41. Home Page: Diabetes Insipidus Mutation Database Nephrogenic and Neurogenic diabetes insipidus Mutations that cause nephrogenic orneurogenic diabetes insipidus have been identified in the following genes http://www.medicine.mcgill.ca/nephros/

Gene Gene AVP Gene ... Other Sites of Interest Nephrogenic and Neurogenic Diabetes Insipidus McGill University and McGill University Health Centre This website is supported by grants to Daniel Bichet Kenneth Morgan from the Canadian Genetic Diseases Network (Federal Networks of Centres of Excellence Program). This website was implemented by Joyce Crumley (2000). Mutations that cause nephrogenic or neurogenic diabetes insipidus have been identified in the following genes: arginine vasopressin receptor 2 ( aquaporin-2 ( prepro-arginine-vasopressin-neurophysin II ( AVP Information on mutations can be retrieved by: name type of mutation location in the gene functional studies For further information, click on one of the menu links at the top of the page. Acknowledgements While reasonable effort has been made to ensure that this website is of high quality, the Montreal Diabetes Insipidus Group makes no warranty, express or implied, as to the accuracy of the information or its suitability for any specific purpose. The Group will not be responsible for any consequences arising out of any inaccuracies or omissions, nor be liable for damages, direct or indirect, that result from the use of this website. Page last modified: 24 October 2003 Site last modified: 24 October 2003

42. Diabetes Insipidus diabetes insipidus. In diabetes insipidus there is a failure to eitherproduce ADH (more common) or for the kidney to respond to http://gucfm.georgetown.edu/welchjj/netscut/endocrinology/diabetes_insipidus.htm

Diabetes Insipidus In Diabetes Insipidus there is a failure to either produce ADH (more common) or for the kidney to respond to ADH (rare); in a sense, it is the opposite end of the spectrum from SIADH where there is too much ADH or oversensitivity to it. In DI there is almost pure water loss, often with maintenance of normal sodium balance. The mean age of onset is 16 years of age, with a slight male predominance. Symptoms : Polyuria (urine output greater than 30mL/kg/day), polydipsia, dilute urine, nocturia, dehydration . May be otherwise asymptomatic, but severe cases will have symptoms of hypernatremia Diagnosis : Urine s.g. less than 1.005. Urine osmolality less than 200 mOsm/kg; serum osmolality will be normal (assuming patient has access to water) to slightly elevated: range 280-295 mOsm per kg. The water deprivation test is used to demonstrate central DI.. Water is restricted until the patient is about 5% dehydrated and the urine reaches a steady-state osmolarity. A test dose of ADH is then administered. In normal patients and those with nephrogenic DI, the urine osmolarity will change less than 5 mOsm/kg. In complete central DI, the osmolarity will double; in partial central DI, there will be an intermediate effect. Treatment : A patient presenting acutely with DI and hypernatremia should be treated for the hypernatremic dehydration . In the longer term, neurogenic may respond to nasal desmopressin (a synthetic analog of ADH). Nephrogenic requires good hydration and monitoring of electrolytes. Thiazide and amiloride may relieve symptoms by depleting total body salt and forcing increased reabsorbtion in the proximal convoluted tubule. The oral hypoglycemic agent chlorpropamide can be used to stimulate ADH secretion in cases of partial central DI, although its use is limited by hypoglycemia. Carbamazepine and clofibrate also stimulate ADH secretion.

43. Diabetes Insipidus Translate this page diabetes insipidus. diabetes insipidus im Internet. Grundlegend für den Diabetesinsipidus ist ein Mangel an ADH, das auch Vasopressin genannt wird. http://www.medizinfo.de/endokrinologie/hypo/diainsipidus.htm

Endokrinologie Bücherliste: Endokrinologie Anatomie und Physiologie Bauchspeicheldrüse und Diabetes Erkrankungen von Hypothalamus und Hypophyse Hormonübersicht ... Wechseljahre der Frau Diabetes insipidus Diabetes insipidus im Internet Kurzinfo: Diabetes insipidus Definition Ein Mangel an ADH führt zu einer Störung im Wasserhaushalt des Körpers. Symptome Flüssigkeitsmangel durch überhöhte Harnproduktion und Harnausscheidung, ständiges Durstgefühl, trockene Haut und Schleimhäute Verstopfung Schlafstörungen , Gereiztheit, bei Kleinkindern möglicherweise Exsikkose, Hypernatriämie mit Verwirrung, Krämpfen bis hin zum Zusammenbruch, bei Säuglingen Durstfieber Therapie Teilweiser zentraler Diabetes insipidus braucht u.U. keine Medikation, vermehrtes Trinken kann ausreichend sein. Ansonsten Medikation mit Desmopressin. Desmopressin auch bei komplettem Diabetes insipidus. Bei renalem Diabetes insipidus Thiaziddiuretika. Regelmäßige Kontrollen und individuelle Anpassung notwendig. Inhaltsübersicht: Formen Krankheitsbild Ursachen Diagnostik ... Top Formen Ein Mangel an ADH führt zu einer Störung im Wasserhaushalt des Körpers.

44. Diabetes Insipidus, Neurogen/central diabetes insipidus, neurogen/central ADH, polydipsi, törst, minirin, insipidus,vasopressin, polyuri, dygnsurin. Nefrogen diabetes insipidus. http://www.internetmedicin.se/dyn_main.asp?page=423&sub=139&item=1

45. The Kidney diabetes insipidus. This disorder is characterized by excretion of large amountsof a watery urine (as much as 30 liters about 8 gallons - each day!); http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/K/Kidney.html

Index to this page The Nephron Formation of Urine Diabetes insipidus Liddle's Syndrome ... An artificial kidney of the future? The Kidney The human kidneys: are two bean-shaped organs, one on each side of the backbone. Represent about 0.5% of the total weight of the body, but receive 20-25% of the total arterial blood pumped by the heart. Each contains from one to two million nephrons Link to graphic showing the location of the kidneys and their blood supply (64K). The Nephron The nephron is a tube; closed at one end, open at the other. It consists of a: Bowman's capsule . Located at the closed end, the wall of the nephron is pushed in forming a double-walled chamber. Glomerulus . A capillary network within the Bowman's capsule. Blood leaving the glomerulus passes into a second capillary network (not shown in the figure) surrounding the Proximal convoluted tubule . Coiled and lined with cells carpeted with microvilli and stuffed with mitochondria. Loop of Henle . It makes a hairpin turn and returns to the Distal convoluted tubule , which is also highly coiled and surrounded by capillaries.

46. THE MERCK MANUALSECOND HOME EDITION, Central Diabetes Insipidus Central diabetes insipidus. Central diabetes insipidus is a lack of antidiuretichormone that causes excessive production of very dilute urine (polyuria). http://www.merck.com/mrkshared/mmanual_home2/sec13/ch162/ch162d.jsp

47. THE MERCK MANUAL, Sec. 17, Ch. 229, Abnormal Renal Transport Bartter s Syndrome. Liddle s Syndrome. click here for navigation help.Nephrogenic diabetes insipidus. (See also diabetes insipidus in Ch. 7.). http://www.merck.com/mrkshared/mmanual/section17/chapter229/229c.jsp

48. Nephrogenic Diabetes Insipidus Nephrogenic diabetes insipidus. What is it? Nephrogenic diabetes insipidus isa disorder in which the kidneys produce large amounts of dilute urine. http://www.hmc.psu.edu/healthinfo/no/nephrogenicdiabetes.htm

49. Diabetes Insipidus diabetes insipidus. diabetes insipidus is a metabolic disorder that causes the patientto produce enormous quantities of urine accompanied by excessive thirst. http://www.hmc.psu.edu/healthinfo/d/diabetesinsipidus.htm

50. Diabetes Insipidus - Keep Kids Healthy Conditions A discussion of diabetes insipidus, which can cause increased urination and excessivethirst, leading to hypernatremia and dehydration. diabetes insipidus. http://www.keepkidshealthy.com/welcome/conditions/diabetes_insipidus.html

Bookstore Site Map Contact Us Help ... What's New? Search this site: Advanced Search Free Newsletters Main Menu Useful Tools Index of Topics Pediatric Problems New! Parenting Tips Symptom Guide Nutrition Immunizations ... Web Links Online Resources What's New Reviews New! Growth Charts Online Forums Vaccine Schedule Baby Names Guide ... Height Calculator Newsletters: Subscribe to get free news, tips and updates. Recommend Us tell a friend about us or email this page to a friend Main Diseases and Conditions Diabetes Insipidus Diabetes inspidus (DI) is a disorder that causes increased urination ( polyuria ) and increased thirst . It is caused by either a decrease in the hormone arginine vasopressin ( central DI ), or because the kidney does not respond correctly to the hormone ( nephrogenic DI ). Arginine vasopressin is a hormone that normally stimulates the collecting ducts of the kidney to reabsorb water, so if it is not able to work correctly, the kidney produces a very large volume of dilute urine. Arginine vasopressin is normally produced in the hypothalamus , and so there can be a decrease in the its production caused by any condition that disrupts the hypothalamus, including brain tumors and head trauma, and some inherited conditions (septo-optic dysplasia). Nephrogenic DI can either be inherited or it can be a side effect of some medications, including Lithium, and some chronic conditions, such as sickle cell anemia, pyelonephritis, and urinary tract obstructions.

51. Diabetes Insipidus Defines diabetes insipidus and reviews the mechanics of normal fluidregulation. Discusses Insipidus. diabetes insipidus. On this page http://kidney.niddk.nih.gov/kudiseases/pubs/insipidus/

Email To A Friend Home : Diabetes Insipidus Diabetes Insipidus On this page: Diabetes Insipidus versus Diabetes Mellitus Normal Fluid Regulation in the Body Central DI Nephrogenic DI ... For More Information Diabetes insipidus (DI) is characterized by excretion of large amounts of dilute urine, which disrupts your body's water regulation. To make up for lost water, you may feel the need to drink large amounts of water. You are likely to urinate frequently, even at night, which can disrupt sleep or, on occasion, cause bedwetting. Because of the excretion of abnormally large volumes of dilute urine, you may quickly become dehydrated if you do not drink enough water. Children with DI may be irritable or listless and, in some cases, may have fever, vomiting, or diarrhea. In its clinically significant forms, it is a rare disease. Top Diabetes Insipidus versus Diabetes Mellitus DI should not be confused with diabetes mellitus, which results from insulin deficiency or resistance leading to high blood glucose. Diabetes insipidus and diabetes mellitus are unrelated, although they can have similar signs and symptoms, like excessive thirst and excessive urination.

52. Diabetes Insipidus - Endocrinology Health Guide Health Guide on diabetes insipidus, a condition that results from insufficientproduction of the antidiuretic hormone. diabetes insipidus. http://www.umm.edu/endocrin/diabins.htm

Endocrinology Health Guide... Pituitary Gland Disorders... Pituitary Tumors Acromegaly ... Glossary Related Resources Within UMM Endocrinology Joslin Diabetes Center School of Medicine Endocrinology Site Endocrinology Health Guide Diabetes Insipidus F A C T : Though produced by the hypothalamus, the portion of the brain that stimulates the pituitary gland, the antidiuretic hormone, is actually stored and released into the bloodstream by the pituitary gland. What is diabetes insipidus? Diabetes insipidus is a condition that results from insufficient production of the antidiuretic hormone by the hypothalamus, the portion of the brain that stimulates the pituitary gland. Normally, the antidiuretic hormone controls the kidneys' output of urine. Diabetes insipidus causes excessive thirst and excessive production of very diluted urine. Causes of diabetes insipidus: Diabetes insipidus can be caused by several conditions, including: malfunctioning hypothalamus malfunctioning pituitary gland damage to hypothalamus or pituitary gland during surgery brain injury tumor tuberculosis blockage in the arteries leading to the brain encephalitis meningitis sarcoidosis (a rare inflammation of the lymph nodes and other tissues throughout the body) What are the symptoms of diabetes insipidus?

53. The Pituitary Foundation | Disorders | Diabetes Insipidus diabetes insipidus (DI) is a disorder in which the kidneys are unableto retain water. This results diabetes insipidus. diabetes insipidus http://www.pituitary.org.uk/disorders/di.htm

Text version Home News Contact Us ... Skip search box SEARCH THIS SITE Advanced search Skip section links DISORDERS Acromegaly Adult GH Deficiency ... Disorders Index LINKS Skip main links The Endocrine System Pituitary Disorders Resources ... About The Pituitary Foundation Diabetes Insipidus Diabetes Insipidus (DI) is a disorder in which the kidneys are unable to retain water. This results in the production of large amounts of urine which in turn makes you feel dry and very thirsty. Neurogenic Diabetes Insipidus This condition is caused by the lack of a water-retaining hormone or chemical in the blood (called vasopressin or ADH ). Neurogenic DI is sometimes referred to as Cranial, Central or Pituitary DI Nephrogenic Diabetes Insipidus This condition is caused by an abnormality in the kidneys which prevents the kidneys from responding to the water-retaining hormone. DI is not related to the type of diabetes most people have heard of, diabetes mellitus Typical symptoms frequent need to pass urine (polyuria) even during the night extreme thirst leading to excessive drinking (polydipsia) imbalance of electrolytes (relatively high levels of sodium and potassium) Top of Page Resources available from The Pituitary Foundation Diabetes Insipidus - patient information booklet (rev 2001).

54. The Pituitary Foundation | Patient Leaflet | Diabetes Insipidus Online version of the patient information leaflet on diabetes insipidusproduced by The Pituitary Foundation. diabetes insipidus. http://www.pituitary.org.uk/resources/di.htm

Text version Home News Contact Us ... Skip search box SEARCH THIS SITE Advanced search Skip section links RESOURCES The Pituitary Gland and its Hormones Acromegaly Adult GH ... Resources Index LINKS Skip main links The Endocrine System Pituitary Disorders Resources ... About The Pituitary Foundation Diabetes Insipidus What is diabetes insipidus and why do we get it? What does it feel like to have DI? Coping with the stress of diabetes insipidus How is it diagnosed? What tests are carried out and how does it feel? ... What DI means to me What is diabetes insipidus and why do we get it? Diabetes insipidus (DI) is a disorder in which your kidneys are unable to retain water. This results in the production of large volumes of urine which in turn makes you feel dry and very thirsty. It is very important to point out that DI is not related to the type of diabetes most people have heard of, diabetes mellitus. In DI , there is no problem with the sugar in the blood or urine. The problem either concerns the lack of a water-retaining hormone or chemical in the blood (called vasopressin; sometimes anti-diuretic hormone) or is sometimes due to an abnormality in the kidneys which prevents them from responding to this hormone. The hormone itself is normally secreted by the pituitary gland , which is located at the base of the brain, just behind the bridge of the nose.

55. HealthlinkUSA Diabetes Insipidus Links FindWhat. You can find diabetes insipidus right now at Info.com. Click here forpage 1 of diabetes insipidus information from the HealthlinkUSA directory. http://www.healthlinkusa.com/435ent.htm

56. HealthlinkUSA Nephrogenic Diabetes Insipidus Links Find Nephrogenic diabetes insipidus at searchwaves.com. Click here for page 1 ofNephrogenic diabetes insipidus information from the HealthlinkUSA directory. http://www.healthlinkusa.com/221ent.htm

57. UAB Health System | Diabetes Insipidus diabetes insipidus. Fact Though produced by the hypothalamus, the Whatis diabetes insipidus? diabetes insipidus is a condition that http://www.health.uab.edu/show.asp?durki=19211

58. HealthCentral - General Encyclopedia - Diabetes Insipidus; Nephrogenic diabetes insipidus; nephrogenic. Alternative names nephrogenic diabetesinsipidus; acquired nephrogenic diabetes insipidus; gypsy s curse http://www.healthcentral.com/mhc/top/000511.cfm

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59. HealthCentral - General Encyclopedia - Diabetes Insipidus General Health Encyclopedia, diabetes insipidus. It can also be causedby a defect in the kidney tubule (nephrogenic diabetes insipidus). http://www.healthcentral.com/mhc/top/000377.cfm

WELCOME! Receive Free Newsletters Join a Community SEARCH FOR: CONSUMER HEALTH INFORMATION TOPIC CENTERS Choose a topic Acne Alcohol Allergies Alternative Medicine Alzheimer's Anemia Arthritis Asthma Baby and Toddler Health Back Care Bipolar Disorder Birth Control Bodywork and Mind/Body Bowel Breast Cancer Cancer Overview Caregiving Chemotherapy Children's Health Cholesterol Circumcision Colds and Flus Colon Cancer Cosmetic Surgery Crohn's Disease Dental Depression Diabetes Diet Drugs Digestion Disabilities Drugs and Medications Eating Disorders Eczema Erectile Dysfunction Eye and Vision Fitness Foot Care GERD/Heartburn Hair Loss Hearing Heart and Circulation Hepatitis Herbs Herpes High Blood Pressure HIV and AIDS Home Remedies Hyperactivity and ADD Immunizations/Vaccines Impotence Incontinence/Bladder Infertility Leukemia Lung Cancer Medical Breakthroughs Medical Expenses Medical Marijuana Men's Health Menopause Mental Health Migraines and Headaches Multiple Sclerosis Nutraceuticals Nutrition and Healthy Eating Osteoporosis Pain Management Parenting Parkinson's Pregnancy and Childbirth Prostate Cancer Prostate Disorders Psoriasis Rheumatoid Arthritis Safety and First Aid Schizophrenia Senior Health Sex and Relationships Sexual Health Skin and Hair Sleep Disorders Smoking Stress Reduction Stroke Substance Abuse and Addiction Teen Health Thyroid Disorders Travel Health Vitamins and Supplements Weight Loss Women's Health Women's Reproductive Cancers Yeast Infection Yoga Search Tips Advertisement Advertisement Main Consumer Health Information Home News Dr. Dean Edell

60. Diabetes Insipidus - Information / Diagnosis / Treatment / Prevention home endocrine disorders pituitary diabetes insipidus diabetes insipidus. diabetes insipidus A very informative diabetes insipidus site. http://www.healthcyclopedia.com/endocrine-disorders/pituitary/diabetes-insipidus

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... pituitary > diabetes insipidus Diabetes Insipidus Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Related Topics Medical Definition Health News Web Directory: Related Topics: Endocrine Disorders/Pancreas/Diabetes Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "diabetes insipidus" Health News: Search millions of published articles for news on Diabetes Insipidus Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: Diabetes Insipidus Foundation Provides information on the different forms of diabetes insipidus. Includes email support group, articles, brochures, FAQs, and other information. Diabetes Insipidus Patient information from the American Academy of Family Physicians.

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