiting Severe problems in the bowel and colon may develop in some cases. In these cases, even if the gastroenteritis has stopped, a child may still exhibit the following symptoms: irritability fatigue small, unexplained bruises or small clot-sized hemorrhages visible in the mucosal lining of the mouth paleness The child may produce little urine because damaged red blood cells and other factors may clog the tiny blood vessels in the kidneys or cause lesions in the kidneys, making the kidneys work harder to remove wastes and extra fluid from the blood. The body's inability to rid itself of excess fluid and waste may, in turn, cause:

62. Hemolytic Uremic Syndrome Detailed information on hemolytic uremic syndrome, including cause, progression, treatment, and statistics. hemolytic uremic syndrome. http://www.healthsystem.virginia.edu/uvahealth/peds_urology/hus.cfm

@import url(/assets/UVAHealth/ssi/css/greystone_advance.css); Adolescent Medicine Allergy/Asthma/Immunology Blood Disorders Burns Cancer Common Injuries/Poison Tips Craniofacial Anomalies Dermatology Diabetes/Endo/Metabolism Eye Care Genitourinary/Kidney High-Risk Newborn High-Risk Pregnancy Infectious Diseases Medical Genetics Mental Health Nervous System Disorders Normal Newborns Oral Health Orthopaedics Pediatric Surgery Respiratory Disorders Terminal Illness in Children Transplantation FIND A DOCTOR MAKE AN APPOINTMENT CALENDAR OF EVENTS CLINICAL TRIALS Hemolytic Uremic Syndrome What is hemolytic uremic syndrome (HUS)? HUS is a rare condition that can lead to kidney failure in children. Kidney failure develops as a result of destruction of the small, functional structures and vessels inside the kidney. HUS is a serious illness and potentially fatal. What causes hemolytic uremic syndrome? HUS is more common during the summer months and may occur in outbreaks. Outbreaks have been reported in daycare centers, water parks, and fast food restaurants as a result of inadequately cooked hamburger meat. HUS is most common in younger children between 6 months and 4 years, but can occur at any age. HUS has several known causes and some unknown causes. Typically in children, HUS develops after an infection with the E. coli bacterium. E. coli may be found in contaminated food such as dairy products and meat. HUS can also develop as a result of taking certain medications, or may result from a cancer present in the body, although these causes are less common. In less than 5 percent of HUS cases, the disorder is inherited by a dominant gene (a gene passed from parent to child with a 50/50 risk) or recessive gene (each parent carries one copy of the gene and the child inherits both copies; the chance is 25 percent with each pregnancy).

63. HUS Home Page This site contains information for anyone interested in learning more about the disease called HUS (hemolytic uremic syndrome) We will show the differences http://www.atypicalhus.50megs.com/

Ecommerce Solution Free Web Space Free Web Site Web Hosting ... Dial up $14.95 or NetZero Internet Service $9.95 The Atypical HUS Website HUS Home Page Treatments - Symptoms Case Studies Contact /Register/Links Page ... Other Organizations of Interest Welcome! This site contains information for anyone interested in learning more about the disease called HUS (Hemolytic Uremic Syndrome) We will show the differences between two types of HUS: Typical HUS and Atypical HUS. The information is presented in both common terminology and also in medical terminology This page is dedicated to all of the children who are battling this disease. So little is known about the disease, and we hope to raise awareness and funds in order to find better treatments. Atypical HUS Atypical HUS (Hemolytic Uremic Syndrome) is not caused by an external agent (such as a bacteria, virus etc). Instead, some sort of internal chain of events sets the HUS off, and the syndrome becomes active. The syndrome is not well understood. It may be a genetic weakness due to a missing or deficient protein or enzyme. It may be a variety of other unknown causes. In either case, Atypical HUS patients have many of the the same symptons as Typical HUS Patients. However, there are quite a number of differences. While the Typical form of the disease may start off more severe, the Atypical form is subject to longer lingering effects, and is much more likely to become a chronic problem. Recurrance is much more common with the Atypical form of the disease.

64. HEMOLYTIC UREMIC SYNDROME - CLINICAL ASPECTS AND OUTCOME OF AN OUTBREAK: REPORT March 1995. hemolytic uremic syndrome CLINICAL ASPECTS AND OUTCOME OF AN OUTBREAK REPORT OF 28 CASES. 2. Drummond KN. hemolytic uremic syndrome then and now. http://www.kfshrc.edu.sa/annals/152/94035ar.html

March 1995 HEMOLYTIC UREMIC SYNDROME - CLINICAL ASPECTS AND OUTCOME OF AN OUTBREAK: REPORT OF 28 CASES AbdelAziz Y. Elzouki, MB, BCh, FAAP; Khalid Mirza, MD; Ayman Mahmood, Msc; Abdul Mohsen Al-Sowailem, Facharzt From the Department of Pediatric Nephrology, Riyadh Medical Complex, Riyadh. Address reprint requests and correspondence to Dr. Elzouki: Consultant and Head, Department of Pediatric Nephrology, Riyadh Medical Complex, P.O. Box 7855, Riyadh 11117, Saudi Arabia. Accepted for publication 10 July 1994. Ann Saudi Med 1995;15(2):113-116. Hemolytic uremic syndrome (HUS) is a clinical syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure.1-3 There are at least two main subgroups that can be identified;4 a typical form of HUS which follows a diarrheal prodrome (D+HUS) and usually occurs in preschool children, and an atypical form which occurs at any age without diarrheal prodrome (D-HUS). Familial and recurrent HUS are occasionally observed.5 The D+HUS occurs in sporadic or epidemic outbreaks. Hemorrhagic colitis is the most common and widely recognized gastrointestinal manifestation of D+HUS. The most common infectious trigger in North America is

65. Urological Disorders, Hemolytic Uremic Syndrome Submit Your Site to the hemolytic uremic syndrome category. Submit Your Site to the hemolytic uremic syndrome category. Health Spotlight. Online Lab Tests, http://www.iseekhealth.com/hemolytic_uremic_syndrome-2296.php

Home About Us Contact Submit Your Site Search : Home Health Conditions and Diseases Urological Disorders ... Hemolytic Uremic Syndrome More Hemolytic Uremic Syndrome Categories: Submit Your Site to the Hemolytic Uremic Syndrome category Atypical Hemolytic Uremic Syndrome - Atypical HUS, is a rare disease among children causing kidney failure and high blood pressure. Offering support and information including, treatment, symptoms, case studies and research. Emergency Medicine - Written by William Shapiro MD., an article about hemolytic uremic syndrome. An introduction, lab studies, treatment and follow up. Kidney Foundation of Canada - A description of hemolytic uremic syndrome, where the bacteria comes from, who develops it, the symptoms and how to prevent E.coli 0157:H7. Methodist Health Care System - Hemolytic uremic syndrome, a description, what causes it, possible progression, treatments and statistics for this disease. Patients Guide - Fact sheet summarizing hemolytic uremic syndrome. WebMD - Information about hemolytic uremic syndrome including a definition, causes, incidence, risk factors, symptoms, signs, tests, treatment, prognosis, possible complications and when to call the doctor.

66. New York City Department Of Health And Mental Hygiene - Communicable Disease - H hemolytic uremic syndrome (HUS). What is hemolytic uremic syndrome (HUS)? HUS is a serious disease that affects the blood clotting system and the kidneys. http://www.nyc.gov/html/doh/html/cd/cdhus.html

New York City Department of Health and Mental Hygiene Bureau of Communicable Disease Hemolytic Uremic Syndrome (HUS) What is Hemolytic Uremic Syndrome (HUS)? HUS is a serious disease that affects the blood clotting system and the kidneys. In severe cases, the red blood cells are destroyed, resulting in anemia and kidney failure. About 2%-7% of infections by the bacteria E. coli 0157:H7 lead to HUS. In 2001, there were two cases reported in New York City residents. Who gets HUS? It is a rare disease, and it affects children more commonly than adults. In the United States, HUS is the principal cause of acute kidney failure in children. Most cases occur in the warmer months between April and October. What causes HUS? Most cases of HUS are caused by infection with the bacteria E. coli 0157:H7. E. coli 0157:H7 infections occur after eating contaminated food, such as undercooked meat, poultry, or dairy products; or through contact with a person who has infectious diarrhea. One in ten children who have E. coli 0157:H7 infection will go on to develop HUS. The bacterium releases a toxin that affects blood flow to the kidney and other vital organs including the brain, pancreas and liver, leading to impaired organ function. This can cause the sudden development of kidney failure, diabetes, hepatitis, and even heart failure. What are the symptoms of HUS?

67. Urology - Hemolytic Uremic Syndrome hemolytic uremic syndrome. What is hemolytic uremic syndrome (HUS)? Hemolytic Statistics related to hemolytic uremic syndrome According http://uuhsc.utah.edu/healthinfo/adult/urology/hemolyt.htm

Hemolytic Uremic Syndrome What is hemolytic uremic syndrome (HUS)? Hemolytic uremic syndrome is a rare condition that mostly affects children under the age of 10. It is often characterized by: damage to the lining of blood vessel walls destruction of red blood cells kidney failure What causes HUS? Most cases of HUS occur after an infection in the digestive tract caused by the E. coli bacterium. E. coli may be found in contaminated food, such as dairy products and meat. How might HUS progress? The first stage of HUS frequently lasts from 1 to 15 days and may include gastrointestinal symptoms such as: abdominal pain bloody diarrhea vomiting Severe problems in the bowel and colon may develop in some cases. In these cases, even if the gastroenteritis has stopped, a child may still exhibit the following symptoms: irritability fatigue small, unexplained bruises or small clot-sized hemorrhages visible in the mucosal lining of the mouth paleness The child may produce little urine because damaged red blood cells and other factors may clog the tiny blood vessels in the kidneys or cause lesions in the kidneys, making the kidneys work harder to remove wastes and extra fluid from the blood. The body's inability to rid itself of excess fluid and waste may, in turn, cause:

68. Hemolytic Uremic Syndrome: Events Of The Past Decade hemolytic uremic syndrome; Intervention studies; Risk factors. http://www.pulsus.com/Paeds/07_08/mcla_ed.htm

forgot your password? ORIGINAL ARTICLE Octo ber 2002, Volume 7, Number 8: Hemolytic uremic syndrome: Events of the past decade PN McLaine This article describes the birth of the Canadian Pediatric Kidney Disease Research Centre (CPKDRC) in 1985 and the activities that have transpired as a result of collaborative research at paediatric centres across Canada. These include the National Retrospective Study of Childhood Hemolytic Uremic Syndrome (HUS), National Prospective Study of Risk Factors for Developing Escherichia coli O157:H7 Infection, and Intervention Studies for the Prevention of HUS. A look to the future describes possible studies to determine potential factors (surrogate markers) to identify children who are at risk for developing HUS following verotoxin-producing E coli gastroenteritis, other intervention studies and a more accurate understanding of permanent renal insufficiency in children who have had HUS.

69. Conference On Hemolytic Uremic Syndrome (HUS) KS Logo, STOP Announces Medical Conference on hemolytic uremic syndrome (HUS). Focus is Longterm Health Implications for Survivors June 01, 2000. advertisement. http://www.kidsource.com/health/HUS.html

S.T.O.P. Announces Medical Conference on Hemolytic Uremic Syndrome (HUS) Focus is Long-term Health Implications for Survivors June 01, 2000 advertisement Source Laurie Girand S.T.O.P. Forums Health, Safety, Nutrition and Kids Related Articles E. Coli Infections Detection and Prevention Information (Chicago, IL.) S.T.O.P. - Safe Tables Our Priority today announced that it is hosting a one day medical conference of specific interest to survivors of E. coli O157:H7, their parents and physicians. Entitled "Long-term Health Implications of Hemolytic Uremic Syndrome: A Multi-Disciplinary Conference," the event will be held on Saturday, October 7, 2000 in Seattle, Washington. Internationally renown medical experts on HUS will be presenting the latest information about health challenges faced by individuals who survive the catastrophic phase of illness and hospitalization. In the United States, Hemolytic Uremic Syndrome, also known as HUS, is the leading cause of acute kidney failure in children. Approximately 90% of children who develop Hemolytic Uremic Syndrome after an infection with E. coli O157:H7 survive but may face a lifetime of complications from the disease. "By the time victims of E. coli O157:H7 poisoning and their loved ones are ready to leave the hospital, they have been through an incredible traumatic and brutally painful experience," said President Nancy Donley. "Oftentimes, there are many lingering medical problems and scores of unanswered questions. This is the first conference of its kind, assembling international authorities on HUS who can provide answers and bring the latest available information to persons most needing it." Though many medical conferences are centered around a single medical specialty, HUS involves so many of the body's systems that physicians and researchers for this event come from many disciplines, including nutrition, hematology, endocrinology, cardiovascular surgery, gastroenterology, and neuropsychology.

70. Hemolytic Uremic Syndrome (HUS), Thrombotic Thrombocytopenic Purpura (TTP), E. C E. coli O157H7 related hemolytic uremic syndrome (HUS) and Thrombotic Thrombocytopenic Purpura (TTP) information, legal cases, news and resources. http://www.marlerclark.com/hus-ttp.html

Marler Clark Sponsored Web Sites OutbreakInc FoodborneIllness About-HUS About-TTP ... FSIS-PFGE Hemolytic Uremic Syndrome (HUS) and Thrombotic Thrombocytopenic Purpura (TTP) Hemolytic uremic syndrome is believed to develop when E. coli O157:H7 enters into a person's circulation through the inflamed bowel wall, releasing a specific chemical system known as shiga-like toxin (SLT). SLT, and probably other chemical mediators, attach to receptors on the inside surface of blood vessel cells (endothelial cells). Some organs appear more susceptible than others to the damage caused by these toxins, possibly due to the presence of increased numbers of toxin-receptors. These organs include the kidney, pancreas, and brain. HUS is now recognized as the most common cause of kidney failure in childhood. E. coli O157: H7 is responsible for over 90% of the cases of HUS that develop in North America. In fact, some researchers now believe that E. coli O157:H7 is the only cause of HUS in children. Thrombotic thrombocytopenic purpura (TTP) is generally recognized as “adult HUS.” There are many possible causes, including E. coli O157:H7, all of which act through the common mechanism of inducing damage in the endothelial cell wall. The damage triggers a cascade of biochemical events that ultimately leads to the characteristic feature of TTP - widespread damage to the heart, brain, kidneys, pancreas and adrenals. Other organs are involved to a lesser degree.

71. Hemolytic Uremic Syndrome : Study Of Prognostic Factors As Seen On The Indian Sc hemolytic uremic syndrome study of prognostic factors as seen on the Indian scene. Dedhia NM, Shah BV, Khanna UB, Almeida AF, Acharya VN. http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1986;volume=32;issue=1

72. Thrombotic Thrombocytopenic Purpura And The Hemolytic Uremic Syndrome 126, No. 11, pp. 1430–1433. Thrombotic Thrombocytopenic Purpura and the hemolytic uremic syndrome. Joel L. Moake, MD a hemolytic uremic syndrome Return to TOC. http://arpa.allenpress.com/arpaonline/?request=get-document&doi=10.1043/0003-998

73. NewYork-Presbyterian Hospital: Health A To Z: Hemolytic Uremic Syndrome Health information about hemolytic uremic syndrome from NewYorkPresbyterian. The University Hospitals of Columbia and Cornell. http://wo-pub2.med.cornell.edu/cgi-bin/WebObjects/PublicA.woa/3/wa/viewHContent?

74. Pediatrics: Invasive Pneumococcal Disease And Hemolytic Uremic Syndrome You are Here Articles Pediatrics August, 2002 Article. Invasive pneumococcal disease and hemolytic uremic syndrome. Hemolyticuremic syndrome Causes of; http://www.findarticles.com/cf_dls/m0950/2_110/90622276/p1/article.jhtml

@import url(/css/us/style.css); @import url(/css/us/searchResult1.css); @import url(/css/us/articles.css); Advanced Search Home Help IN all publications this publication Health Automotive Business Computing Entertainment Health News Reference Sports YOU ARE HERE Articles Pediatrics August, 2002 Content provided in partnership with Print friendly Tell a friend Find subscription deals Invasive pneumococcal disease and hemolytic uremic syndrome Pediatrics August, 2002 by John Brandt Craig Wong Susan Mihm Joan Roberts ... Bradley Warady ABBREVIATIONS. HUS, hemolytic uremic syndrome; D+ HUS, diarrhea-associated hemolytic uremic syndrome; DIC, disseminated intravascular coagulation; SP-HUS Streptococcus pneumoniae-associated hemolytic uremic syndrome; T-antigen, Thomsen-Freidenreich antigen; FFP, fresh-frozen plasma; ESRD, end-stage renal disease; IgM, immunoglobulin M. METHODS Patients were children who were hospitalized with a history of HUS associated with a culture-proven S pneumoniae infection at the Children's Hospital of New Mexico (Albuquerque, NM), Children's Hospital and Medical Center (Seattle, WA), Children's Mercy Hospital (Kansas City, MO), and Texas Children's Hospital (Houston, TX) between 1990 and 1999. SP-HUS patients were compared with a cohort of 17 consecutive, nonepidemic, E coli O157-associated D+ HUS patients who were hospitalized at Children's Hospital and Medical Center in between January 1 and December 31, 1996. The following definitions were used: 2. Glucose intolerance: hyperglycemia requiring insulin therapy

75. Health Information hemolytic uremic syndrome, hemolytic uremic syndrome. What is hemolytic uremic syndrome (HUS)? Statistics related to hemolytic uremic syndrome http://www.baptisthealth.net/greystone/content.jsp?pageid=P01480

76. Penn State Faculty Research Expertise Database (FRED) Faculty Research Expertise Database. HemolyticUremic Syndrome. Gassers Syndrome, hemolytic uremic syndrome. Hemolytic-Uremic Syndromes, Syndrome, Gasser. http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D006463

77. Blackwell Synergy - Cookie Absent Druginduced Thrombotic Thrombocytopenic Purpura/hemolytic uremic syndrome A Concise Review. Carcinoma-associated hemolytic-uremic syndrome. http://www.blackwell-synergy.com/links/doi/10.1111/j.1526-0968.2003.00127.x/enha

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78. Project: The Hemolytic Uremic Syndrome At Child Age (NIWI) from Project The hemolytic u . entire NIWI site (en), Help. Project The hemolytic uremic syndrome at child age. switch to nl. mutation. http://www.niwi.knaw.nl/en/oi/nod/onderzoek/OND1282135/toon

Login NIWI (en) Research Information NOD - Dutch Research Database ... Powered by from "Project: The hemolytic u..." entire NIWI site (en) Project: The hemolytic uremic syndrome at child age Titel Het hemolytisch uremisch syndroom op de kinderleeftijd Abstract * Characterization of the damage on vascular endothelium (particularly human glomerular endothelium) by verocytotoxin, particularly regarding the NO system and prostacyclin release * Long-term prognosis of renal damage in hemolytic uremic syndrome (HUS) patients. The hemolytic-uremic syndrome (HUS) is the main cause of acute renal insufficiency at child age in The Netherlands and is nearly always caused by a verocytotoxin (VT) producing Escherichia coli. The acute mortality is 5% and the prognosis of the renal damage on the long term has been investigated still insufficiently. It has been generally accepted that VT comes into the circulation through the damaged gut wall and then damages the vascular epithelium. This particularly occurs in the arterioles and capillaries of the kidney and to a less extent also in other organs like pancreas and brain. Animal experimental studies have demonstrated that the degree of endothelial damage is determined by the concentration of the receptor for VT (globotriao-sylceramide (Gb3)). With electron microscopy of the kidney biopsy in the acute phase, damaged endothelial cells are observed which have been set free from the basal membrane with clot formation on this endothelium.

79. FATAL HEMOLYTIC UREMIC SYNDROME IN A SIMULTANEOUS KIDNEY-PANCREAS TRANSPLANT PAT FATAL hemolytic uremic syndrome IN A SIMULTANEOUS KIDNEYPANCREAS TRANSPLANT PATIENT RECEIVING DACLIZUMAB, TACROLIMUS,. MYCOPHENOLATE MOFETIL AND STEROIDS. http://www.utmem.edu/transplant/abstracts/itns2000/andersonabstract2.htm

2000 ITNS ABSTRACT FATAL HEMOLYTIC UREMIC SYNDROME IN A SIMULTANEOUS KIDNEY-PANCREAS TRANSPLANT PATIENT RECEIVING DACLIZUMAB, TACROLIMUS, MYCOPHENOLATE MOFETIL AND STEROIDS T. K. Anderson, RN, BBA , T. B. Wood, RN , J. Trofe, PharmD , R. J. Stratta, MD , M. F. Egidi, MD , L. W. Gaber, MD , A. Lo, Pharm D , R. R. Alloway, PharmD , A. O. Gaber, MD . Colleges of Medicine , Pharmacy , and Pathology , University of Tennessee, Memphis, TN This case report illustrates the severity of HUS posttransplantation, which eventually resulted in death when an etiology could not be determined. Transplant clinicians must be alert to the presenting symptoms of this devastating complication so that early diagnosis may result in prompt treatment and better survival. Further studies are necessary to determine the mechanism of action for the development of HUS and its association with donor cocaine abuse, calcineurin inhibitors, CMV, humanized monoclonal antibodies, ganciclovir and HCV. Learning Objectives: Understand the presenting symptoms of HUS posttransplant. Provide information to aid in early diagnosis of HUS in order to improve outcomes.

80. EMedicine - Hemolytic-Uremic Syndrome : Article By Malvinder S Parmar, MD, FRCPC hemolyticuremic syndrome - hemolytic-uremic syndrome (HUS) is a clinical syndrome characterized by progressive renal failure associated with microangiopathic http://www.emedicine.com/med/topic980.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Hematology Hemolytic-Uremic Syndrome Last Updated: January 21, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: HUS, progressive renal failure, microangiopathic hemolytic anemia, thrombocytopenia, acute renal failure, ARF, thrombotic thrombocytopenic purpura, TTP, thrombotic microangiopathies, TMAs, verotoxin-producing Escherichia coli, E coli, VTEC, hamburger disease, Gasser syndrome AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Malvinder S Parmar, MD, FRCPC, FACP , Assistant Professor (VPT), Faculty of Medicine, University of Ottawa; Medical Director of Medical Program, Department of Internal Medicine, Timmins and District Hospital, Ontario Malvinder S Parmar, MD, FRCPC, FACP, is a member of the following medical societies: American College of Physicians American Society of Nephrology Canadian Medical Association Ontario Medical Association , and Royal College of Physicians and Surgeons of Canada Editor(s): Rodger L Bick, MD, PhD

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