1. Birth Disorder Information Directory - CO-CZ List of Sites. Crow Fukase Syndrome (PEP Syndrome, POEMS Syndrome, Shimpo s Syndrome, Takatsuki s Syndrome) crowfukase syndrome. Cryptophthalmos-Syndactyly http://www.bdid.com/defectco.htm

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2. EMedicine - POEMS Syndrome : Article Excerpt By: Wingfield Rehmus, MD, MPH Words, and Related Terms crowfukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma cell The syndrome was termed crow-fukase syndrome (by which it is known http://www.emedicine.com/derm/byname/poems-syndrome.htm

(advertisement) Excerpt from POEMS Syndrome Synonyms, Key Words, and Related Terms: Crow-Fukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma cell dyscrasia, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes Please click here to view the full topic text: POEMS Syndrome Background: Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare multisystemic disease that occurs in the setting of a plasma cell dyscrasia. The pathophysiologic link between the constellation of symptoms and the underlying disease is not well understood, but the link may be related to changes in the levels of a cytokine or a growth factor. POEMS syndrome first was described by Crow in 1956 and then by Fukase in 1968. The syndrome was termed Crow-Fukase syndrome (by which it is known in Japan) by Nakanishi in a study of 102 cases in Japan. In 1980, the acronym POEMS was coined by Bardwick et al based on the 5 main features of the disease, namely, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. No specific case definition for POEMS exists; however, most authors agree that patients with POEMS syndrome should have 3 or more of the 5 features. The pathophysiology of the disease is not known; however, elevated levels of cytokines and growth factors have been implicated. The polyneuropathy associated with POEMS syndrome is a bilateral symmetric disturbance. It involves both motor and sensory nerves, begins distally, and has a progressive proximal spread. Associated cranial or autonomic nerves are not involved. Both demyelination and axonal degeneration are noted.

3. NORD - National Organization For Rare Disorders, Inc. of POEMS Syndrome. crowfukase syndrome. PEP Syndrome. Polyneuropathy-organomegaly- endocrinopathy organomegaly-endocrinopathy-M protein-skin lesions. Shimpo syndrome. Takatsuki syndrome http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=POEMS Syndrom

4. ORPHANET - Rare Diseases - Orphan Drugs Printing version, DISEASE POEMS syndrome, Synonym(s) crowfukase syndrome, No description is available, Clinical signs(23), Other website(s)(4), http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=2905

5. ORPHANET - Rare Diseases - Orphan Drugs D I S E A S E POEMS syndrome. Synonym(s) crowfukase syndrome http://orphanet.infobiogen.fr/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=2905

6. EMedicine - POEM Syndrome : Article Excerpt By: Wingfield Rehmus, MD, MPH and Related Terms crowfukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma then by Fukase in 1968. The syndrome was termed Crow-Fukase (by which it http://www.emedicine.com/derm/byname/poem-syndrome.htm

(advertisement) Excerpt from POEM Syndrome Synonyms, Key Words, and Related Terms: Crow-Fukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma cell dyscrasia, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes Please click here to view the full topic text: POEM Syndrome Background: POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes) syndrome is a rare multisystemic disease that occurs in the setting of a plasma cell dyscrasia. The pathophysiologic link between the constellation of symptoms and the underlying disease is not well understood, but the link may be related to changes in the levels of a cytokine or growth factor. POEMS syndrome first was described by Crow in 1956 and then by Fukase in 1968. The syndrome was termed Crow-Fukase (by which it is known in Japan) syndrome by Nakanishi in a study of 102 cases in Japan. In 1980, the acronym POEMS was coined by Bardwick et al based on the 5 main features of the disease, namely, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. No specific case definition for POEMS exists; however, most authors agree that patients with POEMS syndrome should have 3 or more of the 5 systems involved. The pathophysiology of the disease is not known; however, elevated levels of cytokines and growth factors have been implicated. Polyneuropathy: The polyneuropathy associated with POEMS syndrome is a bilateral symmetric disturbance. It involves both motor and sensory nerves, begins distally, and has a progressive proximal spread. Associated cranial or autonomic nerves are not involved. Both demyelination and axonal degeneration are noted.

7. Untitled JP, Defer GL, Degos JD, Gherardi RK. crowfukase syndrome a case associated with vasospastic angina. A case of crow-fukase syndrome with elevated soluble interleukin-6 receptor http://www.mdinteractive.com/v2/poems.html

Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammapathy, Skin changes Syndrome (POEMS) MEDLINE Early weight loss and high serum tumor necrosis factor-alpha levels in polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome - Ann Neurol 1994 Apr;35(4):501-5, Gherardi RK, et al Castleman's disease in POEMS syndrome with elevated interleukin-6 . - Cancer 1992 Jun 1;69(11):2697-703 Mandler RN, et al Acute arterial obliteration: a new feature of the POEMS syndrome? - Medicine (Baltimore) 1996 Jul;75(4):226-32 Lesprit P, Authier FJ, Gherardi R, Belec L, Paris D, Melliere D, Schaeffer A, Godeau B All-trans-retinoic acid in POEMS syndrome. Therapeutic effect associated with decreased circulating levels of proinflammatory cytokines . - Arthritis Rheum 1996 Aug;39(8):1423-6; Authier FJ, Belec L, Levy Y, Lefaucheur JP, Defer GL, Degos JD, Gherardi RK Crow-Fukase syndrome: a case associated with vasospastic angina. - Acta Neurol (Napoli) 1994 Aug;16(4):170-6; Mochizuki Y, Yoshihashi H, Oishi M, Takasu T, Nozawa K, Uchiyama T, Sawada S The skin changes in the Crow-Fukase (POEMS) syndrome. A case report.

8. Crow-Fukase Syndrome - General Practice Notebook crowfukase syndrome. POEMS is an acronym for polyneuropathy slow onset of mixed motor and sensory polyneuropathy; peripheral nerve http://www.gpnotebook.co.uk/cache/-1046872034.htm

Crow-Fukase syndrome POEMS is an acronym for: polyneuropathy: slow onset of mixed motor and sensory polyneuropathy peripheral nerve demyelination with some axonal degeneration organomegaly: hepatosplenomegaly endocrinopathy: gynaecomastia secondary amenorrhoea diabetes mellitus hypothyroidism monoclonal protein skin changes: hyperpigmentation hypertrichosis skin thickening The underlying pathology is usually an osteosclerotic myeloma. Radiographic surveys often reveal a single osteosclerotic lesion in the spine or proximal long bones. Click here for more information...

9. Alzhheimer JP, Defer GL, Degos JD, Gherardi RK. crowfukase syndrome a case associated with vasospastic angina. A case of crow-fukase syndrome with elevated soluble interleukin-6 receptor http://tuftsneurology.org/webres/poems.htm

POEMS Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammapathy, Skin changes Syndrome MEDLINE Early weight loss and high serum tumor necrosis factor-alpha levels in polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome - Ann Neurol 1994 Apr;35(4):501-5, Gherardi RK, et al Castleman's disease in POEMS syndrome with elevated interleukin-6 . - Cancer 1992 Jun 1;69(11):2697-703 Mandler RN, et al Acute arterial obliteration: a new feature of the POEMS syndrome? - Medicine (Baltimore) 1996 Jul;75(4):226-32 Lesprit P, Authier FJ, Gherardi R, Belec L, Paris D, Melliere D, Schaeffer A, Godeau B All-trans-retinoic acid in POEMS syndrome. Therapeutic effect associated with decreased circulating levels of proinflammatory cytokines . - Arthritis Rheum 1996 Aug;39(8):1423-6; Authier FJ, Belec L, Levy Y, Lefaucheur JP, Defer GL, Degos JD, Gherardi RK Crow-Fukase syndrome: a case associated with vasospastic angina. - Acta Neurol (Napoli) 1994 Aug;16(4):170-6; Mochizuki Y, Yoshihashi H, Oishi M, Takasu T, Nozawa K, Uchiyama T, Sawada S The skin changes in the Crow-Fukase (POEMS) syndrome. A case report.

10. Sitemap Of GPnotebook.co.uk orphenadrine hydrochloride / filoviruses / gradual onset unilateral blindness / IRV (inspiratory reserve volume) / crowfukase syndrome / digits (shortened http://www.gpnotebook.co.uk/sitemap21.htm

This is the GPnotebook.co.uk sitemap, click here to go to the homepage. analgesic nephropathy and NSAIDs genioglossus muscle (anatomy) CHD (myocardial infarction, insulin treatment and driving) hyperaldosteronism (familial, type 1) ... IHD and increased homocysteine levels

11. POEMS Syndrome covered by this report. Synonyms crowfukase syndrome; PEP Syndrome; Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions; http://my.webmd.com/hw/health_guide_atoz/nord789.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Quizzes, Calculators Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report POEMS Syndrome Important It is possible that the main title of the report POEMS Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Crow-Fukase Syndrome PEP Syndrome Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions Shimpo syndrome Takatsuki syndrome Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions Disorder Subdivisions None General Discussion POEMS syndrome is an extremely rare multisystem disorder. POEMS is an acronym that stands for (P)olyneuropathy, disease affecting many nerves; (O)rganomegaly, abnormal enlargement of an organ; (E)ndocrinoapthy, disease affecting certain hormone-producing glands that help to regulate the rate of growth, sexual development, and certain metabolic functions (endocrine system); (M)onoclonal gammopathy or M proteins; and (S)kin defects. Common symptoms include progressive weakness of the nerves in the arms and legs, an abnormally enlarged liver and/or spleen (hepatosplenomegaly), abnormally darkening of the skin (hyperpigmentation) and excessive hair growth (hypertrichosis). Endocrine abnormalities such as failure of the ovaries and testes (gonads) to function properly (primary gonadal failure) and diabetes mellitus type I may be present. Specific endocrine abnormalities associated with POEMS syndrome vary from case to case.

12. Index CrossMcKusick-Breen Syndrome Crosti-Gianotti Syndrome Croup Crouzon Craniofacial Dysostosis Crouzon Syndrome crow-fukase syndrome Cryoglobulinemia, Essential http://my.webmd.com/hw/index/index-topics-C.asp

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13. Blood -- Dispenzieri Et Al. 101 (7): 2496 was shown to be more complex with Crow's1 descriptionof 2 patients with osteosclerotic now call POEMS syndrome, crowfukase syndrome PEP syndrome (plasma cell dyscrasia http://www.bloodjournal.org/cgi/content/full/101/7/2496

QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: Prepublished online as a Blood First Edition Paper on November 27, 2002; DOI 10.1182/blood-2002-07-2299. Abstract of this Article PDF Version of this Article Citation Map Email this article to a friend Similar articles found in: Blood Online PubMed PubMed Citation This Article has been cited by: other online articles Search PubMed for articles by: Dispenzieri, A. Gertz, M. A. Alert me when: new articles cite this article Download to Citation Manager Collections under which this article appears: Clinical Observations, Interventions, and Therapeutic Trials All Versions of this Article: (most recent) Blood, 1 April 2003, Vol. 101, No. 7, pp. 2496-2506 CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS POEMS syndrome: definitions and long-term outcome Angela Dispenzieri Robert A. Kyle Martha Q. Lacy S. Vincent Rajkumar Terry M. Therneau Dirk R. Larson Philip R. Greipp Thomas E. Witzig Rita Basu Guillermo A. Suarez Rafael Fonseca John A. Lust and Morie A. Gertz

14. POEMS Syndrome Arimura K, Increased vascular endothelial growth factor (VEGF) is causative in crowfukase syndrome. Rinsho Shinkeigaku. Hitoshi S, crow-fukase syndrome. http://www.bchealthguide.org/kbase/nord/nord789.htm

document.write(''); var hwPrint=1; var hwDocHWID="nord789"; var hwDocTitle="POEMS Syndrome"; var hwRank="1"; var hwSectionHWID="nord789"; var hwSectionTitle=""; var hwSource="cn6.0"; var hwProdCfgSerNo="wsh_html_031_s"; var hwDocType="NORD"; National Organization for Rare Disorders, Inc. POEMS Syndrome Important It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Crow-Fukase Syndrome PEP Syndrome Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions Shimpo syndrome Takatsuki syndrome Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions Disorder Subdivisions None Related Disorders List Information on the following diseases can be found in the Related Disorders section of this report: Scleroderma Chronic inflammatory demyelinating polyneuropathy (CIDP) Osteosclerotic myeloma General Discussion POEMS syndrome is an extremely rare multisystem disorder. POEMS is an acronym that stands for (P)olyneuropathy, disease affecting many nerves; (O)rganomegaly, abnormal enlargement of an organ; (E)ndocrinoapthy, disease affecting certain hormone-producing glands that help to regulate the rate of growth, sexual development, and certain metabolic functions (endocrine system); (M)onoclonal gammopathy or M proteins; and (S)kin defects. Common symptoms include progressive weakness of the nerves in the arms and legs, an abnormally enlarged liver and/or spleen (hepatosplenomegaly), abnormally darkening of the skin (hyperpigmentation) and excessive hair growth (hypertrichosis). Endocrine abnormalities such as failure of the ovaries and testes (gonads) to function properly (primary gonadal failure) and diabetes mellitus type I may be present. Specific endocrine abnormalities associated with POEMS syndrome vary from case to case.

15. POEMS Syndrome - Quest Diagnostics Patient Health Library covered by this report. Synonyms. crowfukase syndrome; PEP Syndrome; Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions; http://www.questdiagnostics.com/kbase/nord/nord789.htm

document.write(''); var hwPrint=1; var hwDocHWID="nord789"; var hwDocTitle="POEMS Syndrome"; var hwRank="1"; var hwSectionHWID="nord789"; var hwSectionTitle=""; var hwSource="us6.0"; var hwProdCfgSerNo="wsh_html_059_c"; var hwDocType="NORD"; National Organization for Rare Disorders, Inc. POEMS Syndrome Important It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Crow-Fukase Syndrome PEP Syndrome Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions Shimpo syndrome Takatsuki syndrome Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions Disorder Subdivisions None General Discussion POEMS syndrome is an extremely rare multisystem disorder. POEMS is an acronym that stands for (P)olyneuropathy, disease affecting many nerves; (O)rganomegaly, abnormal enlargement of an organ; (E)ndocrinoapthy, disease affecting certain hormone-producing glands that help to regulate the rate of growth, sexual development, and certain metabolic functions (endocrine system); (M)onoclonal gammopathy or M proteins; and (S)kin defects. Common symptoms include progressive weakness of the nerves in the arms and legs, an abnormally enlarged liver and/or spleen (hepatosplenomegaly), abnormally darkening of the skin (hyperpigmentation) and excessive hair growth (hypertrichosis). Endocrine abnormalities such as failure of the ovaries and testes (gonads) to function properly (primary gonadal failure) and diabetes mellitus type I may be present. Specific endocrine abnormalities associated with POEMS syndrome vary from case to case.

16. Entrez PubMed The crowfukase syndrome a study of 102 cases in Japan. Nakanishi T, Sobue I, Toyokura Y, Nishitani H, Kuroiwa Y, Satoyoshi E, Tsubaki http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstra

17. Entrez PubMed Abstract, Increased vascular endothelial growth factor (VEGF) is causative in crowfukase syndrome Rinsho Shinkeigaku. 1999 Jan;39(1)84-5. Japanese. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Link&db=PubMed&dbFrom=PubMed&f

18. Blackwell Synergy - Cookie Absent crowfukase syndrome. crow-fukase syndrome was first introduced to Japan at a clinical conference held under the direction of Fukase in 1968. http://www.blackwell-synergy.com/links/doi/10.1046/j.1440-1789.2000.00309.x/abs/

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19. Blackwell Synergy - Cookie Absent The crowfukase syndrome a study of 102 cases in Japan. Neurology 1984; 34 712-720. MEDLINE Abstract ISI Abstract. crow-fukase syndrome. diabetic nephropathy. http://www.blackwell-synergy.com/links/doi/10.1111/j.1464-5491.2004.01094.x/enha

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20. Crow-Fukase Syndrome : On Medical Dictionary Online Link to the Medical Dictionary Online. crowfukase syndrome. A multisystemic disorder characterized by a sensorimotor polyneuropathy http://www.online-medical-dictionary.org/?q=Crow-Fukase Syndrome

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