61. R: Diagnostic Tests On Patients With Cushing's Syndrome The cushings data frame has 27 rows and 3 columns Tetrahydrocortisone urinary Typeunderlying type of syndrome, coded a (adenoma) , b (bilateral hyperplasia http://rweb.stat.umn.edu/R/library/MASS/html/Cushings.html

R Documentation Diagnostic Tests on Patients with Cushing's Syndrome Description Cushing's syndrome is a hypertensive disorder associated with over-secretion of cortisol by the adrenal gland. The observations are urinary excretion rates of two steroid metabolites. Usage data(Cushings) Format The Cushings data frame has 27 rows and 3 columns: Tetrahydrocortisone urinary excretion rate (mg/24hr) of Tetrahydrocortisone. Pregnanetriol urinary excretion rate (mg/24hr) of Pregnanetriol. Type underlying type of syndrome, coded a (adenoma) , b (bilateral hyperplasia), c (carcinoma) or u for unknown. Source J. Aitchison and I. R. Dunsmore (1975) Statistical Prediction Analysis. References Venables, W. N. and Ripley, B. D. (2002) Modern Applied Statistics with S. Fourth edition. Springer. [Package Contents]

62. ProCOR PROCOR How to diagnose cushings syndrome and Addison s syndrome by EKG. HOWTO DIAGNOSE CUSHING S syndrome AND ADDISON S syndrome BY EKG. Bernard Lown, MD. http://procor.org/story.asp?storyid=shivaniprocor99971&sitecode=procor&lang=L1&p

63. Dictionary Definition Of CUSHING S SYNDROME MEDICAMENTOSUS Dictionary definition of CUSHING S syndrome MEDICAMENTOSUS. Medicaldictionary. Browse Dictionary by alphabet. 0 1 2 3 4 5 6 7 8 9 http://www.dictionarybarn.com/CUSHINGS-SYNDROME-MEDICAMENTOSUS.php

64. Dr. Rose's Peripheral Brain--CUSHING'S SYNDROME CUSHING S syndrome. Dx of prox. mm. wkness duckwalking. Causes Iatrogenic; Cushing sdis. -Pit. adenoma (70% of non-iatrogenic); Ectopic ACTH-secreting tumor. http://faculty.washington.edu/momus/PB/cushings.htm

CUSHING'S SYNDROME Dx of prox. mm. wkness: duck-walking Causes: Iatrogenic Cushing's dis."-Pit. adenoma (70% of non-iatrogenic) Ectopic ACTH-secreting tumor Oat cell lung Ca Carcinoid Pancreatic islet cell Ca Medullary thyroid Ca Pheochromocytoma Adrenal causes Adrenal Ca Adrenal adenoma Micronodular tumors Diagnosis: Dexamethasone suppression test: give a dose of dex late evening and check am cortisol; if it's not low that suggests dx of Cushing's 24h urine free cortisol

65. Cushings Introduction Often called simply Cushing s syndrome , hyperadrenocorticismdescribes the clinical signs referable to the excessive levels of serum http://www.newmanveterinary.com/Cushings.html

Harvey Cushing See Biography Introduction Predilections Breed Associations ... Treatment Introduction: Often called simply " Cushing's Syndrome ", hyperadrenocorticism describes the clinical signs referable to the excessive levels of serum glucocorticoids produced by the adrenal gland Cushing's Disease is a subset of Cushing's Syndrome whereby the excessive production of glucocorticoids by the adrenal gland(s) is specifically due to excessive production of ACTH by the pituitary gland. This is known as Pituitary-Dependent Hyperadrenocorticism (PDH) Autonomous unregulated synthesis of glucocorticoids by the adrenal gland is known as Adrenal-Dependent Hyperadrenocorticism (ADH) The first appreciation for the connection of certain pituitary abnormalities and stomach ulcers (secondary to excessive circulating corticosteroids) was by a fascinating genius and neurosurgeon, Dr. Harvey Cushing (see above T he normal regulation of adrenal gland activity by the pituitary and hypothalamic centers of the central nervous system is shown elsewhere on this website. It is suggested that the reader review that page before proceeding. Predilections (naturally acquired disease) ADH more likely in oldest dogs, on average, though incidences of ADH and PDH occur over the same age range

66. Endocrine Diseases Adrenal Testing E Friedlander. Cushing syndrome. About Cushing s syndrome ( hypercortisolism ) NIDDK/NIH (US). About Conn s syndrome S Chew - cushings Help. http://www.mic.ki.se/Diseases/C19.html

search search staff sitemap ABOUT KAROLINSKA INSTITUTET ... print this page Diseases and Disorders Links pertaining to Endocrine Diseases Alert! Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider. Start Page Contents: Acromegaly Addison's Disease Adrenal Gland Diseases Adrenal Hyperplasia, Congenital ... Wolfram Syndrome Endocrine Diseases Endocrine Pathology [jpeg archive + comments; EC Klatt] Endocrinology information [ED Buckingham] - UTMB (US) Clinical Guidelines for Endocrinologists - Am Assoc of Clin Endocrinologists Patient Factsheets from The Endocrine Society - (US) The British Society for Paediatric Endocrinology and Diabetes EndocrineWeb.com [for patients, by doctors] Pathophysiology of the Endocrine System [Austgen, Bowen, Rouge] - Colorado State Univ. (US) Tayside Endoweb - Tayside Univ Hospitals, Dundee (UK) Maximizing Efficacy of Endocrine Tests: ... [GG Klee] - Clinical Chemistry 1999 Questions and Answers in Clinical Endocrinology - ParkHurstExchange (CA) Case Studies in Endocrine Disorders - Tulane Univ. (US)

67. Cushing's Disease - Pet Health Information From Vet4Petz.com When a tumor develops in the pituitary gland, the resultant condition of Cushing sdisease is referred to as secondary Cushing s syndrome or pituitary http://www.vet4petz.com/articles/cushings.htm

Medical Emergencies Member Login Become a Member Ask the Vet ... Home Page Pet Health: Cushing's Disease Cushing's Disease occurs most commonly in the dog, but is sometimes seen in the cat and ferret as well. The disease is characterized by an excess of a hormone known as cortisol which is produced by the adrenal glands. These paired glands in the dog and cat, are located just above each kidney. The cortisol hormone produced by the adrenal glands is more commonly referred to as adrenaline. This hormone assists all mammals in times of stress, and is sometimes called the "fight or flight" hormone. When in excess, cortisol can cause serious problems. The cortisol produced by the adrenal glands, is under control by another gland located in the base of the brain, called the pituitary gland. This gland is also known as the "master" gland of the body, controlling the production of many hormones such as thyroxin or thyroid hormone as well. Tumors in either the pituitary gland, or the adrenal gland, will ultimately cause the syndrome known as Cushing's disease. When a tumor develops in the pituitary gland, the resultant condition of Cushing's disease is referred to as secondary Cushing's syndrome or pituitary dependant hyperadrenocorticism (PDH). This is the most common form of the disease, occurring in approximately 80% of the patients diagnosed with Cushing's disease.

68. McGraw-Hill Professional Cushing s syndrome http//www.niddk.nih.gov/health/endo/pubs/cushings/cushings.htmThis page, maintained by the NIDDK, provides an overview, in outline format http://books.mcgraw-hill.com/medical/lange/cmdt/ch26.html

Bookstore Home Contact Us Customer Service Help Search Products Search Tips Create Account Edit Account View Cart/Checkout CMDT Chapters Resources Chapter 26: Endocrinology Selected and rated by Addison's Disease http://www.niddk.nih.gov/health/endo/pubs/addison/addison.htm This Web site features a brief overview of Addison's disease, including pathophysiology, diagnosis, and treatment. A list of references for further reading are included. Adrenal Disease: Hematologic, Electrolyte, and Metabolic Disorders http://www.vh.org/Providers/ClinRef/FPHandbook/Chapter06/18-6.html This site, part of the University of Iowa Family Practice Handbook, discusses hypo- and hyperadrenalism in outline form, covering etiology, diagnosis, and treatment. Adrenal Leukodystrophy Module http://www.vh.org/Providers/TeachingFiles/RCW/012696/012696.html This teaching module from the Virtual Hospital provides background information and clinical presentation of ALD, followed by discussions on differential diagnoses, the comparative diagnostic utility of imaging modalities, and concluding remarks. Hyperlinks to accompanying high-quality images are included for reference. Adrenal Pathology Lecture http://views.vcu.edu/pat/education/endocrine/endocrine/adrenal/Index.htm

69. CUSHING'S SYNDROME: THE FACTS YOU NEED TO KNOW CUSHING S syndrome THE FACTS YOU NEED TO KNOW. Written by Paul Margulies,MD WHAT IS CUSHING S syndrome? Cushing s syndrome is a disease http://www.medhelp.org/www/nadf4.htm

CUSHING'S SYNDROME: THE FACTS YOU NEED TO KNOW Written by: Paul Margulies, M.D., F.A.C.P., F.A.C.E. Medical Director - NADF Clinical Associate Professor of Medicine, Cornell University Medical College WHAT IS CUSHING'S SYNDROME? Cushing's Syndrome is a disease caused by an excess of cortisol production or by excessive use of cortisol or other similar steroid (glucocorticoid) hormones. Cortisol is a normal hormone produced in the outer portion, or cortex, of the adrenal glands, located above each kidney. The normal function of cortisol is to help the body respond to stress and change. It mobilizes nutrients, modifies the body's response to inflammation, stimulates the liver to raise the blood sugar, and it helps control the amount of water in the body. Another adrenal cortex hormone, aldosterone, regulates salt and water levels which affects blood volume and blood pressure. Small amounts of androgens (male hormones) are also normally produced in the adrenal cortex. Cortisol production is regulated by adrenocorticotrophic hormone (ACTH), made in the pituitary gland, which is located just below the brain. When too much cortisol is produced in the adrenal glands, or an excess is taken in treating other diseases, significant changes occur in all of the tissues and organs of the body. All of these effects together are called Cushing's Syndrome.

70. EMedicine - Cushing Syndrome : Article By Gail Adler, MD, PhD Background Cushing syndrome is caused by prolonged exposure to Individuals with Cushing syndrome develop moon facies, facial common cause of Cushing syndrome is use of exogenous http://www.emedicine.com/emerg/topic117.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Emergency Medicine Endocrine And Metabolic Cushing Syndrome Last Updated: April 11, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: Cushing's syndrome, Cushing basophilism, Cushing's basophilism, pituitary basophilism AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Gail Adler, MD, PhD , Assistant Professor, Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School Gail Adler, MD, PhD, is a member of the following medical societies: Endocrine Society Editor(s): William Chiang, MD , Assistant Director, Assistant Professor of Clinical Surgery/Emergency Medicine, Department of Emergency Medicine, Bellevue Hospital Center; Francisco Talavera, PharmD, PhD , Senior Pharmacy Editor, Pharmacy, eMedicine; Howard A Bessen, MD

71. Cushing Syndrome & Kidney Disease Subject Cushing syndrome kidney disease Topic Area Kidney/Urinary Stones ForumThe Urology Forum Question Posted By Sherry Kuttner on Sunday, October 18 http://www.medhelp.org/forums/urology/archive/2051.html

Questions in The Urology Forum are currently being answered by by Kevin Pho, M.D., who is board certified in Internal Medicine. Dr. Pho has a private practice in Internal Medicine and is also affiliated with an academic medical center where he works in emergency and inpatient venues. Subject: Topic Area: Kidney/Urinary Stones Forum: The Urology Forum Question Posted By: Sherry Kuttner on Sunday, October 18, 1998 Could you please tell me the effect that Cushing's Syndrome has on kidney function? I have had 5 stones (uric acid) since the first of the year. I have just been diagnosed with Cushing's and I'm not sure if the Cushing's is causing the problem. I'm experiencing an entire suite of hormonal problems and constant pain from the intermittent stones. Thanks for any help! Dear Sherry Kuttner Thanks for your question. Cushing’s syndrome patients have high glucocorticoid production. This glucocorticoid product causes your body to dissolve your bone. Your bone is made of calcium and this is excreted in the urine and is available in the urine to form stones. Your at high risk for osteoporosis. Cushings is not common but other causes of kidneys stones are. I would see a urologist for a metabolic stone work-up and thus give you and your doctor the knowledge to help prevent future stone formation.

72. Cushing' Syndrome Laboratorial Diagnosis - Endocrinology - MEDSTUDENTS Medstudents Homepage. Cushing syndrome Laboratorial Diagnosis. The othertypes of Cushing syndrome are classified according to the following http://www.medstudents.com.br/endoc/endoc7.htm

Endocrinology Medstudents' Homepage Cushing' Syndrome Laboratorial Diagnosis Cushing’s Syndrome may be defined as a persistent and continuous state of endogenous cortisol overproduction, not being in accordance with ordinary circadian rhythm patterns (It was first fully clinically described by Harvey Cushing in 1912 .). As a consequence, it leads to various symptoms and signs, namely: Obesity (90%)* Hypertension (85%) Diminished Glucose Intolerance (80%) Sexual and menstrual dysfunction (76%) Hirsutism and acne (72%) * The main Cushing’s obesity feature is centripetal, but generalized obesity can occur - often to children. Apart from that, the finding of violet estriae, associated or not with the above characteristics, raises the suspicious of the syndrome. Also, it must be stressed out that the term "Cushing’s Disease" is a specific type of Cushing’s Syndrome whose ethiology is Pituitary Adenoma ACTH producer (generally it is due to microadenoma). The other types of Cushing Syndrome are classified according to the following: Cushing’s Syndrome a) ACTH dependent Macro and Microadenoma ACTH producing Pituitary;

73. Bilateral Inferior Petrosal Sinus Sampling In Cushing's Syndrome Major Diagnostic Advance Bilateral Inferior Petrosal SinusSampling in Cushing s syndrome by Beverly MK Biller, MD. http://pituitary.mgh.harvard.edu/e-f-932.htm

Referrals Neuroendocrine Bulletin Archive Guestbook Links Major Diagnostic Advance: Bilateral Inferior Petrosal Sinus Sampling in Cushing's Syndrome by Beverly M.K. Biller, M.D. Referrals Neuroendocrine Bulletin Archive Guestbook Neurosurgery Home ... Links Diagnostic Problem Cushing's syndrome, with its high morbidity and mortality, requires a diagnostic workup which includes verifying the patient's cortisol excess, then documenting the site of hormone overproduction. ACTH-dependent causes include pituitary tumors (Cushings disease) and ectopic ACTH-secreting (or rarely CRH-secreting) tumors, while ACTH-independcnt Cushing's is due to a primary adrenal lesion(Figure 1). Figure 1 From Schteingart DE: Cushing's syndrome in EndocrinoIogy and Metabolisrn Clinics of North America Barkan AL (ed), Vol. 18, No. 2, June 1989; with permission. Figure 2 Reprinted, by permission of The New England Journal of Medicine Vol. 312 p. 101, 1985.

74. Diabetes Mellitus, Type 2, Type 1, And Metabolic Disorders Treatment And Medicat Advanced Search. Cushing s syndrome Main Index. Terms Related to Cushing s syndrome Cushing ssyndrome Main Article, Cushing s syndrome Related Medications. http://www.medicinenet.com/Forum.asp?li=MNI&ag=Y&ArticleKey=334

75. Pituitary Treatment TREATMENT OF CONFIRMED PITUITARY CUSHING’S syndrome. There are threetreatments commonly used in the management of pituitary dependent http://www.marvistavet.com/html/body_pituitary_treatment.html

TREATMENT OF CONFIRMED PITUITARY CUSHING’S SYNDROME There are three treatments commonly used in the management of pituitary dependent Cushing’s disease: Lysodren (also called Mitotane or o,p’-DDD), Nizoral (also called Ketoconazole) and Anipryl (also called L-Deprenyl, Eldepryl or Selegiline). These medications are associated with different side effects potential and expense and any of them can be expected to produce good results in a confirmed case of pituitary Cushing’s disease. LYSODREN: THE TRADITIONAL THERAPY Lysodren (generically known as “mitotane” and chemically known as “o,p’-DDD”) has been the only treatment for pituitary dependent Cushing’s disease until relatively recently. It is convenient to use and relatively inexpensive, though it does have the potential for very serious side effects. Because this medication has been in use for canine Cushing’s disease for decades, most veterinarians have extensive experience with its use and with the monitoring tests needed to prevent side effect difficulties. One of the disadvantages of lysodren therapy is the need for regular monitoring blood tests. HOW THIS MEDICATION WORKS HOW THIS MEDICATION IS USED There are two phases to the treatment of Cushing’s disease with Lysodren: an induction phase to gain control of the disease and a lower dose maintenance phase which ideally lasts for the animal’s entire life.

76. Cushing's Syndrome - Information / Diagnosis / Treatment / Prevention home endocrine disorders pituitary cushing s syndrome Cushing ssyndrome. Cushing s syndrome NIDDK Cushing s Information site. http://www.healthcyclopedia.com/endocrine-disorders/pituitary/cushing's-syndrome

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... pituitary > cushing's syndrome Cushing's Syndrome Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Related Topics Medical Definition Health Portals Health News ... Web Directory: Related Topics: Medicine/Medical Specialties/Endocrinology Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "Cushing's syndrome" Health Portals: FamilyDoctor.org Information Sheets : Cushing's Syndrome and Cushing's Disease MayoClinic.com Health News: Search millions of published articles for news on Cushing's Syndrome Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: Cushing' Syndrome Laboratorial Diagnosis Provides laboratorial diagnosis of Cushing's syndrome.

77. SupportPath.com: Cushing's Syndrome SupportPath.com, Cushing s syndrome. Also called Cushing s Disease, Hypoadrenocorticism. NoneListed. Clinical Trials Research on Cushing s syndrome http://www.supportpath.com/sl_c/cushings_syndrome.htm

Cushing's Syndrome Also called: Cushing's Disease, Hypoadrenocorticism Other topics of interest on SupportPath.com: Hypertension Nutrition Obesity About Us ... here Online Communities / Message Boards... Cushings Help and Support Website: http://www.cushings-support.com/cgi-bin/ib3/ikonboard.cgi Description: Part of the Cushings Help and Support website, this message board provides "Information and support for people with Cushing's disease or other endocrine problems, their friends and families." Registration is required to post. Date Added: 07/19/2002 Online Chats... Note: Regularly scheduled chats are listed on our NEW Online Events Calendar Links in this section are primarily to chat rooms open 24/7 which may or may not be moderated. None Listed Usenet Groups... Note: Your browser must be properly configured to access Usenet groups from this site. None Listed Mailing Lists... None Listed National / International Organizations... None Listed Note: Groups are listed alphabetically by U.S. state and then country. None Listed Cushing's Syndrome Website: http://www.niddk.nih.gov/health/endo/pubs/cushings/cushings.htm

78. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies: 9 studies were found. 1. Recruiting, Study of Hypercortisolism in Cushing s syndromeand StressInduced Pseudo-Cushing s syndrome Condition Cushing s syndrome. http://www.clinicaltrials.gov/search/term=Cushing's Syndrome

Home Search Browse Resources ... About Search results for Cushing's Syndrome [ALL-FIELDS] are shown below. Include trials that are no longer recruiting patients. 9 studies were found. Recruiting New Imaging Techniques in the Evaluation of Patients with Ectopic Cushing's Syndrome Condition: Cushing's Syndrome Recruiting Study of Hypercortisolism in Cushing's Syndrome and Stress-Induced Pseudo-Cushing's Syndrome Condition: Cushing's Syndrome Recruiting Long Term Post Operative Follow-Up of Cushing Syndrome Condition: Cushing Syndrome Recruiting Study of Depression, Peptides, and Steroids in Cushing's Syndrome Condition: Cushing's Syndrome Recruiting Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients with Adrenal Insufficiency Conditions: Adrenal Gland Hyperfunction; Adrenal Gland Hypofunction; Cushing's Syndrome; Healthy Recruiting Genetic Investigation of Pediatric Tumors of the Pituitary Gland Conditions: Abnormalities; Craniopharyngioma; Cushing's Syndrome; Endocrine Disease; Pituitary Neoplasm Recruiting Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex Conditions: Cushing's Syndrome; Hereditary Neoplastic Syndrome; Lentigo; Neoplasm; Testicular Neoplasm

79. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies: 8. Recruiting, New Imaging Techniques in the Evaluation of Patientswith Ectopic Cushing s syndrome Condition Cushing s syndrome. http://www.clinicaltrials.gov/ct/gui/action/SearchAction?term=Bleeding Disorders

80. Pet Owner's Crash Course In Canine Cushing's Disease Dog Owner s Guide; Norma Bennett Wolf, Ohio. Cushing s syndrome. SuperVet, UK. Cushing ssyndrome. Auburn University College of Veterinary Medicine, Alabama. http://www.kateconnick.com/library/cushingsdisease.html

Home About Services Kate Connick ... Site Map Canine Cushing's Disease Cushing's Disease (hyperadrenocorticism) is a common condition in older dogs, often mistaken for the aging process itself. Dogs gain weight, lose hair, urinate in the house, and make owners begin to prematurely consider euthanasia. Yet Cushing's disease is treatable and that treatment can result in a longer, more comfortable life for the dog and its owner. Thus, it is important for the regular pet owner to learn the basic facts about Cushing's disease. In health: In Cushing's Disease: The feedback loop has gone awry in Cushing's disease for one of three reasons: a pituitary tumor, an adrenal tumor, or veterinary interference. The result is a chronic excess of blood cortisol. In effect, the dog is being poisoned with too much cortisol and cannot rely on its own feedback mechanism to regulate the blood cortisol level. Pituitary Dependant Hyperadrenocorticism: The most common cause of Cushing's disease is a microscopic, benign pituitary tumor (microadenoma) which oversecretes ACTH and ignores the adrenals' response. 50% of pituitary tumors are less than 3mm in diameter. The dog's pituitary keeps cranking out ACTH, causing the adrenals to keep cranking out cortisol, yet the pituitary does not respond to the elevated blood cortisol levels by stopping its release of ACTH. 85% of Cushing's cases are pituitary dependent. Dogs with pituitary dependent hyperadrenocorticism tend to have two very large adrenal glands, as both are constantly working to keep up production of excess cortisol.

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