41. Inherited Hypercoagulation Disorders: The Factor V Leiden Mutation: Patient Info Inherited Hypercoagulation Disorders The factor v leiden Mutation. When a wound occurs, several changes take place to minimize blood loss. http://www.telemedicine.arizona.edu/patient_info/benign_disorders/disorders/inhe

Patient Information Resource: Benign Hematologic (Blood) Disorders A collaborative project of the Arizona Telemedicine Program , the Arizona Health Sciences Library and the Arizona Cancer Center See: Inherited Hypercoagulation Disorders: The Factor V Leiden Mutation When a wound occurs, several changes take place to minimize blood loss. First, the blood vessel slows the flow of blood past the wound site. Next, platelets collect at the wound site to form a plug. Finally, fibrin clots form scabs to replace these temporary platelet plugs. heparin or warfarin (Coumadin) or fibrinolytic therapy may be effective. : This web site and its contents are designed for educational purposes only. This web site does not render medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, you should consult your health care provider. Arizona Cancer Center 1515 N. Campbell Ave.

42. Factor V Leiden factor v leiden. factor v leiden is a hypercoagulability disorder where one of the coagulation factors cannot be deactivated. It http://www.fact-index.com/f/fa/factor_v_leiden.html

Main Page See live article Alphabetical index Factor V Leiden Factor V Leiden is a hypercoagulability disorder where one of the coagulation factors cannot be deactivated. It is a genetic disorder, and 3-5% of the population is believed to have this condition. Factor V Leiden is an autosomal dominant condition, where this coagulation factor has a mutation and cannot be destroyed by activated protein C (aPC). The actual point mutation causes an arginine to be replaced with a glutamine, at the 506th amino acid. This is a cleavage site for protein C. As factor V cannot be inactivated, it continues to assist in the production of thrombin, and so thrombi form in the veins. Up to 30% of patients who present with venous thrombosis, or pulmonary embolism have this mutation. This disease can be diagnosed by watching the APTT (the time it takes for blood to clot) as activated protein C is added. With a normal patient, adding aPC increases the APTT. With Factor V Leiden, adding aPC will barely affect the time it takes for blood to clot. PCR , treatment with MnlI, and then DNA electrophoresis will give a quick diagnosis.

43. E-News 2:19 - Factor V Leiden May 12, 2000 Volume 2, Issue 19, Midwifery Today ENews “factor v leiden”, 4) Pregnancy, Clotting, and factor v leiden An Overview. http://www.midwiferytoday.com/enews/enews0219.asp

Home Publications Articles Forums ... Shop FREE Newsletters Read Past Issues Publications Midwifery Today The Birthkit ... Germany 2004 Community Forums International Alliance of Midwives Shop Online Resources Read Articles The Birth Market Find a Midwife Today Find a Doula Today ... Subscribe (Spring 1997) Miscarriage Now on sale for just $8! Direct-entry midwifery? Certified Nurse-Midwifery? What's best for you? Read Paths and find out. Learn about hemorrhage and hemorrhage prevention. Order your copy today. May 12, 2000 Volume 2, Issue 19 Midwifery Today E-News Subscribe Print Page Search Archive Index ... Subscribe to E-News! Code 940 o=o=o=o=o=o=o This issue of Midwifery Today E-News is sponsored by: -Bailey Advertising Co. -Nacer en Casa Conference -Natural Medicine Newsletter -Waterbirth Website Look for their ads below! o=o=o Pregnant? Learn about safe and effective techniques that midwives use. Attend our conference in New York City! WARNING: You will be massaged, honored, respected and loved by midwives from all over the world! Extreme pleasure may be experienced.

44. Consensus Statement On Factor V Leiden Mutation Testing American College of Medical Genetics Consensus Statement on factor v leiden Mutation Testing. Wayne W. Grody, MD, PhD 1 , John H. Griffin http://www.acmg.net/resources/policies/pol-009.asp

American College of Medical Genetics Consensus Statement on Factor V Leiden Mutation Testing Wayne W. Grody, MD, PhD , John H. Griffin, PhD , Annette K. Taylor, MS, PhD , Bruce R. Korf, MD, PhD , and John A. Heit, MD (ACMG Factor V Leiden Working Group) From the: Divisions of Medical Genetics and Molecular Pathology, UCLA School of Medicine, Los Angeles, California; Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California; Kimball Genetics, Denver, Colorado; Division of Genetics and Department of Neurology, Children's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota. SUMMARY OF ISSUES AND RECOMMENDATIONS Issue 1: Which methodology should be used: Factor V Leiden DNA testing or functional activated protein C (APC) resistance testing? Recommendation 1 When appropriate clinical care requires testing for the factor V Leiden allele, either direct DNA-based genotyping or a factor V Leiden-specific functional assay is recommended. Patients who test positive by a functional assay should then be further studied with the DNA test for confirmation and to distinguish heterozygotes from homozygotes. Patients on heparin therapy or with known lupus anticoagulant should proceed directly to molecular testing if the modified functional assay is not used. When relatives of individuals known to have factor V Leiden are tested, the DNA method is recommended. Issue 2: Who should be tested?

45. Factor V Leiden Polymorphism (FV:R506Q) factor v leiden Polymorphism (FV R506Q ). Test Overview. Methodology factor v leiden Mutation by Polymerase Chain Reaction (PCR). http://pathology.mc.duke.edu/coag/fvlflyer2.html

Factor V Leiden Polymorphism (FV Test Overview Resistance to activated protein C (APC) is a frequently identified abnormality in patients with venous thrombosis. In patients presenting with an initial venous thromboembolic event, as many as 21% have APC resistance. Furthermore, in patients with recurrent venous thrombosis, as many as 60% have APC resistance. APC resistance has also been associated with atypical thromboembolic complications, including portal vein thrombosis and cerebral sinus thrombosis. Exposure to certain environmental risk factors, such as surgery, pregnancy, or oral contraceptives, can further increase the risk for a venous thrombotic event. Although APC resistance is a common finding in patients with venous thrombosis, it is seldom identified as a risk factor for arterial thrombosis. Laboratory screening for APC resistance consists of clotting assays that measure the degree of prolongation of the plasma clotting time upon the addition of APC. In more than 90% of cases, APC resistance is linked to a single polymorphism in the factor V gene. This polymorphism, known as Factor V Leiden (Factor V ), involves a single base pair substitution at position 1691 in the factor V gene, resulting in substitution of the arginine (R) at position 506 by glutamine (Q). This substitution blocks an important APC-cleavage site in factor Va after position 506, thereby resulting in a decreased ability of APC to inactivate the procoagulant factor Va. This single polymorphism results in the observed hypercoagulable state that leads to an increased risk for venous thromboembolism.

46. Class II Special Controls Guidance Document: Factor V Leiden DNA Mutation Detect Guidance for Industry and FDA Staff. Class II Special Controls Guidance Document factor v leiden DNA Mutation Detection Systems. http://www.fda.gov/cdrh/oivd/guidance/1236.html

FDA Home Page CDRH Home Page Search CDRH A-Z Index ... Contact CDRH Guidance for Industry and FDA Staff Class II Special Controls Guidance Document: Factor V Leiden DNA Mutation Detection Systems Document issued on: March 16, 2004 For questions regarding this guidance, contact Elizabeth Mansfield at (301) 594-1293, ext. 168 U.S. Department of Health and Human Services Food and Drug Administration Center for Devices and Radiological Health Division of Immunology and Hematology Devices Office of In Vitro Diagnostic Device Evaluation and Safety Contains Nonbinding Recommendations Preface Public Comment: Written comments and suggestions may be submitted at any time for Agency consideration to the Division of Dockets Management, Food and Drug Administration, 5630 Fishers Lane, Room 1061, (HFA-305), Rockville, MD, 20852. Alternatively, electronic comments may be submitted to http://www.fda.gov/dockets/ecomments. Please identify your comments with the docket number listed in the notice of availability that publishes in the Federal Register announcing the availability of this guidance document. Comments may not be acted upon by the Agency until the document is next revised or updated.

47. [Member Story - Factor V Leiden: My Dreams Are Clear] - Trustworthy, Physician-R Learn more, Member Stories, factor v leiden My Dreams Are Clear, WebMD DISCLAIMER. Find a Clinical Trial. factor v leiden Finding Out More. Jennifer s Story. http://content.health.msn.com/content/pages/14/89392.htm

H_URL_BASE="http://help.msn.com/en-us"; H_APP="MSN Health"; H_CONFIG="MSN_Channel_Health.ini"; H_BURL="http://content.health.msn.com/includes/MSNinc/design/framework/fs.htm"; H_TOPIC="CHANNEL_HELP_Health_StartPage.htm"; L_H_APP=H_APP;bSearch=false; MSN Home My MSN Hotmail Shopping ... Money Web Search: Health Email This Page Newsletters Help ... Sign in Search Health Health Home Health Topics Fitness Healthy Living WaterCooler Check out today's buzz Also from MSN Win Dream Trip! Find Senior Housing Lose Weight sponsored Health Mall New Epilepsy Help Whiten Your Smile! Adult ADHD? Tame the Pain Sign up for the Health Newsletter Your e-mail address: Preferred Format HTML (graphical) Plain Text Learn more Member Stories Factor V Leiden: My Dreams Are Clear Member Stories are reader submissions that are not medically reviewed. Contact your doctor for medical advice or treatment. COMMUNITY Find support and ask questions on our message boards: General Health: Barry Wolcott, MD All Message Boards RESOURCES Find a Clinical Trial Factor V Leiden: Finding Out More Jennifer's Story In November 1999, I was taken to the emergency room after several episodes of fainting.

48. A To Z Encyclopedia Topic: Factor V Leiden Clinical Services. Unfortunately, at this time, we are not able to provide information about this condition or procedure. However http://web1.tch.harvard.edu/cfapps/A2ZtopicDisplay.cfm?Topic=Factor V Leiden

49. Factor V Leiden & Pregnancy Loss I am factor v leiden, homozygous, with a healthy son. My sister is heterozygous. Can the factor v leiden abnormality be responsible for this? http://www.ivillagehealth.com/experts/fertility/qas/0,,242115_192851,00.html

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50. GenID :: Factor V - Leiden Factor VLeiden Thromboses are caused by disorders of the coagulation system. The altered Factor V gene product is called factor v leiden (FVL). http://www.aid-diagnostika.com/english/kits/GenID/rdb_2005e_factor5.htm

POSITION : Kits Molecular-diagnostic Kits Factor V-Leiden Prothrombin 20210A ... References Risk Factors of Genetic Thrombosis: Factor V-Leiden and Prothrombin 20210A Reverse hybridization kit for the determination of the mutation FV:Q506 in the Factor V gene and the mutation 20210A in the Factor ll gene RDB 2005E Factor V-Leiden Thromboses are caused by disorders of the coagulation system. One later complication can be the development of a lung emboly. One of the regulating factors of the coagulation system is Activated Protein C (APC), which is a serin protease influencing the coagulation process together with a cofactor by proteolytic inactivation of Factor Va and VIIIa, two components of the coagulation cascade. Factor Va is derived from the Factor V-Protein by cleavage, which in turn is mediated by Factor IIa. According to current knowledge, the resistance against Activated Protein C (APC) is the most common genetic risk factor for venose coagulation disorders. The cause is a point mutation in the Factor V-gene bringing about a substitution of guanin (G) by adenin (A) at position 1691. In the translated protein this results in the substitution of the amino acid arginin by glutamin at the position 506 (FV:Q ). The altered Factor V gene product is called Factor V Leiden (FVL).

51. Factor V (Leiden) Mutation Analysis The factor v leiden mutation leads to the laboratory finding of APCR and is associated with a 7fold increase in venous thromboembolic events in heterozygous http://www.questdiagnostics.com/hcp/intguide/jsp/showintguidepage.jsp?fn=TH_Fact

52. Factor V Leiden (R506Q) - DNA Analysis factor v leiden, DNA Analysis, R506Q Mutation. factor v leiden R506Q mutation DNA ANALYSIS See also Thrombophilia Panel DNA Analysis. http://www.bcmgeneticlabs.org/tests/dna/factorvleiden.html

FACTOR V LEIDEN R506Q mutation DNA ANALYSIS See also: Thrombophilia Panel - DNA Analysis Open Page in New Window Print This Page Return to Search Genetic risk factors are involved in the predisposition of individuals to venous thrombosis. These factors include inherited resistance to activated protein C (APC) as well as deficiencies in antithrombin III, protein C and protein S. APC resistance is a major basis for familial thrombosis and is common in the general population (2-5%). APC resistance is frequently associated with factor V Leiden, a point mutation in the factor V gene. Individuals heterozygous for this mutation have an increased risk for venous thrombosis (approximately 5- to 10-fold). Individuals homozygous for this mutation have an even higher risk for venous thrombosis (approximately 50- to 100-fold). Prophylactic anticoagulation therapy should be considered for carrier individuals at risk in situations where venous stasis is likely (i.e. prolonged bed rest after surgery). Analysis for the Factor V Leiden R506Q mutation is offered as a specific DNA test, or as part of a

53. Factor V Leiden / Thrombophilia Online. Mailing list that offers support and information for persons affected by factor v leiden (thrombophilia), a hereditary blood coagulation disorder. http://www.bchealthguide.org/kbase/shc/shc29fac.htm

document.write(''); var hwPrint=1; var hwDocHWID="shc29fac"; var hwDocTitle="Factor V Leiden / Thrombophilia"; var hwRank="1"; var hwSectionHWID="shc29fac"; var hwSectionTitle=""; var hwSource="cn6.0"; var hwProdCfgSerNo="wsh_html_031_s"; var hwDocType="SHC"; Self Help Clearinghouse Factor V Leiden / Thrombophilia Factor V Leiden Mailing List and Digest Online. Mailing list that offers support and information for persons affected by Factor V Leiden (thrombophilia), a hereditary blood coagulation disorder. Daily digest (condensed version of the mailing list) also available. WEBSITE: http://www.fvleiden.org/mail_list.htm VERIFIED: 3/31/2003 The above information is based upon information available through the "verified" date at the end of each listing. Since American Self-Help Group Clearinghouse's resources are limited; it is not possible to keep every entry in the American Self-Help Group Clearinghouse database completely current and accurate. Please check with the organizations listed for the most current information. For additional information and assistance about self-help groups, please contact the American Self-Help Group Clearinghouse in Cedar Knolls, New Jersey, by email at: info@selfhelpgroups.org

54. Conditions And Diseases, Blood Disorders, Factor V Leiden Submit Your Site to the factor v leiden category. Sponsored factor v leiden Sites. Submit Your Site to the factor v leiden category. Health Spotlight. http://www.iseekhealth.com/factor_v_leiden-1162.php

Home About Us Contact Submit Your Site Search : Home Health Conditions and Diseases Blood Disorders ... Factor V Leiden More Factor V Leiden Categories: Submit Your Site to the Factor V Leiden category Sponsored Factor V Leiden Sites Blood Disorder Products- Lowest Prices At DealTime! Eliminate Body Toxins and Pollutants NOW ! All-natural proprietary herbal blend effectively draws out minerals, drugs, chemical toxins, and heavy metal compounds from the body organs and systems. Guaranteed results. Secure ordering. The Original Neem Company Our name says it all. Your source for high-quality neem bark, leaf, oil and related products. For over 20 years, we are neem. Satisfaction guaranteed. Activated Protein C Resistance - Discusses the thrombotic risks of this inherited disorder, also known as Factor V Leiden. Living with Factor V Leiden - Factor V Leiden is the most common hereditary blood coagulation disorder in the United States. It is present in 5% of the American population. The Role of Activated Protein C Resistance in the Pathogenesis of Venous Thrombosis - Center for Disease Control's page discussing the background of this disorder including study results, testing, and complications.

55. Armed Forces Institute Of Pathology (AFIP) - Welcome factor v leiden. The sensitivity and specificity of factor v leiden mutation detection are each believed to exceed 99%. Indications for Testing. http://www.afip.org/Departments/cell/Factor-V-Leiden.html

Hot Topics Consultation Education What's New? ... Contact Us DEPARTMENT OF CELLULAR PATHOLOGY DIVISION OF MOLECULAR PATHOLOGY Factor V Leiden Submit Five ml of blood in sodium citrate or EDTA anticoagulant (light blue or lavender top tube) Methodology The ThirdWave Invader assay is used to detect a portion of the factor V gene which contains the mutation site. The sensitivity and specificity of Factor V Leiden mutation detection are each believed to exceed 99%. Indications for Testing According to the American College of Medical Genetics, testing for Factor V Leiden is appropriate in the following circumstances: Venous thrombosis in unusual sites (such as hepatic, mesenteric, and cerebral veins). Recurrent venous thrombosis. Venous thrombosis and a strong family history of thrombotic disease. Venous thrombosis in pregnant women or women taking oral contraceptives. Relatives of individuals with venous thrombosis under age 50. Myocardial infarction in female smokers under age 50. Testing may also be appropriate in other situations. Clinical Significance Factor V Leiden mutations have also been linked with thrombotic events other than deep-venous thrombosis, including recurrent miscarriage. In addition, there may be interactions with other risk factors for thrombosis, including use of oral contraceptives, pregnancy, and immobilization.

56. Factor V Leiden/Prothrombin Gene PCR Assay The University of Iowa Department of Pathology LABORATORY SERVICES HANDBOOK, factor v leiden/Prothrombin Gene PCR Assay, Order Code PROTPCR. http://www.medicine.uiowa.edu/Path_Handbook/handbook/test764.html

The University of Iowa Department of Pathology LABORATORY SERVICES HANDBOOK Factor V Leiden/Prothrombin Gene PCR Assay Order Code: PROTPCR Molecular Pathology/Diagnostics 6004 BT GH Order Form: 0-4 Miscellaneous Requisition Specimen: Whole Blood Collection Medium: Lavender top tube (EDTA) Minimum: Adults - 3 ml, lavender top tube (EDTA) Children - 2 ml, lavender top tube (EDTA) Testing Schedule: 0800-1700 Testing offered once per week excluding weekends and University holidays. For additional services, contact Clinical Pathology Resident on-call at pager #3724 or #3404. Analytic Time: 14 days Reference Range: Normal Comments: Genomic DNA is PCR amplified and the presence of the Factor V Leiden and Prothrombin mutations associated with venous thrombosis are assessed simultaneously by gel electrophoresis. CPT codes used; 83890, 83901 (x2), 83894, 83912 Methodology: Polymerase Chain Reaction (PCR) CPT Code: See comments Alphabetic main page Updated: 04/09/2004 Note : The information contained in this handbook is for use by personnel of University of Iowa Health Care. No other use is implied or intended.

57. Factor V Leiden factor v leiden factor v leiden is the most common genetic predisposition risk to venous thromboembolisms. Venous thrombosis is http://genetics.hillcrest.com/factor_v_leiden.htm

Chapman Homepage Molecular Homepage Molecular Test Listing Molecular Requisition Factor V Leiden: Factor V Leiden is the most common genetic predisposition risk to venous thromboembolisms. Venous thrombosis is a worldwide health problem resulting in significant illness and death. Both genetic as well as environmental factors, e.g. smoking and oral contraceptives, contribute to the incidence of the disease. A G1691A mutation (Arg506Gln) in the Factor V gene (chromosome 1q23) leads to a resistance to the anticoagulation factor protein C (APC-resistant). Individuals that carry one copy of this mutation have a 5- to 10-fold increase risk for venous thrombosis; individuals that carry two of these mutations have a 50- to 100-fold increase risk for venous thrombosis. Between 3% and 7% of the US population are carriers of the mutation and at increased risk. Prophylactic anticoagulation therapy should be considered for carriers in high-risk situations such as surgery. REASONS FOR REFERRAL: To determine the potential cause of unexplained thrombosis in children or adults.

58. Hemostasis Reference Laboratory DNA/Factor V Leiden (APC Hemostasis Reference Laboratory DNA Studies (Thrombosis), Next . DNA/factor v leiden (APC Resistance) Mutation. Transaction Code 325003. http://www.psbc.org/medical/labs/coagulation/thrombosisdna01.htm

59. Factor V Leiden Genetic Testing (DNA Testing) at the Clinical Molecular Diagnostic Laboratory of the City of Hope National Medical Center in Duarte, California. factor v leiden. http://www.cityofhope.org/cmdl/factor5.asp

Genetic Testing (DNA Testing) at the Clinical Molecular Diagnostic Laboratory of the City of Hope National ... Center in Duarte, California Factor V Leiden The factor V Leiden mutation, also designated as 1691 G>A or R506Q, is the major heritable risk factor for venous thromboembolism . This mutation in the coagulation factor V gene results in resistance of factor V to inactivation by activated protein C (APC) . Approximately 5% of Caucasians are either heterozygous carriers or homozygous for the factor V Leiden mutation; the prevalences are lower for other ethnic groups To open a printable assay summary in a new window, click the link below. Factor V Leiden Assay Summary (in portable document format (pdf) which requires to view or print; download latest version free References 1. Voorberg, J. et al. (1994). Lancet 2. Zoller, B. and Dahlback, B. (1994). Lancet 3. Bertina, R. M. et al. (1994). Nature 4. Greengard, J. S. et al. (1994). Lancet 5. Sun, X. et al. (1994).

60. Group For Factor V Leiden And PG Highrisk Pregnancy Discussion Board. Group for factor v leiden and PG A lot of ladies here have factor v leiden and MTHFR Kitty. Messages In This Thread. http://interact.pregnancytoday.com/cgi-bin/boards/boardhighrisk.pl?read=2751

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