81. Welcome To PalmBeachPost! diabetic neuropathy. person to injury. diabetic painful neuropathy isdivided into acute and chronic forms. The acute form typically http://www.palmbeachpost.com/health/healthfd/shared/health/adam/ency/article/000

Jobs Autos Real Estate Classifieds ... Today's Post '); document.write(' HEALTH INDEX 5,000+ Area Doctors phone numbers Encyclopedia With symptoms and prevention tips Local Services Find Health services in your neighborhood Ask An Expert Get professional answers to medical questions Video Galleries Doctors explain medical terms and conditions Health Guides For women, children, Latest News Dozens of daily national PB Post Articles The most recent local health stories Today's Post Latest News Weekly Features Post Services GoPBI.com Search The Post: Illustrated Health Encyclopedia Important notice Ency. home Disease D Diabetic neuropathy Overview Symptoms Treatment Prevention Alternative names: Nerve damage - diabetic Definition: a late complication of diabetes mellitus that affects nerve tissue. Causes and Risks People with diabetes may develop temporary or permanent damage to nerve tissue. Nerve injuries are caused by decreased blood flow and high blood-sugar levels , and are more likely to develop if blood-glucose levels are poorly supervised. Some diabetics will not develop nerve damage, while others may develop this condition relatively early. On average, the onset of symptoms occurs 10 to 20 years after diabetes has been diagnosed. Peripheral nerve injuries may affect cranial nerves or nerves from the spinal column and their branches. This type of neuropathy (nerve injury) tends to develop in stages. Early on, intermittent pain and

82. Pain Painful diabetic Neuropathy. Neuropathy or nerve damage due to diabetes canpresent as insensate neuropathy (sensory loss) or painful neuropathy. http://www.diabetes.usyd.edu.au/foot/Pain1.html

Painful Diabetic Neuropathy Neuropathy or nerve damage due to diabetes can present as insensate neuropathy (sensory loss) or painful neuropathy. The majority of people have the insensate type and the consequences and management of this are discussed extensively in this web-site. However approximately 4-7% of patients with diabetes suffer chronic, often distressing symptoms of pain, pins and needles or numbness in their feet. Why do people get painful neuropathy? This question is yet to be fully answered and is the subject of ongoing research. People with poorly controlled diabetes for a long time are more likely to get chronic painful neuropathy. However, many patients with relatively well controlled diabetes also develop it. Painful symptoms can be transient, eg less than 12 months duration. These symptoms are often associated with periods of high blood glucose levels, or paradoxically, when the blood glucose level rapidly improves. In these acute situations, once the blood glucose has stabilised for a few months, the symptoms often spontaneously disappear. Once symptoms have persisted for more than 12 months, they are less likely to disappear on their own. Although good blood glucose control is important for many reasons, striving for very tight blood glucose control is less likely to make the painful symptoms get better when they have been present for this length of time.

83. Study Posting (2997) -- Trial #51906, Diabetic Neuropathy, West Palm Beach, FL Blind, PlaceboControlled, Parallel-Group Study Of 3 Fixed Doses Of EAA-090 InAdult Outpatients With Neuropathic Pain Associated With diabetic Neuropathy. http://www.centerwatch.com/patient/studies/stu51906.html

Trial Information Summary: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of 3 Fixed Doses Of EAA-090 In Adult Outpatients With Neuropathic Pain Associated With Diabetic Neuropathy. Summary: EAA-090 is being developed for the treatment of neuropathic pain associated with diabetic neuropathy. It is a selective antagonist that binds competitively to the glutamate site of the N-methyl-Daspartate (NMDA) receptor. This study will assess the safety and efficacy of 3 fixed oral doses of EAA-090 compared with placebo in subjects with neuropathic pain associated with diabetic neuropathy. Inclusion Criteria: Outpatients. At least 18 years of age. Women of childbearing potential must have a negative serum pregnancy test result at screening. The signed informed consent should reflect an awareness of the stipulations concerning the use of contraception. A woman of childbearing potential is defined as one who is biologically capable of becoming pregnant. This includes women who are using contraceptives or whose partners are either sterile or using contraceptives. Sexually active women participating in the study must use a medically acceptable form of contraception. Medically acceptable forms of contraception include oral contraceptives, injectable or implantable methods, intrauterine devices, or properly used double-barrier methods. Diagnosis of painful diabetic distal symmetric sensory/motor polyneuropathy. The primary site of symptoms must be the lower extremity. Signs and symptoms of diabetic polyneuropathy must be confirmed by a neurologist or endocrinologist. Symptoms referable to painful diabetic neuropathy present for at least 3 months before screening.

84. Priority Press -- Neurology Pain Treatment of diabetic Neuropathy, Migraine and Cluster HeadacheDifferent Approach. Showing Promise for diabetic Neuropathy. http://www.mednet.ca/html/pp00087.htm

PRIORITY PRESS Cardiology Dermatology Endocrinology Gastroenterology ... Urology Links Associations Journals Universities Libraries ... Pharmaceutical Manufacturers American Pain Society 18th Annual Scientific Meeting Fort Lauderdale, Florida / October 21-24, 1999 Pain Treatment of Diabetic Neuropathy, Migraine and Cluster Headache: Different Approach Fort Lauderdale - T he mechanisms of neuropathy, which include y-aminobutyric acid (GABA) action, voltage-gated sodium channels and glutamate receptors may be involved in triggering the symptoms of diabetic neuropathy. These same mechanisms of action also seem to be implicated in the relief of migraine and cluster headaches. Since topiramate works by acting on the voltage-gated sodium and calcium channels, as well as the GABA and glutamate channels, it makes topiramate an investigational choice for relief of these conditions. Open-label reports have investigated the use of topiramate in various neuropathies, with promising results. In a double-blind controlled trial in diabetic neuropathy presented at this meeting, it was shown that topiramate was efficacious. One side effect found in the early clinical trials on topiramate, is a tendency toward weight reduction.

85. Virtual Hospital: University Of Iowa Family Practice Handbook, Fourth Edition: N Neuropathy can be acute and life threatening as in GuillainBarré syndromeor chronic as in diabetic neuropathy. diabetic neuropathy. http://www.vh.org/adult/provider/familymedicine/FPHandbook/Chapter09/10-9.html

For Providers University of Iowa Family Practice Handbook, Fourth Edition, Chapter 9 Neurology: Neuropathy Coleman O. Martin, MD Department of Neurology University of Iowa College of Medicine Peer Review Status: Externally Peer Reviewed by Mosby Overview Neuropathy Classification Anatomic classification Mononeuropathy . Involvement of a single nerve (e.g., carpal tunnel syndrome, meralgia paresthetica). Polyneuropathy . Diffuse involvement of the peripheral nerves (e.g., diabetic neuropathy). Mononeuritis multiplex . Seemingly random involvement of multiple isolated nerves. Can occur in vasculitis, porphyria, diabetes, HIV, and others. Cellular classification Axonal neuropathy . Loss of function from loss of nerve cells. Typically affects longest nerves first with patients describing loss of sensation or paresthesias of the feet. Axonal neuropathy is usually symmetric, although it may be asymmetric early in the course. Weakness occurs late and tends to involve the most distal muscles. Demyelinating neuropathy . Damage to the Schwann cells leads to impairment of nerve conduction. Weakness tends to involve both proximal and distal muscles. Time course Acute neuropathy . Sudden onset of dysfunction from an injury or immunologic attack. Chronic neuropathy . Usually insidious onset with slow progression from low-level ongoing nerve injury. Diagnosis Careful history

86. Neuropathy - References : Online Reference For Health Concerns Neuropathy and diabetic Neuropathy. References. 1) E471E476. Cameron, NE, Cotter,MA Metabolic and vascular factors in the pathogenesis of diabetic neuropathy. http://www.lef.org/protocols/prtcl-082refs.html

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87. Diabetes Portal - Type 2 Return to Index. One of the most common complications of diabetes is diabeticneuropathy. diabetic neuropathy can be painful and disabling. http://www.diabetesportal.com/type2/complic/neuro.htm

Neuropathy Source: American Diabetes Association One of the most common complications of diabetes is diabetic neuropathy. Neuropathy means damage to the nerves that run throughout the body, connecting the spinal cord to muscles, skin, blood vessels, and other organs. Diabetic neuropathy can be painful and disabling. Fortunately, severe forms do not occur often. And many times, symptoms go away after several months. What Is Neuropathy? Diabetic neuropathy is actually a group of nerve diseases. All these disorders affect the peripheral nerves, that is, the nerves that are outside the brain and spinal cord. There are three types of peripheral nerves: motor, sensory, and autonomic. Motor nerve fibers carry signals to muscles to allow motions like walking and fine finger movements. Sensory nerves take messages in the opposite direction. They carry information to the brain about shape, movement, texture, warmth, coolness, or pain from special sensors in the skin and from deep in the body. Autonomic nerves are nerves that are not consciously controlled. These nerves have functions such as controlling the pace of heartbeats, maintaining blood pressure, and controlling sweating. Some symptoms of neuropathy occur when the nerve fibers are lost. If the loss of nerve fibers affects the motor fibers, it can cause muscular weakness. If loss of nerve fibers affects the sensory fibers, it can cause loss of feeling. And if the loss of nerve fibers affects autonomic fibers, it can cause loss of functions not normally under conscious control, like digestion.

88. Diabetic Neuropathy- Medcohealth.com diabetic neuropathy. Source ADAM, Inc. Treatment. The goals of treating diabeticneuropathy are to prevent progression and reduce the symptoms of the disease. http://www.medcohealth.com/medco/consumer/ehealth/ehsarticle.jsp?ltSess=y&articl

89. AAEM - Course Handouts are examined in depth. This handout is bundled with the diabetic Neuropathybooklet. diabetic Neuropathy. diabetic neuropathy is highly http://www.aaem.net/aaem/publications/coursehandouts_page1.cfm

Course Handouts Brochures Bundles Case Reports CD-ROMs ... Closeout Publications Ordering How to Order Download Publications Order Form (PDF 36 KB) Download Brochures Order Form Misc. Information CME Information and Answers Key to Abbreviations AAEM Suggested Reference List CME activity of 2 credit hours in Category 1 is available upon achievement of the education objectives and completion of the self-assessment test and evaluation form. The American Medical Association has determined that non-US licensed physicians who participate in this CME activity are eligible for AMA PRA category 1 credit. Page 1 of 5 Code Numbness, Tingling, Pain, and Weakness: A Basic Course in Electrodiagnostic Medicine Do you need a basic review of electrodiagnostic medicine? This handout covers a range of neuromusculoskeletal disorders from a clinical perspective moving from patient assessment and differential diagnosis to the electrodiagnostic evaluation. Highlighting patients with peripheral neuropathies and focal neuropathies, this course is an absolute must! Anthony A. Amato, MD;

90. Diabetic Neuropathy-WISN-TV Health Center August 20, 2001 445 PM. diabetic neuropathy is a nerve disorder causedby diabetes. Symptoms glucose. How common is diabetic neuropathy? http://wisn-tvhealth.ip2m.com/index.cfm?PageType=itemDetail&Item_ID=337&Site_Cat

91. Neuromuscular Research Research activities are focused on new treatments for patients with diabeticneuropathy, inflammatory demyelinating polyneuropathy (acute and chronic http://www.uhn.ca/programs/neuroscience/neuromuscular.asp

For Health Professionals For Media For Staff Contact Us ... Site Map document.form1.search.onkeypress= CatchEnterKey; Program Groupings Services Nursing Telehealth Neuromuscular Overview Comprehensive Pain Epilepsy Memory Disorders ... Telephone Numbers Patient Population The Neuromuscular Clinic at Toronto Western Hospital specializes in the tertiary care and research of patients with disorders of the nerve, muscle, and neuromuscular junction. The clinic is a tertiary referral Centre for many neurologists (including other neuromuscular specialists) in Ontario and across Canada. It's the largest program in Canada for management of patients with myasthenia gravis. Approximately 3,500 patients attend this clinic annually. About 1,600 procedures are performed annually including highly specialized investigations such as single fibre electromyography (EMG) and quantitative EMG. To improve efficiency and service, the EMG laboratory has state-of-the-art electrodiagnostic equipment, with extensive networking and immediate reporting capabilities. Education The clinic plays an important role in teaching at the post-graduate, medical school and undergraduate levels. Fellows in neuromuscular disorders, neurology residents, medical residents and summer students all learn about the investigation and care of patients with nerve, muscle and neuromuscular diseases. These trainees participate in important clinical research projects involving neuromuscular patients.

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