61. Pathobiology Genetic Disease Information singlegene or chromosomal disorders heart disease, high blood Alzheimer s disease , arthritis Multifactorial inheritance http://icarus.med.utoronto.ca/meaghan2/JuHo/Pathobiology/PBL_show.asp?week_s=9&c

62. Genetic Causes Of Mental Retardation chromosomal disorders affect approximately 7 out of every 1,000 infants.The Most chromosomal disorders happen sporadically. They http://specialed.freeyellow.com/YAdaptUse.html

GENETIC CAUSES OF MENTAL RETARDATION What is genetics? Genetics is "the science that studies the principles and mechanics of heredity, or the means by which traits are passed from parents to offspring" (Glanze, 1996). Through genetics a number of specific disorders have been identified as being genetically caused. One example is fragile X syndrome, a common genetic cause of mental retardation, which is caused by the presence of a single non-working gene (called the FMR-1 gene) on a child's X chromosome. Genetics originated in the mid-19th century when Gregor Mendel discovered over a ten year period of experimenting with pea plants that certain traits are inherited. His discoveries provided the foundation for the science of genetics. Mendel's findings continue to spur the work and hopes of scientists to uncover the mystery behind how our genes work and what they can reveal to us about the possibility of having certain diseases and conditions. The scientific field of genetics can help families affected by genetic disorders to have a better understanding about heredity, what causes various genetic disorders to occur, and what possible prevention strategies can be used to decrease the incidence of genetic disorders. Can a person's genes cause mental retardation?

63. The Kentucky Center For Reproductive Medicine And IVF - Preimplantation Genetic now so advanced, that at this stage is it possible to safely remove a single cell,analyze it for a range of genderspecific chromosomal disorders and ensure http://www.kcrm-ivf.com/pgd_overview.htm

There are many different medical, social, economic or cultural circumstances which put couples under the most intense pressure to produce a child of a specific gender. Scientists have identified thousands of health problems where genes play a part and many gender-related medical disorders can be passed from parent to child. Pre-Implantation Genetic Diagnosis (PGD) is a medical procedure which allows embryos to be tested for gender-related genetic conditions, prior to being placed in the womb, giving the best opportunity to select the gender of your baby. PGD involves tried and tested assisted conception techniques which are safe, reliable and ethically sound. In-vitro fertilization is now widely accepted and this forms the basis of our gender selection program. PGD is beneficial when: Either one of a couple carrying a single gene defect, by testing for specific genetic disorders Women aged 35+, by testing for age-related chromosomal disorders

64. Support Groups disorders. Rainbows down under The main focus of this site is Trisomy18, Trisomy 13 and other related chromosomal disorders. http://www.medgen.ubc.ca/wrobinson/mosaic/support.htm

chromosomal Mosaicism HOME TABLE OF CONTENTS SEARCH BACKGROUND ... GLOSSARY Resources SUPPORT GROUPS Links Directories of support groups Canadian Directory of Genetic Support Groups - a resource guide for families and professionals seeking information on genetic support groups in Canada Directory of online genetic support groups - for sharing medical genetics knowledge and resources with other health care practitioners, patients, and caregivers. Support groups FAQs References Genetics Clinics Listings of support groups Chromosome Deletion Outreach is a non-profit organization providing information and support for families and professionals affected by chromosome deletions, trisomies, inversions, translocations and ring chromosomes The Genetic Alliance is an international coalition of individuals, professionals and genetic support organizations that is working together to enhance the lives of everyone impacted by genetic conditions. GAPS G enetic information a nd P atient s ervices) - Easy-to-understand descriptions of disorders, links to information sites or support group websites, alphabetical listing of support groups, easy-to-understand definitions of medical terms

65. More Chromosomal Disorders First Previous Next Last Index Home Text, Slide 22 of 49. http://www.bhc.edu/EastCampus/leeb/abpsy/abpsych04a/sld022.htm

66. More Chromosomal Disorders More chromosomal disorders. Concordance studies of schizophrenia appear to suggestpossibility of genetic linkage. Verdict is still not entirely final. http://www.bhc.edu/EastCampus/leeb/abpsy/abpsych04a/tsld023.htm

More chromosomal disorders Concordance studies of schizophrenia appear to suggest possibility of genetic linkage Verdict is still not entirely final Current thought re: schizophrenia is that it is genetic. About 50-80% chance that if one monozygote is schizophrenic that the other one will also be schizoprhenic Previous slide Next slide Back to first slide View graphic version

67. CCHS Clinical Digital Library chromosomal disorders Access document Introduction Access document;Contiguous Gene Syndromes Access document; Monogenic Mendelian http://cchs-dl.slis.ua.edu/clinical/genetics/general.htm

Clinical Resources by Topic: Genetic Disorders General Genetic Disorders Clinical Resources Clinical Guidelines Clinical Trials News Miscellaneous Resources See also: Genetic Testing Clinical Resources Harrison's Principles of Internal Medicine 15th Ed.-2001: Table of contents Health Sciences Library subscription INFO Chapter 65: Principles of Human Genetics: Table of contents Impact of Genetics on Medical Practice: Access document Chromosomes and DNA Replication: Access document Organization of DNA into Chromosomes: Access document Replication of DNA and Mitosis: Access document Assortment and Segregation of Genes during Meiosis: Access document Regulation of Gene Expression: Access document Introduction: Access document Structure of Genes: Access document Transcriptional Activation and Repression: Access document Cloning and Sequencing DNA: Access document Introduction: Access document Cloning of Genes: Access document Introduction: Access document Nucleic Acid Hybridization: Access document The Polymerase Chain Reaction: Access document DNA Sequencing: Access document Introduction: Access document Transgenic Mice as Models of Genetic Disease: Access document The Human Genome Project: Access document Introduction: Access document The Genetic Map: Access document The Physical Map: Access document Status of DNA Sequencing: Access document Ethical Issues: Access document Transmission of Genetic Disease: Access document Origins and Types of Mutations: Access document Functional Consequences of Mutations: Access document Genotype and Phenotype: Access document Alleles, Genotypes, and Haplotypes:

68. Gene Stories - Health Some of the commonest chromosomal disorders are a group known as theTrisomies. A Trisomy means a person has three copies of one http://www.bbc.co.uk/health/genes/disorders/chromosomes.shtml

@import url('/includes/tbenh.css') ; Home TV Radio Talk ... A-Z Index WEDNESDAY 2nd June 2004 Text only BBC Homepage Health Genes and Health ... Message Board DNA Detectives About the BBC Contact Us Help Like this page? Send it to a friend! PRINT PAGE Chromosome disorders are due to abnormalities in the normal group of 46 chromosomes that we inherit from our parents. For example, individuals may have more or fewer chromosomes than normal, or there may be structural changes in the chromosomes, where part of one chromosome may be lost or have attached to the end of another chromosome (a condition known as translocation). Some of the commonest chromosomal disorders are a group known as the Trisomies. A Trisomy means a person has three copies of one of their chromosomes instead of two, e.g. in Down's Syndrome or Trisomy 21, there are 3 copies of chromosome number 21. Edward's Syndrome is Trisomy 18 and Patau's syndrome is Trisomy 13. There may also be 3 copies of the sex chromosomes, e.g. in Klinefelter's Syndrome Back Next Related BBC News Nose test for Down's syndrome

69. Chromosome 4, Monosomy 4q It affects males and females in equal numbers. Related Disorders. Otherchromosomal disorders may be similar to Chromosome 4, Monosomy 4q. http://www.bchealthguide.org/kbase/nord/nord793.htm

document.write(''); var hwPrint=1; var hwDocHWID="nord793"; var hwDocTitle="Chromosome 4, Monosomy 4q"; var hwRank="1"; var hwSectionHWID="nord793"; var hwSectionTitle=""; var hwSource="cn6.0"; var hwProdCfgSerNo="wsh_html_031_s"; var hwDocType="NORD"; National Organization for Rare Disorders, Inc. Chromosome 4, Monosomy 4q Important It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Chromosome 4 Long Arm Deletion Chromosome 4q- Syndrome Disorder Subdivisions Interstitial Deletion of 4q, Included Terminal Deletion of 4q, Included Proximal Deletion of 4q, Included Related Disorders List Information on the following diseases can be found in the Related Disorders section of this report: Wolf-Hirschorn Syndrome (4p- Syndrome) Chromosome 11, Monosomy 11q Greig Cephalopolysyndactyly Syndrome Down Syndrome General Discussion Chromosome 4, Monosomy 4q is a chromosomal disorder caused by a partial deletion of the long arm of chromosome 4. The patient may have an extremely prominent forehead (frontal bossing), enlargement of the back part of the head, low placement of ears, short broad hands and feet, unusually small size associated with slow or delayed growth, congenital heart defects, and possible mental retardation. Symptoms Patients with Chromosome 4, Monosomy 4q may have the following symptoms: abnormal skull shape, short nose with abnormal bridge, low-set malformed ears, cleft palate, small jaw, short breastbone, poor or delayed growth, moderate to severe mental retardation, heart defects, defective urinary and reproductive organs (genitourinary defects), small size, small hands and feet, unusually wide-set eyes (hypertelorism), a pointed fifth finger and nail which is very characteristic of this disorder, and diminished muscle tone (hypotonia). There may be abnormal brain development (agenesis of corpus callosum). In some cases, delayed growth and mental retardation may be present without obvious physical abnormalities, making it difficult to diagnose this disorder.

70. Wolf Hirschhorn Syndrome your search term in the Rare Disease Database.) chromosomal disorders that involveextra chromosomes (trisomy) may also be similar to WolfHirschhorn Syndrome. http://www.bchealthguide.org/kbase/nord/nord622.htm

document.write(''); var hwPrint=1; var hwDocHWID="nord622"; var hwDocTitle="Wolf Hirschhorn Syndrome"; var hwRank="1"; var hwSectionHWID="nord622"; var hwSectionTitle=""; var hwSource="cn6.0"; var hwProdCfgSerNo="wsh_html_031_s"; var hwDocType="NORD"; National Organization for Rare Disorders, Inc. Wolf Hirschhorn Syndrome Important It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms WHS Wolf Syndrome Wolf-Hirschhorn Chromosome Region (WHCR) WHCR Chromosome 4, Partial Deletion 4p Partial Deletion of the Short Arm of Chromosome 4 Chromosome 4, Partial Monosomy 4p 4p- Syndrome, Partial Disorder Subdivisions None Related Disorders List Information on the following diseases can be found in the Related Disorders section of this report: Cri-du-Chat Syndrome Down Syndrome General Discussion Wolf-Hirschhorn Syndrome is an extremely rare chromosomal disorder caused by a partial deletion (monosomy) of the short arm ("p") of chromosome 4. Major symptoms may include extremely wide-set eyes (ocular hypertelorism) with a broad or beaked nose, a small head (microcephaly), low-set malformed ears, mental and growth deficiency, heart (cardiac) defects, and seizures. Symptoms Individuals with Wolf-Hirschhorn Syndrome may exhibit low birth weight, growth retardation and deficiency, delayed bone age, an unusually small head (microcephaly), and undescended testicles (cryptorchidism). Failure to thrive, reduced muscle tension (hypotonicity), mental and psychomotor retardation, seizures, and precocious puberty may also occur.

71. Ask NOAH About: Genetic Disorders Syndrome Information and Support (AAKSIS) chromosomal disorders II KlinefelterSyndrome XXY New South Wales Genetics Program, Australia Sex Chromosome http://www.noah-health.org/english/illness/genetic_diseases/geneticdis.html

Ask NOAH About: Genetic Disorders Ask NOAH About: Genetic Disorders is a work-in-progess on diseases that have a known or suspected genetic origin. This page will attempt to keep pace with the the Human Genome Project's published breakthoughs on genetic medicine. If the genetic disorder you need information on is not listed here, please try the NOAH search engine . For information on basic genetics, please visit Ask NOAH About: Genetics, Genomes, Cell Biology, and Cloning What are Genetic Disorders? Genetics Basics The Basics Glossaries Children ... Living with Genetic Diseases Specific Conditions Achromatopsia Adrenoleukodystrophy Aicardi Syndrome Albinism/Hypopigmentation ... Information Resources What Are Genetic Disorders? Genetics Basics The Basics Birth Defects - Merck Manual, 2nd Home Edition Birth Defects - March of Dimes (NOAH PROVIDER) (also in Spanish Changes to Chromosomes - New South Wales Genetics Program, Australia Changes to Chromosomes: Translocations - New South Wales Genetics Program, Australia An Introduction to Genetics and Genetic Testing - Kidshealth ... Genetics and Neuromuscular Diseases - Muscular Dystrophy Association (also in Spanish Genetics Overview - Merck Manual Home Edition Genes and Disease - NCBI ... Genes and Populations - National Institute of General Medical Sciences (also in Spanish Heritable Disorders of Connective Tissue - NIAMS Impact of Medical Genetics - Mountain States Genetics Network Simply Stated: Genetic Myths - Muscular Dystrophy Association ... What are Genetic Disorders? - University of Utah

72. Title: Application Of Microsatellite Genotyping In Chromosomal Application of Microsatellite Genotyping in chromosomal disorders. MingyiChunG. chromosomal disorders can be structural or numerical. http://www.ym.edu.tw/excellence/genome2000/sympo/genotype/ChungMY.html

Genome 2000 Application of Microsatellite Genotyping in Chromosomal Disorders Ming-yi ChunG Department of Medical Research and Education, Veterans General Hospital-Taipei, Taiwan, R.O.C. Microsatellite markers, a.k.a. short tandem repeats (STR) or simple tandem repeats, contain repetitive sequence composed of di-, tri-, or tetra-nucleotides. The number of repeats may vary from one person to another, i.e. polymorphic, and follow Mendelian inheritance. Due to their high informativeness and easy accessibility, these markers have been widely applied in various field of genetic research. Chromosomal disorders can be structural or numerical. Unbalanced chromosome disorders can be further investigated to delineate the nature of the defect, in terms of imprinting/parental origin and size of chromosome involved in the defect by using microsatellite genotyping. Chromosome 22q11 microdeletion syndrome and trisomy 21 will be discussed as examples.

73. The Fertility Center Of New England - Preimplantation Genetic Diagnosis The Center also reports several ongoing pregnancies where PGD wasused for other types of genetic or chromosomal disorders. PGD http://www.fertilitycenter.com/Services/pdg.htm

Genetic Diseases That Can Be Analyzed by PGD (list is not all inclusive): Autosomal-recessive X-linked Chromosomal Fertility Centers of New England Announces World's First Published Report of a Birth from a Cryopreserved Embryo Analyzed by Preimplantation Genetic Diagnosis (PGD) Second success for Fertility Centers of New England in treating chromosomal disorder that causes infertility, miscarriages, and birth defects. Please note: to date, we have completed more than 150 PGD cases and have the first and largest PGD program in New England The Fertility Centers of New England also reports its third success for the PGD program: a healthy baby born from mother who had an inversion of chromosome two. Reading Mass. , February, 2000: A Fertility Centers of New England patient recently delivered a healthy baby girl who represents the world's first published report of a birth from a cryopreserved embryo analyzed by fluorescent in situ hybridization (FISH), a preimplantation genetic diagnosis (PGD) technique. This is the Fertility Centers’ second success in treating a balanced translocation, a chromosomal disorder that can cause infertility, miscarriages, and birth defects. Approximately three percent of partners experiencing recurrent pregnancy loss carry this hidden chromosomal problem. The successful family has a truly remarkable story. The mother carries a balanced translocation of chromosomes 14 and 21 that resulted in the birth of a child with Down's Syndrome, now a seven-year-old boy. Analysis of at least one subsequent miscarriage showed that it was a confirmed translocation, though statistically this should occur only one in six times. Down's Syndrome is the result of an extra chromosome 21; most commonly the result of a random event rather than a balanced translocation. Preimplantation genetic diagnosis (PGD) using the FISH technique was this family's best diagnostic approach for preventing further miscarriages and conceiving a chromosomally normal child. They underwent one IVF cycle and successfully conceived with the transfer of two cryopreserved embryos.

74. Welcome To The Genetics & Public Policy Center More than 3000 individuals have used PGD for chromosomal disorders. · Morethan 1000 PGD cycles have been performed for single gene disorders. http://www.dnapolicy.org/genetics/facts.jhtml

Link 1 xxxxxxx Link 1 xxxxxxx Link 1 xxxxxxx Link 1 xxxxxxx ... Cloning The following facts are select highlights. Genetic Testing Carrier Screening: · Carrier screening identifies individuals who have an alteration in one or more genes. Carrier screening can occur at the population level, in more targeted groups based on ethnic background, or in individuals who are at-risk because of their family history. · Many of the diseases for which carrier testing is undertaken are autosomal recessive. In these cases, if both parents carry a mutation in a gene for the same disease, there is a 25% chance with each pregnancy that the offspring will inherit the disease. · The most common diseases screened for in the general population or within selected groups are: sickle cell disease, Tay-Sachs disease, canavan’s disease and cystic fibrosis. Many other diseases can be tested for based on ethnic background or family history. Preimplantation Genetic Diagnosis (PGD): · PGD was originally developed as an alternative to prenatal diagnosis for couples at increased risk of transmitting a single gene or chromosomal abnormality to their offspring. · More recently, PGD has been used in conjunction with certain IVF patients to screen embryos for aneuploidy with the goal of increasing IVF success rates.

75. Genetic Disorders Ex. Diabetes, Hypertension; chromosomal disorders. abnormal chromosomeor wrong number of chromosomes. Can result from a cellular http://www.som.tulane.edu/departments/peds_respcare/genetic.htm

Genetic Disorders A review Causes Types of Defects Single Gene Defects Chromosomal defects ... Specific Syndromes Causes of Genetic Health Problems Inherited genetic diseases caused by abnormal groups of genes passed down from one generation to the next. Ex. CF, Phenylketonuria, and muscular dystrophy. Spontaneous Genetic mutations are caused by an error in DNA replication leading to a base substitution or an insertion or deletion of one or two base pairs from the DNA. Somatic genetic disease caused by the sudden appearance of an abnormal form of a gene in one part of the body. Ex. Cancer. Chromosomal Aberrations abnormalities of chromosomal structure. Ex. Down Syndrome. Types of Defects Genetic: caused by an abnormal gene or groups of genes. There are 3 types: Single mutant genes of large effect. (Mendelian disorders) Multifactorial inheritance: the defect is influence by genetic and environmental factors. Ex. Diabetes, Hypertension Chromosomal disorders. : abnormal chromosome or wrong number of chromosomes. Can result from a cellular "accident" or from a parent who carries a chromosomal aberration Congenital Defects: " born with" unusual growth or development.

76. MeSH-D Terms Associated To MeSH-C Term Chromosomal Disorders MeSHD terms associated to MeSH-C term chromosomal disorders, Nervous System,G2D Home. The number indicates the strength of the association http://www.bork.embl-heidelberg.de/g2d/c2d.pl?Chromosomal_Disorders,_Nervous_Sys

77. What Is Cri Du Chat Syndrome Undoubtedly this accounts for the relative paucity of information on Cri du Chat,as compared to more commonly known chromosomal disorders such as Down s http://www.thehutchpage.com/aboutcriduchat.htm

What is Cri du Chat Syndrome? Cri du Chat (KREE doo SHAH) Syndrome is a chromosomal disorder where the short arm of the fifth chromosome is lost from the first cell of life. All of our genes are attached to chromosomes. So when a piece of a chromosome is lost, so is a piece of the genetic code that makes us who we are. In approximately 90 percent of cases, including Vincent's, both parents are chromosomally normal and the deletion occurs spontaneously for reasons that geneticists cannot yet explain. The syndrome is rare. Estimates of its occurrence range from one in 30,000 to one in 50,000 live births. Undoubtedly this accounts for the relative paucity of information on Cri du Chat, as compared to more commonly known chromosomal disorders such as Down's Syndrome. Like most chromosomal disorders, Cri du Chat presents an array of developmental challenges intellectual as well as physical. Mental retardation ranges from mild to severe, with most cases falling into the moderate range. Communication is the most significant challenge for persons with this syndrome. Some form of sign language is a must. Physical development is impaired primarily by low muscle tone, which underscores the importance of early intervention in the form of physical therapy. It is considered exceptional for a child with this syndrome to walk before 3 years old. Some people with the syndrome are never able to walk at all.

78. Untitled Document for transfer. PGD can also be used to detect diseases related to theY chromosome and other chromosomal disorders. PGD can detect http://www.institutocefer.com/ingles/diagn.htm

What is genetic embryo diagnosis? Pre-implantation genetic diagnosis (PGD) consists of studying part of an embryo's genetic makeup before it is transferred to the mother's uterus. The aim of PGD is to detect whether embryos are affected by a specific genetic or chromosomal disorder. The CEFER Reproduction Institute, in collaboration with the Department of Cellular Biology and Physiology of the Autonomous University of Barcelona, can carry out PGD on embryos when required for medical purposes. How is PGD done? PGD consists of performing a biopsy (taking a sample) on each embryo when they reach the phase in which they consist of 6-8 cells. The zona pellucida (the outer shell of the egg which is maintained in the embryo) is partially dissolved with an acidic solution. A needle is then inserted through the hole and one or two cells that form the embryo are removed. These cells, especially their nuclei, are considered reliable indicators of an embryo's genetic makeup. While the rest of the embryo is kept in a culture medium (embryos are stored in the laboratory under ideal conditions for ensuring their survival and growth), the nucleus of the extracted cell is studied either by FISH (Fluorescent In Situ Hybridization) or PCR (the amplification of a segment of DNA through a polymerase chain reaction).

79. Using Karyotypes To Predict Genetic Disorders HomeGenetic Disorder CornerWhat Can Our Chromosomes Tell Us? Using Karyotypes to Predict Genetic disorders Examples of genetic disorders caused by chromosomal deletions are http://gslc.genetics.utah.edu/units/disorders/karyotype/karyotypeinfo.cfm

Genetic Science Learning Center at the Eccles Institute of Human Genetics University of Utah Home ... What Can Our Chromosomes Tell Us? Using Karyotypes to Predict Genetic Disorders Using Karyotypes to Predict Genetic Disorders A normal human karyotype has 46 chromosomes : 22 pairs of autosomes and 2 sex chromosomes. What happens when a person has something different, such as: Too many or too few chromosomes? Missing pieces of chromosomes? Mixed up pieces of chromosomes? Too many or too few chromosomes To understand how our cells might end up with too many or too few chromosomes, we need to know how the cells normally get 46 chromosomes. First we need to understand meiosis . Meiosis is the cell division process that produces egg and sperm cells ( gametes ), which normally have 23 chromosomes each. Open in new window If eggs and sperm only have one set of chromosomes, then how do we end up with 46 chromosomes? During fertilization, when the egg and sperm fuse, the resulting zygote has two copies of each chromosome needed for proper development, for a total of 46. Open in new window How can cells end up with too many or too few chromosomes?

80. Developmental Disability And Mental Retardation ResearchDevelopmental Disability Laboratory aims at medical,sociological and educational research of developmental disabilitiesmental retardation with chromosomal abnormality,autistic disorders,physical developmental disorders,intoxication. http://www.matsuishi-lab.org

Matsuishi Laboratory Unit of Neuropsychiatry Department of Special Education, Faculty of Education and Human Sciences,Yokohama National University, Japan The first of our research theme is the examinations of the medical causes of developmental disability, particularly mental retardation with chromosomal abnormality. The second is the epidemiological study in Yokohama City , the second largest city in Japan with the population of 3.4 million.The third is the study on the autistic disorders, particularly its social aspects and the clinical classification of this disorder. The fourth theme is the relationship and collaboration between education and medicine, particularly special education. We plan to use these research results for medical treatment and educational process. We present the results of our research and would like to discuss those medical and social problems presented from international point of view. Profile of our Lab. Staff and Collaborator Epidemiology Mental Retardation Incidence in Yokohama City The administrative management for mentally retarded persons An Epidemiological Study on the Cause of Mental Retardation in Yokohama City Pathology The Brain Structure as the Intermediary for the Emotions The Cerebral Limbic System etc- Recent knowledge concerning the neural development disorder hypothesis of schizophrenia with interpretations and observations of the Wagner brain case Chromosomal Abnormalities ... Intoxication(carbon monoxide intoxication) .Autistic Disorder Autism and Vocational training Autism and Early Detection Nosology of Autism Understanding and Supporting the Activities of Autistic PatientsBased on the Fundamentals of Cognitive Science and the Science of the Brain ... Major Revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM) Medicine and Special Education

A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Page 4     61-80 of 100    Back | 1  | 2  | 3  | 4  | 5  | Next 20