41. Targeting Hard-to-kill Fungal Infections Targeting hardto-kill fungal infections. Reston, VA – Killing thedisease without killing the patient is an old dilemma for doctors http://www.eurekalert.org/pub_releases/2004-02/sonm-thf021204.php

Public release date: 12-Feb-2004 Contact: Gavin McDonald gmcdonald@kamber.com Society of Nuclear Medicine Targeting hard-to-kill fungal infections Reston, VA – Killing the disease without killing the patient is an old dilemma for doctors fighting cancer and some of the tougher microorganisms such as fungal infections in individuals with suppressed immune systems. Drugs have little effect when a patient's own immune system isn't available to help, and these fungi can resist external radiation that would kill even a perfectly healthy human. But they can be easily killed by a very small dose of radiation inside their cells. Monoclonal antibodies can be designed to deliver radiation to specific cell types while sparing surrounding tissue. These designer antibodies, armed with radioactive isotopes, have been found to be highly effective against some types of cancer, but the combination may also be useful in other types of serious disease. This technique is known as radioimmunotherapy (RIT). A study appearing in the February issue of The Journal of Nuclear Medicine demonstrates that radioimmunotherapy (RIT) provides a new, highly effective way to kill Cryptococcus neoformans and Histoplasma capsulatum, the fungi responsible for fungal meningitis and pneumonia, using much smaller levels of radiation than required to kill the fungi by external radiation. The study used organism-specific monoclonal antibodies coupled with radioactive isotopes of bismuth or rhenium.

42. Heart Drug Might Help Fight Chronic Fungal Infections have determined why a drug routinely used to treat heart arrhythmias might becomea crucial addition to fighting chronic fungal infections, they report online http://www.eurekalert.org/pub_releases/2003-06/jhmi-hdm060503.php

Public release date: 5-Jun-2003 Contact: Joanna Downer jdowner1@jhmi.edu Johns Hopkins Medical Institutions Heart drug might help fight chronic fungal infections Johns Hopkins scientists have determined why a drug routinely used to treat heart arrhythmias might become a crucial addition to fighting chronic fungal infections, they report online in the Journal of Biological Chemistry. Last year, scientists elsewhere noted the drug's ability to kill fungi. Now, a Johns Hopkins research team has found that amiodarone kills by disrupting cells' interior and exterior calcium balance. Importantly, this is completely different from the way in which commonly used antifungal agents miconazole and fluconazole stop fungal growth, say the researchers. In their experiments, a combination of amiodarone and either of the "azoles" killed dramatically more fungi than expected. "This antiarrhythmic drug, in low doses, combined with azoles looks very promising in the lab and appears to be worth taking a look at clinically," says Rajini Rao, Ph.D., associate professor of physiology in the Johns Hopkins School of Medicine's Institute for Basic Biomedical Sciences. "The azoles prevent fungi from growing, but don't actually kill them the immune system is supposed to do that. Amiodarone kills them instead of keeping them dormant." While fungal infections in general are easy to get rid of, in patients with depressed immune systems or with conditions like cystic fibrosis that increase susceptibility to chronic or recurring fungal infections, prolonged use of azoles can lead to the fungus becoming resistant to treatment. Finding a way to treat severe and life-threatening fungal infections with an option that boosts the effects of azoles without relying on the strength of the immune system is attractive, says Rao, who studies how calcium is brought into cells.

43. UAB Health System | Fungal Infections Of The Skin fungal infections of the Skin. Skin fungi live in These fungal infectionscause only a small amount of irritation. Other types of fungal http://www.health.uab.edu/show.asp?durki=20806

44. Posters And Abstracts: Fungal Infections 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy. Posters andAbstracts fungal infections. September 27 30, 2002, San Diego, California http://www.medscape.com/viewprogram/2041

Register Log In June 2, 2004 Return to Medscape coverage of: 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy Posters and Abstracts: Fungal Infections September 27 - 30, 2002, San Diego, California This activity is not sanctioned by, nor a part of, the 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy. Click here for more information on this Medscape program. Contents Fungal Infections The treatment of invasive fungal diseases is an ongoing clinical challenge, particularly in people with compromised immune systems following disease- or treatment-related complications. Indeed, reports indicate that invasive fungal infections affect between 10% and 25% of patients with acute leukemia treated by allogeneic hematopoietic stem cell transplantation, and that over 50% of these patients die. In patients with disseminated infections or persistent neutropenia, the death rate climbs to nearly 100%. Varied success in managing these infections has been achieved with the traditional antifungal therapies amphotericin B and 5-fluorocytosine, as well as with the newer agents fluconazole and itraconazole. However, limitations of these agents include adverse side effects, as well as an inability to effectively treat some refractory infections or the uncommon fungi (such as Fusarium or Scedosporium species) that are occurring more frequently. The need for improved therapies to prevent and treat primary and secondary infections has led to further developments of antifungal drugs, such as voriconazole, a member of a class of drugs known as the triazoles.

45. Voriconazole Treats Invasive Fungal Infections In Of children with probable or proven invasive fungal infections,86% responded to treatment with voriconazole. http://www.medscape.com/viewarticle/474977

46. Fungal Infections fungal infections can affect various parts of the body and sometimes be difficultto treat. Find out more about fungal infections of the skin, hair, and nails. http://dermatology.about.com/cs/fungalinfections/

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') About Dermatology Skin Diseases Infections Infection Fungus Home Essentials Do I Need a Dermatologist? Help, I have a rash! ... The Biology of Hair zau(256,152,145,'gob','http://z.about.com/5/ad/go.htm?gs='+gs,''); Derm Photos Glossary Beauty Skin Diseases ... Help zau(256,138,125,'el','http://z.about.com/0/ip/417/0.htm','');w(xb+xb); Stay Current Subscribe to the About Dermatology newsletter. zau(256,152,100,'hs','http://z.about.com/5/ad/hs.htm?zIhsid=00',''); Search Dermatology Fungal Infections All about fungal infections of the skin, hair, and nails. Alphabetical Recent Up a category Ringworm - Tinea Corporis Ringworm, also known as tinea corporis, is a superficial fungal infection of the skin. Find out more about what the ringworm rash looks like, how it is diagnosed, and how it is treated. Jock Itch Jock itch is a common fungal infection that affects more men than women. Find out more about this infection and what can be done to treat it. Athlete's Foot - Tinea Pedis Athlete’s foot, or tinea pedis, is a very common fungal infection experienced by up to 70% of the population at some time in their life. Learn more about the types of athlete's foot and how they are treated. Athlete's Foot Facts Information about athlete's foot from your About Orthopedics Guide.

47. National Skin Center fungal infections Of The Skin. Fig. Make sure you use your own personalitems because fungal infections are easily transmissible. http://www.nsc.gov.sg/cgi-bin/WB_ContentGen.pl?id=165&gid=33

48. National Skin Center 5. fungal infections. fungal infections. Make sure you use your own personalitems because these fungal infections are easily transferable. http://www.nsc.gov.sg/cgi-bin/WB_ContentGen.pl?id=98&gid=26

49. Topical And Oral Treatments For Foot Fungal Infections [January 2003; 107-3] Topical and oral treatments for foot fungal infections. fungal infections ofthe foot are remarkably common, affecting about 15% of people in the UK. http://www.jr2.ox.ac.uk/bandolier/band107/b107-3.html

@import "../styles/advanced.css"; Skip navigation Back issue listing Subject Index Journal listing by subject Topical and oral treatments for foot fungal infections Systematic reviews Results for topical azoles Results for topical allylamines Results for topical undecanoates ... Comment and costs Fungal infections of the foot are remarkably common, affecting about 15% of people in the UK. Topical fungicides, some available without prescription from chemists, are the first treatment option. When they fail, oral fungicides can be tried. Two systematic reviews tell us how effective these are. Systematic reviews Both systematic reviews [1,2] had a wide search strategy for randomised trials. As well as at least 10 electronic databases, several journals were hand searched and companies and schools of podiatry in the UK were asked for unpublished trials. For skin infections, only trials that used microscopy and culture were included. The outcome was cure rate at follow up from the reported mycological results, with negative results on microscopy and no growth on culture. Results for topical azoles Twelve trials with more than 10 patients in both treatment groups compared azoles with placebo (Figure 1). Usually treatment was for four to six weeks, and follow up for four to 10 weeks.

50. HPA - Infections | Topics A-Z | Fungal Infections fungal infections. News, Picture used with permission. New national surveillancestudy on invasive fungal infection in very low birth weight infants. http://www.hpa.org.uk/infections/topics_az/fungal_infections/menu.htm

Home Divisions Topics A - Z Publications ... Sitemap JavaScript Date Search Advanced Search CDR Weekly CDPH Influenza ... Deliberate Release To enlarge text select view then text size on your browser. This site uses Adobe Acrobat Download here Fungal Infections Aspergillus flavus Image used with permission from The Aspergillus Trust News Picture used with permission New national surveillance study on invasive fungal infection in very low birth weight infants The Health Protection Agency (HPA)

51. FUNGAL INFECTIONS EeDerm, Conditions Fungal. fungal infections. The topical products for nailfungal infection (Trosyl and Loceryl lacquer) are of limited benefit. http://www.swis.net/excg/derm/derm7.htm

EeDerm FUNGAL INFECTIONS If you suspect tinea please send generous scrapings of the skin or clippings of the nail to the Laboratory for direct examination and culture and please send these specimens before you start treatment with systemic or topical anti-fungals. NOTES: Think of tinea in any scaly rash that is not obviously psoriasis or eczema etc. Asymmetrical scaly rashes should alert you to the possibility of tinea. Nail dystrophy. Do undress the patients and look carefully for psoriasis. Remember that candida does not respond to Griseofulvin or systemic Terbinafine (Lamisil). Scalp ringworm and kerion do not respond to topical anti-fungal treatment alone. Terbinafine (Lamisil) Itraconazole (Sporanox This has the advantage of treating yeasts (such as candida) as well as dermatophytes. It is often prescribed for nails in the Sporanox Pulse form, giving it for one week out of four. Pityriasis Versicolor Use Nizoral Shampoo, or Cream if localised, or alternatively Selsun Shampoo. If very widespread give Itraconazole (Sporanox) orally 200 mg per day for seven days. Pityriasis Images Index More than you usually need or want to know about fungi, but useful for looking up odd reports from the local laboratory.

52. Fungal Infection fungal infections of the skin are known as ringworm (tinea). However, somefungal infections, such as athlete’s foot, tend to occur repeatedly. http://www.hmc.psu.edu/healthinfo/f/fungalinfection.htm

53. H2 Fungal Infections Of Man P /H2 fungal infections of Man. Superficial. Cutaneous- Cutaneous fungal infectionsare those which involve skin, hair or nails without invasion of the tissues. http://endeavor.med.nyu.edu/courses/microbiology/courseware/infect-disease/Fungi

Fungal Infections of Man Here will be a consideration of fungal species commonly associated with infections in humans While fungi are ubiquitous in nature,they are primarily involved in degradation of organic waste material and very few cause human disease (other areas of importance are in food and drug technology). Representative fungal organisms of medical importance in human disease to be considered here are: Candida albicans (skin infections, enteritis, vaginitis, thrush, systemic disease) Cryptococcus neoformans (meningitis, pulnonary and disseminated disease, skin, bone lesions) Blastomyces dermatitidis (chronic granulomatous and suppurative disease; mutiple organs systems may be affected) Microsporum canis, Microsporum gypsum (Tinea Capitis, Tinea Corporis, Tinea Barbae) General features of Fungi Before one can discuss these organisms, it is important to understand that fungi are eucaryoytes and therefore differ from the procaryotic bacteria in size ,structural organization, life cycle and modes of multiplication. Their complexity of organization and variety of modes of reproduction helps one to differentiate among them on the basis of morphological features and therefore microscopic observations as well as cultural characteristics is an important part of their identification protocol.

54. EMedicine Health - Yeast And Fungal Infections Yeast and fungal infections, Choose from the articles below to learn aboutthe symptoms, diagnosis, and treatment of yeast and fungal infections. http://www.emedicinehealth.com/collections/CO1578.asp

Search June 2, 2004 Registration Healthcare Professionals High cholesterol can affect children. Is your child at risk? About 1 million people in the United States have Crohn disease. What are treatment options? Is there a connection between IBD and Crohn Disease? About one third of those with diabetes do not know they have it. Are you one? Two million or more Americans have schizophrenia. Is someone you love affected? One third of those with asthma are children. What are the symptoms and triggers? Asthma Cholesterol Crohn Disease Diabetes ... Mental Health Yeast and Fungal Infections Choose from the articles below to learn about the symptoms, diagnosis, and treatment of yeast and fungal infections. Candidiasis (Yeast Infection) Sporotrichosis Athlete's Foot Diaper Rash ... Anal Itching Search About Us Privacy Code of Ethics Contact Us ... Healthcare Professionals We subscribe to the HONcode principles. Verify here

55. U.S. Pharmacist Superficial fungal infections. Considerations in Treatment Plans. 1. Superficialfungal infections are among the most common infections in the world. http://www.uspharmacist.com/index.asp?show=article&page=8_1247.htm

56. Fungal Infections - Information / Diagnosis / Treatment / Prevention home infectious diseases fungal fungal infections. Information• Diagnosis • Treatment • Prevention. External links (marked http://www.healthcyclopedia.com/infectious-diseases/fungal.html

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... infectious diseases > fungal Fungal Infections Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Subtopics Related Topics Medical Definition Health News ... Web Directory: Subtopics: Fungal > Aspergillosis Fungal > Blastomycosis Fungal > Candida Fungal > Coccidioidomycosis Fungal > Cryptococcosis Fungal > Histoplasmosis Fungal > Mycotoxins Fungal > Tinea Infections Related Topics: Health Products/Conditions and Diseases/Fungal Open Directory: Science/Biology/Genetics/Eukaryotic/Fungal Open Directory: Science/Biology/Mycology Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "fungal" Health News: Search millions of published articles for news on Fungal Infections Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles.

57. Opportunistic Fungal Infections Opportunistic fungal infections. To begin the lecture, click the STARTbutton above. Objective. If you are the first time visitor, you http://www.pitt.edu/~super1/lecture/lec5411/

Lists of Lectures Front Page Opportunistic Fungal Infections To begin the lecture, click the START button above. Objective If you are the first time visitor, you might want to know [ How to navigate within and outside the lecture This is a beta version. Your comments to this version would be highly appreciated as well. Submit Your comments

58. Fungal Infections Of The Skin - Dermatologychannel is a whole set of disorders related to infections by fungi (singularfungus). Many of these fungal infections affect the skin. http://www.dermatologychannel.net/fungalinfections/

Home Search SiteMap Ask the Dr. ... Medical Store advertisement advertisement FUNGAL INFECTIONS Overview Risk Factors Types Symptoms ... FAQs CONDITIONS Acne Alopecia (Baldness) Birthmarks Blistering Disorders ... Blood Vessel Disorders Dermatitis (Eczema) Follicle Disorders Fungal Infections Lyme Disease ... Viral Infections RESOURCES Anatomy Clinical Trials Links MDLocator ... What Is a Dermatologist? ABOUT US Healthcommunities.com Pressroom Testimonials Overview Most people are familiar with infections and diseases caused by bacteria and viruses, but many are unaware that there is a whole set of disorders related to infections by fungi (singular: fungus). Many of these fungal infections affect the skin. Doctors give some fungal infections of the skin the general name "tinea." Superficial fungal infections are found in the top layers of the skin and mucous membranes, the hair, and the nails. Examples of fungal infections of the skin and other external surfaces include athlete’s foot, jock itch, ringworm, and candida. These can affect the hair and nails as well. Deep fungal infections invade deeper layers of the skin and hair follicles and can spread to the blood or internal organs. Fungi Fungi are a unique group of organisms that have some plantlike characteristics. Examples of fungi include mushrooms, mold, and yeast. Fungi differ from plants, however, in two major ways: (1) their cell walls are made of chitin, rather than cellulose, and (2) they lack the ability to make their own food by photosynthesis; thus they grow directly on their food source. This food source can be the human skin.

59. DrWeil.com Herbal Medicine Chest: Fungal Infections Balanced Living Home Health fungal infections fungal infectionsfungal infections of the skin include ringworm and jock itch. http://www.drweil.com/app/cda/drw_cda.html-command=GlossaryDetail-pt=Glossary-gl

Home About Us Contact Us Member Login/Profile Mon May 31, 2004 Mind/Body/Spirit Health Conditions Home Health Remedies The Healthy Kitchen Recipes Food As Medicine Herbal Medicine Chest Like-Minded Practitioners Commercial Friends Find a Therapist Powered By Psychology Today Within miles 1 mile 2 miles 5 miles 10 miles 20 miles 50 miles Balanced Living Home Health Fungal Infections PRINT THIS PAGE SEND THIS TO A FRIEND FUNGAL INFECTIONS advertisement Have a question, but couldn't find an answer? Ask Dr. Weil Related Wellness Therapies: Herbal Medicine Rooting out Ringworm? About Us Contact Us ... Site Map All material provided on the DrWeil.com Web site is provided for informational or educational purposes only. Consult a physician regarding the applicability of any opinions or recommendations with respect to your symptoms or medical condition.

60. Fungal Infections Subscribe now . fungal infections. A fungal infections of the toenailare fairly common and until recently, difficult to eradicate. http://healthlink.mcw.edu/article/901216271.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: By keywords: Receive Health Link via email! Subscribe now >> Fungal Infections Q: About three years ago, I first noticed that the toenails of my big toes were getting thick and yellowish. At first I thought it was "athlete's foot" and I treated it with over-the-counter substances like Tinactin to no avail. I also tried home remedies like soaking my feet in vinegar and in tea. They don't seem to be getting any worse, but the nails are hard to cut and are somewhat tender (I'm a 40-year-old otherwise healthy man and do NOT have scaly skin on my feet). Since then, I've heard that there is no cure for fungus nails (which I'm assuming this is), but recently I read about a new drug in USA Today. Could you enlighten me on this please? A: Fungal infections of the toenail are fairly common and until recently, difficult to eradicate. Several anti-fungal drugs have been developed which are about 80% effective in treating nail infections. Itraconazole (Sporanox), a capsule taken once a week for 4 months, is the drug preferred by Dr. Daniel Zivony, dermatology resident at the Medical College of Wisconsin. He cautions that while the infection may respond initially, there is a high relapse rate, and the nails may require another course of treatment. Drawbacks include the cost of the drug, about $5 per capsule, and a rare side effect of hepatitis.

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