21. Entrez PubMed Click here to read factor v leiden mutation and pregnancy complications Article in Lithuanian Abraitis V, Mongirdiene A, Mockeviciene A. Clinic of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

22. Factor V Leiden - Information / Diagnosis / Treatment / Prevention home blood disorders blood coagulation factor v leiden factor v leiden. Information • Diagnosis • Treatment • Prevention. http://www.healthcyclopedia.com/blood-disorders/blood-coagulation/factor-v-leide

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... blood coagulation > factor v leiden Factor V Leiden Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Related Topics Health News Web Directory: Related Topics: Cardiovascular Disorders/Vascular Disorders/Thrombosis Genetic Disorders Health News: Search millions of published articles for news on Factor V Leiden Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: Activated Protein C Resistance Discusses the thrombotic risks of this inherited disorder, also known as Factor V Leiden. Factor Five Leiden Support Support for sufferers of the Factor Five Leiden blood clotting disorder, an inherited blood condition discovered in 1995. History, glossary, and meeting information (Oregon). Living with Factor V Leiden Factor V Leiden is the most common hereditary blood coagulation disorder in the United States. It is present in 5% of the American population.

23. Factor V Leiden factor v leiden Factor 5 Leiden. PCR for factor v leiden Responsible for 95% of APC resistance; Does NOT require that patient be off Anticoagulation. http://www.fpnotebook.com/HEM26.htm

Home About Links Index ... Editor's Choice document.write(code); Advertisement Hematology and Oncology Coagulopathy Assorted Pages Coagulation Bleeding Disorders Dysfibrinogenemia Hemophilia A Factor IX Deficiency ... Perioperative Anticoagulation Factor V Leiden Factor 5 Leiden APC Resistance Activated Protein C resistance Book Home Page Cardiovascular Medicine Dentistry Dermatology Emergency Medicine Endocrinology Gastroenterology General Medicine Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Hematology and Oncology Index Anemia Cancer Coagulopathy Cardiovascular Medicine Dermatology Endocrinology Otolaryngology Examination Gastroenterology Hemoglobin Hemolysis Histiocytosis HIV Infectious Disease Laboratory Leukemia General Pulmonology Lymph Marrow Neurology Obstetrics Orthopedics Pediatrics Pharmacology Platelet Prevention Procedure Psychiatry Rheumatology Sarcoma Surgery Symptom Evaluation Vascular Page Coagulopathy Index Bleeding Bleeding Dysfibrinogenemia Bleeding Hemophilia A Bleeding Hemophilia B Bleeding Von Willebrands Clotting Pathway Background Clotting Pathway Common Clotting Pathway Extrinsic Clotting Pathway Inhibition Clotting Pathway Intrinsic DIC Hypercoagulable Hypercoagulable Antithrombin III Hypercoagulable APC resistance Hypercoagulable Fibrinolysis Hypercoagulable Protein C-S Epidemiology

24. Factor V factor v leiden / APC resistentie. 1 op de 5 mensen is drager van factor v leiden. Hiervan Wat is factor v leiden / APC resistentie? Factor http://www.factorvleiden.nl/factor5.htm

Sitemap Lotgenotencontact Forum E-mail ... Redactie Dit ad(d)ertje onder het gras, leid je direct naar de mailinglist Startpagina N ieuws T ... Links Factor V Leiden / APC resistentie 1 op de 5 mensen is drager van Factor V Leiden. Hiervan krijgt een groot gedeelte nooit klachten. Wat is Factor V Leiden / APC resistentie? Factor V Leiden / APC resistentie (ongevoeligheid) is de meest voorkomende stollingsafwijking . Deze twee termen lijken verwarrend maar eigenlijk zijn het twee termen voor één afwijking. Kort samengevat: Door een defect op het vijfde gen (factor V) krijgt APC niet de kans zijn werk te doen. Met APC is niets mis, het gaat fout in Factor V. Acht procent van de Nederlandse bevolking heeft een APC resistentie en heeft hierdoor een zes keer zo groot risico op trombose In combinatie met anticonceptie is dit risico zelfs veertig keer zo groot. Twintig tot veertig procent van mensen die een trombose hebben gehad hebben een APC resistentie / Factor V Leiden. Factor V is een van de twaalf stollingsfactoren die zijn vastgelegd in onze genen. Het zorgt ervoor dat het bloed stolt waar dat nodig is, bijvoorbeeld bij een wond. Factor V werkt samen met Factor X, maar maakt ook gebruik van proteïne C en proteïne S om de stolling op tijd te stoppen (het inactiveert / remt Factor V op het juiste moment). Net genoeg om de wond te dichten en net niet genoeg om stolsels te vormen. Andere " stollingsremmers " zijn

25. Factor V Leiden Beginpagina — Ziekten en aandoeningen — factor v leiden factor v leiden Meer informatie. factor v leiden startpagina; Lotgenotencontact; http://www.erfocentrum.nl/zena/facto.php

erfelijkheid.nl winkel mail ons nieuwsbrief ... sitemap ZIEKTEN EN AANDOENINGEN ERFELIJKHEID LITERATUUR (PARA)MEDICI Beginpagina ... Ziekten en aandoeningen Factor V Leiden Factor V Leiden Synoniem APC resistentie Korte beschrijving Factor V Leiden is een aangeboren en erfelijke bloedstollingziekte. Door Factor V Leiden blijft het bloed stollen. De factor V in het bloed is afwijkend. Daardoor kan het APC niet functioneren. APC betekent: geactiveerd Proteïne C. Het APC heeft een taak bij het stoppen van de bloedstolling. Als iemand een wondje heeft komt daar door bloedstolling een korstje op. Eerst vormt zich een voorlopig afdeklaagje. Aan dit afdeklaagje hechten zich stoffen, onder andere factor V. Factor V heeft de functie de bloedstolling te stoppen zodra het korstje stevig genoeg is. Maar bij ongevoeligheid voor APC (APC resistentie) reageert Factor V te langzaam op de werking van APC. Daardoor wordt het bloed te stolbaar. Stolseltjes kunnen vervolgens aangroeien en ergens in het lichaam een verstopping in de bloedbaan veroorzaken. Dit leidt tot trombose. Trombose komt vaak voor in de bloedvaten van de benen. Trombose kan ook op andere plaatsen in het lichaam voorkomen. Als het in de longen optreedt is er sprake van longembolie. Sommige situaties verhogen de kans dat Factor V Leiden opspeelt. Zoals het gebruik van de anticonceptiepil, zwangerschap, roken of te weinig bewegen.

26. PT 20210 Why get the factor v leiden test and PT 20210 test; when to get the factor v leiden test and PT 20210 test for venous thromboembolism; what sample is needed. http://www.labtestsonline.org/understanding/analytes/pt_20210/glance.html

27. Factor V Leiden And PT 20210: The Test Explains how factor v leiden and PT 20210 are used; when factor v leiden and PT 20210 are used; what the results of factor v leiden and PT 20210 might mean. http://www.labtestsonline.org/understanding/analytes/factor_v_and_pt20210/test.h

TESTS Test not listed? A/G Ratio ACE ACT ACTH AFB Culture AFP Maternal AFP Tumor Marker Albumin Aldosterone Allergies ALP Alpha-1 Antitrypsin ALT Amylase ANA Antibody Tests Apo A Apo B ApoE Genotyping aPTT AST Autoantibodies Bilirubin Blood Culture Blood Gases Blood Smear BMP BNP Bone Markers BRCA BUN C-peptide CA-125 CA 15-3 CA 19-9 Calcium Cardiac Risk CBC CEA Celiac Disease Tests CF Gene Mutation Chlamydia Chloride Cholesterol CK CK-MB CMP CMV Coagulation Factors Complement Levels Cortisol Creatinine Creatinine Clearance CRP CRP, high-sensitivity Cystatin C D-dimer DHEAS Differential DLDL EGFR Electrolytes Electrophoresis ESR Estrogen Estrogen Receptors Factor V Leiden Fecal Occult Blood Ferritin fFN Fibrinogen Flu Tests Folate Fructosamine FSH Genotypic Resistance GFR GGT Glucose Gonorrhea Gram Stain Growth Hormone H-pylori hCG HDL Hematocrit Hemoglobin Hemoglobin Variants Hepatitis A Hepatitis B Hepatitis C Her-2/neu Herpes HIV Antibody HLA-B27 Home Tests Homocysteine HPV hs-CRP IGF-1

28. UAB Health System | Blood Disorder (Factor V) Answer You are probably asking about a condition called factor v leiden, since Factor V deficiency is a very rare bleeding disorder. http://www.health.uab.edu/show.asp?durki=61617&site=734&return=18687

29. Factor V Leiden: Should All Pregnant Women Be Tested For Clotting Disorders? factor v leiden Should all pregnant women be tested for clotting disorders? One of my friends experienced a stillbirth. It was http://www.parentsplace.com/pregnancy/trimester1/qas/0,,166389_433344,00.html

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30. Public Health Genetics Unit: Thrombophilia And Leiden Factor V factor v leiden is the most common form of hereditary thrombophilia in the UK. Hormone replacement therapy and the factor v leiden mutation. Arterioscler. http://www.phgu.org.uk/info_database/diseases/thrombosis/thrombophilia.html

Text-only sitemap Home About Newsletter ... Search Thrombophilia and Leiden Factor V See Explanatory Notes Contents: Genetics Factor V (Leiden) thrombophilia Other hereditary forms of thrombophilia Gene-environment interactions ... On-line information Thrombophilia is the term used to refer to an inherited or acquired disorder of the haemostatic (blood clotting) system that causes an increased risk of venous thrombosis (blood clots in the veins). Examples of venous thrombosis include DVT (deep vein thrombosis) of the limbs or pulmonary embolism; these conditions are sometimes grouped together as venous thromboembolism, or VTE. The incidence of VTE in the general populations of Western countries is around 1-3 per 1000 individuals. Treatment of venous thromboembolism uses anti-coagulants, typically heparin in the acute phase of VTE followed by a period of treatment with coumadin to prevent further VTEs. Long-term management of patients who have experienced thrombosis includes avoidance of risk factors that make thromboembolism more likely, and the use of prophylactic (preventative) anti-coagulant therapy in situations where risk is known to be increased, for instance during surgery. Genetics Factor V (Leiden) thrombophilia Inherited thrombophilia is a genetically determined predisposition to venous thromboembolism, and may be caused by a number of known mutations. Factor V Leiden is the most common form of hereditary thrombophilia in the UK. Between 3 and 7% of the Caucasian population have a single copy of the mutant Factor V Leiden gene (

31. Genaissance - Solutions - GLP Genotyping - Factor V Leiden factor v leiden is associated with the following complications venous thrombosis (blood clots, especially with oral contraceptives); deep vein thrombosis (DVT http://www.dna.com/products_services/capabilitiesServices_cg_factor.asp

Available Assays Choose an Assay... APOE COMT Factor V Leiden PPAR This mutation is in the initial cleavage site of Factor Va, which disrupts the recognition by Activate Protein C. The result is a long-lived Factor Va and a hypercoaguable state. The clinical name for this condition is Activate Protein C resistance (APCR), which is the most common inherited risk factor in venous thrombosis. Heterozygosity for this mutation is associated with a 5 to 10-fold increased risk of developing a venous thrombitic episode while homozygosity for this mutation is associated with a 50 to 100-fold increased risk. Factor V Leiden is associated with the following complications: venous thrombosis (blood clots, especially with oral contraceptives); deep vein thrombosis (DVT, blood clots in veins); unexplained miscarriage; blood clots in the lungs or anywhere else; gall bladder dysfunction; preeclampsia and/or eclampsia (toxemia while pregnant); and stroke and/or heart attack. Phenotype expression: Blood clots Therapeutic significance: Cardiovascular disease What gene codes for: Clotting factor Indications for use of assay: Concern of thrombophilia Allele Description: The FV allele is a G1691 to A substitution that results in an Arg506 to Gln amino acid change.

32. Factor V Leiden - Medical Dictionary Definitions Of Popular Medical Terms MedicineNet Home MedTerms medical dictionary AZ List factor v leiden. Advanced Search. http://www.medterms.com/script/main/art.asp?articlekey=25022

33. Factor V Leiden / Thrombophilia factor v leiden Mailing List and Digest. factor v leiden / Thrombophilia factor v leiden Mailing List and Digest Online. Mailing http://my.webmd.com/hw/health_guide_atoz/shc29fac.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Quizzes, Calculators Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... Factor V Leiden Mailing List and Digest Factor V Leiden / Thrombophilia Factor V Leiden Mailing List and Digest Online. Mailing list that offers support and information for persons affected by Factor V Leiden (thrombophilia), a hereditary blood coagulation disorder. Daily digest (condensed version of the mailing list) also available. WEBSITE: http://www.fvleiden.org/mail_list.htm VERIFIED: 3/31/2003 The above information is based upon information available through the "verified" date at the end of each listing. Since American Self-Help Group Clearinghouse's resources are limited; it is not possible to keep every entry in American Self-Help Group Clearinghouse database completely current and accurate. Please check with the organizations listed for the most current information. For additional information and assistance about self-help groups, please contact the American Self-Help Group Clearinghouse in Cedar Knolls, New Jersey, by email at: info@selfhelpgroups.org

34. Factor V Leiden Genetic Testing distributed. Professor FE Preston, Rutledge Mews 3 Southbourne Road Sheffield S10 2QN, factor v leiden, P20210A, Citrated whole blood. http://www.ukneqas.org.uk/Directory/HAEM/fact5lei.htm

United Kingdom National External Quality Assessment Service "helping to ensure clinical laboratory test results are accurate, reliable and comparable wherever they are produced" Navigation About EQA Directory Scheme Webs ... Webmaste r Office Members Participants Director Address Investigations covered Material distributed Professor FE Preston Rutledge Mews 3 Southbourne Road Sheffield Factor V Leiden, P20210A Citrated whole blood personal email Manager / other staff Year started Recognised UK NEQAS talwoods@coageqa. demon.co.uk Mr TAL Woods telephone scheme email CPA(UK) Accreditation Distributions / samples coag@ukneqas.org.uk Awaiting inspection fax scheme web UK public/private labs UK non-clinical labs www.ukneqasbc.org Performance assessment Information provided Non-UK labs by country Availability The purpose of the scheme is to provide external quality assessment of genetic tests for disorders of haemostasis, in the first instance, the Factor V Leiden mutation In addition to the main function of EQA, the scheme also hopes to offer advisory support in trouble-shooting. Meetings for participants are organised on an annual basis (c.f.), with presentations from authoritative speakers and open discussion on current scheme issues

35. Factor V Leiden Mutation - Encyclopedia Article About Factor V Leiden Mutation. encyclopedia article about factor v leiden mutation. factor v leiden mutation in Free online English dictionary, thesaurus and encyclopedia. http://encyclopedia.thefreedictionary.com/Factor V Leiden mutation

Dictionaries: General Computing Medical Legal Encyclopedia Factor V Leiden mutation Word: Word Starts with Ends with Definition Factor V Leiden is a hypercoagulability disorder in which one of the coagulation factors Coagulation is a fairly complex process by which liquid blood becomes solid clots. It is an important part of hemostasis where a damaged blood vessel is ultimately covered by a fibrin clot to stop blood loss. Disorders in coagulation can lead to hemorrhage, thrombosis, or embolism. Ordinarily coagulation is initiated within seconds after an injury occurs when platelets form a plug at the site of injury. This is called primary hemostasis . Following this, various plasma components, called clotting factors respond (in a complex cascade) to form fibrin strands which strengthen the platelet plug. Click the link for more information. cannot be deactivated. It is a genetic disorder A genetic disorder , or genetic disease is a disease caused, at least in part, by the genes of the person with the disease. There are a number of possible causes for genetic defects: They may be caused by an unwelcome mutation, as are most cancers.

36. Factor V Leiden - Encyclopedia Article About Factor V Leiden. Free Access, No Re More results from encyclopedia.thefreedictionary.com PDF CPPCPP http://encyclopedia.thefreedictionary.com/Factor V Leiden

Dictionaries: General Computing Medical Legal Encyclopedia Factor V Leiden Word: Word Starts with Ends with Definition Factor V Leiden is a hypercoagulability disorder in which one of the coagulation factors Coagulation is a fairly complex process by which liquid blood becomes solid clots. It is an important part of hemostasis where a damaged blood vessel is ultimately covered by a fibrin clot to stop blood loss. Disorders in coagulation can lead to hemorrhage, thrombosis, or embolism. Ordinarily coagulation is initiated within seconds after an injury occurs when platelets form a plug at the site of injury. This is called primary hemostasis . Following this, various plasma components, called clotting factors respond (in a complex cascade) to form fibrin strands which strengthen the platelet plug. Click the link for more information. cannot be deactivated. It is a genetic disorder A genetic disorder , or genetic disease is a disease caused, at least in part, by the genes of the person with the disease. There are a number of possible causes for genetic defects: They may be caused by an unwelcome mutation, as are most cancers.

37. Circulation -- Ornstein And Cushman 107 (15): 94 Cardiology Patient Page. factor v leiden. The clot remains in place while other enzymes repair the damaged blood vessel. What Is factor v leiden? http://circ.ahajournals.org/cgi/content/full/107/15/e94

PDF Version of this Article Citation Map Email this article to a friend Similar articles found in: Circulation Online PubMed PubMed Citation Search PubMed for articles by: Ornstein, D. L. Cushman, M. Alert me when: new articles cite this article Download to Citation Manager Collections under which this article appears: Deep vein thrombosis Heparin Coumarins Thrombophilia ... Thrombosis risk factors Circulation. Cardiology Patient Page Factor V Leiden Deborah L. Ornstein, MD Mary Cushman, MD, MSc From the Departments of Medicine (D.L.O., M.C.) and Pathology (M.C.), Hematology/Oncology Unit, University of Vermont/Fletcher Allen Health Care, Burlington, Vt. Correspondence to Deborah L. Ornstein, MD, Department of Medicine, Vermont Center for Thrombosis and Hemostasis, University of Vermont/Fletcher Allen Health Care, UHC Campus, St Joseph 3, 1 South Prospect St, Burlington, VT 05401. E-mail deborah.ornstein@vtmednet.org You may have been tested for the condition known as factor V Leiden (pronounced factor five lye -den) because you or someone in your family has had a blood clot in one of the deep veins of the body (also called deep vein thrombosis, or DVT) or a

38. Resistance To Activated Protein C Resistance to activated protein C due to Factor V R506Q (factor v leiden). THE PREVALENCE OF factor v leiden IN THE GENERAL POPULATION. http://www.jr2.ox.ac.uk/bandolier/bandopubs/keeling.html

@import "../styles/advanced.css"; Resistance to activated protein C due to Factor V R506Q (Factor V Leiden) David Keeling BSc MD MRCP MRCPath Consultant Haematologist Oxford Haemophilia Centre, Churchill Hospital, Oxford. The Discovery of Resistance to Activated Protein C and Identification of the Mechanism. The phenomenon of resistance to activated protein C (APC) was discovered only three years ago. Dahlback and colleagues identified a middle aged man with a personal and a family history of thrombosis whose APTT did not show the expected prolongation when exogenous APC was added to his plasma [1]. The same phenomenon was found in several of the patient's relatives. The mechanism was unknown but inheritance of a deficiency of a cofactor for APC was hypothesised. This proved not to be the case and one year later the molecular defect was identified as a point mutation in factor V (FV) [2]. The mutation was a G to A substitution at nucleotide position 1,691. This results in the arginine at position 506 (coding triplet CGA) being replaced by a glutamine (coding triplet CAA). Using the single letter amino-acid code the mutant FV can therefore be written as FV R506Q but is more often referred to as FV Leiden (Figure 1). Figure 1. The G to A point mutation results in the arginine at the protein C cleavage site being replaced by glutamine.

39. Factor V Leiden Mutation Analysis factor v leiden Mutation Analysis. Number. 511154. CPT. Use. Detection of Leiden mutation in factor V gene, causing increased risk of thrombosis. Limitations. http://www.labcorp.com/datasets/labcorp/html/chapter/mono/mg001200.htm

40. UCHSC DNA Diagnostic Laboratory-Factor V Leiden Testing UCHSC DNA Diagnostic Laboratory DNA Analysis for Venous Thrombosis (factor v leiden Mutation). General Information The Factor V http://www.uchsc.edu/sm/peds/dnalab/fv.htm

UCHSC DNA Diagnostic Laboratory DNA Analysis for Venous Thrombosis (Factor V Leiden Mutation) General Information: The Factor V Leiden mutation (R560Q) is present in 20-40% of patients with venous thrombosis, 40-65% of adults from families with unexplained thrombophilia, and approximately 95-100% of patients with the phenotype of activated protein C (APC) resistance. The Factor V Leiden mutation is a significant risk factor for venous thrombosis, particularly in the homozygous state or in combination with additional risk factors such as pregnancy, use of oral contraceptives or surgery. Methodology: This test includes preparation of DNA from peripheral blood and PCR based analysis for direct detection of the common Factor V Leiden mutation (R506Q). PCR is performed pursuant to a license agreement with Roche Molecular Systems, Inc. Use: Identification of individuals heterozygous or homozygous for the Factor V Leiden mutation. Indications: Venous thrombosis or history of a thrombotic event, activated protein C resistance by laboratory analysis, presence of another hereditary coagulation disorder (protein C deficiency, protein S or antithrombin III), family history of thrombosis or known Factor V Leiden mutation. V Leiden mutation. Specimen Requirements: Please see Instructions for Shipping and Handling Specimens Turnaround Time: 3-7 days (time required for culture of tissue specimens not included.) Cases are prioritized on an individual basis.

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