61. Hemolytic Anemia hemolytic anemia is a disorder in which the red blood cells are destroyed too soon. What causes hemolytic anemia? What are the symptoms of hemolytic anemia? http://www.dental.am/eng/anemia/2.html

Russian version Health News Online Pharmacy Family Health AIDS/HIV Allergies Alternative Medicine Anemia ... Weight Loss Health Tools Body Mass Index calculator Ideal Body Weight for Men Ideal Body Weight for Women Calories for Men ... Birth Gender Chart Health newsletter Get a Web Site Medical links RSS/XML News Feed Feedback What is hemolytic anemia? The Basics Anemia Symptoms of Anemia Hemolytic Anemia Iron-Deficiency Anemia ... Sickle Cell Anemia Hemolytic anemia is a disorder in which the red blood cells are destroyed too soon. What causes hemolytic anemia? certain medications infections congenital abnormalities autoimmune disorder What are the symptoms of hemolytic anemia? The following are the most common symptoms for hemolytic anemia, however, each individual may experience symptoms differently. fatigue paleness increased heart rate breathlessness yellowish skin (jaundice) dark, tea-colored urine enlarged spleen The symptoms of hemolytic anemia may resemble other blood disorders or medical problems. Consult your physician for a diagnosis. How is hemolytic anemia diagnosed?

62. VetNet - Resistant Idiopathic Thrombocytopenia And Autoimmune Hemolytic Anemia I Resistant Idiopathic Thrombocytopenia and Autoimmune hemolytic anemia in dogs. Joanne Dickson s notes on AIHA have been reproduced below with her permission. http://www.vetnet.co.uk/aiha/aiha_dog2.html

Resistant Idiopathic Thrombocytopenia and Autoimmune Hemolytic Anemia in dogs. Joanne Dickson's notes on AIHA have been reproduced below with her permission. These are dedicated to her dog Meisha. Lets define the terms of the disease one at a time. "Autoimmune" literally means the immunity against the self. "Hemolytic" is the destruction of red blood cells. "Anemia" is a clinical sign, not a disease. Anemia is defined as a decrease in the number of red blood cells (RBC's) or the amount of hemoglobin, resulting in a decrease in the oxygen- carrying capacity of the blood. The symptoms or clinical signs of AIHA can appear suddenly or they may be gradual and progressive. The signs are usually related to the lack of oxygen and manifest themselves in the form of weakness, lethargy, and an increase in the heart and respiration rate. Pale mucous membranes (gums, ears, eyelids) may be observed. The dog also may appear to be jaundice. This is due to a build up of bilirubin, one of the breakdown products of hemoglobin. Vomiting or abdominal pain may be present. Owners may note the presence of blood in the urine or stool. An increase in temperature may also be observed in some dogs. A diagnosis of AIHA is made on the basis of these clinical signs as well as a CBC. A Coomb’s test should be performed to confirm the diagnosis. A small percentage of dogs that have AIHA will test negative on the Coomb’s test. Most of the time, a specific cause for AIHA is unrecognized. Many theories exist, but the ultimate answer is "We don’t know." Dr. Jean Dodds, a veterinarian studying immunology, states in her

63. Warm Antibody Hemolytic Anemia,Autoimmune Hemolytic Anemia Warm Reacting Antibod Warm Antibody hemolytic anemia,Autoimmune hemolytic anemia Warm Reacting Antibody Disease. html). hemolytic anemia Definition. Red http://www.icomm.ca/geneinfo/waha.htm

Warm Antibody Hemolytic Anemia,Autoimmune Hemolytic Anemia Warm Reacting Antibody Disease For Information on Workshops and Seminars for Special Needs Children click here The GAPS INDEX to Information on the Internet about Genetic Disorders and Birth Defects Genetic Information and Patient Services, Inc. (GAPS) HOME DISORDERS GLOSSARY Warm Antibody Hemolytic Anemia also known as: Autoimmune Hemolytic Anemia Warm Reacting Antibody Disease (as defined by the National Organization for Rare Disorders Warm Antibody Hemolytic Anemia is an autoimmune disorder characterized by the premature destruction of red blood cells by the body's natural defenses against invading organisms (antibodies). Normally, the red blood cells have a life span of approximately 120 days before they are removed by the spleen. In an individual affected with Warm Antibody Hemolytic Anemia, the red blood cells are destroyed prematurely and bone marrow production of new cells can no longer compensate for their loss. The severity of the anemia is determined by the time the red blood cells are allowed to survive and by the capacity of the bone marrow to continue new red blood cell production.

64. Hereditary Spherocytic Hemolytic Anemia,Acholuric Jaundice,Chronic Acholuric Jau Hereditary Spherocytic hemolytic anemia,Acholuric Jaundice,Chronic Acholuric Jaundice,Congenital hemolytic anemia,Congenital Hemolytic Jaundice,Congenital http://www.icomm.ca/geneinfo/hsha.htm

For Information on Workshops and Seminars for Special Needs Children click here The GAPS INDEX to Information on the Internet about Genetic Disorders and Birth Defects Genetic Information and Patient Services, Inc. (GAPS) HOME DISORDERS GLOSSARY Hereditary Spherocytic Hemolytic Anemia (as defined by the National Organization for Rare Disorders also known as: Acholuric Jaundice Chronic Acholuric Jaundice Congenital Hemolytic Anemia Congenital Hemolytic Jaundice Congenital Spherocytic Anemia Hereditary Spherocytosis HS Icterus (Chronic Familial) Minkowski-Chauffard Syndrome Spherocytic Anemia Spherocytosis Hereditary Spherocytic Hemolytic Anemia is a rare blood disorder characterized by defects within red blood cells (intracorpuscular) that result in a shortened survival time for these cells. Red blood cells (erythrocytes) normally circulate for a few months and when they die off are replaced by new erythrocytes. However, in Hereditary Spherocytic Hemolytic Anemia, the cells die prematurely. They also have low amounts of fats (lipid) in the cell membranes and an abnormally small amount of surface area.

65. Ask NOAH About: Anemia KidsHealth Anemia KidsHealth Aplastic Anemia - Lucile Packard Children s Hospital hemolytic anemia - Lucile Packard Children s Hospital Iron Deficiency http://www.noah-health.org/english/illness/blood/anemia.html

Ask NOAH About: Anemia What is Anemia? Care and Treatment Information Resources Basic Descriptions Anemia in Children ... Organizations What Is Anemia? Basic Descriptions About Anemia - KidsHealth All About Anemia - Anemia Life Line Anaemia Due to Red Cell Loss - BUPA Anemia - KidsHealth ... Anemia - Methodist Healthcare System, Houston TX (also in Spanish Anemia: When Low Iron is the Cause - American Academy of Family Physicians (also in Spanish Anemia, General - Mayo Clinic Anemia in Young Women - InteliHealth Anemias - ... Women's Health: Anemia - American Institute of Preventive Medicine Blood Basics Blood - TeensHealth Facts About Blood - Methodist Healthcare System, Houston TX Introduction to Hematology - Puget Sound Blood Center Red Blood Cells - Puget Sound Blood Center ... Anemia in Pregnancy Anemia in Children About Anemia - KidsHealth Anemia - KidsHealth Aplastic Anemia - Lucile Packard Children's Hospital Hemolytic Anemia - Lucile Packard Children's Hospital ... Thalassemia Anemia in Teens Iron and Teens: A Guide to Anemia Prevention - Children's Hospital, Boston MA

66. Adult Health Advisor 2003.2: Anemia grow. hemolytic anemia This Jaundice (yellow skin and eyes) may be a symptom of hemolytic anemia. How is it diagnosed? Your health http://www.med.umich.edu/1libr/aha/aha_anemia_crs.htm

Adult Health Topics All Health Topics Find a UMHS Doctor T his information is not a tool for self-diagnosis or a substitute for medical treatment. You should speak to your physician or make an appointment to be seen if you have questions or concerns about this information or your medical condition. Search Adult Topics Search All Topics T his information is not a tool for self-diagnosis or a substitute for medical treatment. You should speak to your physician or make an appointment to be seen if you have questions or concerns about this information or your medical condition. Index Anemia What is anemia? Anemia is a blood disorder that is defined as: a level of red blood cells (RBCs) that is below normal, or a level of hemoglobin that is below normal (hemoglobin is the oxygen-carrying protein in red blood cells). There are several forms of anemia, such as: iron deficiency anemia hemolytic anemia (destruction of RBCs) vitamin B-12 deficiency anemia folic acid deficiency anemia anemias caused by inherited abnormalities of RBCs (for example, sickle cell anemia and thalassemia)

67. Diagnosis Of Immune-mediated Hemolytic Anemia Diagnosis of Immunemediated hemolytic anemia. 3,4 Primary IMHA is synonymous with idiopathic and autoimmune-mediated hemolytic anemia (AIHA). http://www.vet.uga.edu/vpp/clerk/hiers/

Diagnosis of Immune-mediated Hemolytic Anemia Kristin M. Hiers, DVM; Kenneth Latimer, DVM, PhD; Perry J. Bain, DVM, PhD; Paula M. Krimer, DVM, DVSc Class of 2003 (Hiers) and Department of Pathology (Latimer, Bain, Krimer), College of Veterinary Medicine, The University of Georgia, Athens, GA 30602-7388 Introduction Immune-mediated hemolytic anemia (IMHA) is an accelerated destruction of red blood cells due to the attachment of immunoglobulin and/or complement to the erythrocyte membrane. It is a common cause of severe anemia and hemolysis in dogs with a mortality rate of over 40%. IMHA can be classified as primary or secondary depending on the cause of the red cell destruction. Secondary IMHA involves hemolysis due to an immunologic reaction to a "non-self" antigen. Possible causes include infection, chemical agents, drugs, or neoplastic disease. Primary IMHA is synonymous with idiopathic and autoimmune-mediated hemolytic anemia (AIHA). There is a true autoantibody specific for the self-antigen of the red cell membrane. Normally the immune system recognizes self-antigen and does not respond to it. This is the principle of self-tolerance. It is thought that when something triggers a change in immunoregulation, such as infection, there may be a loss of self-tolerance and subsequent autoimmune disease. There is a genetic predisposition for the development of AIHA

68. Hemolytic Anemia ImmuneMediated hemolytic anemia (IMHA) is a serious and often life threatening disorder in dogs and cats. What is Immune-Mediated hemolytic anemia? http://www.gcvs.com/internists/imha.htm

Search for: Search Tips Directions What is Immune-Mediated Hemolytic Anemia? Immune-Mediated Hemolytic Anemia (IMHA) is a serious and often life threatening disorder in dogs and cats. IMHA results from an inappropriate immune response to the animals own red blood cells. IMHA can be classified as primary or secondary. With primary IMHA, the immune system malfunctions and begins to treat the red blood cells as if they were foreign invaders and begins to produce antibodies against the red blood cells. This response is similar to what would occur against bacteria. No underlying cause for this inappropriate reaction can be identified. With secondary IMHA, an underlying disease condition such as infection, parasites, cancer or a reaction to a drug or vaccine causes a change in the red blood cells, which in turn stimulates the immune system to attack the cells. Autoagglutination is often associated with clotting disorders including pulmonary thromboembolism (PTE), which are blood clots in the lungs. Intravascular hemolysis tends to be more severe and carries a worse prognosis than extravascular hemolysis.

69. Hemolytic Anemia hemolytic anemia. What is hemolytic anemia? What are the symptoms of hemolytic anemia? The following are the most common symptoms of hemolytic anemia. http://www.healthsystem.virginia.edu/uvahealth/peds_hematology/hemoanem.cfm

@import url(/assets/UVAHealth/ssi/css/greystone_advance.css); Adolescent Medicine Allergy/Asthma/Immunology Blood Disorders Burns Cancer Common Injuries/Poison Tips Craniofacial Anomalies Dermatology Diabetes/Endo/Metabolism Eye Care Genitourinary/Kidney High-Risk Newborn High-Risk Pregnancy Infectious Diseases Medical Genetics Mental Health Nervous System Disorders Normal Newborns Oral Health Orthopaedics Pediatric Surgery Respiratory Disorders Terminal Illness in Children Transplantation FIND A DOCTOR MAKE AN APPOINTMENT CALENDAR OF EVENTS CLINICAL TRIALS Hemolytic Anemia What is hemolytic anemia? Hemolytic anemia is a disorder in which the red blood cells are destroyed faster than the bone marrow can produce them. The term for destruction of red blood cells is "hemolysis." There are two types of hemolytic anemia: intrinsic - the destruction of the red blood cells due to a defect within the red blood cells themselves. Intrinsic hemolytic anemias are often inherited, such as sickle cell anemia and thalassemia. These conditions produce red blood cells that do not live as long as normal red blood cells. extrinsic - red blood cells are produced healthy but are later destroyed by getting trapped in the spleen, destroyed by infection, or destroyed from drugs that can affect red blood cells. The following lists some of the causes of extrinsic hemolytic anemia, also called autoimmune hemolytic anemia:

70. Hematology And Blood Disorders - Hemolytic Anemia hemolytic anemia What is hemolytic anemia? The term for excessive destruction of red blood cells is “hemolysis.” There are two types of hemolytic anemia http://www.chkd.org/Hematology/hemoanem.asp

More Health Information Adolescent Medicine Allergy/Immunology Anesthesiology Arthritis Burns Cardiology Craniofacial Dental Medicine Dermatology Developmental Peds Diabetes Digestive Ear, Nose, Throat Genetics Gastroenterology Growth Hematology High Risk Newborn High Risk Pregnancy Infectious Disease Mental Health Neonatology Nephrology Neurology Normal Newborn Normal Pregnancy Oncology Ophthalmology Orthopedics Otolaryngology Pediatric Intensive Care Pediatric Surgery Pediatrics Physical Medicine Plastic Surgery Respiratory/Pulmonology Rheumatology Safety Surgery Terminal Transplant Urology Site Search For a doctor who specializes in this topic, click here. Hemolytic Anemia What is hemolytic anemia? Hemolytic anemia is a disorder in which the red blood cells are destroyed faster than the bone marrow can produce them. The term for excessive destruction of red blood cells is “hemolysis.” There are two types of hemolytic anemia: intrinsic - the destruction of the red blood cells due to a defect within the red blood cells themselves. Intrinsic hemolytic anemias are often inherited, such as sickle cell anemia and thalassemia. These conditions produce red blood cells that do not live as long as normal red blood cells. extrinsic - red blood cells are produced healthy but are later destroyed by getting trapped in the spleen, destroyed by infection, or destroyed from drugs that can affect red blood cells. Often, antibodies are produced that attack the red blood cells. This is called autoimmune hemolytic anemia. Some of the disorders that cause autoimmune hemolytic anemia include:

71. Hemolytic Anemia- Medcohealth.com hemolytic anemia is a condition of an inadequate number of circulating red blood cells (anemia), caused by premature destruction of red blood cells. http://www.medcohealth.com/medco/consumer/ehealth/ehsarticle.jsp?ltSess=y&articl

72. BioMed Central | Full Text | Autoimmune Hemolytic Anemia Occurred Prior To Evide Autoimmune hemolytic anemia occurred prior to evident nephropathy in a patient with chronic hepatitis C virus infection case report Isao Ohsawa 1 , Yuki http://www.biomedcentral.com/1471-2369/4/7

home journals A-Z journals by subject advanced search ... Volume 4 Viewing options Abstract Full text PDF Pre-publication history Other links: E-mail to a friend Download references Post a comment PubMed record ... Related articles in PubMed Search PubMed For Ohsawa I Uehara Y Hashimoto S Endo M ... Ohi H Key E-mail Corresponding author Case report Autoimmune hemolytic anemia occurred prior to evident nephropathy in a patient with chronic hepatitis C virus infection: case report Isao Ohsawa Yuki Uehara Sumiko Hashimoto Morito Endo Takayuki Fujita and Hiroyuki Ohi Internal medicine II Nihon University School of Medicine, Tokyo, Japan Department of laboratory medicine, Nihon University School of Medicine, Tokyo, Japan Clinical laboratory, Nihon University Itabashi hospital, Tokyo, Japan BMC Nephrology The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2369/4/7 Received Accepted Published Outline Abstract Abstract Background Case presentation Conclusions ... Pre-publication history Background Renal involvement in patients with chronic hepatitis C virus infection has been suggested to be due to a variety of immunological processes. However, the precise mechanism by which the kidneys are damaged in these patients is still unclear.

73. Entrez PubMed Click here to read Autoimmune hemolytic anemia occurred prior to evident nephropathy in a patient with chronic hepatitis C virus infection case report. http://www.biomedcentral.com/pubmed/12946280

Entrez PubMed Nucleotide Protein ... Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes 3D Domains Domains Gene GEO GEO DataSets HomoloGene Journals MeSH NCBI Web Site OMIM PMC PopSet SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: Sort Author Journal Pub Date Text File Clipboard E-mail Order BMC Nephrol. 2003 Aug 29;4(1):7. Related Articles, Links Autoimmune hemolytic anemia occurred prior to evident nephropathy in a patient with chronic hepatitis C virus infection: case report. Ohsawa I, Uehara Y, Hashimoto S, Endo M, Fujita T, Ohi H.

74. Hemolytic Anemia & Vaccines hemolytic anemia vaccines. Drugs hemolytic anemia citations. Duval D, Giger U.Vaccineassociated immune-mediated hemolytic anemia in the dog. http://www.whale.to/vaccines/hemolytic.html

Hemolytic anemia Drugs "Acute Autoimmune Hemolytic Anemia Following DTP Vaccination: Report of a Fatal Case and Review of the Literature" Downes KA, Domen RE, McCarron KF, Bringelsen KA. Acute autoimmune hemolytic anemia following DTP vaccination: report of a fatal case and review of the literature. Clin Pediatr (Phila). 2001 Jun;40(6):355-8. Review. No abstract available.PMID: 11824181 [PubMed - indexed for MEDLINE] Duval D, Giger U. Vaccine-associated immune-mediated hemolytic anemia in the dog. J Vet Intern Med. 1996 Sep-Oct;10(5):290-5. PMID: 8884713 [PubMed - indexed for MEDLINE] This study provides the first clinical evidence for a temporal relationship of vaccine-associated IMHA in the dog. Haneberg B , et al. Acute hemolytic anemia related to diphtheria-pertussis-tetanus vaccination. Acta Paediatr Scand. 1978 May;67(3):345-50. PMID: 654911; UI: 78183820.

75. Drugs & Hemolytic Anemia Drugs hemolytic anemia. Girard D, Damon H, Diday M, Vallas M, Meyer F, Savoye B. Acute immunoallergic hemolytic anemia induced by sulindacRev Med Interne. http://www.whale.to/a/hemolytic.html

Girard D, Damon H, Diday M, Vallas M, Meyer F, Savoye B. [Acute immunoallergic hemolytic anemia induced by sulindac] Rev Med Interne. 1994 Mar;15(3):217-8. French. No abstract available. PMID: 8059138 [PubMed - indexed for MEDLINE] Hirosawa S, Murakami N, Kudo H, Momoi H, Kamiyama R. [Case of autoimmune hemolytic anemia with subsequent development of lymphoma 7 years later] Nippon Naika Gakkai Zasshi. 1983 Sep;72(9):1171-6. Japanese. No abstract available. PMID: 6663187 [PubMed - indexed for MEDLINE] Hansen PB. [Fatal autoimmune hemolytic anemia probably induced by treatment with piroxicam] Ugeskr Laeger. 1988 Mar 7;150(10):607-8. Danish. No abstract available. PMID: 3354087 [PubMed - indexed for MEDLINE] Haneberg B, Matre R, Winsnes R, Dalen A, Vogt H, Finne PH. Acute hemolytic anemia related to diphtheria-pertussis-tetanus vaccination. Acta Paediatr Scand. 1978 May;67(3):345-50.PMID: 654911 [PubMed - indexed for MEDLINE] Inzoli MR, Almici C. [Autoimmune hemolytic anemia during therapy with alpha-methyldopa] Haematologica. 1973;58(3):169-71. Italian. No abstract available. PMID: 4198238 [PubMed - indexed for MEDLINE]

76. Immunne Mediated Hemolytic Anemia And Limping In A Dog Is... - Q&A immunne mediated hemolytic anemia and limping in a dog is immunne mediated hemolytic anemia and limping in a dog is there a connection. http://www.faqs.org/qa/qa-5453.html

immunne mediated hemolytic anemia and limping in a dog is... Internet RFC Index Usenet FAQ Index Other FAQs Documents Search Search FAQs Home Answered Questions Question by lana Submitted on 10/8/2003 Related FAQ: rec.pets.dogs: Canine Medical Information [Part 1/2] FAQ Rating: Not yet rated Rate this question: N/A Worst Weak OK Good Great immunne mediated hemolytic anemia and limping in a dog is there a connection Your answer will be published for anyone to see and rate. Your answer will not be displayed immediately. If you'd like to get expert points and benefit from positive ratings, please create a new account or login into an existing account below. Your name or nickname: If you'd like to create a new account or access your existing account, put in your password here: Your answer: Check spelling FAQS.ORG reserves the right to edit your answer as to improve its clarity. By submitting your answer you authorize FAQS.ORG to publish your answer on the WWW without any restrictions. You agree to hold harmless and indemnify FAQS.ORG against any claims, costs, or damages resulting from publishing your answer. FAQS.ORG makes no guarantees as to the accuracy of the posts. Each post is the personal opinion of the poster. These posts are not intended to substitute for medical, tax, legal, investment, accounting, or other professional advice. FAQS.ORG does not endorse any opinion or any product or service mentioned mentioned in these posts.

77. Looking For Info On Hemolytic Anemia In Jrt's Sadie Died @... - Q&A looking for info on hemolytic anemia in jrt s sadie died @ looking for info on hemolytic anemia in jrt s sadie died @ 2yrs of age. http://www.faqs.org/qa/qa-3824.html

looking for info on hemolytic anemia in jrt's sadie died @... Internet RFC Index Usenet FAQ Index Other FAQs Documents Search Search FAQs Home Answered Questions Question by suzette Submitted on 9/12/2003 Related FAQ: rec.pets.dogs: Jack Russell Terriers Breed-FAQ Rating: Not yet rated Rate this question: N/A Worst Weak OK Good Great looking for info on hemolytic anemia in jrt's sadie died @ 2yrs of age. Your answer will be published for anyone to see and rate. Your answer will not be displayed immediately. If you'd like to get expert points and benefit from positive ratings, please create a new account or login into an existing account below. Your name or nickname: If you'd like to create a new account or access your existing account, put in your password here: Your answer: Check spelling FAQS.ORG reserves the right to edit your answer as to improve its clarity. By submitting your answer you authorize FAQS.ORG to publish your answer on the WWW without any restrictions. You agree to hold harmless and indemnify FAQS.ORG against any claims, costs, or damages resulting from publishing your answer. FAQS.ORG makes no guarantees as to the accuracy of the posts. Each post is the personal opinion of the poster. These posts are not intended to substitute for medical, tax, legal, investment, accounting, or other professional advice. FAQS.ORG does not endorse any opinion or any product or service mentioned mentioned in these posts.

78. The Turkish Journal Of Pediatrics Successful management of severe chronic autoimmune hemolytic anemia with low dose cyclosporine and prednisone in an infant. Neþe http://tjp.dergisi.org/text.php3?id=101

79. Medical Encyclopedia BACK, Back to main Health Information page Disease hemolytic anemia. There are a number of specific types of hemolytic anemia which are described individually. http://www.medstarhealth.org/body.cfm?id=124&action=display&articlenum=571

80. Research In Canine Immune-mediated Hemolytic Anemia RESEARCH IN CANINE IMMUNEMEDIATED hemolytic anemia. *J Hemostatic abnormalities in dogs with immune-mediated hemolytic anemia. J http://www.vet.purdue.edu/depts/vcs/research/scottmondogimmune.html

RESEARCH IN CANINE IMMUNE-MEDIATED HEMOLYTIC ANEMIA *J. Catharine Scott-Moncrieff, MA, VetMB, MS, MRCVS, DACVIM, DECVIM, DSAM (765) 494-1107 *contact person M. Brooks, DVM, PhD A collaboration with The Comparative Coagulation Section, College of Veterinary Medicine, Cornell University. Development of a therapeutic strategy for prevention of thromboembolism in canine immune-mediated hemolytic anemia (IMHA). A previous study at Purdue University documented a 30% mortality rate for canine IMHA, with thromboembolic events the most common cause of death documented at necropsy. Fifty percent of the dogs in this study had low plasma antithrombin (AT) activity. The most likely cause of low AT in dogs with IMHA is accelerated consumption due to disseminated intravascular coagulation (DIC), and DIC was either confirmed or suspected in 75% of the study dogs. A new ongoing study will determine whether replacement of AT and other anti- and pro-coagulant factors found in plasma can decrease the incidence of thromboembolism and improve survival in dogs with IMHA. Relevant publications: Scott-Moncrieff JC, Treadwell NG, Brooks M, McCullough SM. Hemostatic abnormalities in dogs with immune-mediated hemolytic anemia.

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