61. Ride For Life: New Gene For Rare Inherited Paralysis May Aid ALS New Gene for Rare Inherited paralysis May Aid ALS. Posted October 3, 2003 in is nocure for HSP, which is also sometimes called familial spastic paraparesis or http://www.rideforlife.com/archives/000647.html

Categories: ALS News ALS Research ALS Spotlight Commentary ... All Archives Navigate: Ride for Life Home ALS News Center Lenny's Place - ALS Forum About Ride for Life ... ALS Support Groups Search: New Gene for Rare Inherited Paralysis May Aid ALS Posted October 3, 2003 in ALS Research Merion Publications A single mutation in a single gene is enough to slowly rob people of their ability to walk, scientists from the University of Michigan and the University of Pennsylvania report today. And while the inherited defect itself is rare, its discovery may help researchers unravel the mysteries of much more common paralyzing conditions, from spinal cord injury to Lou Gehrig's disease. In a paper published online today in the American Journal of Human Genetics, and scheduled for the journal's October issue, the U-M and Penn team describes a new gene, called NIPA1, for a form of hereditary spastic paraplegia, or HSP. HSP is the name given to a group of disorders affecting about 20,000 Americans. HSP gradually disables its victims as long nerve cells in the spinal cord degenerate and muscles weaken and become spastic. It is often misdiagnosed as other nerve disorders, including multiple sclerosis, cerebral palsy, and amyotrophic lateral sclerosis (also called Lou Gehrig's disease). There is no cure for HSP, which is also sometimes called familial spastic paraparesis or Strumpell-Lorain disease. Treatment is limited to physical therapy and exercise to help retain as much muscle function as possible, drug treatment to tame spastic muscle movements, and medication to treat patients' bladder and bowel control problems, and depression.

62. New Gene For Rare Inherited Paralysis May Aid Other Spinal Cord Research, Too » New Gene For Rare Inherited paralysis May Aid Other Spinal Cord Research, Too. nocure for HSP, which is also sometimes called familial spastic paraparesis or http://www.medschoolchat.com/displayarticle236.html

Wednesday, June 02, 2004 [ 04:06 PM ] M edical S chool ... hat - Med School Article - Medical Diagnosis Medical Dictionary Med School Essay Help Hello Future Doc Register Login Own a medical website? Join our Network What is new T Y W Articles Comments Members Reviews ... Topics T Y W eek Navigation Home MSC Store Palm Pilot Store World Map Users Area Mini Quiz FREE Registration Forgot password? Chat Area Forums SHOUT box Live Chat Rooms! GuestMAP Chat Transcripts Game Room Useful Information Downloads School Reviews More Reviews Topics Web Links Exam Materials MCAT Help USMLE Help Essay Help Cheap Medical Books Basic Sciences Medicine USMLE MCAT More Cheap Books... Info/Help Trouble Ticket Top 10 Partner Sites Partner Sites: EssayEdge Residency.info Photo Gallery Med School Guide ... New Gene For Rare Inherited Paralysis May Aid Other Spinal Cord Research, Too Story Tools Send to a friend Printer friendly page Get PDF RELATED LINKS A single mutation in a single gene is enough to slowly rob people of their ability to walk, scientists from the University of Michigan and the University of Pennsylvania report today.

63. PubMed Medline Query 4 Swiss families with the pure form of hereditary spastic spinal paralysis. See RelatedArticles Clinical heterogeneity of familial spastic paraplegia linked http://perso.wanadoo.fr/asl.spastic/fichierslies/medline.htm

Docs Per Page: Entrez Date limit: 30 Days 60 Days 90 Days 180 Days 1 Year 2 Years 5 Years 10 Years No Limit citations 1-50 displayed (out of 144 found), page 1 of 3 Citation report Abstract report MEDLINE report ASN.1 report Related articles protein links nucleotide links structure links genome links for the articles selected (default all). documents on this page through Loansome Doc El-Shanti HE, et al. [See Related Articles] A clinical study of a large inbred kindred with pure familial spastic paraplegia. Brain Dev. 1999 Oct;21(7):478-82. PMID: 10522526; UI: 99450361. Cruz Martinez A, et al. [See Related Articles] Central motor conduction in hereditary motor and sensory neuropathy and hereditary spastic paraplegia. Electromyogr Clin Neurophysiol. 1999 Sep;39(6):331-5. PMID: 10499202; UI: 99428990. Hazan J, et al. [See Related Articles] A fine integrated map of the SPG4 locus excludes an expanded CAG repeat in chromosome 2p-linked autosomal dominant spastic paraplegia. Genomics. 1999 Sep 15;60(3):309-19.

64. New Gene For Rare Inherited Paralysis May Aid Other Spinal Cord Research, Too New gene for rare inherited paralysis may aid other spinal cord research, too. nocure for HSP, which is also sometimes called familial spastic paraparesis or http://www.focusonals.com/new_gene_for_rare_inherited_paralysis_may_aid_other_sp

Home What Is ALS? Symptoms Diagnosis ... Search MEDLINEplus New gene for rare inherited paralysis may aid other spinal cord research, too Oct. 2003 Contact: Kara Gavin kegavin@umich.edu University of Michigan Health System ANN ARBOR, MI – A single mutation in a single gene is enough to slowly rob people of their ability to walk, scientists from the University of Michigan and the University of Pennsylvania report today. And while the inherited defect itself is rare, its discovery may help researchers unravel the mysteries of much more common paralyzing conditions, from spinal cord injury to Lou Gehrig's disease. In a paper published online today in the American Journal of Human Genetics, and scheduled for the journal's October issue, the U-M and Penn team describes a new gene, called NIPA1, for a form of hereditary spastic paraplegia, or HSP. HSP is the name given to a group of disorders affecting about 20,000 Americans. HSP gradually disables its victims as long nerve cells in the spinal cord degenerate and muscles weaken and become spastic. It is often misdiagnosed as other nerve disorders, including multiple sclerosis, cerebral palsy, and amyotrophic lateral sclerosis (also called Lou Gehrig's disease). There is no cure for HSP, which is also sometimes called familial spastic paraparesis or Strumpell-Lorain disease. Treatment is limited to physical therapy and exercise to help retain as much muscle function as possible, drug treatment to tame spastic muscle movements, and medication to treat patients' bladder and bowel control problems, and depression.

65. Hum. Mol. Genet. -- Abstracts: Hentati Et Al. 3 (8): 1263 Tanguy, and E. Bertini Infantile ascending hereditary spastic paralysis (IAHSP)Clinical features of a new locus for recessive familial spastic paraparesis to http://hmg.oupjournals.org/cgi/content/abstract/3/8/1263

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: Email this article to a friend Similar articles found in: Hum. Mol. Genet. Online PubMed PubMed Citation This Article has been cited by: other online articles Search PubMed for articles by: Hentati, A. Siddique, T. Alert me when: new articles cite this article Download to Citation Manager ARTICLES Linkage of 'pure' autosomal recessive familial spastic paraplegia to chromosome 8 markers and evidence of genetic locus heterogeneity A Hentati, MA Pericak-Vance, WY Hung, S Belal, N Laing, RM Boustany, F Hentati, M Ben Hamida and T Siddique Department of Neurology, Northwestern University Medical School, Chicago, IL 60611. 'Pure' familial spastic paraplegias (FSP) are neurodegenerative disorders that are clinically characterized by progressive spasticity of the lower limbs and are inherited as autosomal dominant (DFSP) or autosomal recessive (RFSP) traits. The primary defect in FSP is unknown. Genetic linkage analysis was applied to five RFSP families from Tunisia. In four of these

66. New Gene For Rare Inherited Paralysis May Aid Other Spinal Cord Research, Too New Gene for Rare Inherited paralysis May Aid Other Spinal Cord Research, Too. nocure for HSP, which is also sometimes called familial spastic paraparesis or http://www.mcpf.org/displayarticle.asp?articleId=213

67. HEALTHMEDNET familial Non Hemolytic Non Obstructive Jaundice. familial Periodic paralysis.familial Polyposis. familial spastic Paraparesis. familial Tremor. Family Health. http://www.epscorp.com/healthmednet/f.htm

Directory Index HEALTHMEDNET Example Report Request ... DataBase Note: The names were derived from the specific illness/disease source directories. Therefore, there are some variations in the names. When ordering a list of URLs for your illness/disease, where possible, include the general usage, technical, acronym, and/or abbreviation names. Fabry Disease Facelifts Facet Degeneration (Low Back Pain) Facet Joint Problems Facial and Head Injuries Facial Asymmetry Facial Dermatoses Facial Hemiatrophy Facial Infection Facial Injuries (Cheek, Chin, or Jaw) Facial Injury: First Aid Facial Nerve Paralysis Facial Nerve Problems Facial Nerve Weakness or Paralysis (Bell's Palsy) Facial Neuralgia (Tic Douloureux) Facial Pain Facial Pain and Sinus Pain Facial Palsy Facial Paralysis Facial Tics Facioscapulohumeral Facioscapulohumeral Muscular Dystrophy (Landouzy-Dejerine) Facio-Scapulo-Humeral-Muscular D. Factitious Disorders Factitious Hyperthyroidism Factitous Disorder Factor II Deficiency Factor IX Deficiency Factor IX Hemophilia Factor V Deficiency Factor VII Deficiency Factor VIII Deficiency Hemophilia Factor X Deficiency Factor XII (Hageman Factor) Deficiency Factor XIII Deficiency Fahr's Disease Fahr's Syndrome Failure failure to thrive Fainting Fainting and Dizziness Fainting- What Causes It Fainting: Action Fainting: First Aid Fairbank Disease Falciparum Malaria Fall Allergies Fallopian Tube Fallopian tube procedures [in Infertility] Fallot's Tetrology Falls Falls and Hip Fractures Falls, Old Age

68. The Worster-Drought Syndrome And Other Syndromes Of Dementia With Spastic Parapa familial presenile dementia with spastic paralysis. J Neurol Psychopathol 1933;1427–34. Aform of familial presenile dementia with spastic paralysis. http://neur.allenpress.com/neuronline/?request=get-document&issn=0022-3069&volum

69. Variant Alzheimer Disease With Spastic Paraparesis: Neuropathological Phenotype A form of familial presenile dementia with spastic paralysis. Brain 1940;63237–54.33. A form of familial presenile dementia with spastic paralysis. http://neur.allenpress.com/neuronline/?request=get-document&issn=0022-3069&volum

70. Children's Neurobiological Solutions New Gene For Rare Inherited paralysis May Aid Other Spinal Cord Research, Too nocure for HSP, which is also sometimes called familial spastic paraparesis or http://www.cnsfoundation.org/newsletter/newsletter_47/newsletter_06.html

Issue 47.0, September 28th, 2003 E-mail this to a friend New Gene For Rare Inherited Paralysis May Aid Other Spinal Cord Research, Too ANN ARBOR, MI - A single mutation in a single gene is enough to slowly rob people of their ability to walk, scientists from the University of Michigan and the University of Pennsylvania report today. And while the inherited defect itself is rare, its discovery may help researchers unravel the mysteries of much more common paralyzing conditions, from spinal cord injury to Lou Gehrig's disease. In a paper published online today in the American Journal of Human Genetics, and scheduled for the journal's October issue, the U-M and Penn team describes a new gene, called NIPA1, for a form of hereditary spastic paraplegia, or HSP. HSP is the name given to a group of disorders affecting about 20,000 Americans. HSP gradually disables its victims as long nerve cells in the spinal cord degenerate and muscles weaken and become spastic. It is often misdiagnosed as other nerve disorders, including multiple sclerosis, cerebral palsy, and amyotrophic lateral sclerosis (also called Lou Gehrig's disease).

71. Neurology -- Abstracts: Murillo Et Al. 53 (1): 50 To characterize a new gene locus for familial spastic paraparesis (FSP Tanguy, andE. Bertini Infantile ascending hereditary spastic paralysis (IAHSP) Clinical http://www.neurology.org/cgi/content/abstract/53/1/50

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: Figures Only for this Article Full Text of this Article Citation Map Email this article to a friend Correspondence: Submit a response to this article Similar articles found in: Neurology Online PubMed PubMed Citation This Article has been cited by: other online articles Search PubMed for articles by: Murillo, F. M. Hoffman, E. P. Alert me when: new articles cite this article Download to Citation Manager Neurology American Academy of Neurology Articles Genetic localization of a new locus for recessive familial spastic paraparesis to 15q13-15 H. Kobayashi, MD, PhD E. Pegoraro, MD, PhD G. Galluzzi, PhD G. Creel, MD C. Mariani, MD E. Farina, MD E. Ricci, MD G. Alfonso, MD R. M. Pauli, MD, PhD and E. P. Hoffman, PhD ehoffman@cnmc.org OBJECTIVE: To characterize a new gene locus for familial spastic paraparesis (FSP). BACKGROUND: FSP is a genetically heterogeneous group of upper motor neuron syndromes. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked disorder. Four loci

72. Neurologic Manifestations Christopher Reeve paralysis Foundation. Cure paralysis Now. Worlds Wheelchair Culture. Hereditaryspastic Paraplegia/familial spastic Paraperesis C Stapley. http://www.mic.ki.se/Diseases/C10.597.html

search search staff sitemap ABOUT KAROLINSKA INSTITUTET ... print this page Diseases and Disorders Links pertaining to Neurologic Manifestations Alert! Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider. Start Page Contents: Agnosia Amnesia Aphasia Apraxias ... Vertigo Cerebellar Ataxia Classification of Ataxias - Washington U./School of Med. (US) Hereditary Ataxia Overview - GeneTests The US National Ataxia Foundation - Minneapolis European Federation of Hereditary Ataxias Int'l Network of Ataxia Friends De ADCA-Vereniging Nederland [cerebellar atrophy/ataxia syndrome] - (NL) About Episodic Ataxia [Mark ? ] Chorea Sydenham's Chorea (St. Vitus' Dance, Rheumatic Chorea) - Adam, via MedlinePlus The legend about Vitus - Catholic Online Saints Tardive Dyskinesia (not on MeSH) About Tardive Dyskinesia [JR Brasic] - eMedicine Tardive Dyskinesia [B Alexander] - Virtual Hoispital Dystonia Dystonia Dialogue , and about

73. Full Listing DEFECTS AND ABNORMALITIES, BRACHIAL PLEXUS paralysis, BRAIN INJURED familial HYPERCHOLESTEROLAEMIA,familial HYPERLIPIDAEMIA, familial spastic PARAPLEGIA, FAMILY http://www.doctor.gp/help/full_listing.htm

DIRECTORY OF BRITISH SELF HELP GROUPS AND SUPPORT ORGANISATIONS by Steve and Julie Garrill Home

74. Entrez PubMed This syndrome probably represents a new type of familial spastic paraparesis. Musclespasticity/metabolism; paralysis/genetics*; paralysis/metabolism; http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3

75. Entrez PubMed familial spastic paraparesis an adrenoleukodystrophy phenotype? spasticity/genetics*;Muscle spasticity/metabolism; paralysis/genetics*; paralysis/metabolism; http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstra

76. Volume 67 January - December 1944 A form of familial presenile dementia with spastic paralysis. C . WorsterDrought, JG . Greenfield and WH . McMenemey. Pages 38 - 43. http://www3.oup.co.uk/jnls/supplements/braini/hdb/Volume_67/Issue_01/670038.sgm.

Volume 67: January - December 1944 Issue 1: March 1944 Abstract A form of familial presenile dementia with spastic paralysis C Worster-Drought JG Greenfield and WH McMenemey Pages: Part of the OUP Brain WWW service General Information Click here to register with OUP. This page is maintained by OUP admin Last updated 13 May 97 Part of the OUP Journals World Wide Web service Oxford University Press, 1997

77. Volume 63 January - December 1940 A form of familial presenile dementia with spastic paralysis. C . WorsterDrought, JG . Greenfield and WH . McMenemey. Pages 237 - 254. http://www3.oup.co.uk/jnls/supplements/braini/hdb/Volume_63/Issue_03/630237.sgm.

Volume 63: January - December 1940 Issue 3: September 1940 Abstract A form of familial presenile dementia with spastic paralysis C Worster-Drought JG Greenfield and WH McMenemey Pages: Part of the OUP Brain WWW service General Information Click here to register with OUP. This page is maintained by OUP admin Last updated 13 May 97 Part of the OUP Journals World Wide Web service Oxford University Press, 1997

78. VI. DISEASES OF THE NERVOUS SYSTEM AND SENSE ORGANS INFLAMMATORY pathetic, or vegetative system Excludes familial dysautonomia Riley Includescerebral palsy NOS spastic infantile paralysis congenital spastic http://www.nber.org/mortality/1995/docs/ch06.txt

79. Entrez PubMed screening of the ALS2 gene in sporadic and familial amyotrophic lateral in a homogeneousphenotype of infantileonset ascending spastic paralysis with bulbar http://ghr.nlm.nih.gov/gene=als2/show/PubMed

Entrez PubMed Nucleotide Protein ... Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes 3D Domains Domains Gene GEO GEO DataSets HomoloGene Journals MeSH NCBI Web Site OMIM PMC PopSet SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Limits: 10 Years Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: Sort Author Journal Pub Date Text File Clipboard E-mail Order Items 1-20 of 23 of 2 Next Green CB, Cheng G, Chandra J, Mukherjee P, Ghannoum MA, Hoyer LL. Related Articles, Links RT-PCR detection of Candida albicans ALS gene expression in the reconstituted human epithelium (RHE) model of oral candidiasis and in model biofilms. Microbiology. 2004 Feb;150(Pt 2):267-75.

80. Entrez PubMed No abstract, Juvenile familial amyotrophic lateral sclerosis two siblings. Abstract,Infantileonset ascending hereditary spastic paralysis is associated with http://ghr.nlm.nih.gov/condition=amyotrophiclateralsclerosistype2/show/PubMed

Entrez PubMed Nucleotide Protein ... Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes 3D Domains Domains Gene GEO GEO DataSets HomoloGene Journals MeSH NCBI Web Site OMIM PMC PopSet SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Limits: 5 Years Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: Sort Author Journal Pub Date Text File Clipboard E-mail Order Items 1-16 of 16 One page. Hand CK, Devon RS, Gros-Louis F, Rochefort D, Khoris J, Meininger V, Bouchard JP, Camu W, Hayden MR, Rouleau GA. Related Articles, Links Mutation screening of the ALS2 gene in sporadic and familial amyotrophic lateral sclerosis. Arch Neurol. 2003 Dec;60(12):1768-71.

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