81. Vascular Headache Of Migraine Type hemiplegic migraine. Definition Vascular headache featured by motor phenomena which persists during and after the headache. This http://medlib.med.utah.edu/pain_center/education/outlines/headache/vascular.html

Vascular Headache of Migraine Type Headache Classification Quickmenu Vascular Muscle-contraction Combined Nasal vasomotor reaction Delusional, hypochondriacal Nonmigrainous vascular Traction Cranial inflammation Migraine with aura (Classic migraine) Migraine without aura (Common) migraine "Cluster" headache "Hemiplegic" and "ophthalmoplegic" migraine ... "Lower half" headache Migraine with aura (Classic migraine) Definition Recurrent attacks of headache, widely varied in intensity, frequency and duration. Attacks are commonly unilateral in onset, associated with anorexia, and, sometimes, nausea and vomiting. Headaches are preceded by sharply defined transient visual and other sensory or motor prodromes or both. Cause Etiology unknown. Appears to be related to disordered brain physiology. Up to 70% of patients have a positive family history for headache. Frequently, the headache is an abnormal response to stress. The aura may be secondary to cerebral vasospasm; the head pain may be a result of activation of the trigeminovascular system. Age of onset usually starts during childhood or teenage years, up to 40 years of age.

82. Migraine:c hemiplegic migraine occurs both sporadically and as a familial syndrome. This entity is defined as vascular headache featured http://www.wfubmc.edu/neurology/migraine/migc.html

MIGRAINE WITH PROLONGED AURA AND MIGRAINOUS INFARCTIONS In the new classification of migraine, Subtype 1.6 indicates complications of migraine. This would include all of the permanent defects discussed in this section. Focal symptoms and signs of the aura may persist beyond a headache phase. In the previous classification, this was termed complicated migraine. It is now defined by the IHS classification with two labels with increased specificity. If the aura lasts for longer than one hour but less than one week, the term migraine with prolonged aura is applied. If the signs persist for more than one week or a neuroimaging procedure demonstrates a stroke, a migrainous infarction has occurred. As pointed out previously, mid or later life the aura may not be followed by headache and has been termed or . Migraine with aura (classic) in early reports was sometimes referred to as "ophthalmic migraine" (to be differentiated from ophthalmoplegic migraine, a subtype of migraine with aura). Migraine with aura is further reviewed under the headings: Cerebral, Ophthalmoplegic, Retinal, Basilar, and Other Varieties. Cerebral A variety of cerebral symptoms may occur in migraine with aura, including motor, visual, and other sensory defects. As pointed out previously, if the aura lasts for more than one hour , but less than one week, the term migraine with prolonged aura is applied. However, if the signs persist for more than one week, or a neuroimaging procedure shows a stroke the term used is

83. Neuroscience: Hemipeligic Migraines? For starters it is hemiplegic migraine infodmtri007 200404-21 2302 (link). Re For starters it is hemiplegic migraine infoanan_ab 2004-04-21 2329 (link). http://www.livejournal.com/community/neuroscience/38596.html

Matt ( ) wrote in neuroscience Current mood: curious Hemipeligic Migraines? A friend of the family who happens to be a neurologist(but has not seen any of her results) suggested it may have been a hemipeligic migraine. Does anyone have any ideas? Does anyone know much about hemipeligic migraines? How long with these functional-impairments last? Is there anything that one could do to help someone with a hemipeligic migraine? Thank you. Post a new comment For starters it is Hemiplegic Migraine link Well for a short answer of symptoms Someone in her family should have it, if it really is Hemiplegic Migraines. From the way you describe it, the severity would dictate that she probablly should have stayed for a wee bit longer under observation. But then again that could be a matter of how you reacted to it and how you were worried about her. Peace Reply to this Thread Re: For starters it is Hemiplegic Migraine link There isn't anyone in her family that I know of that suffers from migraines of any form... and she says this is the first time she's ever had a migraine. It does seem to fit all the other criteria and I'm extrapolating that there is a non-familial form based on the semantics of that website. And they did want to keep her for observation longer, but she refused and wanted to get out of their as soon as possible. She had hoped to get back to school and back in class, but soon realized she still couldn't read or think normally.

84. BioSpace News: Migraine (Story from Reuters expired) (9/3/02) (See Story from BBC News) (9/3/02); hemiplegic migraine More Common In Denmark Than Previously Thought NEW YORK (Reuters http://www.biospace.com/news_rxtarget.cfm?RXTargetID=149&SR=121

85. The Human Brain Conference 2002 - Free Oral Communications And Posters, Abstract A UNIQUE CACNA1A MISSENSE MUTATION CAUSES PHENOTYPES OF SPINOCEREBELLAR ATAXIA TYPE 6 (SCA6) AND FAMILIAL hemiplegic migraine (FHM) IN PATIENTS FROM A LARGE http://www.thehumanbrain.org/p_alonso.htm

The Human Brain: The Structural Basis for Understanding Human Brain Function and Dysfunction +++ INTERNATIONAL CONFERENCE +++ ROME +++ IRCCS SANTA LUCIA +++ Oct. 5-10, 2002 +++ Home Greetings Overview (Calendar) Objectives ... Speakers Program Lectures Posters Workshops Educational Material ... Picture Gallery Isabel Alonso Rua do Campo Alegre, 823 - Porto - Portugal e-mail: ialonso@ibmc.up.pt Poster Presentation: A UNIQUE CACNA1A MISSENSE MUTATION CAUSES PHENOTYPES OF SPINOCEREBELLAR ATAXIA TYPE 6 (SCA6) AND FAMILIAL HEMIPLEGIC MIGRAINE (FHM) IN PATIENTS FROM A LARGE FAMILY. Alonso I.1,2, Tuna A.3, Coelho J.1, Barros J.3, Sequeiros J.1,2, Silveira I.1,2 Coutinho P.4 Porto - Portugal

86. : The AMEDEO Literature Guide of 5 Families With Familial hemiplegic migraine....... C, Lennox GG et al Expanding the Phenotypic Spectrum of the CACNA1A Gene T666M Mutation A http://www.amedeo.com/medicine/mig/archneu.htm

Home HIV Medicine FAQ Unsubscribe ... GoldenLinks4Doctors.com The Best Medical Websites Migraine Free Subscription Articles published in Arch Neurol Retrieve available abstracts of 12 articles: HTML format Single Articles April 2004 BARBANTI P , Fabbrini G Migraine and Tourette syndrome. Arch Neurol 2004;61:606-7. PubMed Related articles SILBERSTEIN SD , Neto W, Schmitt J, Jacobs D, et al Topiramate in migraine prevention: results of a large controlled trial. Arch Neurol 2004;61:490-5. PubMed Related articles Abstract available November 2003 KWAK C, Vuong KD, Jankovic J Migraine headache in patients with Tourette syndrome. Arch Neurol 2003; 60: 1595-8. PubMed Related articles Abstract available May 2003 KORS EE, Haan J, Giffin NJ, Pazdera L, Schnittger C, Lennox GG et al Expanding the Phenotypic Spectrum of the CACNA1A Gene T666M Mutation: A Description of 5 Families With Familial Hemiplegic Migraine. Arch Neurol 2003; 60: 684-8. PubMed Related articles Abstract available KOEPPEN AH Familial hemiplegic migraine. Arch Neurol 2003; 60: 663-4. PubMed Related articles LESNIK OBERSTEIN SA, van den Boom R, Middelkoop HA, Ferrari MD, Knaap YM, van Houwelingen HC et al

87. : The AMEDEO Literature Guide February 2004 MOSKOWITZ MA , Bolay H, Dalkara T Deciphering migraine mechanisms Clues from familial hemiplegic migraine genotypes. Ann Neurol 2004;55276280. http://www.amedeo.com/medicine/mig/annneuro.htm

Home HIV Medicine FAQ Unsubscribe ... GoldenLinks4Doctors.com The Best Medical Websites Migraine Free Subscription Articles published in Ann Neurol Retrieve available abstracts of 9 articles: HTML format Single Articles February 2004 MOSKOWITZ MA , Bolay H, Dalkara T Deciphering migraine mechanisms: Clues from familial hemiplegic migraine genotypes. Ann Neurol 2004;55:276-280. PubMed Related articles Abstract available January 2004 BURSTEIN R, Collins B, Jakubowski M Defeating migraine pain with triptans: A race against the development of cutaneous allodynia. Ann Neurol 2004; 55: 19-26. PubMed Related articles Abstract available BURSTEIN R , Jakubowski M Analgesic triptan action in an animal model of intracranial pain: a race against the development of central sensitization. Ann Neurol 2004;55:27-36. PubMed Related articles Abstract available September 2003 VANMOLKOT KR, Kors EE, Hottenga JJ, Terwindt GM, Haan J, Hoefnagels WA et al Novel mutations in the Na+, K+-ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions. Ann Neurol 2003; 54: 360-6.

88. Baylor Neurology Case Of The Month presentation suggested a TIA, embolic stroke, or complex partial seizure with a postictal paralysis (though one might also consider a hemiplegic migraine). http://www.bcm.tmc.edu/neurol/challeng/pat27/summary.html

Patient #27 Summary and Discussion Chalmer McClure, M.D., Ph.D. Neurology Resident Diagnosis: Ischemic stroke secondary to postinfectious focal varicella vasculitis Patient #27 presented with the sudden onset of transient inability to talk accompanied by left-sided weakness. These episodes lasted only 30 to 60 seconds and subsequently resolved (with the exception of the last episode, which left a sustained deficit). The distribution of involvement (face, arm and leg) suggests a subcortical process, though the inability to talk suggests cortical involvement. However, the finding of left-sided weakness associated with a true aphasia would be very unusual unless the person in question was left-handed and the lesion/process involved subcortical as well as cortical structures (in other words, a large stroke). Speech arrest can be seen with sudden neurological deficits in several areas including non-dominant subcortical regions, but the speech arrest is usually transient as in this case. The child's initial clinical presentation suggested a TIA, embolic stroke, or complex partial seizure with a post-ictal paralysis (though one might also consider a hemiplegic migraine). Stroke in the young is often the result of an underlying metabolic abnormality or overwhelming intercurrent illness. Focal seizures may result from structural abnormalities, stroke, or a parasitic infection such as neurocysticercosis, among others. As the child's illness progressed, and results of the laboratory studies and radiographic images became available, the differential diagnosis was narrowed.

89. Publications cerebral edema and fatal coma after minor head traumrole of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine. http://www.medfac.leidenuniv.nl/lab-frants/migraine/Publications.htm

Dutch Migraine Genetic Research Group (DMGRG) Key publications before 1999 Lesnik Oberstein SA, van den Boom R, van Buchem MA, van Houwelingen HC, Bakker E, Vollebregt E, Ferrari MD, Breuning MH, Haan J. Cerebral microbleeds in CADASIL. Neurology. 2001 Sep 25;57(6):1066-70. Ophoff RA, DeYoung J, Service SK, Joosse M, Caffo NA, Sandkuijl LA, Terwindt GM, Haan J, van den Maagdenberg AM, Jen J, Baloh RW, Barilla-LaBarca ML, Saccone NL, Atkinson JP, Ferrari MD, Freimer NB, Frants RR. Hereditary vascular retinopathy, cerebroretinal vasculopathy, and hereditary endotheliopathy with retinopathy, nephropathy, and stroke map to a single locus on chromosome 3p21.1-p21.3. Am J Hum Genet. 2001 Aug;69(2):447-53. Diener HC, Tfelt-Hansen P, de Beukelaar F, Ferrari MD, Olesen J, Dahlof C, Mathew N. The efficacy and safety of sc Alniditan vs. sc Sumatriptan in the acute treatment of migraina randomized, double-blind, placebo-controlled trial. Cephalalgia. 2001 Jul;21(6):672-9. Kors EE, Terwindt GM, Vermeulen FL, Fitzsimons RB, Jardine PE, Heywood P, Love S, van den Maagdenberg AM, Haan J, Frants RR, Ferrari MD. Delayed cerebral edema and fatal coma after minor head traumrole of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine.

90. Familial Hemiplegic Migraine Mutations Increase Ca2+ Influx Through Single Human Familial hemiplegic migraine mutations increase Ca 2+ influx through single human Ca V 2.1 channels and decrease maximal Ca V 2.1 current density in neurons. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=130625&rendertype=abst

91. Molecular Pharmacology Of Voltage are studied. These mutations were found in patients with a rare form of migraine (familial hemiplegic migraine). From this work http://homepage.uibk.ac.at/homepage/c740/c74029/calciumchannelprojects.html

Molecular Pharmacology of Voltage-Gated Calcium Channels (Head: J. Striessnig) Research Projects, Coworkers and Publications Are you familiar with voltage-gated ion channels in general and voltage-gated calcium channels in particular? If not, get a brief introduction here Our research currently focusses on two major topics: Physiology, pharmacology and pharmacotherapeutic potential of L-type calcium channels Role of Cav2.1 calcium channels for migraine pathophysiology 1. Physiology, pharmacology and pharmacotherapeutic potential of L-type calcium channels In this project the physiological role and the biophysical properties of Ca v 1.3 and Ca v 1.4 L-type calcium channels will be investigated. These channels are present at much lower abundance in most neuronal, endocrine and muscle cells than other L-type channel subunits. Interestingly, the biophysical properties of Cav1.3 allow it to serve pacemaker functions in brain and heart. The effects of alternative splicing on channel function, its modulation by neurotransmitters, enzymes and drugs and its expression in different tissues will be studied. The consequences of its gene-knockout have been described by us recently. The knockout mice deserve further characterization and provide a nice model to investigate the physiological role of this channel. A novel mouse model has recently been generated by our group which will allow to determine which pharmacological effect selective activation of Ca

92. Arquivos De Neuro-Psiquiatria - Translate this page further genetical studies are necessary to establish if these cases are different sources of weel-known migraine subtypes as the familial hemiplegic migraine. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000100022&l

93. Correspondence And Outreach - Patient's Letters Patient Linda Wilkins Feb 27 2002. I have hemiplegic migraine headaches which occur several times a month, or perhaps only every several months. http://www.paincare.org/pain_management/correspondence/patient_letters/show.php?

94. Correspondence And Outreach - Patient's Letters Patient Linda Wilkins Mar 13 2002. For the past six years I have suffered with familial hemiplegic migraine headaches, often several a month. http://www.paincare.org/pain_management/correspondence/patient_letters/show.php?

95. IHC: Gene Mutation Identified For Familial Hemiplegic Migraine Type 2 Title IHC Gene Mutation Identified for Familial hemiplegic migraine Type 2 URL http//www.pslgroup.com/dg/23B166.htm Doctor s Guide September 30, 2003. http://www.docguide.com/dg.nsf/PrintPrint/61DFDD506A261BF485256DB1004CF362

To print: Select File and then Print from your browser's menu Title: IHC: Gene Mutation Identified for Familial Hemiplegic Migraine Type 2 URL: http://www.pslgroup.com/dg/23B166.htm Doctor's Guide September 30, 2003 By Larry Schuster ROME, ITALY September 30, 2003 Italian researchers have identified a gene mutation on chromosome 1 that is associated with 10% to 20% of familial hemiplegic migraine type 2 (FHM2), according to a report presented here on September 15 th at the 11 th Congress of the International Headache Society. Giorgio Casari, PhD, department of neuroscience, San Raffaele Scientific Institute, Milan, Italy, and his research team narrowed the FHM2 locus by linkage analysis on 2 large Italian families affected by pure familial hemiplegic migraine. Dr. Casari said their research demonstrated that mutations of the alpha 2 subunit of the sodium-potassium pump are responsible for FHM2. "Functional data show that a putative pathogenetic mechanism is triggered by a loss of function of a single allele of the sodium potassium pump," Dr. Casari reported. Commenting on the report in her summary of the day's most significant papers, Marie-Germaine Bousser, MD, department of neurology, Lariboisière Hospital, Paris, France, called the presentation the "highlight of [the] day" and an "important finding" that links loss of genetic function to this inherited form of migraine.

96. GEMdatabase - Browse Titles Familial hemiplegic migraine This review focuses on the diagnosis, management, and genetic counseling of patients and families with hemiplegic migraine. http://www.gemdatabase.org/GEMDatabase/BrowseTitles.asp?curpage=13

97. Study Posting (1512) -- Trial #55941, Migraine (Pediatric), Norfolk, VA Blind, Dose Comparison Study of an Investigational Drug in Pediatric Subjects Between the Ages of 6 and 18 years with Basilar/hemiplegic migraine Headaches. http://www.centerwatch.com/patient/studies/stu55941.html

Trial Information Summary: A Double-Blind, Dose Comparison Study of an Investigational Drug in Pediatric Subjects Between the Ages of 6 and 18 years with Basilar/Hemiplegic Migraine Headaches We are currently conducting a research study for children and adolescents with Basilar/Hemiplegic Migraine Headaches. Children and adolescents who suffer from Basilar/Hemiplegic Migraine Headaches typically experience occasional moderate to severe headaches, pounding in nature, often accompanied by nausea or vomiting and discomfort caused by light or sound. In addition to these symptoms they will typically experience two or more of the following symptoms: vertigo, double vision, decreased hearing, numbness, and altered level of consciousness. In between their headaches these youngsters are usually symptom free and healthy. If this describes your adolescent, he or she may be eligible for this research study. To be eligible to participate, your adolescent must: Be 6-18 years of age and weigh at least 55 pounds Have an average of at least 4 migraines-days per month during the previous 3 months prior to screening Be in good health and willing to take the study medication as directed by the study doctor All study related clinic visits, testing, and study medications are provided at no cost.

98. AllRefer Health Health Links Directory Conditions And Diseases Conditions and Diseases Neurological Disorders Headaches migraine hemiplegic . Uncover resources and links to Web sites related to Conditions and Diseases Neurological Disorders Headaches http://www.1uphealth.com/links/migraine-hemiplegic.html

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