41. Blackwell Synergy - Cookie Absent Pain in diabetic neuropathy case study whole patient management.P diabetic neuropathies The Nerve Damage of Diabetes. Available http://www.blackwell-synergy.com/links/doi/10.1111/j.1471-0552.2004.00795.x/enha

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42. Blackwell Synergy - Cookie Absent MEDLINE Abstract ISI Abstract. 4. Dyck PJ, Giannini C. Pathologic alterationsin the diabetic neuropathies of humans a review. diabetic neuropathies. http://www.blackwell-synergy.com/links/doi/10.1111/j.1399-543X.2004.00041.x/enha

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43. PNS Meeting Poster Abstracts - Diabetic And Other Metabolic Neuropathies in the regulation of nerve damage, and suggest a potential effect of antiinflammatoryand/or anti-immune drugs in the treatment of diabetic neuropathies. http://pns.ucsd.edu/PostH.abstracts.html

Back to Program PNS Home Diabetic and Other Metabolic Neuropathies Abstracts Poster Session 3 THE INFLUENCE OF MOMORDICA CHARANTIA FRUIT JUICE ON PERIPHERAL NERVE STRUCTURE IN EXPERIMENTAL DIABETES Ahmed I. , Sharma A.K., Samad P.A. Faculty of Med., United Arab Emirates University, Al Ain, UAE Momordica charantia fruit is traditionally used as a vegetable and is known to have hypoglycemic effect in human and experimental diabetes. Ultrastructural observations were made on myelinated fibers in the tibial nerve of streptozotocin-diabetic rats. Four groups of male Wistar rats, aged 12 weeks were studied over a period of four months: untreated diabetic rats, diabetic rats treated with M charantia, controls treated with M charantia and age-matched controls. Blood glucose concentrations were significantly reduced in M charantia M charantia treated diabetic animals, these parameters were intermediate between untreated diabetics and age-matched controls without showing significant difference when compared with either group. The axon to fiber ratio ('g'ratio) did not differ between any of the experimental groups. In conclusion, the administration of M charantia fruit juice reduced blood glucose levels and partially corrected the structural abnormalities of peripheral nerves in experimental diabetes.

44. Ask NOAH About: Diabetes Trial Type 1 Diabetic Foot Ulcers - CenterWatch Diabetic Gastroparesis - CenterWatchdiabetic neuropathies - ClinicalTrials.gov Diabetic Neuropathy http://www.noah-health.org/english/illness/diabetes/diabetes.html

Ask NOAH About: Diabetes What is Diabetes? Complications and Related Concerns Living with Diabetes The Basics Dictionaries/Glossaries Causes and Risk Factors Diagnosis and Symptoms ... Nutrition Care and Treatment Information Resources Medications Monitoring Prevention Transplants ... Support What is Diabetes? The Basics Beginner's Guide to Diabetes - Joslin Diabetes Center Diabetes - MEDLINEplus (also in Spanish ) (Interactive Flash Presentation) Diabetes: Taking Charge of Your Diabetes - American Academy of Family Physicians (also in Spanish Diabetes: What the Diagnosis Means - American Academy of Family Physicians Diabetes Checklist: What You Need to Know - Joslin Diabetes Center Diabetes Checklist: Questions to Ask Your Doctor - Joslin Diabetes Center ... Diabetes Facts - Canadian Diabetes Association (also in French Diabetes Mellitus - Merck Manual, 2nd Home Edition Diabetes Overview - National Institute of Diabetes and Digestive and Kidney Diseases ... What is Diabetes? - National Center for Farmworker Health (also in Spanish Dictionaries/Glossaries Diabetes Dictionary - National Institute of Diabetes and Digestive and Kidney Diseases (also in Spanish Diabetes Dictionary - Canadian Diabetes Association Causes and Risk Factors Am I at Risk for Type 2 Diabetes? - National Institute of Diabetes and Digestive and Kidney Diseases

45. Diabetic Complications: Nephropathic Complications diabetic neuropathies can be divided into the focal and diffuse forms, and thelatter may be further divided into small and large fiber neuropathies. http://www.diabetesliving.com/comps/neurpthc.htm

SOURCE: American Diabetes Association's 59th Scientific Sessions, June 21, 1999 NEUROPATHIC COMPLICATIONS AARON I. VINIK, MD, PhD This session was devoted to a discussion and presentation of the pathogenesis of diabetic neuropathy and the scope for different forms of intervention. It has become abundantly clear that diabetic neuropathy is not a single disorder but rather, a complex heterogeneous syndrome with a variety of clinical presentations based upon differences in etiologic mechanisms. Diabetic neuropathies can be divided into the focal and diffuse forms, and the latter may be further divided into small and large fiber neuropathies. This distinction is important since the clinical presentation is so varied and the pathogenesis and approaches to treatment are dictated by the underlying pathogenic mechanism. The focal forms of neuropathy are, for the most part, entrapment syndromes or mononeuritides that respond to specific forms of treatment aimed at the pathology. These generally do not behave like the diffuse somatic and autonomic neuropathies, are self-limiting, and in certain instances treatments can be directed at specific targets. For example, nerve entrapments may require splinting, diuretics, or local anesthetic and steroid injection. The situation is quite different in the proximal neuropathies that are often inflammatory conditions, which if recognized will respond to anti-inflammatory or immune therapies. The bain of existence is, however, the distal symmetric polyneuropathies (DSPN).

46. Medication That Treats Seizures Might Also Relieve Debilitating Leg Aches In Dia diabetic neuropathies nerve damage caused by diabetes can affect practicallyany organ system, including the digestive tract, heart and sex organs. http://www.slu.edu/readstory/newsinfo/1802

E-News Sign Up Calendar FAQs Contact: Nancy Solomon Phone: 314.977.8017 solomonn@slu.edu News Release November 7, 2002 Medication that Treats Seizures Might Also Relieve Debilitating Leg Aches in Diabetics ST. LOUIS Patients who have nerve damage in their legs and arms with pain from diabetes may be eligible for a clinical trial at Saint Louis University to test the effectiveness of an investigational medication for pain relief. "Diabetic peripheral neuropathy is a chronic and debilitating disorder," says Ghazala Hayat, M.D., associate professor of neurology at Saint Louis University School of Medicine and principal investigator for the study. "It affects your quality of life. Patients can wake up with pain and go to bed with pain. They may hurt so badly they can't enjoy life. Many are willing to try anything." Saint Louis University is the only place in St. Louis that is researching whether a medication commonly given to treat seizures can control the pain from diabetic peripheral neuropathy. Typically, antidepressants, "numbing medications" and prescriptions such as OxyContin may be used for pain control. "Trileptal (oxcarbazepine), which is used to treat seizures, has shown some efficacy in treating diabetic neuropathy because it works on the nerve fibers to calm and stabilize them," Dr. Hayat says.

47. Alexa Web Search - Subjects > Health > ... > Neurological Disorders > Peripheral diabetic neuropathies Subjects Health Neurological Disorders Peripheral Nervous System diabetic neuropathies. Sort http://www.alexa.com/browse/general?catid=594595&mode=general

48. (ATN) Neuropathy Nutrient Therapies nutrient therapies for HIVrelated neuropathies, there has been a fair amount ofresearch (mostly in other countries) on their use for diabetic neuropathies. http://www.aegis.com/pubs/atn/1996/atn25009.html

ATN) Neuropathy: Nutrient Therapies AIDS TREATMENT NEWS No. 250 - July 5, 1996 Lark Lands Dr. Lands also has had lifelong diabetes, and is an expert on diabetic neuropathy, which has been much better researched than neuropathy caused by HIV. She believes that some (not all) kinds of HIV-related neuropathy may be similar to the diabetic condition, and may respond to some of the same treatments. AIDS TREATMENT NEWS asked Dr. Lands if we could interview her on what has been learned about treating diabetic neuropathy, and how that might apply to HIV. It turned out to be more practical to publish a section of Dr. Lands' new book than to conduct a separate interview. Readers should know that Dr. Lands emphasizes an integrated program of HIV disease management including antivirals and other mainstream medical treatments, nutritional approaches, and other kinds of therapy rather than using nutrition to treat only a specific symptom. Also, her book includes a detailed section on different kinds of HIV neuropathies. Other sections focus in detail on specific nutrients and other therapies, providing much information not included here. Unfortunately the book is not yet available. But readers should know about potential therapies which, although not conclusively proven and not officially approved, are supported by research, and have appeared to be helpful for many people. Patients should talk with their physician before using any therapy, including nutritional treatments. Even if the physician is not familiar with or does not approve of the treatment, he or she may know about specific cautions or contraindications, due to a patient's medical condition.

49. Burning Feet Due To Diabetic Neuropathy diabetic Neuropathy. The neuropathies are the most common of all the late complicationsof diabetes and give rise to much suffering among diabetic patients. http://www.medscape.com/viewarticle/460912

50. U.S. Pharmacist diabetic Peripheral Neuropathy. Several anticonvulsants have been used effectivelyto treat painful neuropathies, including diabetic peripheral neuropathy. http://www.uspharmacist.com/index.asp?show=article&page=8_996.htm

51. Diabetic Foot, The: Diagnosing And Managing Chronic Painful Diabetic Neuropathy One common classification scheme is based on anatomical distribution and includestwo main types of diabetic neuropathy diffuse neuropathies and focal http://www.findarticles.com/cf_dls/m0MDQ/1_7/114708489/p1/article.jhtml

@import url(/css/us/style.css); @import url(/css/us/searchResult1.css); @import url(/css/us/articles.css); Advanced Search Home Help IN all publications this publication Health Automotive Business Computing Entertainment Health News Reference Sports YOU ARE HERE Articles Diabetic Foot, The Spring, 2004 Content provided in partnership with Print friendly Tell a friend Find subscription deals Diagnosing and managing chronic painful diabetic neuropathy - Review Diabetic Foot, The Spring, 2004 by Susan J. Benbow Christina Daousi Ian A. MacFarlane Introduction A global epidemic of diabetes has emerged, largely as a result of increasingly sedentary lifestyles and a rising prevalence of obesity. Neuropathy is one of the most common and troublesome complications of diabetes, and the number of people afflicted is likely to increase steadily as the incidence of diabetes in the developed world rises. Although foot ulceration is the most commonly recognised complication of peripheral neuropathy (Boulton, 2000), neuropathic pain can also occur, causing significant morbidity and impairment in quality of life (Benbow et al, 1998). This article reviews the frequency of chronic painful neuropathy, and provides an update on its recognition and management. Diabetic neuropathy is not a single entity but a heterogeneous group of disorders that encompasses a wide range of abnormalities. One common classification scheme is based on anatomical distribution and includes two main types of diabetic neuropathy: diffuse neuropathies and focal neuropathies (Table 1; Thomas, 1997).

52. Neurometer® CPT Technical Report: SNCT Evaluation Of Diabetic Neuropathy 6,7) These types of neuropathies can be treated with IvIg and other types of therapiesbut if left undetected they can ultimately condemn a diabetic patient to http://www.neurotron.com/diab001.html

Neurometer CPT Technical Report Neuroselective Sensory Nerve Conduction Threshold (sNCT) Evaluation of Diabetic Neuropathy The following is a brief discussion about the use of the Neurometer CPT electrodiagnostic sNCT evaluation for the evaluation of diabetic neuropathy. The sNCT procedure had its origins in the evaluation of diabetic neuropathy patients at Johns Hopkins University School of Medicine, Department of Neurology in 1980. That clinical research led the FDA to grant permission to market the Neurometer CPT device in 1986. Presently, there are more than 275 peer reviewed articles demonstrating clinical utility of the Neurometer CPT evaluation. Approximately 20% of the publications involve the characterization of diabetic neuropathy, including a recent publication appearing in The Lancet The sNCT is the only electrodiagnostic sensory evaluation procedure able to quantify hyperesthesia as well as hypoesthesia. Hyperesthetic conditions reflect inflamed or irritated sensory nerve fibers that have not yet lost their functioning (i.e. become hyperesthetic). Hypoesthesia is associated with a more advanced stage of neuropathy and represents a loss of function. Hyperesthesia occurs before hypoesthesia as peripheral nerve damage progresses. Detection of hyperesthesia permits earlier therapeutic intervention, thereby improving the prognosis, with the potential of limiting more severe damage and reducing the cost of care. A recent publication from the Japanese Journal of Diabetes

53. Neuropathy Trust: An Introduction To Diabetic Neuropathy Perhaps the common shingles virus may prove, in the future, to be involvedin the diseaseprocess of some neuropathies of “unknown cause”. http://www.neuropathy-trust.org/mainpages/education/phn/intro.htm

Home Biography Join Today Support ... External Resources POST HERPETIC NEURALGIA: PREFACE Thankfully information provision and support-mechanisms are now beginning to be viewed as an essential part of a more holistic approach to medical-treatment, particularly where neuropathic pain is involved. We have spoken to many doctors and nurses specialising in this area of medicine: Most are aware of the difficulties faced by some patients and are supportive of the work that the Neuropathy Trust, and other groups, are doing. We sincerely hope that it will complement the useful work being done in pain-clinics and by those existing patient groups who do their best to help other people in need. Kind Regards Andrew Keen [Chief Executive Officer, Neuropathy Trust] June, 2002 continue.. Home Bio Join ... Resources Site Update: www.neurocentre.com privacy security Web site authoring: KeenDynamics Preferred Screen Resolution Flash Status: Enabled Acknowledgments The Neuropathy Trust is most grateful to Dr Andrew SC Rice (MB BS MD FRCA) for advising us on the medical aspects of this information.

54. Neuropathy Trust: The Spectrum Of Diabetic Neuropathy As with other peripheral neuropathies, diabetic neuropathy may involve one nerve(mononeuropathy) or several specific nerves (mononeuritis multiplex). http://www.neuropathy-trust.org/mainpages/education/dn/page6.htm

Home Biography Join Today Support ... External Resources DIABETIC NEUROPATHY: The spectrum of chronic neuropathy As with other peripheral neuropathies, diabetic neuropathy may involve one nerve (mononeuropathy) or several specific nerves (mononeuritis multiplex). Most commonly, diabetic neuropathy is diffuse affecting many peripheral nerves and is then referred to as polyneuropathy. This polyneuropathy tends to occur in a glove and stocking distribution i.e. involving arms and hands and legs and feet. However in diabetes the lower limbs are most commonly affected. As the neuropathy affects sensory nerves, loss of sensation is a predominant symptom, however many patients may remain asymptomatic throughout. Others may suddenly acquire symptoms at any point throughout their illness but others will have measurable symptoms from the outset. Due to this varied spectrum of expression (figure 1), diagnosis and predicting prognosis for sufferers is imprecise. A staging system (Figure 2) may be useful to provide a framework for the diagnosis and management of diabetic neuropathy. It may also help sufferers to understand how symptoms may change as the disease progresses and what might happen if the signs are ignored. The aim of diabetic management strategies is to detect people at risk early on in the spectrum and aim to prevent, or at least delay progression to the next stage. [Boulton,Gries, Jervell]

55. Medical Encyclopedia diabetes, diabetic, early, expectations, factors, groups, health, incidence, injuries,injury, levels, may, nerve, nerves, neuropathies, neuropathy, pain http://www.medstarhealth.org/body.cfm?id=124&action=display&articlenum=693

56. Neurodiagnostic Skin Biopsies At MGH: Small Fiber Neuropathies Painful diabetic neuropathy can come on in the very earliest stages of diabetes,before any other symptoms of the disease develop and before the diabetes has http://neuroskinbiopsy.mgh.harvard.edu/smallfiber.htm

MGH NEURODIAGNOSTIC SKIN BIOPSY SERVICE HOME REQUISITION FORMS FOR REFERRING PHYSICIANS ABOUT OUR SKIN BIOPSIES ABOUT SMALL-FIBER NEUROPATHIES DIRECTIONS TO THE MGH WHOM TO CONTACT About small-fiber neuropathies Suggestions for patients with painful small-fiber sensory neuropathy Rapid progress is being made in this field, which will hopefully lead to better treatments. Get tested for treatable causes of neuropathy Some patients with painful small-fiber sensory neuropathies have underlying causes that can be treated. It is important to look for these causes, because treating them may help reverse the nerve damage. In the United States, diabetes mellitus (high blood sugar) is a leading cause of painful neuropathy. Painful diabetic neuropathy can come on in the very earliest stages of diabetes, before any other symptoms of the disease develop and before the diabetes has even been diagnosed. So patients with painful neuropathy should be tested for diabetes. Heavy alcohol drinking can also damage nerves and should be avoided by neuropathy patients. HIV or AIDS can cause neuropathy, as can some of the drugs used to treat HIV.

57. DiabetoValens.com - The Diabetes Guide Diabetes The Body. diabetic Neuropathy Complication Of The Nerves.Diabetes and nerves? Other neuropathies involving diabetics are http://my.diabetovalens.com/complications/neuropathy.asp

Search We subscribe to the HONcode principles. Verify here Diabetic Neuropathy - Complication Of The Nerves Diabetes and nerves? Well what is diabetes got to do with nerves? If this is what at the top of your mind then this information is for you. According to a recent article published in the current opinion in neurology,one of the most respected neurology journals,there are multiple factors that cause diabetic neuropathy. there is increasing evidence that abnormalities in the pylol pathway,nerve regeneration and the sodium and calcium channels(the systems and processes that are concerned with the transmission of impulses through the nerves)are linked to the development of diabetic neuropathy. There are different types of neuropathies caused in connection with diabetes and the most common among them is peripheral neuropathy.The greatest danger from this type of neuropathy is the development of foot ulcers. Diabetes neuropathy may be of varying severity and severe neuropathy can even result in weakness and loss of balence during walking.The symptoms usually start as changes in sensation in the toes and gradually moves up to involve the foot and then the entire leg.Symptoms range from numbness to cramping and stabbing pain. Other neuropathies involving diabetics are: Autonomic neuropathy: The autonomic nervous system supplies nerve fibres to various parts of the body like the heart,the alimentary tract, sweat glands,urinary bladder and the genitalia. The ANS controls the automatic functions of the body, and autonomic neuropathy might cause distruptions in the blood pressure,sweating mechanism,diabetic diarrhea, and stomach malfunction, called diabetic gastroparesis.

58. Peripheral Neuropathy Wellness Center Peripheral neuropathies, other than diabetic, have responded to some nutrientssuch as vitamins B3, niacinamide, folic acid, potassium, vinpocetine and http://www.rxwellnesscenter.com/Neuropathy.asp

Home Wellness Centers Healthy Bodies Healthy Lives ... Health Concerns Peripheral Neuropathy Products Recommendations Catalogue Ask a Pharmacist ... About Us Peripheral Neuropathy Center See Below for: Wellness Plan Pharmacist Recommendations Related Health Concerns Additional Information General Health Information Peripheral neuropathy is caused by inflammation of the nerves outside the central nervous system. It is commonly associated with diabetes and consists of several clinical types including sensory, motor, automatic and mixed. The most common type is a chronic symmetrical sensory neuropathy (pain associated on opposite sides of the body) affecting the nerves of the lower limbs and often the gastronomic nerves, resulting in pain, skin ulcers and autonomic disturbances (not under voluntary control). There is little research dealing with non-conventional treatment of peripheral neuropathy, other than in diabetic related cases. Several nutrients and herbals have been shown to help diabetic neuropathy including vitamins B6, B12, C, and E. Inositol, magnesium, zinc, quercetin, gingko biloba, and gamma linoleic acid have shown promise as well. Diabetic cases require specific nutritional considerations (see our Diabetes Wellness Center) which must be closely followed for overall long term positive effects.

59. Details For ABC Of Diabetes the diabetic foot; diabetic neuropathy 2 autonomic neuropathy; diabetic neuropathy3 - mononeuropathy and acute painful neuropathies; nephropathy; pregnancy http://www.bmjbookshop.com/shop/product_display.asp?productid=0727911899&product

60. Graduate Program In Neuroscience At The University Of Minnesota 1. In skin of patients with peripheral neuropathies of different types with emphasison diabetic patients undergoing pancreas or Islet transplantation. http://www.neuroscience.umn.edu/ProStu/facprof/kennedy.html

Return to: U of M Home One Stop Directories Search U of M ... Seminars Search Neuroscience var sc_project=262066; var sc_invisible=1; WWW Graduate Program William R. Kennedy, M.D. Professor, Department of Neurology E-mail: Web Page: http://kennedylab.med.umn.edu/ Research Interests: Quantitation of cutaneous nerves to study diabetic neuropathy Dr. Kennedy is applying immunohistochemistry, confocal microscopy, and computer processing to quantify nerves in human skin and gastrointestinal tract. The objective is for earlier diagnosis of neuropathy, nerve injury and evaluation of therapeutic trials. Evaluation of diabetic patients after pancreas and islet transplantation is a special interest. The work has expanded into investigation of the microbiology of wound healing and trophic factors on regeneration of wounds and their reinervation. We have also developed minimally invasive micro methods to study unmyelinated nociceptors regeneration after micro mechanical and chemical (capsaicin) wounds on mice, pigs, human volunteers and patients. The work requires close cooperation with neurologists, surgeons, internists and pathologists.

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