41. What Is Cushing's Syndrome? WHAT IS CUSHING S syndrome? Introduction. Men have decreased fertility withdiminished or absent desire for sex. What Causes Cushing s syndrome? http://cushings.homestead.com/files/Printing/CushingsInfo.html

WHAT IS CUSHING'S SYNDROME? Introduction Cushing's syndrome is a hormonal disorder caused by prolonged exposure of the body's tissues to high levels of the hormone cortisol. Sometimes called "hypercortisolism," it is relatively rare and most commonly affects adults aged 20 to 50. An estimated 10 to 15 of every million people are affected each year. What Are the Symptoms? Symptoms vary, but most people have upper body obesity, rounded face, increased fat around the neck, and thinning arms and legs. Children tend to be obese with slowed growth rates. Other symptoms appear in the skin, which becomes fragile and thin. It bruises easily and heals poorly. Purplish pink stretch marks may appear on the abdomen, thighs, buttocks, arms and breasts. The bones are weakened, and routine activities such as bending, lifting or rising from a chair may lead to backaches, rib and spinal column fractures. Most people have severe fatigue, weak muscles, high blood pressure and high blood sugar. Irritability, anxiety and depression are common. Women usually have excess hair growth on their faces, necks, chests, abdomens, and thighs. Their menstrual periods may become irregular or stop. Men have decreased fertility with diminished or absent desire for sex.

42. Pituitary Network Association - Disorders - Cushing's Disease Cushing s syndrome. The cause of Cushing s syndrome is a pituitary adenoma in over70% of adults and in approximately 6070% of children and adolescents. http://www.pituitary.com/disorders/cushings.php

Cushing's Syndrome Cushing's syndrome is a debilitating endocrine disorder characterized by excessive cortisol levels in the blood which may be the result of a tumor of the pituitary gland, adrenal glands (located above the kidneys) or from tumors or cancer arising elsewhere in the body (ectopic ACTH producing tumors). Cushing's disease refers specifically to excessive ACTH secretion by a pituitary tumor (also called pituitary adenoma). The cause of Cushing's Syndrome is a pituitary adenoma in over 70% of adults and in approximately 60-70% of children and adolescents. Most pituitary ACTH-secreting adenomas are small in size (microadenomas). Overall, Cushing's Disease is relatively rare, affecting 10 to 15 of every million people each year, and most commonly affects adults aged 20 to 50 years. Women account for over 70% of cases. Symptoms and signs of Cushing's syndrome and disease may include: Change in body habitus: weight gain in face (moon face), above the collar bone (supraclavicular) and on back of neck (buffalo hump) Skin changes with easy bruising, purplish stretch marks (stria) and red cheeks (plethora)

43. Cushing's Syndrome Psychiatric aspects of Cushing s syndrome by Kelly WF Diabetes Care Centre,Middlesbrough General Hospital, UK. QJM 1996 Jul; 89(7)54351 ABSTRACT. http://www.biopsychiatry.com/cushings.htm

Psychiatric aspects of Cushing's syndrome by Kelly WF Diabetes Care Centre, Middlesbrough General Hospital, UK. QJM 1996 Jul; 89(7):543-51 ABSTRACT P CRF LHPA Stress Options ... The Good Drug Guide The Responsible Parent's Guide To Healthy Mood Boosters For All The Family

44. Cushing's Syndrome / Cushing's Help And Support I. Causes of Cushing s syndrome. Masculinizing effects seen in female patients.III. Most Common Signs and Symptoms of Cushing s syndrome. Central obesity. http://www.cushings-help.com/syndrome1.htm

Cushing's Syndrome Visit the Message Boards For More Support Today is ...and it's about time there was some support for Cushing's! Wednesday is CHAT NIGHT From Cushing's Syndrome Allan D. Marks, MD Cushing's syndrome: the clinical signs, symptoms, and laboratory abnormalities caused by excessive exposure to cortisol (or its synthetic analogs). I. Causes of Cushing's syndrome Cushing's "disease" (bilateral adrenal hyperplasia caused by an ACTH -secreting adenoma of the pituitary gland Makes up about 80% of total "syndrome" Basophilic adenoma of pituitary - In about 50% with Cushing's syndrome Chromophobe adenoma of pituitary - In 10% of Cushing's "disease" (often large) Inappropriately high level of CRH (corticotropin releasing hormone) Adrenal tumors (10 to 15% of total Cushing's syndrome) Benign adenomas more common than adenocarcinomas Ectopic ACTH syndrome (10 to 15% of total Cushing's syndrome) Production of ACTH (or similar peptide) by nonendocrine tumor (small cell carcinoma of lung in more than 50%). Only form of Cushing's syndrome that is more common in men "Iatrogenic", caused by steroids given by physician

45. Cushing's Syndrome / Cushing's Help And Support Cushing s syndrome Part One 15 Oct 1999 Featured Article by Troya Renee Yoder,used with permission as originally posted on Suite 101.com, Pituitary http://www.cushings-help.com/syndrome.htm

Cushing's Syndrome Visit the Message Boards For More Support Today is ...and it's about time there was some support for Cushing's! Wednesday is CHAT NIGHT Cushing's Syndrome - Part One 15 Oct 1999 Featured Article by Troya Renee Yoder, used with permission as originally posted on Suite 101.com, Pituitary Disorders What is Cushing's Syndrome? First described by the physician, Harvey Cushing , in 1912, Cushing’s syndrome (sometimes called hypercortisolism) refers to a disorder in which the body suffers from prolonged exposure to high levels of the stress hormone cortisol . Because of the gradual nature of the disease, the time between the onset of symptoms and the diagnosis of Cushing’s is often long and frustrating. The Cortisol Production Pathway In order to understand how Cushing’s syndrome arises, it is necessary to briefly examine the cortisol pathway. First, the hypothalamus secretes corticotropin releasing hormone (CRH). CRH stimulates the pituitary gland to secrete ACTH , which causes the adrenal glands to release cortisol into the bloodstream. A biologic feedback loop exists in which the

46. Cushing S Disease In The Dog Cushing s syndrome. What is Cushing s syndrome? Cushing s syndrome isa disorder whereby the hormone cortisol is produced to excess. http://www.supervet.co.uk/dog/cushings.html

47. AllRefer Health - Cushing's Syndrome (Hypercortisolism) Cushing s syndrome (Hypercortisolism) information center covers causes, prevention,symptoms, diagnosis, treatment, incidence, risk factors, signs, tests http://health.allrefer.com/health/cushings-syndrome-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia You are here : AllRefer.com Health Cushing's Syndrome Cushing's Syndrome Definition Prevention Treatment Expectations or Prognosis ... Go To Main Page Alternate Names : Hypercortisolism Definition A disease caused by increased production of cortisol or by excessive use of cortisol or other steroid hormones. Endocrine Glands Cushing's syndrome is a condition that results from an excess of cortisol, a hormone produced by the adrenal glands. The most common cause of Cushing's syndrome is Cushing's disease caused by excessive production of adrenocorticotropic hormone ( ACTH ) by the pituitary gland. ACTH stimulates the

48. AllRefer Health - Exogenous Cushing's Syndrome (Corticosteroid-Induced Cushing's Cushing s syndrome Exogenous (Corticosteroid-Induced Cushing s syndrome, Cushing ssyndrome - Corticosteroid Induced, Iatrogenic Cushing s syndrome http://health.allrefer.com/health/cushings-syndrome-exogenous-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia You are here : AllRefer.com Health Exogenous Cushing's Syndrome Cushing's Syndrome - Exogenous Definition Prevention Treatment Expectations or Prognosis ... Go To Main Page Alternate Names : Corticosteroid-Induced Cushing's Syndrome, Cushing's Syndrome - Corticosteroid Induced, Iatrogenic Cushing's Syndrome Definition Exogenous Cushing's syndrome is a form of Cushing's syndrome caused by administration of glucocorticoid (also called corticosteroid) hormones, such as prednisone. Hypothalamus Hormone Production Cushing's syndrome is named after the surgeon Harvey Cushing. It is a group of clinical signs and symptoms caused by a chronic excess of glucocorticoids, which are hormones produced by the adrenal glands. Glucocorticoids affect many body functions and are essential for survival, but when the level of these hormones is too high, it can cause serious problems. The most important glucocorticoid is the "stress hormone" cortisol. The pituitary gland, a small gland at the base of the brain, regulates cortisol production by secreting a hormone called adrenocorticotropic hormone (ACTH).

49. Cushing's Syndrome Cushing syndrome. Cushing s Bibliography. Boscaro M, Barzon L, Fallo F,Sonino N. Cushing s syndrome. Lancet 2001; 357 783791. Lucarotti http://www.surgical-tutor.org.uk/system/hnep/cushings.htm

Up Tracheostomy Foreign bodies ENT disorders ... Neck lumps in children Cushing syndrome Cushing's syndrome results from cortisol excess Commonest cause is iatrogenic from the use of exogenous steroid medication Cushing's disease has an incidence of 1 per 100.000 / year Female : male is 5:1 Peak incidence is 30-50 years Aetiology Primary adrenal disease (20%) Adrenal adenoma Adrenal carcinoma Adrenal cortical hyperplasia Secondary adrenal disease Cushing's disease = Due to ACTH secreting pituitary microadenoma (70%) Ectopic ACTH production from a malignancy (10%) Small cell carcinoma of the lung Carcinoid tumours Medullary carcinoma of the thyroid Pseudo-Cushing's syndrome Major depressive illness Alcohol excess Clinical features Symptoms Signs Weight gain Truncal obesity Menstrual irregularity Plethora Hirsuitism in women 'Moon' face Headache Hypertension Thirst Bruising Back pain Striae Muscle weakness Buffalo hump Abdominal pain Acne Lethargy / depression Osteoporosis Investigation The clinical picture often does not allow identification of the cause of Cushing's syndrome Investigations are aimed at: A biochemical confirmation of the diagnosis of Cushing's syndrome Identifying the site of the pathological lesion - adrenal, pituitary, ectopic production

50. Bbc.co.uk - Health - Illnesses And Conditions - Cushing's Syndrome Cushing s syndrome By Dr Rob Hicks Caps on the kidneys Too much of a goodthing Characteristic effects Uncovering and sorting out the problem. http://www.bbc.co.uk/health/conditions/cushings.shtml

@import url('/includes/tbenh.css') ; Home TV Radio Talk ... A-Z Index WEDNESDAY 2nd June 2004 Text only BBC Homepage Health Home Lifestyle Home ... Conditions QUICK GUIDE A-Z Children's Ailments IN-DEPTH Addictions Allergies Arthritis Asthma ... Help Like this page? Send it to a friend! A-Z Illnesses and Conditions Cushing's Syndrome By Dr Rob Hicks Caps on the kidneys Too much of a good thing Characteristic effects ... Uncovering and sorting out the problem The hormone Cortisol is essential in helping the body to prepare and respond effectively to physical and emotional stress. Too much Cortisol, however, can have quite the opposite effect as people who suffer with Cushing's syndrome, named after the Boston neurosurgeon Harvey Cushing, know all too well. Caps on the kidneys The adrenal glands are very important manufacturers of different hormones. These help to control blood pressure and salt and water balance, and help our immune system fight off infection and deal with stress and illness. There are two adrenal glands, and each one sits like a cap on top of the kidney. The inner part of the gland secretes adrenalin and noradrenaline. The outer part of the adrenal gland is made up of three zones that secrete a group of hormones collectively called corticosteroids or the adrenal hormones . These are: Aldosterone - this regulates salt and water loss through the kidneys and so helps control blood pressure.

51. Cushing's Syndrome Cushing s syndrome. Cushing’s syndrome, Dexamethasone suppressiontest (overnight) and/or cortisol (free) urine are performed http://www.rcpa.edu.au/pathman/cushings.htm

This site has been updated. Please go to www.rcpamanual.edu.au This page will be permanently removed on 30th September 2004. Please update your links. Cushing's syndrome Dexamethasone suppression test (overnight) and/or cortisol (free) - urine dexamethasone suppression test (long) incl ACTH levels, provides the definitive diagnosis and differentiates pituitary from adrenal causes. Electrolytes. Diagnostic imaging, as appropriate. Pituitary-dependent adrenal hyperplasia. Corticotroph adenoma Adrenal adenoma/carcinoma Ectopic ACTH syndrome Iatrogenic (corticosteroid therapy)

52. Cushing's Syndrome -- Part Of The Endocrine Resource Center Cushing s syndrome part of the Endocrine Resource Center, featuring informationon Addison s Disease, Cushing s syndrome, Hyperparathyroidism, Multiple http://www.thyroid-info.com/endocrine/cushings-syndome.htm

Sticking Out Our Necks, the FREE Monthly Thyroid News Report, Enter your email address here for a free subscription Or Click Here to Send a "Subscribe" Email Home Newsletters Bookstore ... ENDOCRINE CENTER Latest Update: SEARCH SITE Cushing's Syndrome Endocrine Resource Center Adapted by Mary Shomon Introduction What Are the Symptoms? What Causes Cushing's Syndrome? ... What Other Resources Are Available? Introduction Cushing's syndrome is a hormonal disorder caused by prolonged exposure of the body's tissues to high levels of the hormone cortisol. Sometimes called "hypercortisolism," it is relatively rare and most commonly affects adults aged 20 to 50. An estimated 10 to 15 of every million people are affected each year. What Are the Symptoms? Symptoms vary, but most people have upper body obesity, rounded face, increased fat around the neck, and thinning arms and legs. Children tend to be obese with slowed growth rates. Other symptoms appear in the skin, which becomes fragile and thin. It bruises easily and heals poorly. Purplish pink stretch marks may appear on the abdomen, thighs, buttocks, arms and breasts. The bones are weakened, and routine activities such as bending, lifting or rising from a chair may lead to backaches, rib and spinal column fractures. Most people have severe fatigue, weak muscles, high blood pressure and high blood sugar. Irritability, anxiety and depression are common.

53. The Pituitary Foundation | GP Fact File | 4. Cushing's Disease Pituitary Foundation Fact Sheet. Incidence 56 New Cases per million per year. Cushing sDisease. Cushing s syndrome is caused by excessive circulating cortisol. http://www.pituitary.org.uk/gp-factfile/4-cushings.htm

Text version Home News Contact Us ... Skip search box SEARCH THIS SITE Advanced search Skip section links GP FACT SHEETS 1. Introduction 2. Non-Functioning Tumour 3. Acromegaly 5. Hyperprolactinaemia ... GP Fact File Index LINKS Skip main links The Endocrine System Pituitary Disorders Resources ... About The Pituitary Foundation Pituitary Foundation Fact Sheet Incidence: New Cases per million per year ACTH ACTH by a pituitary tumour and consequent hypersecretion of cortisol. Other causes are an adrenal tumour or an ectopic tumour secreting ACTH Presenting symptoms psychiatric disturbance (often characterised by amplification of previous personality traits) moon face - particularly filling in of the temporal fossa weight gain - central obesity muscle wasting and proximal myopathy (patients have difficulty standing from a seated position without use of arms) thin skin * - tendency to bruise hirsutism (caused by androgen excess) violaceous striae ACTH levels, tends to protect against this.

54. The Pituitary Foundation | Disorders | Cushing's Disease Cushing s syndrome describes the condition resulting from too muchexposure to steroid hormones. The commonest cause of Cushing s http://www.pituitary.org.uk/disorders/cushings.htm

Text version Home News Contact Us ... Skip search box SEARCH THIS SITE Advanced search Skip section links DISORDERS Acromegaly Adult GH Deficiency ... Disorders Index LINKS Skip main links The Endocrine System Pituitary Disorders Resources ... About The Pituitary Foundation ACTH Typical symptoms behaviourial changes, depression and mood swings, occasionally psychological problems can be severe face tends to be rounder (moon face) and redder weight gain around the trunk (central obesity) muscle wasting and proximal myopathy (patients have difficulty standing from a seated position without use of arms) tendency to bruise easily irregular periods (oligomenorrhoea) or loss of normal menstrual function (amenorrhoea) - females impotence - males reduced fertility decrease in sex drive increase in hair growth on the face and body (hirsutism) increase in blood pressure development of mild diabetes mellitus Top of Page Resources available from The Pituitary Foundation - patient information booklet (1994). Proceedings of the Inaugural Pituitary Foundation Conference (page 4).

55. Cushing's Syndrome Information of Cushing s syndrome. The adrenalsare two glands, each perched on the upper part of the two kidneys....... Cushing s syndrome Information. http://www.arthritis-symptom.com/a-c/cushings-syndrome.htm

Have an arthritis question Contact us Link to Arthritis-Symptom.com And help arthritis suffers find the information they need If you are not familiar with Cetyl Myristoleate for the treatment of arthritis then you need to check out this site. Search our site Join our Arthritis discussion group Here Arthritis symptoms Rheumatoid arthritis ... Pain Other Types of Arthritis A - C D - G H-L M-P ... Procedures MORE INFO Ankylosing Spondylitis Arthris Pain Fibromylgia Rheumatoid ... Treatment Cushing's syndrome Information Cushing's syndrome, also known as hypercortisolism, occurs when a person's tissues are exposed to an excess of the hormone cortisol. When the appropriate amount of cortisol is released by the adrenal glands, it helps regulate blood pressure, energy production, the ability to fight disease, and how the body maintains itself and responds to stress. But too much cortisol can alter the normal function of these processes, resulting in the symptoms of Cushing's syndrome Description of Cushing's syndrome The adrenals are two glands, each perched on the upper part of the two kidneys. The outer part of the gland is known as the cortex; the inner part is known as the medulla. Each of these parts of the adrenal gland is responsible for producing different types of hormones. Regulation of hormone production and release from the adrenal cortex involves the pituitary gland, a small gland located at the base of the brain. The pituitary gland releases a hormone called Adrenocorticotropic Hormone (ACTH) which travels through the bloodstream to the adrenal cortex, where it encourages the production and release of cortisol and other steroid hormones.

56. Cushing's,Adrenal Cortex Adenoma,Adrenal Hyperfunction Resulting From Pituitary Cushing s syndrome. Cushing s syndrome, also known as hypercortisolism, occurswhen a person s tissues are exposed to an excess of the hormone cortisol. http://www.icomm.ca/geneinfo/cushings.htm

Cushing's,Adrenal Cortex Adenoma,Adrenal Hyperfunction resulting from Pituitary ACTH Excess,Adrenal Neoplasm,Cushing's III,Ectopic ACTH Syndrome,Ectopic Adrenocorticotropic Hormone Syndrome For Information on Workshops and Seminars for Special Needs Children click here The GAPS INDEX to Information on the Internet about Genetic Disorders and Birth Defects Genetic Information and Patient Services, Inc. (GAPS) HOME DISORDERS GLOSSARY Cushing's Disease also known as: Adrenal Cortex Adenoma Adrenal Hyperfunction resulting from Pituitary ACTH Excess Cushing's III Ectopic ACTH Syndrome Ectopic Adrenocorticotropic Hormone Syndrome Cushing Syndrome is a rare endocrine disorder characterized by a variety of symptoms and physical abnormalities that occur due to excessive amounts of certain hormones (corticosteroids) produced by the adrenal glands. (as defined by the NICHD Publications Cushing's Syndrome Contents: Who gets it? What are it's symptoms? What causes Cushing's syndrome? How is it diagnosed? ... What about the future? Cushing's syndrome, also known as hypercortisolism, occurs when a person's tissues are exposed to an excess of the hormone cortisol. When the appropriate amount of cortisol is released by the adrenal glands, it helps regulate blood pressure, energy production, the ability to fight disease, and how the body maintains itself and responds to stress. But too much cortisol can alter the normal function of these processes, resulting in the symptoms of Cushing's syndrome.

57. Cushings Standards for Screening for Cushing s syndrome. INTRODUCTION. If cyclical Cushing ssyndrome is suspected, repeat testing may be required on several occasions. http://www.acb.org.uk/welshaudit/cushings.htm

Standards for Screening for Cushing's Syndrome INTRODUCTION A survey of urine free cortisol measurements in use in Wales, presented at an audit meeting in May 1995, showed wide variations in practice and the need to review methods used for screening for Cushing's syndrome. A further survey on this latter topic was presented at another audit meeting in May 1996. The following standards are recommended in the light of the presentations and discussions at these meetings and consultation with the Welsh Endocrine and Diabetes Society. STANDARDS Patient Assessment The diagnosis or exclusion of Cushing's syndrome can be difficult and it is recommended that non-expert clinicians should seek the advice of a consultant physician or paediatrician with specialist endocrinology experience. Laboratory tests should not be used in isolation; results should be interpreted together with a full clinical assessment of the patient. Choice of Test First-line screening tests must have high sensitivity to minimise the incidence of false negative results and reference (cut-off) values chosen to achieve these aims. The overnight dexamethasone suppression test is particularly recommended, but 24 hour urine free cortisol determination is also suitable. Measurement of 9 am serum cortisol alone is not adequate. In many cases it is desirable to perform more than 1 test. If cyclical Cushing's syndrome is suspected, repeat testing may be required on several occasions.

58. »»Cushings-Syndrome Reviews«« cushingssyndrome Reviews. Related Subjects Crohns-Disease More Pagescushings-syndrome Page 1 2. Search for a Health Issue Book. http://www.health-issue-books.com/Crohns-Disease/Cushings-Syndrome/Cushings-Synd

Cushings-Syndrome Reviews Related Subjects: Crohns-Disease More Pages: Cushings-Syndrome Page 1 Book reviews for "Cushings-Syndrome" sorted by average review score: Nutrition and Cushing syndrome (SuDoc HE 20.3002:C 95) Published in Unknown Binding by U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, Clinical Center (1991) Author: U.S. Dept of Health and Human Services Amazon base price: Average review score: No reviews found. The Official Patient's Sourcebook on Cushing's Syndrome: A Revised and Updated Directory for the Internet Age Published in Paperback by Icon grp int (August, 2002) Author: Icon Health Publications Amazon base price: Average review score: No reviews found. Related Subjects: Crohns-Disease More Pages: Cushings-Syndrome Page 1 Search for a Health Issue Book Sort by: Rank Last Modified Date Title Path Reverse Sort

59. Cushing's Syndrome http://www.meddean.luc.edu/lumen/MedEd/medicine/endonew/cushings/cushings.htm

60. 24Dr.com Reference Library - Encyclopaedia - Cushing's Syndrome CUSHING S syndrome. What is it? What is the treatment? Treatment of Cushing’ssyndrome depends on the cause of the overproduction of cortisol. http://www.24dr.com/reference/encyclopaedia/cushings.htm

Search for in All of 24Dr.com Contact points Dictionary Encyclopaedia eShop Library News Medicines Information Symptoms Travel Clinic Home Register / Login Dictionary Encyclopaedia Travel clinic Drug database Library Contact points Common symptoms Illustrations Feedback CUSHING'S SYNDROME What is it? Cortisol is a natural substance produced by the adrenal gland. It can also be produced synthetically. What are the symptoms? In women, there may be increased growth of facial and body hair, and menstrual periods may become irregular or stop completely. Exposure to too much cortisol can occur for different reasons such as long-term use of glucocorticoid hormones to treat inflammatory illnesses; pituitary adenomas (benign tumors of the pituitary glands) which secrete increased amounts of adrenocorticotropic hormone (ACTH); ectopic ACTH syndrome (a condition in which ACTH is produced by various types of potentially malignant tumors that occur in different parts of the body); and adrenal tumors (tumors of the adrenal glands). What is the treatment?

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