81. Targeting Breast Cancer Using Diptheria Toxin Targeting Breast Cancer Using diptheria Toxin. Senyon Choe, Ph. D. TheSalk Institute for Biological Studies. Award Type ITaMoCA, Innovative http://www.ucop.edu/srphome/bcrp/progressreport/abstracts/innov/2cb0063.html

Targeting Breast Cancer Using Diptheria Toxin Senyon Choe, Ph. D. The Salk Institute for Biological Studies Award Type: ITaMoCA, Innovative Treatments Modalities Duration: 2 yrs., 1996-1998 Initial Award Abstract Normally, the growth of human breast cells is closely controlled by the levels of hormones (such as estrogen) and growth-promoting proteins (such as heregulin). Heregulins are a class of proteins known to promote the unwanted growth of breast cancer cells under certain conditions. The overabundance of heregulin on the surface of breast cancer cells often indicates that the cancer has progressed to the stage that the cells are no longer responsive to estrogen treatment using a drug like tamoxifen. The counter balancing activities of these two classes of molecules, steroid hormones and growth-promoting proteins, are important in determining the progression of breast cancer. The ultimate goal of this proposal is to disrupt this balance in order to stop growth of breast cancer cells. In practice, our specific aim is to design a toxin protein that will kill cells carrying the growth-promoting protein heregulin. Diphtheria toxin is known to kill certain types of cells carrying a specific receptor protein on their surface. This toxin will serve as the starting material in our design of a new toxin for killing breast cancer cells. Our strategy is to create a toxin variant that is capable of recognizing and killing only those cancer cells carrying heregulin. We hypothesize that the targeted delivery of this toxin variant to these cells will effectively reduce the overall growth of breast cancer.

82. Victorian Llanfyllin - A Child Dies Of Diptheria The most common of the illnesses mentioned in school Log Books were scarlet fever,measles, whooping cough and diptheria. 17 November Death from diptheria. http://history.powys.org.uk/school1/llanfyllin/annie.shtml

home page places topics teachers Llanfyllin and district Victorian school days Search in Digital History The death of little Annie Davies Drawing by Rob Davies Schools in Victorian times always went in fear of infectious diseases which could spread rapidly when children from a wide area came together in the schoolroom. The most common of the illnesses mentioned in school Log Books were scarlet fever, measles, whooping cough and diptheria . Some diseases could be killers, and could become very serious very quickly. The example on this page is from Bwlchycibau School in Poor little Annie Davies was absent from school with a sore throat which led to her funeral just 8 days later ! 13th November 17th November 21st November These entries from the 1896 school Log Book read - 13 November "Annie Davies, and Mabel Owen are ill suffering from sore throats and cold". 17 November "Death from Diptheria. Annie Davies, the scholar mentioned above, died this morning".

83. 1875 -Diptheria Is Raging In Brockport, Cuba, Allegany Co., Is Afflicted With Th Batavia, Genesee County, New York State. Friday, July 231875. diptheriais raging in Brockport. Medina has 700 scholars on its school rolls. http://www.buffalonian.com/hnews/1875dipheria-miscnews.html

Neighboring Counties: Progressive Batavian Batavia, Genesee County, New York State Friday, July 23-1875 Diptheria is raging in Brockport. Medina has 700 scholars on its school rolls. Cuba, Allegany Co., is afflicted with the small pox. Steuben county has 51 Methodist Episcopal churches. There are about forty cheese factories in Wyoming county. Work has been suspended at the Union Car Works at East Buffalo. Wyoming county has a fund of $8,500 to build a soldiers' monument. They have a man dress-maker in Buffalo. Can such things bein America? A fire at Buffalo Sunday burned two shops belonging to the Buffalo and Philadelphia R.R., valued at $5,500. A female burglar was sentenced last Saturday in Buffalo to ten years imprisonment in the Erie county penitentiary.Canandaigua has 27 places licensed to sell liquor. The 'Messenger' of that place says: "No wonder the jail is crowded." A drunken man fell over the bank at Niagara on Tuesday, falling a distance of over one hundred feet and came out alive. The Lockport correspondent of the Buffalo 'Sunday News' takes a gloomy view of the financial situation of the business community in the city of Locks. He asserts "that with the exception of perhaps one or two instances there is not a merchant on Main St. who is, or has been for the past two months, paying their expenses."

84. DIPTHERIA IN THE FORMER SOVIET UNION 24.01.99, diptheria IN THE FORMER SOVIET UNION, News. Medscape http//www.medscape.com/govmt/CDC/EID/1998/v04.n04/e0404.04.vite/pnte0404.04.vite.html http://www.vaccinetwork.org/archivio/difterite/1999/24.01.99.html

DIPTHERIA IN THE FORMER SOVIET UNION News Medscape http://www.medscape.com/govmt/CDC/EID/1998/v04.n04/e0404.04.vite/pnt-e0404.04.vite.html Diphtheria in the Former Soviet Union: Reemergence of a Pandemic Disease Charles R. Vitek and Melinda Wharton, Centers for Disease Control and Prevention, Atlanta, Georgia, USA [Emerging Infectious Diseases 4(4):539-550, 1998. Centers for Disease Control] Abstract The massive reemergence of diphtheria in the Newly Independent States of the former Soviet Union marked the first large-scale diphtheria epidemic in industrialized countries in 3 decades. Factors contributing to the epidemic included a large population of susceptible adults; decreased childhood immunization, which compromised what had been a well-established childhood vaccination program; suboptimal socioeconomic conditions; and high population movement. The role of a change in the predominant circulating strains of Corynebacterium diphtheriae in this epidemic remains uncertain. Massive, well-coordinated international assistance and unprecedented efforts to vaccinate adults were needed to control the epidemic. Introduction In the 1990s, a massive epidemic throughout the Newly Independent States of the former Soviet Union marked the reemergence of epidemic diphtheria in industrialized countries. Diphtheria had been well controlled in the Soviet Union for more than 2 decades after universal childhood immunization was initiated in the late 1950s (Figure 1). Although all of the Newly Independent States were affected, three quarters of the more than 140,000 cases (Table 1) and two thirds of the more than 4,000 deaths reported since 1990[1-3] were reported by the Russian Federation.

85. PillSupplier.com - Conditions And Diseases/Infectious Diseases/Bacterial/Dipther Category diptheria. HOME ABOUT US ORDER STATUS BMI CALCULATOR FAQ CONTACTUS. Conditions and Diseases/Infectious Diseases/Bacterial/diptheria. Links http://www.pillsupplier.com/dir/1075/

Category: Diptheria HOME ABOUT US ORDER STATUS BMI CALCULATOR ... CONTACT US Prescription Drugs Diet Pills Adipex Bontril Didrex ... Login Conditions and Diseases/Infectious Diseases/Bacterial/Diptheria Links: An Old Plague Coming Back to Haunt Us: Diphtheria [rate it] [review it] Approximately 1200 deaths per year have resulted from the ongoing diphtheria epidemic in the former Soviet Union which began in 1990 and is still going strong. Diphtheria [rate it] [review it] An acute bacterial disease that can infect the body in two areas: the throat (respiratory diphtheria) and the skin (skin or cutaneous diphtheria). Diphtheria - Dr. Greene [rate it] [review it] Information on this childhood disease and immunization against it. eMedicine: Diphtheria [rate it] [review it] Emergency MD offers a clinical report on the respiratory form of diphtheria, including risk factors, common symptoms and treatments for this infectious disease. HealtHub [rate it] [review it] A brief definition of diptheria, followed by links to overviews, research articles, diagnosis, treatment and prevention. Search Looking for something in particular?

86. Health, Pharmacy, Drugs And Medications, D: Diptheria Toxoid With Tetanus Pertussis Hepatitis B and Polio. Certiva Full prescribinginformation from RxList. DTaP Vaccine - FamilyDoctor.org http://www.combose.com/Health/Pharmacy/Drugs_and_Medications/D/Diptheria_Toxoid/

Top Health Pharmacy Drugs and Medications ... Certiva - Full prescribing information from RxList. DTaP Vaccine - FamilyDoctor.org - Information for Patients in English or Spanish. Diptet - Full prescribing information from RxList. Tripedia - Full prescribing information from RxList. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor The combose.com directory is based on the Open Directory and has been modified and enhanced using our own technology. About ComboSE Download Combose Toolbar

87. Diphtheria Facts Diphtheria. Diphtheria is a very contagious and potentially lifethreatening bacterial disease. Diphtheria usually attacks the throat and nose. In more serious cases, it can attack the heart and nerves. http://www.astdhpphe.org/infect/dip.html

Diphtheria Diphtheria is a very contagious and potentially life-threatening bacterial disease. Diphtheria usually attacks the throat and nose. In more serious cases, it can attack the heart and nerves. Because of widespread immunization, diphtheria is very rare in the United States. Diphtheria is re-emerging in some areas of the world where immunization practices are lax. Routine vaccination of both children and adults is essential to prevent the re-emergence of diphtheria in the United States. What is diphtheria? Diphtheria is a very contagious and potentially life-threatening infection that usually attacks the throat and nose. In more serious cases, it can attack the nerves and heart. Because of widespread immunization, diphtheria is very rare in the United States. However, some people are not adequately vaccinated, and cases still occur. What is the infectious agent that causes diphtheria? Diphtheria is caused by Corynebacterium diphtheriae, a bacterium. The bacterium produces a toxin (poison) that is carried in the bloodstream. Where is diphtheria found?

88. Diphtheria Diphtheria. The Disease. Years ago, diphtheria was a widespread and greatly feared disease. Through the 1920's it struck about 150 000 people a year, and killed about 15 000 of them. http://www.ecbt.org/diphther.htm

Diphtheria The Disease Years ago, diphtheria was a widespread and greatly feared disease. Through the 1920's it struck about 150,000 people a year, and killed about 15,000 of them. Since then, these figures have dropped considerably, thanks to parents who have gotten their children immunized against this terrible disease. There were only 918 cases in 1960, 435 in 1970, and 128 in 1976. Today, only a few cases occur each year. Diphtheria is caused by a germ that lives in the mouth, throat, and nose of an infected person. It is easily passed to others through coughing or sneezing. Early symptoms of diphtheria are a sore throat, a slight fever, and chills. Usually, the disease develops in the throat. It can make it hard to swallow and even cause the patient to suffocate. Some people may be infected but not appear ill. They can also spread the infection. If diphtheria is not properly treated, or not treated in time, the bacteria may produce a powerful poison. This poison can spread throughout the body causing serious complications such as heart failure or paralysis. About 1 person in 10 who gets diphtheria dies from it. Immunization Diphtheria vaccine is usually given together with tetanus and pertussis vaccines in a shot called DTaP.

89. Facts About... Diphtheria The Facts About Diphtheria. What is diphtheria? Diphtheria is an acute infectiousdisease caused by a bacterium called Corynebacterium diphtheriae. http://www.amm.co.uk/pubs/fa_diphtheria.htm

The Facts About... Diphtheria What is diphtheria? Diphtheria is an acute infectious disease caused by a bacterium called Corynebacterium diphtheriae . This disease affects the upper respiratory tract and very occasionally the skin. Virulent strains of C. diphtheriae produce a toxin which can damage heart and nervous tissues, although non-toxigenic strains can cause a localised infection. A diphtheria-like illness is sometimes caused by another toxin-producing bacterium Corynebacterium ulcerans . Immunisation against diphtheria was introduced on a national scale throughout the United Kingdom in the early 1940s and resulted in a dramatic drop in the number of cases and deaths from the disease. For example, in 1940, 46,281 cases and 2,480 deaths were notified, compared with 37 cases and six deaths in 1957. Diphtheria is now rare in England and Wales, nearly all new cases are acquired abroad, and only two deaths due to diphtheria have been recorded since 1972. How does diphtheria spread and what symptoms does it cause?

90. Facts About Diphtheria For Adults Facts About Diphtheria For Adults. What is diphtheria? Diphtheria is an acute bacterial disease that usually affects the tonsils, throat, nose and/or skin. Click here for additional information http://www.nfid.org/factsheets/diphtadult.html

Facts About Diphtheria For Adults What is diphtheria? Diphtheria is an acute bacterial disease that usually affects the tonsils, throat, nose and/or skin. It is passed from person to person by droplet transmission, usually by breathing in diphtheria bacteria after an infected person has coughed, sneezed or even laughed. It can also be spread by handling used tissues or by drinking from a glass used by an infected person. Diphtheria can lead to breathing problems, heart failure, paralysis and sometimes death. Prevention There is a vaccine for diphtheria. Most people receive their first dose as children in the form of a combined vaccine called DTP (diphtheria-tetanus-pertussis). For adults, a combination shot, called a Td booster, protects against both tetanus and diphtheria. It should be administered once every 10 years after age 7 to maintain immunity. Symptoms In its early stages, diphtheria may be mistaken for a severe sore throat. Other symptoms include a low-grade fever and enlarged lymph nodes (swollen glands) located in the neck. Another presentation of diphtheria can be skin lesions that may be painful, red and swollen. Symptoms usually appear 2 to 4 days after infection, with a range of 1 to 6 days. People carrying diphtheria germs are contagious for up to 4 weeks without antibiotic therapy, even if they themselves do not develop symptoms. Who should get Td vaccine?

91. CDC Travelers' Health Information On Diphtheria, Tetanus, And Pertussis Diphtheria, Tetanus, and Pertussis http://www.cdc.gov/travel/diseases/dtp.htm

Contents Destinations Outbreaks Diseases Vaccinations ... USDA/APHIS Importing food, plant, animal products U.S. State Department Pan American Health Organization World Health Organization Home ... Purchase Diphtheria, Tetanus, and Pertussis Description Diphtheria is an acute bacterial disease involving primarily the tonsils, pharynx, larynx, nose, skin, and occasionally other mucous membranes. The characteristic lesion is marked by a patch or patches of an adherent grayish membrane with a surrounding inflammation. Pertussis is an acute bacterial disease involving the respiratory tract, characterized by prolonged paroxysmal coughing. Persons in all age groups can be infected. Complications and deaths from pertussis are most common among infants. Occurrence Diphtheria remains a serious disease throughout much of the world. In particular, large outbreaks of diphtheria occurred in the 1990s throughout Russia and the independent countries of the former Soviet Union. Most life-threatening cases occurred in unvaccinated or inadequately immunized persons. Children traveling to countries where the risk of diphtheria is high should be vaccinated according to the Recommended Childhood Immunization Schedule . Travelers to disease-endemic areas may be at increased risk for exposure to toxigenic strains of

92. Notice To Readers: Update On The Supply Of Tetanus And Diphtheria Toxoids And Of Notice to Readers Update on the Supply of Tetanus and Diphtheria Toxoidsand of Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5010a3.htm

Notice to Readers: Update on the Supply of Tetanus and Diphtheria Toxoids and of Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine During the last quarter of 2000, the U.S. Public Health Service learned of a shortage of tetanus and diphtheria toxoids (Td) and tetanus toxoid (TT) resulting from decreased production of these vaccines by the two U.S. manufacturers. Previously published recommendations outlined priorities for use of the limited supply of Td and TT ( ) . The shortage was expected to be resolved by early 2001; however, on January 10, 2001, Wyeth Lederle (Pearl River, New York)* announced it had stopped production of tetanus toxoid-containing products. Although a small amount of Td is produced by the University of Massachusetts for local distribution, Aventis Pasteur (Swiftwater, Pennsylvania) is now the sole nationwide distributor of Td and TT. Aventis Pasteur is shipping limited quantities of vaccine to assure a wide distribution of available doses. In accordance with previous recommendations, priority will be given to clinics and hospitals that treat acute wounds; continuing to prioritize Td and TT use will be necessary until supplies are restored (

93. Diphtheria Is it a bad sore throat, or could it be something worse? Find out how to immunize and protect your family against diphtheria in this article for parents. http://kidshealth.org/parent/infections/bacterial_viral/diphtheria.html

KidsHealth Parents Infections Signs and Symptoms: In its early stages, diphtheria can be mistaken for a bad sore throat. A low-grade fever and swollen neck glands are the other early symptoms. The toxin, or poison, caused by the bacteria can lead to a thick coating in the nose, throat, or airway. This coating is usually fuzzy gray or black and can cause breathing problems and difficulty in swallowing. In more advanced stages, the patient may have difficulty breathing or swallowing, complain of double vision, have slurred speech, or even show signs of going into shock (pale, cold skin; rapid heartbeat; sweating; and an anxious appearance). Go to next page Printer -friendly version Email this article to a friend Send email to us Jump to another section of this article Diphtheria Description Prevention Incubation and Contagiousness ... Home Treatment Reviewer name and date on last page About Us Contact Us Partners Editorial Policy Note: All information on KidsHealth is for educational purposes only. For specific medical advice, diagnoses, and treatment, consult your doctor.

94. The Methodist Hospital - Data Not Available We re very sorry, but data for this page is currently unavailable.This page is currently not available. Please notify us of this http://www.methodisthealth.com/infectious/diptheri.htm

We're very sorry, but data for this page is currently unavailable. This page is currently not available. Please notify us of this occurrence by filling out our Contact Us form. Click the Back button and try a different option from the Menu. We appreciate your continued support, and sincerely apologize for the inconvenience. Please check back later to access this page. Methodist Customer Support

95. WHO/OMS: Diphtheria World Health Organization, World Health Organization. WHO Fact Sheet Vaccines andImmunization Background information on Diphtheria and its control. Newsletter. http://www.who.int/health-topics/diphtheria.htm

WHO Fact Sheet Vaccines and Immunization Background information on Diphtheria and its control Newsletter Global defence against the infectious disease threat Accès au français Catalogue Disease Outbreak News Weekly Epidemiological Record WHO Home Search ... (c) WHO/OMS 2001

96. BabyCenter | Community: BBS - Vaccine Concerns For Baby | Tetanus And Diptheria You seem to have disabled JavaScript. To take full advantage of oursite and functionality, we recommend you enable Javascript. How? http://bbs.babycenter.com/board/baby/babywellness/11967/thread/1010845

var ACM, oPopup, oDefPopup, offsetTop=10, offsetLeft=10; You seem to have disabled JavaScript. To take full advantage of our site and functionality, we recommend you enable Javascript. How? Preconception Pregnancy Baby ... Vaccine concerns for baby "Tetanus and Diptheria Vaccine" Posts: Last Post: May 4, 2004, 4:23 PM (PDT) JOIN IN: See all Boards Create a new thread Add a message WATCHES: My watches Start watching this thread HOW TO: Getting started Community Guidelines Back to Vaccine concerns for baby Messages First Last Author: May 4, 2004 , 4:23 PM (PDT) http://www.vaclib.org/basic/health/boostershots.htm Adults Don't Need Booster Shot of Diphtheria, Tetanus If you believe the experts only 60% of American adults have adequate immunization to ward off diphtheria infections and 72% are protected against tetanus. Tetanus is a sometimes-fatal illness caused by toxin-producing bacteria that usually takes hold in a cut or wound. The disease is characterized by painful muscle spasms or contractions. Diphtheria is caused by another type of bacteria that primarily attack the larynx, tonsils and throat. The toxin produced by the bug can damage the nerves and heart.

97. Nat'l Academies Press, Adverse Events Associated With Childhood Vaccines: (1994) Adverse reactions following tetanus toxoid injection . http://books.nap.edu/books/0309048958/html/67.html

Read more than 3,000 books online FREE! More than 900 PDFs now available for sale HOME ABOUT NAP CONTACT NAP HELP ... ORDERING INFO Items in cart [0] TRY OUR SPECIAL DISCOVERY ENGINE Questions? Call 800-624-6242 Adverse Events Associated with Childhood Vaccines: Evidence Bearing on Casuality Institute of Medicine ( IOM CHAPTER SELECTOR: Openbook Linked Table of Contents Front Matter, pp. i-x Contents, pp. xi-xvi 1 Executive Summary, pp. 1-18 2 Causality and Evidence, pp. 19-33 3 Neurologic Disorders, pp. 34-58 4 Immunologic Reactions, pp. 59-66 5 Diptheria and Tetanus Toxoids, pp. 67-117 6 Measles and Mumps Vaccines, pp. 118-186 7 Polio Vaccines, pp. 187-210 8 Hepatitis B Vaccines, pp. 211-235 9 Haemophilus Influenzae Type B Vaccines, pp. 236-273 10 Death, pp. 274-304 11 Need for Research and Surveillance, pp. 305-308 Appendix A: Executive Summary from 'Adverse Effects of Pertu..., pp. 309-317 Appendix B: Strategies for Gathering Information, pp. 318-334 Appendix C: Glossary, pp. 335-341 Appendix D: Committee and Staff Biographies, pp. 342-347 Bibliography, pp. 348-450

98. Immunization Action Coalition - Diphtheria 1 Diphtheria Image 1. Click here for a larger image size. Click here for thelargest image size. Courtesy of Centers for Disease Control and Prevention. http://www.immunize.org/images/ca.d/ipcd1861/img0001.htm

Diphtheria Image Click here for a larger image size. Click here for the largest image size Courtesy of Centers for Disease Control and Prevention child has diphtheria thick gray coating over back of throat coating can eventually expand down through airway if not treated, the child could die from suffocation Diphtheria can cause serious illness kills 1 of 10 people infected with it Diphtheria germ lives in mouth, nose, and throat of an infected person spreads through direct contact with an infected person Once infected takes 2-5 days to get sick Symptoms some people might not feel or look sick others might have sore throat fever chills difficulty swallowing thick gray coating over the back of the throat Complications within 6-10 days serious problems can occur suffocation paralysis heart failure coma death Photos index Home Page Immunization Action Coalition 1573 Selby Avenue St. Paul MN 55104 E-mail: admin@immunize.org Web: http://www.immunize.org/ Tel: (651) 647-9009 Fax: (651) 647-9131 This page was updated on June 26, 2002

A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Page 5     81-98 of 98    Back | 1  | 2  | 3  | 4  | 5