1. EMedicine - Hemolytic Uremic Syndrome : Article By William Shapiro, MD hemolytic uremic syndrome hemolytic uremic syndrome (HUS) is characterized by acute renal failure, microangiopathic hemolytic anemia, fever, and http://www.emedicine.com/emerg/topic238.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Emergency Medicine Hematology And Oncology Hemolytic Uremic Syndrome Last Updated: July 29, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: HUS AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: William Shapiro, MD , Consulting Staff, Department of Urgent Care and Emergency Medicine, Scripps Clinic and Research Foundation William Shapiro, MD, is a member of the following medical societies: American Academy of Emergency Medicine American College of Emergency Physicians , and American College of Physicians Editor(s): William Gossman, MD , Assistant Professor, Department of Emergency Medicine, Chicago Medical School; Project Medical Director, Department of Emergency Medicine, Mount Sinai Hospital; Francisco Talavera, PharmD, PhD , Senior Pharmacy Editor, Pharmacy, eMedicine; Jeffrey L Arnold, MD, FACEP, FAAEM

2. Hemolytic Uremic Syndrome hemolytic uremic syndrome (HUS) is characterized by destruction of red blood cells, damage to the lining of blood vessel walls, and, in severe cases, kidney http://www3.bc.sympatico.ca/me/patientsguide/huspg.htm

Hemolytic (HEE-mo-LIT-ik) uremic (yoo-REE-mik) syndrome is a rare condition affecting mostly children under the age of 10. Hemolytic uremic syndrome (HUS) is characterized by destruction of red blood cells, damage to the lining of blood vessel walls, and, in severe cases, kidney failure. Most cases of HUS occur after an infection in the digestive system caused by the Escherichia coli bacterium found on contaminated food like meat, dairy products, and juice. The first stages of HUS frequently present with gastrointestinal symptoms such as abdominal pain, vomiting, and bloody diarrhea. This stage lasts from 1 to 15 days. Recovery from this acute colitic phase is the rule. However, more severe problems in the bowel and colon may develop in some cases. (The most vulnerable and severely stricken of children with HUS can die during the first acute stage of the diseasebetween 5 percent and 10 percent.) For most children with HUS, the vomiting and diarrhea stop after 2 or 3 days. Even when the gastroenteritis has stopped, the child does not recover full health, remaining pale, tired, and irritable. The bacteria originally lodged in the digestive system make toxins that enter the bloodstream, and these toxins destroy red blood cells. Small, unexplained bruises or small clot-sized hemorrhages visible in the mucosal lining of the mouth may occur because the toxins also destroy the platelets, cells that normally contribute to the clotting system. The damaged red blood cells and other factors may clog the tiny blood vessels in the kidneys or cause lesions in the kidneys, making the kidneys work harder to remove wastes and extra fluid from the blood. The child may produce little urine as a result. The body's inability to rid itself of excess fluid and waste may in turn cause hypertension or swelling of the hands and feet or may cause generalized fluid accumulation (edema).

3. Discovery Health Hemolytic Uremic Syndrome hemolytic uremic syndromeBy John Wegmann, MD hemolytic uremic syndrome is a poorly understood condition that affects the blood and kidneys http://health.discovery.com/diseasesandcond/encyclopedia/2701.html

4. Hemolytic Uremic Syndrome (HUS) Disease Fact Sheet Series hemolytic uremic syndrome(HUS) What is hemolytic uremic syndrome? hemolytic uremic syndrome (HUS) is a serious disease that affects the kidneys and blood clotting system. http://www.dhfs.state.wi.us/healthtips/BCD/HUS.htm

Topics A-Z Reference Center Search Disease Fact Sheet Series: Hemolytic Uremic Syndrome(HUS) What is Hemolytic Uremic Syndrome? Hemolytic Uremic Syndrome (HUS) is a serious disease that affects the kidneys and blood clotting system. It is a rare disease but is more common in children, especially those less than five years of age, than in adults. What are the symptoms of Hemolytic Uremic Syndrome? Hemolytic Uremic Syndrome may be mild or severe. In severe cases, kidney function is greatly reduced and dialysis (purification of an individual’s blood with an artificial kidney) may be necessary to temporarily take over the function of the kidneys. Abnormalities of the blood clotting system can create a bleeding tendency, and the blood count may be low (anemia). Transfusions of blood or blood clotting factors (platelets) are often needed in severe cases. Most individuals with HUS recover completely and kidney function returns to normal. However, a prolonged hospital stay is often required. What causes HUS?

5. Notifiable Condition: Hemolytic Uremic Syndrome (HUS) Notifiable Conditions Index page for hemolytic uremic syndrome (HUS) Click here to download a copy. hemolytic uremic syndrome (HUS) New requirements for the reporting of hemolytic uremic syndrome (HUS) were instituted in December of 2000 http://www.doh.wa.gov/notify/nc/hus.htm

You are here: DOH Home Notifiable Conditions » HUS Index Search Employees Site Directory: Notifiable Conditions: HUS Other links concerning Notifiable Conditions Local Health Jurisdictions How to Report a Notifiable Condition Reporting Forms Glossary ... EpiTrends Posters PDF documents require the free Acrobat Reader. Click here to download a copy Hemolytic Uremic Syndrome (HUS) HUS in Washington State New requirements for the reporting of hemolytic uremic syndrome (HUS) were instituted in December of 2000. In the first year of reporting, DOH received 3 case reports. HUS is most commonly a complication of infection with E. coli O157:H7, but can occur following infection with non O157 E. coli Shigella , and other bacterial pathogens. Purpose of Reporting and Surveillance Because HUS is an important sequela of infection with E. coli

6. NORD - National Organization For Rare Disorders, Inc. General Discussion. HemolyticUremic Syndrome (HUS) is a very rare disorder that primarily affects Symptoms of Hemolytic-Uremic Syndrome usually become apparent three to 10 days http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Hemolytic Ure

7. HUS Home Page Atypical HUS, is a rare disease among children causing kidney failure and high blood pressure. Offering support and information including, treatment, symptoms, case studies and research. http://AtypicalHus.50megs.com

Ecommerce Solution Free Web Space Free Web Site Web Hosting ... Dial up $14.95 or NetZero Internet Service $9.95 The Atypical HUS Website HUS Home Page Treatments - Symptoms Case Studies Contact /Register/Links Page ... Other Organizations of Interest Welcome! This site contains information for anyone interested in learning more about the disease called HUS (Hemolytic Uremic Syndrome) We will show the differences between two types of HUS: Typical HUS and Atypical HUS. The information is presented in both common terminology and also in medical terminology This page is dedicated to all of the children who are battling this disease. So little is known about the disease, and we hope to raise awareness and funds in order to find better treatments. Atypical HUS Atypical HUS (Hemolytic Uremic Syndrome) is not caused by an external agent (such as a bacteria, virus etc). Instead, some sort of internal chain of events sets the HUS off, and the syndrome becomes active. The syndrome is not well understood. It may be a genetic weakness due to a missing or deficient protein or enzyme. It may be a variety of other unknown causes. In either case, Atypical HUS patients have many of the the same symptons as Typical HUS Patients. However, there are quite a number of differences. While the Typical form of the disease may start off more severe, the Atypical form is subject to longer lingering effects, and is much more likely to become a chronic problem. Recurrance is much more common with the Atypical form of the disease.

8. Hemolytic Uremic Syndrome hemolytic uremic syndrome (HUS) is characterized by the acute onset of microangiopathic hemolytic anemia, renal......hemolytic uremic syndrome, POST DIARRHEAL. Disease Code 11550. Clinical http://wdhfs.state.wy.us/dx_criteria/hus.htm

HEMOLYTIC UREMIC SYNDROME, POST DIARRHEAL Disease Code: 11550 Clinical Description: Hemolytic uremic syndrome (HUS) is characterized by the acute onset of microangiopathic hemolytic anemia, renal injury, and low platelet count. Thrombotic thrombocytopenic purpura (TTP) is also characterized by these features but also can include central nervous system involvement and fever, and may have a more gradual onset. Most cases of HUS (but few cases of TTP) occur after an acute gastrointestinal illness (usually diarrheal). Only HUS or TTP occurring after an acute diarrheal illness is reportable. Case Classification: Probable: An acute illness diagnosed as HUS or TTP that meets the laboratory criteria, but for which circumstances of onset (within three weeks after onset of acute diarrhea or bloody diarrhea) have not been determined, or an acute illness diagnosed as HUS or TTP, with onset within 3 weeks of onset of an acute or bloody diarrhea, that meets the laboratory criteria except that microangiopathic changes are not confirmed. Confirmed: An acute illness diagnosed as HUS or TTP, that both meets the laboratory criteria and began within 3 weeks of onset of an acute or bloody diarrhea. Comment: Some investigators consider HUS and TTP to be part of a continuum of disease. Therefore, criteria for diagnosing TTP on the basis of central nervous system involvement and fever are not provided because cases diagnosed clinically as postdiarrheal TTP should also meet the criteria for HUS. These cases are reported as postdiarrheal HUS.

9. Hemolytic Uremic Syndrome hemolytic uremic syndrome. 2000 COl VI No. 135; Stewart CL and Tina LU. hemolytic uremic syndrome. Pediatrics in review 1993;14(6)218-224; Moghal NE. http://www.theberries.ns.ca/Archives/HUS.html

Hemolytic Uremic Syndrome Hemolytic uremic syndrome (HUS) is a predominantly pediatric condition that consists of the simultaneous triad of hemolytic anemia, thrombocytopenia and acute renal failure. Although uncommon, occurring in approximately 100 children in Canada per year, it is the most common cause of acute renal failure in children and is fatal in a small percentage o children (less than 5%). The recent E. coli epidemic in Walkerton, Ontario and ongoing concern about coliform contamination of water supplies has resulted in discussion of HUS in the media and has raised awareness of HUS in the general public. Timely diagnosis and optimal management require physicians to be knowledgeable about this syndrome and when to suspect HUS. HUS - Causative Factors HUS is commonly divided into two groups; those occurring after a diarrheal illness and non-diarrheal HUS. Diarrhea associated HUS is the most common, comprising 75% of all the cases. The most common causative agent is Escherichia coli 0157:H7. Most E.coli 0157 infections result in mild diarrhea but hemorrhagic colitis can occur. HUS occurs in about 10% of children with E.coli 0157:H7 hemorrhagic colitis. Diarrhea associated HUS usually occurs in young children (7 months to 6 years), predominantly in summer and early fall. Sources of contamination include undercooked meat, unpasteurized milk or juice or contaminated water. It can be passed from person to person. Other bacterial diarrheal agents that can cause HUS include Shigella and Salmonellas.

10. Hemolytic Uremic Syndrome Factsheet on this complication of some E. coli infections. http://kidney.niddk.nih.gov/kudiseases/pubs/childkidneydiseases/hemolytic_uremic

Email To A Friend Also see: Kidney Disease in Children Series Home Kidney Disease in Children : Hemolytic Uremic Syndrome Hemolytic Uremic Syndrome Hemolytic (HEE-mo-LIT-ik) uremic (yoo-REE-mik) syndrome, or HUS, is one of the most common causes of sudden, short-term kidney failure in children. In severe cases, this acute kidney failure may require several sessions of dialysis to take over the kidneys' job of filtering wastes from the blood, but most children recover without permanent damage to their health. Most cases of HUS occur after an infection of the digestive system by Escherichia coli bacterium, which is found in contaminated foods like meat, dairy products, and juice. Some people have contracted HUS after swimming in pools or lakes contaminated with feces. Washing and cooking foods adequately, avoiding undercooked meats, and avoiding unclean swimming areas are the best ways to protect your children from this disease. The infection of the digestive tract is called gastroenteritis and may cause the child to vomit and have stomach cramps and bloody diarrhea. Most children who experience gastroenteritis recover fully in 2 or 3 days and do not develop HUS. In a few children, however, HUS develops when the bacteria lodged in the digestive system make toxins that enter the bloodstream and start to destroy red blood cells. Symptoms of HUS may not become apparent until a week after the digestive problems. The child remains pale, tired, and irritable. Other symptoms include small, unexplained bruises or bleeding from the nose or mouth that may occur because the toxins also destroy the platelets, cells that normally help clotting.

11. Hemolytic Uremic Syndrome Home Kidney Urologic Diseases AZ List of Topics and Titles hemolytic uremic syndrome. hemolytic uremic syndrome. Hemolytic (HEE http://kidney.niddk.nih.gov/kudiseases/pubs/hemolyticuremic/

Email To A Friend Home : Hemolytic Uremic Syndrome Hemolytic Uremic Syndrome Hemolytic (HEE-mo-LIT-ik) uremic (yoo-REE-mik) syndrome is a rare condition affecting mostly children under the age of 10. Hemolytic uremic syndrome (HUS) is characterized by destruction of red blood cells, damage to the lining of blood vessel walls, and, in severe cases, kidney failure. Most cases of HUS occur after an infection in the digestive system caused by the Escherichia coli bacterium found on contaminated food like meat, dairy products, and juice. The first stages of HUS frequently present with gastrointestinal symptoms such as abdominal pain, vomiting, and bloody diarrhea. This stage lasts from 1 to 15 days. Recovery from this acute colitic phase is the rule. However, more severe problems in the bowel and colon may develop in some cases. (The most vulnerable and severely stricken of children with HUS can die during the first acute stage of the diseasebetween 5 percent and 10 percent.) For most children with HUS, the vomiting and diarrhea stop after 2 or 3 days. Even when the gastroenteritis has stopped, the child does not recover full health, remaining pale, tired, and irritable. The bacteria originally lodged in the digestive system make toxins that enter the bloodstream, and these toxins destroy red blood cells. Small, unexplained bruises or small clot-sized hemorrhages visible in the mucosal lining of the mouth may occur because the toxins also destroy the platelets, cells that normally contribute to the clotting system.

12. Methodist Health Care System hemolytic uremic syndrome, a description, what causes it, possible progression, treatments and statistics for this disease. http://www.methodisthealth.com/urogen/hemolyt.htm

13. Hemolytic Uremic Syndrome Home Kidney Urologic Diseases AZ List of Topics and Titles Kidney Disease in Children hemolytic uremic syndrome. hemolytic uremic syndrome. http://kidney.niddk.nih.gov/kudiseases/pubs/childkidneydiseases/hemolytic_uremic

Email To A Friend Also see: Kidney Disease in Children Series Home Kidney Disease in Children : Hemolytic Uremic Syndrome Hemolytic Uremic Syndrome Hemolytic (HEE-mo-LIT-ik) uremic (yoo-REE-mik) syndrome, or HUS, is one of the most common causes of sudden, short-term kidney failure in children. In severe cases, this acute kidney failure may require several sessions of dialysis to take over the kidneys' job of filtering wastes from the blood, but most children recover without permanent damage to their health. Most cases of HUS occur after an infection of the digestive system by Escherichia coli bacterium, which is found in contaminated foods like meat, dairy products, and juice. Some people have contracted HUS after swimming in pools or lakes contaminated with feces. Washing and cooking foods adequately, avoiding undercooked meats, and avoiding unclean swimming areas are the best ways to protect your children from this disease. The infection of the digestive tract is called gastroenteritis and may cause the child to vomit and have stomach cramps and bloody diarrhea. Most children who experience gastroenteritis recover fully in 2 or 3 days and do not develop HUS. In a few children, however, HUS develops when the bacteria lodged in the digestive system make toxins that enter the bloodstream and start to destroy red blood cells. Symptoms of HUS may not become apparent until a week after the digestive problems. The child remains pale, tired, and irritable. Other symptoms include small, unexplained bruises or bleeding from the nose or mouth that may occur because the toxins also destroy the platelets, cells that normally help clotting.

14. Kidney Foundation Of Canada A description of hemolytic uremic syndrome, where the bacteria comes from, who develops it, the symptoms and how to prevent E.coli 0157H7. http://www.kidney.ca/hus-e.htm

15. EID V1 N4: Hemolytic Uremic Syndrome EID Volume 1 * Number 4 OctoberDecember 1995. Commentary. hemolytic uremic syndrome. Download Article. Along with a report of the first outbreak of hemolytic uremic syndrome (HUS) caused by Shiga-like toxin (SLT) producing E. http://www.cdc.gov/ncidod/EID/vol1no4/cameron.htm

EID Volume 1 * Number 4 October-December 1995 Commentary Hemolytic Uremic Syndrome Download Article Along with a report of the first outbreak of hemolytic uremic syndrome (HUS) caused by Shiga-like toxin (SLT) producing E. coli in Australia , this issue of Emerging Infectious Diseases presents three papers detailing the investigations of pediatric HUS cases linked to Shiga toxin (ST) and SLT producing bacteria. Goldwater and Bettelheim present a case of pediatric HUS associated with SLT producing Escherichia coli (SLTEC) O48:H21 in South Australia; this strain has not previously been recognized as an SLTEC. Saeed et al. report on the increasingly common identification of HUS in Saudi Arabia, its association with multiple-antibiotic-resistant Shigella dysenteriae type 1, and the inherent dangers of treating such patients with ampicillin and nalidixic acid. Al-Qawari et al. report on the results of active surveillance for dysentery and HUS in Saudi Arabia and discuss a possibly elevated risk for HUS in patients with bloody diarrhea who are hospitalized and treated with nalidixic acid during an outbreak of S. dysenteriae type

16. WebMD Health - 404 Error Information about hemolytic uremic syndrome including a definition, causes, incidence, risk factors, symptoms, signs, tests, treatment, prognosis, possible complications and when to call the doctor. http://my.webmd.com/content/healthwise/92/22841.htm

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17. Hemolytic Uremic Syndrome - Health And Medical Information: Diseases And Conditi MedicineNet Home Diseases Conditions AZ List hemolytic uremic syndrome. Advanced Search. hemolytic uremic syndrome. What is hemolytic uremic syndrome? http://www.medicinenet.com/hemolytic_uremic_syndrome/article.htm

MedicineNet Home > Hemolytic Uremic Syndrome Advanced Search Printer-Friendly Format Add to Favorites Email to a Friend ... Next page Hemolytic Uremic Syndrome What is hemolytic uremic syndrome? Hemolytic uremic syndrome (HUS) is a condition in which there is clumping of platelets within the kidney's small blood vessels resulting in educed blood flow to the kidney leading to kidney failure. The partial blockage of the blood vessels also leads to destruction of red cells (hemolysis) - the effects on red cells are similar to throwing a tomato through chicken wire. Platelets are also decreased which contributes to bleeding problems. What are the causes of hemolytic uremic syndrome? There are many causes for this syndrome and E. coli bacteria (particularly serotype E. coli 0157:H7) is one of them. Others include shigella bacteria, drugs, tumors, pregnancy, and systemic lupus erythematosus. HUS associated with E. coli bacteria has been in the news due to several deaths associated with undercooked beef and tainted unpasteurized apple juice. These cases typically begin with severe abdominal cramps and diarrhea which may become bloody by the second or third day. Nausea and vomiting is present in approximately half of the patients. Most patients recover in 7-10 days, but some (6%) go on to have HUS. This is most likely to happen in children and the elderly. Some patients develop neurological problems such as seizures. Many patients require

18. What Is HUS? HAMBURGER DISEASE ( Escherichia coli O157H7) hemolytic uremic syndrome( HUS) vvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvv. What is HUS? hemolytic uremic syndrome (HUS) is a disease that affects the kidneys http://www.cheori.org/cpkdrc/what_is_hus.htm

HAMBURGER DISEASE Escherichia coli H EMOLYTIC U REMIC S YNDROME (HUS) vvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvv What is HUS? Hemolytic Uremic Syndrome (HUS) is a disease that affects the kidneys and other organs. It poses a substantial threat to children as one of the leading causes of sudden acute kidney failure. HUS is most common in the warmer months of the year and follows a gastrointestinal illness caused primarily by a particular strain of bacteria known as Escherichia coli O157:H7. This gastrotintestinal illness has been nicknamed A Hamburger Disease . While other types of E. coli are common in the gastrotintestinal tract of healthy humans, this particular strain (O157:H7) is not usually present. These E. coli O157:H7 bacteria produce extremely potent toxins which are the main cause of the symptoms related to the gastrointestinal illness. The most common symptoms of E. coli O157:H7 gastroenteritis (Hamburger Disease) include: DIARRHEA (often with blood in the stools) ABDOMINAL CRAMPS VOMITING Some individuals may develop fever with this infection. People of all ages can get E. coli

19. KFOC - Hemolytic Uremic Syndrome hemolytic uremic syndrome What is hemolytic uremic syndrome? Hemolytic Uremic Who develops hemolytic uremic syndrome? Approximately one http://www.kidney.ca/english/publications/factsheets/hemolytic.htm

Profile Programs Volunteering Offices ... Main Page Hemolytic Uremic Syndrome What is hemolytic uremic syndrome? Hemolytic Uremic Syndrome (HUS), commonly referred to as "Hamburger Disease", is a disease that affects the kidneys and other organs. It poses a substantial threat to Canadian children as one of the leading causes of both acute and chronic kidney failure. HUS is more commonly seen in the warmer months of the year, following a gastrointestinal illness caused primarily by a particular strain of bacteria known as E.coli 0157:H7. While other types of E.coli are commonly found in the gastrointestinal tract of healthy humans, this particular strain (0157:H7) is not usually present except in diarrheal illnesses. This bacteria (E.coli 0157:H7) is known to produce toxins, which are the main cause of the symptoms related to the gastrointestinal illness. The most common symptoms of E.coli 0157:H7 Gastroenteritis are the following: diarrhea bloody diarrhea vomiting abdominal cramps fever People of all age groups are at risk for E.coli 0157:H7 gastroenteritis; however, young children and the elderly are at greater risk for more severe symptoms. This infection is highly contagious. Thousands of Canadians are identified with this infection each year and many epidemics have been reported in Canada (the most recent being Walkerton), the United States, and Europe.

20. Hemolytic-Uremic Syndrome HemolyticUremic Syndrome hemolytic uremic syndrome. Book, Home Page. http://www.fpnotebook.com/HEM61.htm

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