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  1. Crigler-Najjar Syndrome

21. HealthCentral - General Encyclopedia - Crigler-Najjar Syndrome
General Health Encyclopedia, criglernajjar syndrome. Causes, incidence, and risk factors crigler-najjar syndrome is inherited as an autosomal recessive trait.
http://www.healthcentral.com/mhc/top/001127.cfm
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22. Disease Directory : Genetic Disorders : Crigler-Najjar Syndrome
Diseases Genetic Disorders criglernajjar syndrome. AllRefer Health - crigler-najjar syndrome Symptoms Signs (Arias crigler-najjar syndrome.
http://www.diseasedirectory.net/Genetic_Disorders/Crigler-Najjar_Syndrome/defaul
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23. Disease Directory : NEJM -- Treatment Of The Crigler-Najjar Syndrome Type I With
Diseases Genetic Disorders criglernajjar syndrome NEJM Treatment of the crigler-najjar syndrome Type I with Directory Listing.
http://www.diseasedirectory.net/detailed/25426.aspx
Wednesday, June 02, 2004 Genetic Disorders
Aarskog Syndrome

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Ablepharon-Macrostomia Syndrome
... Crigler-Najjar Syndrome : NEJM Treatment of the Crigler-Najjar Syndrome Type I with ...
Directory Listing
Title: NEJM Treatment of the Crigler-Najjar Syndrome Type I with ...
Description: PreviousPrevious, Volume 338:1422-1427, May 14, 1998, Number 20. Next Next. Treatment of the Crigler–Najjar Syndrome Type I with Hepatocyte Transplantation.
Date Added: 2/16/2004 5:22:40 PM
URL: http://content.nejm.org/cgi/content/short/338/20/1422

24. ORPHANET® Crigler-Najjar Syndrome
ORPHANET. Orphanet database access. criglernajjar syndrome. Direct access to data Summary crigler-najjar syndrome is a very rare disease
http://www.orpha.net/static/GB/criglernajjarsyndrome.html

25. Crigler-Najjar, Syndrome : Sites Et Documents Francophones
Translate this page Crigler-Najjar, syndrome. Menu général CISMeF. Arborescence(s) du thesaurus MeSH contenant le mot-clé Crigler-Najjar, syndrome crigler-najjar syndrome
http://www.chu-rouen.fr/ssf/pathol/criglernajjarsyndrome.html
Crigler-Najjar, syndrome Menu général CISMeF Définition [MeSH Scope Note ; traduction CISMeF] : Forme familiale d'hyperbilirubinémie congénital transmise autosomale récessive. Elle est caractérisée par un ictères et des lésions cérébrales provoquées par une insuffisance en glucuronyl transférase dans le foie et la conjugaison défectueuse de la bilirubine.
Synonyme(s) MeSH Crigler-Najjar, maladie ; Ictère familial congénital Crigler-Najjar
Arborescence(s) Crigler-Najjar, syndrome Crigler-Najjar syndrome
maladies et malformations congénitales, héréditaires et néonatales
métabolisme et nutrition, maladies Position du mot-clé dans l' (les) arborescence(s) : Vous pouvez consulter Ou consulter ci-dessous une sélection des principales ressources :
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    Site éditeur Orphanet base de données sur les maladies rares et les médicaments orphelins. Direction Générale de la Santé / INSERM ;

26. Health Library -
criglernajjar syndrome type I is inherited as an http//www.PICKonline.org Crigler-Najjar Association 3134 mauckc@msn.com Internet www.criglernajjar.com.
http://yalenewhavenhealth.org/library/healthguide/IllnessConditions/topic.asp?hw

27. Genetic Disorders, Crigler-Najjar Syndrome
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28. Genetic Disorders, Crigler-Najjar Syndrome
Category Home Health Conditions and Diseases Genetic Disorders criglernajjar syndrome. * Site Title · The name of the site.
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29. Health, Conditions And Diseases, Genetic Disorders: Crigler-Najjar Syndrome
Disorders. Austin Health Information An overview of crigler-najjar syndrome including symptoms, treatment and prevention. Crigler
http://www.combose.com/Health/Conditions_and_Diseases/Genetic_Disorders/Crigler-
Top Health Conditions and Diseases Genetic Disorders ... Crigler-Najjar Syndrome
Related links of interest: An inherited disorder of bilirubin metabolism in which bilirubin cannot be changed into its water-soluble form, bilirubin glucuronide. This is caused by an enzyme imbalance in the liver. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor The combose.com directory is based on the Open Directory and has been modified and enhanced using our own technology.

30. Disease - Crigler-Najjar Syndrome - Hartford, Connecticut , Saint Francis Care
Disease crigler-najjar syndrome. Prevention Genetic counseling is recommended for prospective parents with a family history of crigler-najjar syndrome.
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Disease - Crigler-Najjar syndrome
Liver anatomy Definition: Crigler-Najjar syndrome is an inherited disorder in which bilirubin (a substance made by the liver) cannot be changed into its water-soluble form, bilirubin glucuronide. This causes jaundice (yellow discoloration of skin and eyes) and organ malfunctions. Alternative Names: Glucuronyl transferase deficiency (type I Crigler-Najjar); Arias syndrome (type II Crigler-Najjar) Causes And Risk: Crigler-Najjar syndrome is caused by an abnormal gene which fails to produce a functional enzyme (bilirubin glucuronyltransferase) capable of converting bilirubin into a water-soluble and therefore, easily excreted form. As a result, bilirubin can build up in the body, which can damage the brain and other organs. The syndrome is inherited as an autosomal recessive trait. This means that the child must get the defective gene from both parents to develop the severe form of the condition. Parents who are carriers (with just one defective gene) have about half the normal enzyme activity of a normal adult. Infants who inherit the trait from both parents (this is called homozygous for the abnormal gene) develop severe jaundice (hyperbilirubinemia) beginning a few days after birth. If these infants are not treated, they may develop

31. Crigler-Najjar Syndrome
criglernajjar syndrome. Definition Alternative Names Glucuronyl transferase deficiency (type I Crigler-Najjar); Arias syndrome (type II Crigler-Najjar).
http://www.drkoop.com/ency/article/001127.htm
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Crigler-Najjar syndrome
Definition: Crigler-Najjar syndrome is an inherited disorder in which bilirubin (a substance made by the liver) cannot be changed into its water-soluble form, bilirubin glucuronide. This causes jaundice (yellow discoloration of skin and eyes) and organ malfunctions.
Alternative Names: Glucuronyl transferase deficiency (type I Crigler-Najjar); Arias syndrome (type II Crigler-Najjar)
Causes, incidence, and risk factors: Crigler-Najjar syndrome is caused by an abnormal gene which fails to produce a functional enzyme (bilirubin glucuronyltransferase) capable of converting bilirubin into a water-soluble and therefore, easily excreted form. As a result, bilirubin can build up in the body, which can damage the brain and other organs. The syndrome is inherited as an autosomal recessive trait. This means that the child must get the defective gene from both parents to develop the severe form of the condition. Parents who are carriers (with just one defective gene) have about half the normal enzyme activity of a normal adult.

32. Crigler-Najjar Syndrome
criglernajjar syndrome. Liver biopsy, enzyme assay for low-absent Glucuronyl transferase activity; A family history of crigler-najjar syndrome.
http://www.drkoop.com/ency/article/001127sym.htm
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Crigler-Najjar syndrome
Alternative Names: Glucuronyl transferase deficiency (type I Crigler-Najjar); Arias syndrome (type II Crigler-Najjar)
Symptoms:
  • A family history of Crigler-Najjar syndrome Yellow skin (jaundice) and eyes (icterus) that begins on the 2nd or 3rd day of life and progressively worsens Jaundice that persists beyond 2 weeks of life without an obvious cause Confusion and changes in thinking (resulting from brain toxicity of bilirubin)

Signs and tests: Tests used to evaluate the liver function include:
Review Date: 11/8/2002
Reviewed By: David G. Brooks, M.D., Ph.D., Division of Medical Genetics, University of Pennsylvania Medical Center, Philadelphia, PA. Review provided by VeriMed Healthcare Network.

33. Crigler-Najjar Syndrome - General Practice Notebook
criglernajjar syndrome. crigler-najjar syndrome is a rare form of congenital non-haemolytic hyperbilirubinaemia. Type I Crigler-Najjar
http://www.gpnotebook.co.uk/cache/349175813.htm
Crigler-Najjar syndrome Crigler-Najjar syndrome is a rare form of congenital non-haemolytic hyperbilirubinaemia. Type I Crigler-Najjar syndrome is characterised by a total deficiency of hepatic glucuronyl transferase. It is inherited as an autosomal recessive. Conjugated bilirubin is absent from the serum. The majority die with kernicterus in the first year of life. Phototherapy can reduce the serum bilirubin by 50% and may be performed at home. Type II Crigler-Najjar syndrome is characterised by a partial deficiency of glucuronyl transferase. It is inherited as an autosomal dominant. Patients given phenobarbital often survive into adult life. Phototherapy may be used to lower the serum bilirubin level.
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34. Crigler-Najjar Syndrome - General Practice Notebook
criglernajjar syndrome. Medical search. crigler-najjar syndrome is a rare form of congenital non-haemolytic hyperbilirubinaemia.
http://www.gpnotebook.co.uk/medwebpage.cfm?ID=349175813

35. Conditions And Diseases - Crigler-Najjar Syndrome Top Links
criglernajjar syndrome Web Site Links. Austin Health Information - An overview of crigler-najjar syndrome including symptoms, treatment and prevention.
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Crigler-Najjar Syndrome Web Site Links HealthCentral - General Encyclopedia A look at crigler-najjar syndrome including, the symptoms, treatment, diagnosis, prognosis and prevention.
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Davidson College Biology Department
A brief description of crigler-najjar syndrome along with some links for further study.
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An overview of crigler-najjar syndrome including symptoms, treatment and prevention.
Crigler-Najjar Disease
Bi-lingual site with information and links on this disease.
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General information about crigler najjar syndrome type I, followed by further resources.
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36. Crigler-Najjar Syndrome- Medcohealth.com
criglernajjar syndrome. Source ADAM, Inc. Genetic counseling is recommended for prospective parents with a family history of crigler-najjar syndrome.
http://www.medcohealth.com/medco/consumer/ehealth/ehsarticle.jsp?topicID=HE:Dise

37. RU News: First International Conference Treatment Of Crigler-Najjar Syndrome
What Treatment of criglernajjar syndrome First international conference on rare, fatal liver disease that affects Amish, Mennonites and others.
http://www.rockefeller.edu/pubinfo/liver.nr.html
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What: Treatment of Crigler-Najjar Syndrome: First international conference on rare, fatal liver disease that affects Amish, Mennonites and others. Who: Experts from around the world When: Monday, May 27, 8 a.m. to 5:45 p.m., and Tuesday, May 28, 8 a.m. to noon Where: Weiss Building, Room 305, at The Rockefeller University 1230 York Ave., New York City Crigler-Najjar Syndrome is a nearly always fatal genetic disorder that afflicts newborns. The disease is a deficiency in an enzyme that people need to control the production of bilirubin. When too much bilirubin accumulates, jaundice and severe brain damage occurs. Bilirubin is produced during the breakdown of hemoglobin, the blood's oxygen-carrying red pigment. Currently the disease is treated with phototherapy, to breakdown the bilirubin, followed by liver transplantation. However, liver transplantations may take place after permanent brain damage occurs. Investigators at The Rockefeller University have developed tin-mesoporphyrin, a drug that inhibits hemoglobin from breaking down. Currently, scientists are testing the drug in clinical trials. While the disease occurs worldwide, populations such as the Amish and Mennonites in which family and genetic histories can be established, afford an excellent opportunity for scientists and health care professionals to learn more about Crigler-Najjar Syndrome. Expected as attendees are a 31-year-old woman who is the oldest known living patient with Crigler-Najjar Syndrome, five Mennonite children with the disorder and their families as well as parents of patients from the United States, Canada, England, Germany and India.

38. Genetic Disorders: Crigler-Najjar Syndrome
Genetic Disorders criglernajjar syndrome. An overview of crigler-najjar syndrome including symptoms, treatment and prevention. Crigler-Najjar Disease.
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An overview of crigler-najjar syndrome including symptoms, treatment and prevention.
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Bi-lingual site with information and links on this disease.
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A look at crigler-najjar syndrome, a definition, epidemiology, pathogenesis, clinical features, investigation and management.
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39. :: Ez2Find :: Crigler-Najjar Syndrome
com/criglernajjar; Davidson College Biology Department Site Info - Translate - Open New Window A brief description of crigler-najjar syndrome along with
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40. Crigler-Najjar Syndrome
The New Health Directory, Directory, Home Health Conditions and Diseases Genetic Disorders criglernajjar syndrome (5) See Also
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