1. Hemiplegic Migraine hemiplegic migraine. http://www.achenet.org/kids/hemi.php

In This Section Kids Get Headache Too! Realaudio: NPR Interview Understand Pediatric Headaches Headaches in Children ... Summary A frightening attack of sudden onset of unilateral weakness (one-sided weakness). Weakness may involve face/arm/leg. If the right side of the body is the affected side, the individual may not be able to speak. May be triggered by mild head injury. There is a familial form, with a first degree relative affected. (i.e., father, mother, uncle, aunt) The headache follows the onset of weakness. The weakness may last one hour to days, but usually resolves in 24 hours. The familial form has been identified on chromosome 19 in 50%-60% of cases. Other causes of acute onset weakness must be considered before the diagnosis is made. Next headache type: chronic daily headache American Council for Headache Education achehq@talley.com This page last modified Tuesday, January 9, 2001

2. National Headache Foundation: Hemiplegic Migraine hemiplegic migraine. A very rare form of migraine which is considered to be one of the more severe types of migraine With hemiplegic migraine, there is often a familial occurrence http://www.headaches.org/consumer/topicsheets/hemiplegic.html

Consumer Topics Medications Spanish Topics HEMIPLEGIC MIGRAINE A very rare form of migraine which is considered to be one of the more severe types of migraine. The sufferer may develop some temporary motor paralysis and/or sensory disturbances on one side of the body, immediately followed by the headache. This may be accompanied by numbness or a pins-and-needles sensation. The neurological symptoms usually leave when the headache appears. With hemiplegic migraine, there is often a familial occurrence. A physician should be consulted for this type of headache.

3. Familial Hemiplegic Familial hemiplegic migraine. hemiplegic migraine is characterized by the onset of unilateral (One sided) sensory or motor signs during an episode of migraine. http://www.headachepainfree.com/familial_hemiplegic_migraine.htm

HeadachePainfree.Com Familial Hemiplegic Migraine Hemiplegic Migraine is characterized by the onset of unilateral (One sided) sensory or motor signs during an episode of migraine. Hemisyndromes are more common in children than in adults and may be characterized by numbness of the face, arm, and leg; unilateral weakness; and aphasia (Inability to express words). More than one attack is uncommon in the pediatric age group. Hemiplegic migraine occurs in two forms, sporadic and familial, both of which typically begin in childhood and cease with adulthood. The age of onset of hemiplegic migraine may be earlier than that of common migraine. The attacks are frequently precipitated by minor head injury. Accompanying changes in consciousness ranging from confusion to coma are a feature of hemiplegic migraine , especially in childhood, and occur in 23 percent of patients. The hemiplegic migraine is characterized by neurologic deficits that range from mild hemiparesis to full hemiplegia. The deficit may persist for some time after the headache. The hemiplegia may be part of the aura and last less than 1 hour, or it may continue through the headache phase and last for days or weeks. It is often associated with pernicious nausea, vomiting, dehydration, and despair. Even though symptoms usually last for hours or days, affected individuals are rarely left with permanent deficits. It is unusual for a child to develop a completed stroke after a single episode. Hemiplegic migraine in an older child or adolescent has a relatively good prognosis and a positive family history of similar hemiplegic events is often elicited.

4. Treatment Of Sporadic Hemiplegic Migraine With The Calcium-Channel Blocker Verap neuronal calcium channel dysfunction underlie hemiplegic migraine, and is calcium channel blocker 4 patients with sporadic hemiplegic migraine (SHM) who were responsive only http://www.headachedrugs.com/archives/hemiplegic.html

Home About Dr. Robbins Archived Articles Headache Books ... Back to List Title: Author: Date: Source: Treatment of Sporadic Hemiplegic Migraine with the Calcium-Channel Blocker Verapamil Yu W. Horowitz SH Posted: June 2003 Neurology Key questions: Does neuronal calcium channel dysfunction underlie hemiplegic migraine, and is calcium channel blocker therapy effective? Method: The authors describe 4 patients with sporadic hemiplegic migraine (SHM) who were responsive only to oral or intravenous verapamil – not to other common migraine therapies. The authors had previously reported a successful response to intravenous verapamil in familial hemiplegic migraine (FHM); this study confirms the efficacy of this agent. Conclusions: If new genetic studies have revealed de novo mutation of CACN1A1 in patients with SHM, then it may be part of the spectrum of FHM syndrome. Neuronal calcium channel dysfunction may underlie the pathogenesis of both forms of hemiplegic migraine; the calcium-channel blocker verapamil is an effective treatment for both disorders. Home About Dr. Robbins

5. ER News - November/December 1996 - Migraine Gene Article discusses rare form of hemiplegic migraine linked to gene on chromosome 19. http://www.pnl.gov/er_news/12_96/migraine.htm

Migraine Gene Discovered A n abnormally structured gene is the culprit in familial hemiplegic migraine, a rare inherited form of migraine. People with a similar neurological disorder, episodic ataxia type-2, have other alterations in the same gene, researchers found. The gene resides on chromosome 19, the organization and structure of which has long been studied by Lawrence Livermore National Laboratory's Human Genome Center. Three years ago, medical scientists at Leiden University in The Netherlands initiated a collaboration with the LLNL researchers to complete the physical mapping of the chromosome and clone the DNA of the gene for this form of migraine. Armed with the cloned DNA fragments and data from human patients studies, the Dutch researchers discovered the gene that regulates the transport of calcium into specific classes of brain cells. The researchers noted alterations in the DNA sequence in patients from the migraine families. These alterations result in the production of nonfunctional protein, which prevents calcium from being properly transported. The movement of calcium into brain cells regulates the release of neurotransmitters, which are critical elements in the network of communication among cells of the nervous system. While the type of Familial Hemiplegic Migraine associated with this gene is rare, many of its symptoms are similar to those of more common migraines. Scientists believe knowledge gained in studying this form of migraine will help understand the cause of other forms of the disorder.

6. ACHE Articles As it turns out, a definite inheritance pattern has been found in a few families who suffer with a severe form of migraine called hemiplegic migraine. http://www.achenet.org/articles/gardner.php

Genes and Migraine By Kathy Gardner, MD Many migraineurs have other family members who also suffer with migraine headache. Mom used to have migraine headaches with her menstrual cycle, grandmother once had "sick" headaches, and brother has "sinus" headaches which are less severe but sound strangely similar to migraine if you ask questions about symptoms and triggers. For years scientists have argued whether disorders such as migraine that tend to run in families do so because of shared genes or the shared environment. People often assume that any disorder that occurs in several family members must be genetic. However, families tend to share similar diets, exposures and lifestyles, all of which might be involved in making someone susceptible to a specific disorder. A combination of genetic and environmental factors seems to be the best overall explanation for most common disorders, including migraine. Nevertheless, the fact that you occasionally find large families with many members suffering from migraine suggest a stronger genetic basis for those particular families. As it turns out, a definite inheritance pattern has been found in a few families who suffer with a severe form of migraine called hemiplegic migraine. Hemiplegic Migraine The inherited or "familial" form of hemiplegic migraine is a rare disorder found in families where two or more people suffer migraine-type headache associated with a "stroke-like" aura of weakness on one side of the body. Other neurologic symptoms can also occur and might include visual loss, difficulty with speech, confusion and numbness. In these families, hemiplegic migraine has an

7. Case - Familial Hemiplegic Migraine Lymphomas. Melanoma. Menopause. Migraine. Multiple Sclerosis. Mycoses. Nephrology Other EMail this case to a colleague. Familial hemiplegic migraine. Presented by http://www.docguide.com/gpc.nsf/doc?CreateDocument&n=24&id=48dde4a73e09a

8. Headaches Types | Migraine hemiplegic migraine If you suffer from this rare but severe type of migraine with aura, you probably also have a family history of it. http://www.headaches.org/consumer/educationalmodules/completeguide/migraine2.htm

Headache MIGRAINE Symptoms There are several types of migraine, all share basic features, and each person will suffer this headache in a unique way. Generally, however, migraine often begins as a dull ache and then develops into a constant, throbbing and pulsating pain that you may feel at the temples, as well as the front or back of one side of the head. The pain is usually accompanied by nausea and vomiting, and sensitivity to light and noise. The two most prevalent types of migraine are migraine with aura (formerly referred to as classic migraine) and migraine without aura (formerly referred to as common migraine). Migraine without Aura As we have said, migraine is a vascular headache, which means the headache is associated with changes in the size of the arteries inside and around the skull. During the pre-headache phase, blood vessels constrict; when vascular dilation occurs, the migraine begins. The blood vessels are thought to become inflamed as well as swollen, and it is believed that migraine pain is caused by this inflammation, as well as by the pressure on the swollen walls of the blood vessels. Most migraine sufferers experience two to four headaches per month; but, some people can get one every few days, and others may only have one or two a year. Most migraine headaches last at least four hours, although very severe ones can last up to a week. Headaches may begin at any time of the day or night; and while a sufferer may wake up with one, a migraine will rarely awaken a person from sleep.

9. Familial Hemiplegic Migraine Information Diseases Database Familial hemiplegic migraine, Disease Database Information Send Familial hemiplegic migraine to medical search engines http://www.diseasesdatabase.com/sieve/item1.asp?glngUserChoice=4693

10. Hemiplegic Migraines - Information / Diagnosis / Treatment / Prevention hemiplegic migraines. Web Directory ? American Council for Headache Education hemiplegic migraine Page List of symptoms associated with hemiplegic migraine. http://www.healthcyclopedia.com/neurological-disorders/headaches/migraine/hemipl

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... migraine > hemiplegic Hemiplegic Migraines Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Medical Definition Health News Web Directory: Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "hemiplegic" Health News: Search millions of published articles for news on Hemiplegic Migraines Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: American Council for Headache Education Hemiplegic Migraine Page List of symptoms associated with hemiplegic migraine. Migraine Gene Discovered Article discusses rare form of hemiplegic migraine linked to gene on chromosome 19. National Headache Foundation Brief description of the condition.

11. DOE Document - Genetic Heterogeneity Of Familial Hemiplegic Migraine Familial hemiplegic migraine (FHM) is a distinctive form of migraine with an autosomal dominant mode of inheritance. The migrainelike attacks are associated with transient hemiparesis. five unrelated pedigrees with multiple members suffering from hemiplegic migraine were investigated http://rdre1.inktomi.com/click?u=http://www.osti.gov/energycitations/product.bib

12. GeneReviews: Familial Hemiplegic Migraine http://www.genetests.org/query?dz=fhm

13. GeneReviews: Familial Hemiplegic Migraine Your browser does not support HTML frames so you must view Familial hemiplegic migraine in a slightly less readable form. Please follow this link to do so. http://www.geneclinics.org/profiles/fhm/

Your browser does not support HTML frames so you must view Familial Hemiplegic Migraine in a slightly less readable form. Please follow this link to do so.

14. Hemiplegic Migraine - General Practice Notebook hemiplegic migraine. hemiplegic migraine is a term used to describe the migraine syndrome that is associated with a weakness or sensory http://www.gpnotebook.co.uk/cache/1154482184.htm

hemiplegic migraine Hemiplegic migraine is a term used to describe the migraine syndrome that is associated with a weakness or sensory loss of the limbs on one side of the body. The headache usually precedes the weakness by a day or more. The limbs gradually return to normal over several days. Often there is a family history of this type of migraine, usually with an autosomal dominant inheritance. It is always necessary to exclude another possible underlying cause for the hemiplegia such as an angioma. It is a rare form of migraine. Click here for more information...

15. Hemiplegic Migraine - General Practice Notebook hemiplegic migraine. Medical search. hemiplegic migraine is a term used to describe the migraine syndrome that is associated with http://www.gpnotebook.co.uk/medwebpage.cfm?ID=1154482184

16. Entrez PubMed Click here to read Familial hemiplegic migraine and episodic ataxia type2 are caused by mutations in the Ca2+ channel gene CACNL1A4. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8

17. Migrainepage Discussion Forum - "hemiplegic Migraine" Migrainepage Discussion Forum. HomeConferencesMigraine Discussion( Protected) Original message. zimmtree@aol.com. Jan25-03, 0206 PM (CMT) " hemiplegic migraine" My son was diagnosed with hemiplegic http://www.migrainepage.com/dcforum/discussion/8133.html

Migrainepage Discussion Forum "hemiplegic migraine" Email this topic to a friend Printer-friendly version of this topic Archived thread - Read only Previous Topic Next Topic Home Conferences ... Migraine Discussion (Protected) Original message zimmtree@aol.com Jan-25-03, 02:06 PM (CMT) "hemiplegic migraine" My son was diagnosed with hemiplegic migraines over one year ago. He is being treated at Children's Hospital in Boston. He is on many meds...calcium channel blockers, anti-seizure meds, pain meds, antidepressants, and vitamins. We use relaxation techniques, distraction, and rest. When he has "attacks", he is paralyzed on his left side, has confusion and disorientation, sometimes blackouts, drooping face, speech impairment, visual disturbance, and then the horrible pain that can last for months. Some people seizure and coma can occur. We are hoping that once we get through puberty, to see some sort of "remission". If anyone out there has dealt with this and improved, please let me know. It would be great for my son to know this and possibly communicate with someone. He doesn't think he will ever be "better". Thank you

18. Entrez PubMed Click here to read hemiplegic migraine induced by exertion. Razavi M, Razavi B, Fattal D, Afifi A, Adams HP Jr. Department of Neurology http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

19. NEJM -- The Clinical Spectrum Of Familial Hemiplegic Migraine Associated With Mu Original Article from The New England Journal of Medicine The Clinical Spectrum of Familial hemiplegic migraine Associated with Mutations in a Neuronal http://content.nejm.org/cgi/content/abstract/345/1/17

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 345:17-24 July 5, 2001 Number 1 Next The Clinical Spectrum of Familial Hemiplegic Migraine Associated with Mutations in a Neuronal Calcium Channel Anne Ducros, M.D., Ph.D., Christian Denier, M.D., Anne Joutel, M.D., Ph.D., Michaelle Cecillon, Christelle Lescoat, Katayoun Vahedi, M.D., Francoise Darcel, M.D., Eric Vicaut, M.D., Ph.D., Marie-Germaine Bousser, M.D., and Elisabeth Tournier-Lasserve, M.D. Full Text PDF Editorial by Hoffman, E. P. ... Chapters at Harrison's ABSTRACT Background Familial hemiplegic migraine, an autosomal dominant disorder characterized by attacks of transient hemiparesis followed by a migraine headache, is divided into pure familial hemiplegic migraine (affecting 80 percent of families) and familial hemiplegic migraine with permanent cerebellar signs (affecting 20 percent of families). Mutations in which encodes a neuronal calcium channel, are present in 50 percent of families with hemiplegic migraine, including all those with cerebellar signs.

20. NEJM -- Sign In Editorial from The New England Journal of Medicine hemiplegic migraine Downstream of a SingleBase Change. http://content.nejm.org/cgi/content/full/345/1/57

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