41. Creutzfeldt-Jakob Disease (CJD) Fact Sheet disease Fact Sheet Series creutzfeldtjakob disease (CJD). What is creutzfeldt-jakob disease (CJD)? CJD is a rare incurable disease http://www.dhfs.state.wi.us/healthtips/BCD/creutzfeldt.htm

Topics A-Z Reference Center Search Disease Fact Sheet Series: Creutzfeldt-Jakob Disease (CJD) What is Creutzfeldt-Jakob disease (CJD)? CJD is a rare incurable disease of humans that affects the nervous system and results in rapidly progressive dementia, loss of motor control, paralysis, and death. It is one of several related diseases called transmissible spongiform encephalopathies or TSEs for short. The term "encephalopathy" means the brain is affected, and the term "spongiform" refers to the microscopic holes seen in the brain, giving it a sponge-like appearance. Various animal species have distinct types of TSEs. In addition to CJD which affects humans, other TSEs include bovine spongiform encephalopathy (BSE, also known as "mad cow disease"), scrapie in sheep, and chronic wasting disease (CWD) in deer and elk. What causes CJD? It is caused by a recently identified agent called a prion , which is a self-replicating protein. The current theory is that the normal form of the prion, found in all people, is converted into an abnormal form. This abnormal CJD prion produces the brain lesions that result in the disease. What causes this conversion of normal protein into a disease producing prion?

42. Bmj.com Venters 323 (7317): 858 Education and debate. New variant creutzfeldtjakob disease the epidemic that never was. A new variant of creutzfeldt-jakob disease in the UK. http://bmj.com/cgi/content/full/323/7317/858

Home Help Search/Archive Feedback ... Respond to this article Read responses to this article Related letters in BMJ See related This week in BMJ item PubMed citation Related articles in PubMed Download to Citation Manager This article has been cited by other articles Citation Map Search Medline for articles by: Venters, G. A Alert me when: New articles cite this article Collections under which this article appears: variant Creutzfeld-Jakob Disease Other Epidemiology BMJ 2001;323:858-861 ( 13 October ) Education and debate New variant Creutzfeldt-Jakob disease: the epidemic that never was George A Venters consultant in public health medicine Lanarkshire Health Board, Hamilton ML3 OTA In 1996 a new variant of Creutzfeldt-Jakob disease was described and tentatively linked to bovine spongiform encephalopathy as a possible cause. Since then a number of studies have been undertaken in an attempt to confirm ingestion of the prion that causes bovine spongiform encephalopathy as the cause of new variant Creutzfeldt-Jakob disease. What was initially a speculation has now evolved into orthodoxy among the medical profession in the United Kingdom if not the whole of Europe, although in the United

43. Cjdfoundation.org/info.html creutzfeldtjakob disease - Wikipedia, the free encyclopediacreutzfeldt-jakob disease. From Wikipedia, the free encyclopedia. External link. US Center for disease Control, creutzfeldt-jakob disease information. http://cjdfoundation.org/info.html

44. Creutzfeldt-Jakob Disease - Wikipedia, The Free Encyclopedia More results from en.wikipedia.org CJD CJD contacts. Contact details for organisations concerned with creutzfeldtjakob disease (CJD) and Bovine Spongiform Encephalopathy (BSE). CJD contacts. http://en.wikipedia.org/wiki/Creutzfeldt-Jakob

Creutzfeldt-Jakob Disease From Wikipedia, the free encyclopedia. (Redirected from Creutzfeldt-Jakob Creutzfeldt-Jakob Disease (CJD) is a brain disorder characterized by memory loss, jerky movements, gait disorder, rigid posture , and seizures due to a rapid loss of cerebral cells caused by transmissible proteins called prions . The disease is correctly diagnosed in anywhere from one to two people per million and it usually appears in mid-life with an average disease onset age of 50. The prion that is believed to cause Creutzfeldt-Jakob exhibits an amino acid sequence and configuration which makes it in soluble in water , while the normal protein is highly soluble. So, as the numbers of defective prion proteins propagate and increase exponentially , the process leads to a huge load of insoluble prions in affected cells . This load of proteins disrupts cell function and causes cell death. Once the prion is transmitted, the defective proteins invade the brain like a forest fire and the patient dies within a few months (a few patients live for about 1-2 years). The defective protein can be transmitted by human growth hormone products

45. Discovery Health Creutzfeldt-Jakob Disease The classic form of creutzfeldtjakob disease, or CJD, is an infectious disease that causes progressive brain damage and death. http://health.discovery.com/diseasesandcond/encyclopedia/300.html

46. Creutzfeldt-Jakob Disease . Before 1995, creutzfeldt-jakob disease was not well known outside the medical profession....... creutzfeldtjakob disease. Definition. http://www.healthatoz.com/healthatoz/Atoz/ency/creutzfeldt-jakob_disease.html

Encyclopedia Index C Home Encyclopedia Encyclopedia Index C Creutzfeldt-Jakob disease Definition Creutzfeldt-Jakob disease (CJD) is a transmissible, rapidly progressing, fatal neurodegenerative disorder called a spongioform degeneration related to "mad cow disease." Description Before 1995, Creutzfeldt-Jakob disease was not well known outside the medical profession. Even within it, many practitioners did not know much about it. Most doctors had never seen a case. With the recognition of a so-called "new variant" form of CJD and the strong possibility that those with it became infected simply by eating contaminated beef, CJD has become one of the most talked-about diseases in the world. Additionally, the radical theory that the infectious agent is a normal protein that has been changed in its form also has sparked much interest. First described in the early twentieth century independently by Cretzfeldt and Jakob, CJD is a neurodegenerative disease causing a rapidly progressing dementia ending in death, usually within eight months of symptom onset. It also is a very rare disease, affecting only about one in every million people throughout the world. In the United States, CJD is thought to affect about 250 people each year. CJD affects adults primarily between ages 50 and 75. Spongiform encephalopathies The most obvious pathologic feature of CJD is the formation of numerous fluid-filled spaces in the brain (vacuoles) resulting in a sponge-like appearance. CJD is one of several human "spongiform encephalopathies," diseases that produce this characteristic change in brain tissue. Others are kuru; Gerstmann-Straussler-Scheinker disease, a genetic disorder predominantly characterized by cerebellar ataxia (a kind of movement disorder); and fatal familial insomnia, with symptoms of progressive sleeplessness, weakness, and dysfunction of the nervous system that affects voluntary and involuntary movements and functions.

47. Creutzfeldt-Jakob Disease: Types, Symptoms & Treatment Expert information and the best noncommercial links on creutzfeldt-jakob disease. What is creutzfeldt-jakob disease? creutzfeldt http://www.helpguide.org/elder/creutzfeldt_jakob.htm

ON THIS PAGE: What is Creutzfeldt-Jakob Disease? What are the types of Creutzfeldt-Jakob Disease? What are the symptoms of Creutzfeldt-Jakob Disease? What is the treatment for Creutzfeldt-Jakob Disease? ... Related topics What is Creutzfeldt-Jakob Disease? Creutzfeldt-Jakob Disease is degenerative brain disorder, known as a prion disease. Prions are types of protein. Normal prion proteins are harmless, but infectious forms of the prion protein are thought to cause Creutzfeldt-Jakob disease and other diseases. Prion diseases affect both humans and certain animals, including cows and sheep. Mad cow disease (bovine spongiform encephalopathy) is a prion disease. Prion diseases are rare and fatal. Creutzfedlt-Jakob Disease (CJD) is a the most known prion disease which affects humans. Prion diseases are rare, invariably fatal brain disorders, which occur both in humans and certain animals. They first came to public attention in the mid 1980s in the form of the BSE epidemic in the United Kingdom. BSE (bovine spongiform encephalopathy) is also known as mad cow disease and it is a prion disease found in cattle. About one person per million per year is affected by Creutzfeldt-Jakob, which means about 250-300 new cases in the United States per year.

48. InteliHealth: Creutzfeldt-Jakob Disease format. creutzfeldtjakob disease. Health A to Z, Reviewed by the Faculty of Harvard Medical School creutzfeldt-jakob disease (CJD) http://www.intelihealth.com/IH/ihtIH/WSIHW000/9339/9768.html

chrome_imgPreload('gifChr_mid_but_home_mo_1','http://img.intelihealth.com/i/C/Chr_mid_but_home-o.gif'); chrome_imgPreload('gifChr_mid_but_comm_mo_2','http://img.intelihealth.com/i/C/Chr_mid_but_comm-o.gif'); chrome_imgPreload('gifChr_mid_but_dental_mo_3','http://img.intelihealth.com/i/C/Chr_mid_but_dental-o.gif'); chrome_imgPreload('gifChr_mid_but_drug_mo_4','http://img.intelihealth.com/i/C/Chr_mid_but_drug-o.gif'); chrome_imgPreload('gifChr_mid_but_askexpert_mo_5','http://img.intelihealth.com/i/C/Chr_mid_but_askexpert-o.gif'); chrome_imgPreload('gifChr_mid_but_medical_mo_6','http://img.intelihealth.com/i/C/Chr_mid_but_medical-o.gif'); chrome_imgPreload('gifChr_mid_but_chats_mo_7','http://img.intelihealth.com/i/C/Chr_mid_but_chats-o.gif'); chrome_imgPreload('gifchr_mid_but_news_mo_8','http://img.intelihealth.com/i/c/chr_mid_but_news-o.gif'); chrome_imgPreload('gifChr_mid_but_privacy_mo_9','http://img.intelihealth.com/i/C/Chr_mid_but_privacy-o.gif'); Advertisement Creutzfeldt-Jakob Disease (CJD) What Is It? Symptoms Diagnosis Expected Duration ... Additional Info What Is It? Creutzfeldt-Jakob disease (CJD) is a rare, fatal brain disorder associated with the presence of a misshapen protein in the brain, known as a prion. Although prion-associated diseases are not well understood, scientists theorize that prions cause damage by causing healthy proteins in the brain to take the prion shape, so these too become damaging particles. This slow chain-reaction of damaged proteins occurs over many years and results in brain damage.

49. Alzheimer Disease: Related Dementias, Creutzfeldt-Jakob Disease, CJD creutzfeldtjakob disease. It provides an overview of dementias related to Alzheimer disease.. What is creutzfeldt-jakob disease? http://www.alzheimer.ca/english/disease/dementias-creutzfeldt.htm

In this section: Introduction Creutzfeldt-Jakob Disease Lewy body Dementia Pick's Disease ... Vascular Dementia Related page: What Is Alzheimer Disease? Creutzfeldt-Jakob Disease [Note: If you plan to print this page, please also print the introduction page to Related Dementias. It provides an overview of dementias related to Alzheimer Disease.] What is Creutzfeldt-Jakob Disease? Creutzfeldt-Jakob Disease (CJD) is a form of progressive dementia characterized by loss of nerve cells and degeneration of nerve cell membranes leading to the production of small holes in the brain. How does Creutzfeldt-Jakob Disease affect the person? CJD usually has rapid onset and decline. Early symptoms include lapses in memory, mood swings similar to depression, lack of interest and social withdrawal. The person may become unsteady on his/her feet. Later symptoms may include blurred vision, sudden jerking movements and rigidity in the limbs. The person may experience slurred speech and have difficulty swallowing. Eventually, movement and speech are lost.

50. CRUETZFEDLT-JAKOB DISEASE creutzfeldtjakob disease. What is creutzfeldt-jakob disease? creutzfeldt-jakob disease (CJD) is a rare, fatal brain disorder caused by a prion. http://www.idph.state.il.us/public/hb/hbcjdhlb.htm

CREUTZFELDT-JAKOB DISEASE What is Creutzfeldt-Jakob disease? Creutzfeldt-Jakob disease (CJD) is a rare, fatal brain disorder caused by a prion. The disease causes mental deterioration and a variety of neurological symptoms, and usually leads to death within a year of onset. Threre are various forms of CJD; in about 85 percent of the cases, the cause is unknown. One form of CJD may be linked to consumption of beef in Great Britain. Another form is familial or genetic, that is, relatives of a CJD case with the form are more likely to develop the disease than other persons. Many Americans first heard of the disease in 1983 when they learned it had claimed the life of New York City Ballet choreographer George Balanchine. How does CJD affect the patient? In early stages of the disease, patients may experience failing memory, changes in behavior, lack of coordination or visual disturbances. As the illness progresses, mental deterioration becomes pronounced, involuntary movements (especially muscle jerks) appear, and the patient may become blind, develop weakness in the arms or legs, and ultimately lapse into a coma. Death is usually due to infections in the bedridden, unconscious patient. Symptoms of CJD can be similar to those seen in other progressive neurological disorders such as Alzheimer's disease and other dementias. However, CJD causes unique changes in brain tissue that, at this time, can be detected only by surgical biopsy or at autopsy.

51. CREUTZFELDT-JAKOB DISEASE/BOVINE SPONGIFORM ENCEPHALOPATHY creutzfeldtjakob disease/BOVINE SPONGIFORM ENCEPHALOPATHY. INCIDENCE. The incidence of classical CJD is approximately 1 in 1,000,000. http://www.nfid.org/factsheets/cj.html

CREUTZFELDT-JAKOB DISEASE/BOVINE SPONGIFORM ENCEPHALOPATHY INCIDENCE The incidence of classical CJD is approximately 1 in 1,000,000. CJD in persons under 30 years old has an incidence of 5 in 1,000,000,000. SEQUELAE The disease is uniformly fatal in cases that are recognized with clinical syndrome. COST Unknown. The recent withdrawal of blood products by the American Red Cross due to possible contamination by infected blood donors was estimated to be a $50 million loss. The Canadian Red Cross also did a massive recall of blood plasma products. TRANSMISSION Most cases are sporadic with unknown mechanism of transmission. Five percent of cases are familial. CJD induced inadvertently by medical treatment include a) following surgical procedures, b) following cadaveric corneal or dura transplants and c) following growth hormone therapy derived from cadaveric pituitary glands. RISK GROUPS 1) Classical CJD is predominantly a disease of the elderly with peak number of deaths at age 65-69, 2) familial CJD, 3) iatrogenic (see Transmission). SURVEILLANCE The diagnostic error in clinical diagnosis of CJD is 25 percent with reluctance on the part of pathologists to confirm the diagnosis by necropsy.

52. Creutzfeldt-Jakob Disease (CJD) - Medical Dictionary Definitions Of Popular Medi MedicineNet Home MedTerms medical dictionary AZ List creutzfeldtjakob disease (CJD). Advanced Search. creutzfeldt-jakob disease (CJD) Index. http://www.medterms.com/script/main/art.asp?articlekey=2863

53. Gale Encyclopedia Of Medicine Creutzfeldt-Jakob Disease You are Here Articles Gale Encyclopedia of Medicine Article. creutzfeldtjakob disease. Gale Encyclopedia of Medicine by Richard Robinson. Definition. http://www.findarticles.com/cf_0/g2601/0003/2601000381/p1/article.jhtml?term=gal

54. British Medical Journal: Bovine Spongiform Encephalopathy And Variant Creutzfeld You are Here Articles British Medical Journal April 7, 2001 Article. Bovine spongiform encephalopathy and variant creutzfeldtjakob disease. http://www.findarticles.com/cf_0/m0999/7290_322/74089375/p1/article.jhtml?term=c

55. Mad Cow Disease And Humans Article describes how mad cow disease (variant creutzfeldtjakob disease) is transmitted, its symptoms, and diagnosis. http://rarediseases.about.com/cs/priondiseases/a/080600.htm

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') About Rare / Orphan Diseases Types of Diseases Infectious Diseases ... Rare cancers zau(256,152,145,'gob','http://z.about.com/5/ad/go.htm?gs='+gs,''); Is it a Rare Disease? Rare Diseases A - B Rare Diseases C - D Rare Diseases E - H ... Help zau(256,138,125,'el','http://z.about.com/0/ip/417/0.htm','');w(xb+xb); Stay Current Subscribe to the About Rare / Orphan Diseases newsletter. zau(256,152,100,'hs','http://z.about.com/5/ad/hs.htm?zIhsid=00',''); Search Rare / Orphan Diseases Email to a friend Print this page Stay Current Subscribe to the About Rare / Orphan Diseases newsletter. Suggested Reading Sheep Slaughtered for Suspicion of Mad Cow Disease Elsewhere on the Web CDC: BSE and CJD NINDS: Creutzfeldt-Jakob Disease Most Popular ALD and Lorenzo's Oil The Elephant Man's Bones Reveal Mystery Prune Belly (Eagle-Barrett) Syndrome Progeria Syndromes ... Mad Cow Disease and Humans What's Hot Autoimmune Kidney Disease Tourette Syndrome Christmas Disease Bugs, PANDAS, and Tics ... Dystonia and Botox Injections Mad Cow Disease and Humans From Mary Kugler Your Guide to Rare / Orphan Diseases Sign up for my Newsletter Degenerative fatal brain disorder Variant Creutzfeldt-Jakob disease is the "mad cow" disease that people contract when they are exposed to food contaminated with bovine spongiform encephalopathy (BSE). A case of BSE in the United States was confirmed in 2003. The Centers for Disease Control and Prevention (CDC) monitors the incidence in the United States of all types of Creutzfeldt-Jakob disease.

56. Virtual Hospital : Health Topics A-Z : Creutzfeldt-Jakob Disease creutzfeldtjakob disease. All Topics Adult Patient Topics Adult Provider Topics Pediatric Patient Topics Pediatric Provider Topics. For Adult Providers. http://www.vh.org/navigation/vh/topics/adult_provider_creutzfeldt-jakob_disease.

Health Topics A-Z Creutzfeldt-Jakob Disease All Topics Adult Patient Topics Adult Provider Topics Pediatric Patient Topics ... Pediatric Provider Topics For Adult Providers Infectious Diseases of the Central Nervous System For Adult Patients Aging Begins at 30: British Beef and Dementia Aging Begins at 30: Mad Cow Dietary Supplement Aging Begins at 30: Mad Cows and Englishmen, Deer, Elk, and Americans, too Aging Begins at 30: Mad Cows, Scrapie Sheep and the Human Nervous System ... UI Health Care Home http://www.vh.org/navigation/vh/topics/adult_provider_creutzfeldt-jakob_disease.html

57. Human Growth Hormone And Creutzfeldt-Jakob Disease : NIDDK The creutzfeldtjakob disease (CJD) Foundation Inc. creutzfeldt-jakob disease (Fact Sheet of the National Institute of Neurological Disorders and Stroke, NIH). http://www.niddk.nih.gov/health/endo/pubs/creutz/creutz.htm

"You are now leaving the NIDDK website. The NIDDK is not responsible for the content of web pages found on this linked website. Links to nonfederal organizations are provided solely as a service to our users. These links do not indicate an endorsement of these organizations by NIDDK or the federal government." Nonprofit Organizations Offering Support and Information General Information Articles from Medical Journals Nonprofit Organizations Offering Support and Information MAGIC (Major Aspects of Growth in Children) Foundation is a national, nonprofit organization that provides support and education about growth disorders in children and growth hormone deficiency in adults. Staff will help connect you with others who have similar interests or concerns. The Human Growth Foundation (HGF) is a nonprofit organization concerned with children's growth disorders and adult growth hormone deficiency. HGF can send you a brochure on adult growth hormone deficiency. The foundation also sponsors an Internet mailing list to support the exchange of information about adult growth hormone deficiency and adult growth hormone replacement therapy. To subscribe, follow the instructions on the HGF web page The Creutzfeldt-Jakob Disease (CJD) Foundation Inc.

58. News 10 Now 24 Hour Local News ALL NEWS Woman dies from creutzfeldtjakob disease Updated 5/13/2004 730 AM By News 10 Now Staff, CATHY HILDRETH, A woman diagnosed with http://news10now.com/content/all_news/?ArID=18638&SecID=83

59. Apr_Subject Frequently Asked Questions about creutzfeldtjakob disease (CJD) Updated August 2003 What is creutzfeldt-jakob disease (CJD)? What http://www.moh.govt.nz/moh.nsf/wpg_Index/About-CJD

ABOUT Frequently Asked Questions about Creutzfeldt-Jakob Disease (CJD) Updated August 2003 What is Creutzfeldt-Jakob Disease (CJD)? What is variant Creutzfeldt-Jakob Disease (vCJD)? What are the unique differences between CJD and vCJD? What causes variant CJD? ... top of page What is Creutzfeldt-Jakob Disease (CJD)? Creutzfeldt-Jakob Disease is a rare fatal brain disorder which was first recognised more than 80 years ago. There is no effective treatment and no reliable test to predict the disease. Approximately 85 percent of Creutzfeldt-Jakob Disease illnesses occur spontaneously without any known cause. Other causes include certain medical treatments that are no longer used such as human growth hormone injections and dural grafts (brain membrane). The symptoms may take 30 years to develop. Since the disease was identified by Dr. Alfons Maria Jakob in the 1920's, over 3,000 cases have been reported world-wide. What is variant Creutzfeldt-Jakob Disease (vCJD)? A new and more aggressive strain of the disease which was identified in the United Kingdom in 1996. It produces similar symptoms to classical CJD though the disease develops more rapidly. Variant CJD is thought to be contracted by eating meat infected with bovine spongiform encephalitis (BSE) which has been described as "mad cow disease". It historically has affected people in the 16 to 52 year age group. The mean age is 28 years.

60. Mad Cow Disease (Creutzfeldt-Jakob) - The Doctors Lounge(TM) You are here creutzfeldtjakob disease (Mad cow disease in cattle). Mad Cow disease. In humans are mainly (16-20) Kuru; creutzfeldt-jakob disease (sCJD). http://www.thedoctorslounge.net/clinlounge/diseases/neurology/cjd.htm

Advanced Search SELECT A SPECIALTY Medical Specialties Cardiology Gynecology Infertility Internal Medicine Nephrology Obstetrics Oncology Pathology Pharmacology Student Home Forum Humor Jobs ... Med Students Your browser does not support inline frames or is currently configured not to display inline frames. Student Articles Medical Tutorials Medical Games Mnemonics ... Disease Database Other Sections Cardiology Fertility Gynecology Internal Medicine ... Pharmacology Professional Medical Oath Medline search Guidelines search Article search ... Abbreviations Favorites Medical Directory Medical Calculators Membership You are here: Creutzfeldt-Jakob disease (Mad cow disease in cattle) Creutzfeldt-Jakob disease (CJD) is a degenerative disease of the central nervous system (CNS) that is caused by infectious proteins called prions. send to a friend printer friendly version Related CJD and the protein only hypothesis Creutzfeldt-Jakob disease (CJD) is a degenerative disease of the central nervous system (CNS) that is caused by infectious proteins called prions. CJD typically presents with dementia and myoclonus, is relentlessly progressive, and usually results in death within a year of onset. Most patients with CJD are between 50 and 75 years of age; however, patients as young as 17 years and as old as 83 years have been recorded.

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