41. Paraplegia, Hereditary Spastic covered by this report. Synonyms familial spastic Paraplegia; FSP; HSP;spastic Spinal familial paralysis; Strumpell s familial Paraplegia; http://my.webmd.com/hw/health_guide_atoz/nord398.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Quizzes, Calculators Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report Paraplegia, Hereditary Spastic Important It is possible that the main title of the report Paraplegia, Hereditary Spastic is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Familial Spastic Paraplegia FSP HSP Spastic Spinal Familial Paralysis Strumpell's Familial Paraplegia Strumpell-Lorrain Familial Spasmodic Paraplegia Strumpell Disease Strumpell-Lorraine Syndrome Disorder Subdivisions Hereditary spastic paraplegia, complicated Hereditary spastic paraplegia, uncomplicated ("pure")

42. SPF - Spastic Paraplegia Foundation Home Page to the spastic Paraplegia Foundation, Inc familial spastic Paraparesis (or paraplegia), spastic Paraplegia, Strümpell Disease, Hereditary CharcotDisease, spastic Spinal paralysis http://www.sp-foundation.org/

Welcome to the Spastic Paraplegia Foundation, Inc. (SPF) Alerts and Breaking News Research and Beyond Conference and TeamWalk SPF awards $10,000 Grant See Calendar for events April-May E-News March E-News The SPF is the only non-profit organization in the Americas dedicated exclusively to neurodegenerative disorders called Primary Lateral Sclerosis (PLS) and Hereditary Spastic Paraplegia* (HSP). These diseases attack one's ability to walk, often leaving their victims in wheelchairs. They can also rob people of their ability to use their hands and arms, and even to speak. In very rare conditions, they can also cause mental retardation, dementia, epilepsy or other neurologic problems. The Spastic Paraplegia Foundation is a 100% volunteer-managed and operated organization devoted to supporting research to discover the causes and cures for these devastating diseases and to providing critical information and support programs to people affected by them. We are enormously grateful to our

43. Paraplegia, Hereditary Spastic - Quest Diagnostics Patient Health Library covered by this report. Synonyms. familial spastic Paraplegia; FSP; HSP;spastic Spinal familial paralysis; Strumpell s familial Paraplegia; http://www.questdiagnostics.com/kbase/nord/nord398.htm

document.write(''); var hwPrint=1; var hwDocHWID="nord398"; var hwDocTitle="Paraplegia, Hereditary Spastic"; var hwRank="1"; var hwSectionHWID="nord398"; var hwSectionTitle=""; var hwSource="us6.0"; var hwProdCfgSerNo="wsh_html_059_c"; var hwDocType="NORD"; National Organization for Rare Disorders, Inc. Paraplegia, Hereditary Spastic Important It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Familial Spastic Paraplegia FSP HSP Spastic Spinal Familial Paralysis Strumpell's Familial Paraplegia Strumpell-Lorrain Familial Spasmodic Paraplegia Strumpell Disease Strumpell-Lorraine Syndrome Disorder Subdivisions Hereditary spastic paraplegia, complicated Hereditary spastic paraplegia, uncomplicated ("pure") General Discussion According to researchers, changes (mutations) of many different genes may cause HSP. In most cases, such mutations appear to be transmitted as an autosomal dominant trait. More rarely, mutations for HSP may be inherited as an autosomal recessive or X-linked recessive trait. The basic underlying defect or defects in HSP are unknown. However, associated symptoms appear to result from progressive degenerative changes of regions of the spinal cord (corticospinal tracts) that convey motor impulses from the brain to muscles involved in controlling certain voluntary movements Resources WE MOVE (Worldwide Education and Awareness for Movement Disorders)

44. Paraplegia familial spastic Paraplegia (FSP) is also known Hereditary spastic Paraplegia HomePage In depth look quadriplegia, paraplegia, and paralysis information for http://www.health-nexus.com/paraplegia.htm

Health-Nexus.Net Health-Nexus.Org The #1 Health information site Home ... Up Search Health-Nexus for: Match ALL words Match ANY word Email this page to a friend ! Post a question or comment on our Message Board Home Page Health Specialties Health News ... Alternative Health Options Substance Abuse Animal Health Search: Books Magazines Video Keywords: Find it Here Paraplegia apssci.org: Home : American Paraplegia Society (APS) Paraplegia OVERVIEW: FUNCTIONAL OUTCOMES: THORACIC, LUMBER, AND SACRAL INJURIES - PARAPLEGIA T-1 injuries are the first level with normal hand function. HSPinfo.org - Hereditary Spastic Paraplegia Site Information about the spinal cord disorder known as Familial Spastic Paraparesis (FSP), also known as Hereditary Spastic Paraplegia (HSP) or Strumpell-Lorrain. NINDS Hereditary Spastic Paraplegia Information Page Hereditary Spastic Paraplegia information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS). ... SPF - Spastic Paraplegia Foundation Home Page Spastic Paraplegia Foundation (SPF) Home Page. The SPF is responsible for the spread of information involving upper motor neuron disorders called Hereditary Spastic Paraplegia (HSP) and Primary ...

45. Spastic 35, cp spastic. 4. spastic paraplegia. 24, familial paraparesis spastic. 4. spasticcerebral palsy. 22, 3. spastic diplegia. 17, spastic paralysis. 3. spastic bowel.16, http://www.websters-online-dictionary.org/definition/english/Sp/Spastic.html

Philip M. Parker, INSEAD. Spastic Definition: Spastic Spastic Adjective . Relating to or characterized by spasm; "a spastic colon"; "spastic paralysis is a spastic form of cerebral palsy". . Suffering from spastic paralysis; "a spastic child". . Affected by involuntary jerky muscular contractions; resembling a spasm; "convulsive motions"; "his body made a spasmodic jerk"; "spastic movements". Noun . A person suffering from spastic paralysis. Source: WordNet 1.7.1 Date "spastic" was first used: references Etymology: Websters 1913 Specialty Definition: Spastic Domain Definition Health 1. of the nature of or characterized by spasms. 2. hypertonic, so that the muscles are stiff and the movements awkward. 3. a person exhibiting spasticity, such as occurs in spastic paralysis or in cerebral palsy. ( references Medicine Relating or referring to spasm; affected with spasm; characterized by a spasm or spasms. Source: European Union. references Relating or belonging to spasm; produced by spasm; one affected with spasticity. Source: European Union.

46. Hereditary Spastic Paraplegia The Official Patient s Sourcebook on HEREDITARY spastic PARAPLEGIA (familial spasticParaplegia; spastic Spinal familial paralysis; Strumpell Disease; Strumpell http://www.icongrouponline.com/health/Hereditary_Spastic_Paraplegia.html

ICON Health Publications Official Health Sourcebooks The Official Patient's Sourcebook on HEREDITARY SPASTIC PARAPLEGIA (Familial Spastic Paraplegia; Spastic Spinal Familial Paralysis; Strumpell Disease; Strumpell-Lorrain Familial Spasmodic Paraplegia; Strumpell-Lorraine Syndrome; Strumpell's Familial Paraplegia) Revised and Updated for the Internet Age P A P E R B A C K Paperback Book Paperback Book Order by phone: 800-843-2665 (within USA) 1-201-272-3651 (from outside USA) Paperback Book Shipped in 3 to 5 business days E B O O K Electronic File * E-Book version sent via e-mail in 2 business days Electronic File *E-Book version sent via e-mail in 2 business days Pages Price $28.95(USD) ISBN Published Synopsis A comprehensive manual for anyone interested in self-directed research on Hereditary Spastic Paraplegia. Fully referenced with ample Internet listings and glossary. Related Conditions/Synonyms Familial Spastic Paraplegia; Spastic Spinal Familial Paralysis; Strumpell Disease; Strumpell-Lorrain Familial Spasmodic Paraplegia; Strumpell-Lorraine Syndrome; Strumpell's Familial Paraplegia Description Table of Contents Introduction Overview Organization Scope Moving Forward PART I: THE ESSENTIALS Chapter 1. The Essentials on Hereditary Spastic Paraplegia: Guidelines

47. Strümpell-Lorrain Disease (www.whonamedit.com) French), spasmodic infantile paraplegia, spastic congenital paraplegia, spasticfamilial paraplegia, spastic familial paralysis, spastic infantile paralysis http://www.whonamedit.com/synd.cfm/1759.html

Home List categories Eponyms A-Z Biographies by country ... Contact Whonamedit.com does not give medical advice. This survey of medical eponyms and the persons behind them is meant as a general interest site only. No information found here must under any circumstances be used for medical purposes, diagnostically, therapeutically or otherwise. If you, or anybody close to you, is affected, or believe to be affected, by any condition mentioned here: see a doctor. Strümpell-Lorrain disease Also known as: Strümpell's familial paraplegia Strümpell-Lorrain type Strümpell-Lorrain familial spasmodic paraplegia Synonyms: Facial spastic paraplegia, familial spastic paraplegia, familial spastic paraparesis, French settlement dsease, hereditary spastic paraparesis, hereditary spastic paraplegia, paraplégie spasmodique familiale (French), spasmodic infantile paraplegia, spastic congenital paraplegia, spastic familial paraplegia, spastic familial paralysis, spastic infantile paralysis, spastic spinal familial paralysis Associated persons: Maurice Lorrain Ernst Adolf Gustav Gottfried von Strümpell Description: A familial form of paraplegia characterized by spasticity – hypertonicity and weakness - limited mainly to the lower extremities. This is followed by involvement of upper limbs, dysarthria, and dysphagia. Degeneration of the pyramidal tract of the spinal cord and of the columns of Goll is the principal histological feature. Ocular complications may include strabismus, pupillary defects, macular degeneration, and optic atrophy. Occurs in either sex, but is more common in young males. This is a very rare disease, with a frequency of about 1 in 30.000 persons. It is most common in Nordic countries. Inheritance is autosomal recessive (usually), or sex-linked.

48. Www.whonamedit.com A familial form of intermittent hypocalcaemic paralysis spastic paraplegia of thelower extremities and mental resulting in chronic bulbar paralysis, which may http://www.whonamedit.com/syndlist.cfm/103

Home List categories Eponyms A-Z Biographies by country ... Contact Whonamedit.com does not give medical advice. This survey of medical eponyms and the persons behind them is meant as a general interest site only. No information found here must under any circumstances be used for medical purposes, diagnostically, therapeutically or otherwise. If you, or anybody close to you, is affected, or believe to be affected, by any condition mentioned here: see a doctor. Eponyms in category: Paralysis 98 main and alternative entries found. Albert Mouchet's syndrome (Mouchet's paralysis) A historical term for a paralysis of the cubital nerve following fractures of the external condyle of the humerus in childhood. Albright-Hadorn syndrome A now obsolete eponym used to indicate the occurrence of paroxysmal hypokalemic muscular paralysis associated with osteomalacia in patients with renal tubular acidosis. Balint's syndrome A syndrome combining paralysis of visual fixation, optic ataxia, and impairment of visual fixation. Balint-Holmes syndrome (Balint's syndrome) A syndrome combining paralysis of visual fixation, optic ataxia, and impairment of visual fixation.

49. Hereditary Spastic Paraplegia Spasmodic Paraplegia, Strumpell s familial Paraplegia, Spasmodic Infantile Paraplegia,spastic Congenital Paraplegia, spastic Spinal familial paralysis). http://www.kumc.edu/gec/support/hsp.html

Hereditary Spastic Paraplegia / Familial Spastic Paraparesis (Strumpell-Lorrain Familial Spasmodic Paraplegia, Strumpell's Familial Paraplegia, Spasmodic Infantile Paraplegia, Spastic Congenital Paraplegia, Spastic Spinal Familial Paralysis) Hereditary Spastic Paraplegia / Familial Spastic Paraparesis - web page: http://www.geocities.com/HotSprings/Spa/2847/ To locate a genetic counselor or clinical geneticist in your area: Professional Genetics Societies Genetic clinics, centers, departments Genetic Societies Clinical Resources ... Search Genetics Education Center Debra Collins, M.S. CGC , Genetic Counselor, dcollins@kumc.edu This site subscribes to the principles of the HONcode (Health on the Net, Code of Conduct for Medical and Health Web Sites) of the Health On the Net Foundation

50. Dorlands Medical Dictionary syndrome. hereditary cerebrospinal paralysis, hereditary spastic paraplegia.hyperkalemic periodic paralysis, see familial periodic p. http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszS

51. FSP:Patient-Informations accepted · FSP familial spastic paraplegia · HSP - Hereditary spastic paraplegia· SPG - spastic paraplegia · SSP - spastic spinal paralysis Division http://www.fsp-info.de/engl/infopat.htm

Disease History Name of the Disease The two Frenchmen Lorrain and Charcot made the same experience what is an explanation for the following names the disease was first given: Later the following definitions were added: The abbreviations which are mainly used still today can partly be lead back to the above names. However, the English designations have been widely accepted: Division and Classification Thanks to Anita Harding from London we have now a classification of this clinically heterogeneous clinical picture. Basically, the disease is divided into a "pure" and a "complicated" form, whereas the "complicated" form additionally to the spastic shows other symptoms like epilepsy or dernence. In the order of their discovery the forms of "pure" spastic are genetically divided into SPG1 to SPG7. These designations stand for externally similar clinical pictures, which however have to be attributed to different genes or devolution forms. Genetics Because of the growing importance of genetics and molecular biology various researcher (groups) try to find out, whether the different forms of this illness can be attributed to one or several genes (carrier of genetic information). And they want to find which ways the devolution runs within the families. There is a dominant and a recessive characteristic and a difference is made between sex-specific and neutral transmission.

52. The FSP Page - Familial Spastic Paraparesis Strümpell s familial paraplegia, spasmodic infantile paraplegia, spastic congenitalparaplegia, spastic spinal familial paralysis, hereditary spastic http://www.geocities.com/HotSprings/Spa/2847/

Welcome to the FSP Page! Familial Spastic Paraparesis Hereditary Spastic Paraplegia The FSP Page now has a new name and new location! Please vist our new site at: Spastic Paraplegia Foundation- http://sp-foundation.org Hereditary spastic paraplegia is an inherited spinal cord disorder characterized by gradual development of muscle weakness, spasms, and stiffness of the legs. Symptoms may be first noticed in early childhood, or at any age though adulthood. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms may appear, or the weakness and stiffness may spread to other parts of the body. The terms "Hereditary Spastic Paraplegia" (HSP) and "Familial Spastic Paraparesis" (FSP) are the commonly used names in the United States for this disorder. For those in Europe, "Strumpell-Lorrain" is probably more common. These terms all refer to the same set of disorders. Other names associated with this disease are Strümpell-Lorrain familial spasmodic paraplegia, Strümpell's familial paraplegia, spasmodic infantile paraplegia, spastic congenital paraplegia, spastic spinal familial paralysis, hereditary spastic paraparesis, and familial spastic paraplegia.

53. SPF - Spastic Paraplegia Foundation Home Page for HSP familial spastic Paraparesis (or paraplegia), spastic Paraplegia, StrümpellDisease, Hereditary CharcotDisease, spastic Spinal paralysis, Diplegia http://sp-foundation.org/

Welcome to the Spastic Paraplegia Foundation, Inc. (SPF) Alerts and Breaking News Research and Beyond Conference and TeamWalk SPF awards $10,000 Grant See Calendar for events April-May E-News March E-News The SPF is the only non-profit organization in the Americas dedicated exclusively to neurodegenerative disorders called Primary Lateral Sclerosis (PLS) and Hereditary Spastic Paraplegia* (HSP). These diseases attack one's ability to walk, often leaving their victims in wheelchairs. They can also rob people of their ability to use their hands and arms, and even to speak. In very rare conditions, they can also cause mental retardation, dementia, epilepsy or other neurologic problems. The Spastic Paraplegia Foundation is a 100% volunteer-managed and operated organization devoted to supporting research to discover the causes and cures for these devastating diseases and to providing critical information and support programs to people affected by them. We are enormously grateful to our

54. General Search FSD French Settlement Disease FSP - familial spastic paraparesis Hereditary spasticgait spastic paraplegia spastic Spinal paralysis spasticity SSP http://www.athenadiagnostics.com/site/product_search/search.asp

Test Names for Keyword(s) Test Name Code Synonyms ADmark Tau/Aß42 CSF Analysis and Interpretation (Symptomatic) Alzheimer's Amyloid Beta 42 Dementia ADmark Alzheimer's ApoE Apolipoprotien E Dementia ADmark Alzheimer's Dementia Presenilin-1 PS-1 ADmark Profile (Symptomatic) Alzheimer's Amyloid Beta 42 ApoE Apolipoprotien E Dementia ADmark Alzheimer's Dementia Presenilin-1 PS-1 Amyloidosis Evaluation (TTR) ATTR Familial Amyloid Cardiomyopathy Familial Amyloid Polyneuropathy (FAP) Transthyretin (TTR) Amyloidosis Aprataxin DNA Sequencing Test Ataxia ARX DNA Sequencing Test Abnormal genitalia Agenesis of the corpus callosum Autistic features Infantile spasms Seizures Atlastin (SPG3A) DNA Sequencing Test Diplegia spinalis progressiva FSD - French Settlement Disease FSP - familial spastic paraparesis Hereditary progressive spastic paraplegia HSP - hereditary spastic paraparesis Spastic gait Spastic paraplegia Spastic Spinal Paralysis Spasticity SSP - Spastic spinal paralysis Strümpell Disease or Strümpell-Lorrain-Disease Autosomal Dominant Ataxia Evaluation Marie ataxias Multiple system atrophy Olivopontocerebellar atrophy (OPCA) Spinocerebellar ataxia (SCA) Botulinum Toxin Type A Antibody Test Botox Carpal Tunnel Syndrome Evaluation HMSN Median neuropathy Chorea Differential Evaluation HD Huntington's chorea Chromosome Analysis - Routine Congenital abnormality Downs Syndrome (Trisomy 21) Dysmorphism

55. Genetic Testing French Settlement Disease FSP familial spastic paraparesis Hereditary spastic gaitspastic paraplegia spastic Spinal paralysis spasticity Strümpell http://www.athenadiagnostics.com/site/product_search/test_description_template.a

56. New Gene For Rare Inherited Paralysis May Aid Other Spinal Cord Research, Too New gene for rare inherited paralysis may aid other spinal cord research, too. nocure for HSP, which is also sometimes called familial spastic paraparesis or http://www.eurekalert.org/pub_releases/2003-09/uomh-ngf092503.php

Public release date: 25-Sep-2003 Contact: Kara Gavin kegavin@umich.edu University of Michigan Health System New gene for rare inherited paralysis may aid other spinal cord research, too ANN ARBOR, MI – A single mutation in a single gene is enough to slowly rob people of their ability to walk, scientists from the University of Michigan and the University of Pennsylvania report today. And while the inherited defect itself is rare, its discovery may help researchers unravel the mysteries of much more common paralyzing conditions, from spinal cord injury to Lou Gehrig's disease. In a paper published online today in the American Journal of Human Genetics, and scheduled for the journal's October issue, the U-M and Penn team describes a new gene, called NIPA1, for a form of hereditary spastic paraplegia, or HSP. HSP is the name given to a group of disorders affecting about 20,000 Americans. HSP gradually disables its victims as long nerve cells in the spinal cord degenerate and muscles weaken and become spastic. It is often misdiagnosed as other nerve disorders, including multiple sclerosis, cerebral palsy, and amyotrophic lateral sclerosis (also called Lou Gehrig's disease). There is no cure for HSP, which is also sometimes called familial spastic paraparesis or Strumpell-Lorain disease. Treatment is limited to physical therapy and exercise to help retain as much muscle function as possible, drug treatment to tame spastic muscle movements, and medication to treat patients' bladder and bowel control problems, and depression.

57. Spastic Medline NLM definition paralysis of the on spastic paraplegia Hereditary spasticparaplegia factsheet Support Groups familial spastic Paraplegia Support Group http://www.ion.ucl.ac.uk/library/patient/spastic.htm

Spastic paraplegia Medline NLM definition: paralysis of the legs and lower part of the body. PubMed search on spastic paraplegia Hereditary spastic paraplegia factsheet: National Institute for Neurological Disorders and Stroke Support Groups Familial Spastic Paraplegia Support Group FSP Group Secretary, 18 Tainter's Brook, Uckfield, East Sussex, TN22 1UQ, England Provides information and advice, runs a telephone helpline. WE MOVE 204 West 84th Street, New York, NY 10024, USA Outside the US, Tel: 212-241-8567 Fax: 212-987-7363 Email: wemove@wemove.org Excellent website on movement disorders. Includes: Information on disorders and treatment; Answers to FAQ's; An international listing of support and advocacy organizations and links to their web sites; A schedule of regional and national support group events; Web chats; News on the latest research; Links to other sites of interest and affinity groups.

58. HealthCentral - General Encyclopedia - Familial Periodic Paralysis and tests The health care provider may suspect familial periodic paralysis basedon a Weakness is flaccid rather than spastic and is greater in the http://www.healthcentral.com/mhc/top/000312.cfm

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59. NORD - National Organization For Rare Disorders, Inc. Synonyms of Paraplegia, Hereditary spastic FSP; familial spastic Paraplegia;HSP; spastic Spinal familial paralysis; Strumpell Disease; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Paraplegia, H

60. Fahr's Disease with increased muscle stiffness (rigidity) and restricted movements (spastic paralysis). reportsin the medical literature, Fahr s Disease is often familial. http://www.bchealthguide.org/kbase/nord/nord597.htm

document.write(''); var hwPrint=1; var hwDocHWID="nord597"; var hwDocTitle="Fahr's Disease"; var hwRank="1"; var hwSectionHWID="nord597"; var hwSectionTitle=""; var hwSource="cn6.0"; var hwProdCfgSerNo="wsh_html_031_s"; var hwDocType="NORD"; National Organization for Rare Disorders, Inc. Fahr's Disease Important It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Cerebrovascular Ferrocalcinosis Fahr Disease Nonarteriosclerotic Cerebral Calcifications SPD Calcinosis Striopallidodentate Calcinosis Idiopathic Basal Ganglia Calcification (IBGC) Disorder Subdivisions None Related Disorders List Information on the following diseases can be found in the Related Disorders section of this report: Parkinson Disease General Discussion According to reports in the medical literature, Fahr's Disease is often familial. Familial Fahr's Disease may be transmitted as an autosomal recessive trait or, in other affected families (kindreds), may have autosomal dominant inheritance. In other instances, the condition appears to occur randomly for unknown reasons (sporadically). Some experts suggest that the condition may sometimes result from an unidentified infection during pregnancy affecting the developing fetus (intrauterine infection). Symptoms Fahr's Disease is marked by abnormal calcium deposits in areas of the brain, notably the basal ganglia, cerebral cortex, dentate nucleus, subthalamus and red nucleus areas. Loss of brain cells also occurs. These mineral deposits may also be found in areas where the myelin sheath surrounding nerves has been lost (demyelination), and in fatty (lipid) deposits. The heads of people with Fahr's Disease are often smaller than normal and appear to be round.

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