61. Charcot-Marie-Tooth Disease By Anonymous I have CMT (charcotmarie-tooth disease), a genetic neurological disease that causes deformities in the extremities and pain in the hands and feet. http://www.rxmarihuana.com/shared_comments/Charcot_Marie_Tooth.htm

Charcot-Marie-Tooth Disease by Anonymous

62. Closing In On Treatment For Charcot-Marie-Tooth Disease? Interuniversity Institute of Biotechnology Closing in on treatment for charcotmarie-tooth disease? Charcot-Marie-Tooth (CMT) is http://www.eurekalert.org/pub_releases/2004-05/vfii-cio050704.php

Public release date: 7-May-2004 Contact: Ann Van Gysel ann.vangysel@vib.be VIB, Flanders Interuniversity Institute of Biotechnology Closing in on treatment for Charcot-Marie-Tooth disease? Charcot-Marie-Tooth (CMT) is a hereditary disorder of the peripheral nervous system that strikes 1 person in every 2500. Increasing debilitation of the muscles ultimately leads to their disappearance in the lower legs, feet and hands. Now, researchers from VIB (the Flanders Interuniversity Institute for Biotechnology) have discovered a piece of the molecular puzzle of this disease. Two small 'heat shock' proteins turn out to be crucial - faults in the coding genes lead to the disease. Additional research has shown that these proteins play an important role in many other neurodegenerative disorders as well. This research moves us a step closer to the development of new therapies. CMT, a serious disorder without a cure CMT, the most common hereditary disorder of the peripheral nervous system, leads to debilitation of the muscles in the lower legs, feet and hands. The clinical picture is extremely variable, but older patients sometimes require a wheelchair. Today, only supportive treatment is available; there are still no effective therapies to retard or stop the progress of the disease. More insight into the molecular processes of this disease is essential for diagnosis and potential treatment. And exploration of the genes involved is a crucial step in this. VIB research findings Joy Irobi and her colleagues - under the direction of Vincent Timmerman and Peter De Jonghe of the Department of Molecular Genetics, University of Antwerp - are concentrating on the genetic and biological study of hereditary disorders of the peripheral nervous system. The largest cells in our body, our peripheral neurons can be 1 meter long in bundles of nerve fibers extending from the spinal cord to the feet.

63. Charcot-marie-tooth Disease Ailment Name charcotmarie-tooth disease. Join this Community get help by emailing and chatting to others, and sharing information and experiences, http://www.thirdaid.com/conditions/Charcot-marie-tooth_Disease.htm

Home Your Registration Details Ailment Name: Charcot-marie-tooth Disease Join this Community Registration (Details given below are only for use in the Community and under no circumstances is your information ever provided to other 3rd parties. Required Information How would you like to be known? Birthdate: document.RegistrationForm.birthdate_day.options[birthdate_current_Day].selected=true; January February March April May June July August September October November December document.RegistrationForm.birthdate_month.options[birthdate_current_Month].selected=true; E-mail: (confidential) Please note: If you enter your email address incorrectly you will not be able to access this site. You are a ... Sufferer Carer Doctor For how long? year(s) State/Province/City: Country: Select a Country Afghanistan Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua And Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Columbia Comoros Congo Cook Islands Costa Rica Cote DnullIvoire (Ivory Coast) Croatia (Hrvatska) Cuba Cyprus Czech Republic D.P.R. Korea

64. Charcot-Marie-Tooth Disease Survey And Information charcotmarie-tooth disease - Survey and Information © 1997-2003 All rights reserved. This Site was created and is maintained http://www.geocities.com/dgosling_rn/

We subscribe to the HONcode principles of the Health On the Net Foundation and the Medinex Code Of Online Excellence ******PLEASE READ and Text Only and Version To Print Check Your Drugs for information and interactions with other drugs. CMT - What is it? Heredity In CMT by Lamar CMT Internet Links ... Website Awards "Charcot-Marie-Tooth Disease - Survey and Information" This Site was created and is maintained and funded by Dorothy B. Gosling Reg.N. and Privacy Policy Others have donated their time, money and expertise for the benefit of all CMTers. Some Web Page Design features supplied by Webmaster Email: D. B. Gosling Changes last made on: Monday, May 24, 2004

65. Charcot-Marie-Tooth Disease CMTnet charcotmarie-tooth disease Information CMTnet is a repository of information for research and treatment of Charcot-Marie-Tooth (CMT). http://www.doctorpage.com/findit/Diseases_and_Conditions/Charcot_Marie_Tooth_Dis

doctorpage Diseases and Conditions Charcot Marie Tooth Disease Displaying listings 1-4 CMTUS email support + discussion group for people with CMT A global, private, CMT email discussion group for sharing positive living ideas, practical solutions and new research modalities. 56 Links, polls, open 7 days, 24 hours per day. All with CMT are wellcome! http://www.egroups.com/group/CMTUS CMTnet: Charcot-Marie-Tooth Disease Information CMTnet is a repository of information for research and treatment of Charcot-Marie-Tooth (CMT). CMT is a hereditary progressive neuromuscular disorder that primarily effects the extremities. http://www.ultranet.com/~smith/CMTnet.html Charcot-Marie-Tooth Disease National Institutes of Health, Bethesda, Maryland 20892 Written August 1996 Index: : Charcot-Marie-Tooth disorder is an inherited neurological disease characterized by a slowly progressive ... http://www.ninds.nih.gov/healinfo/DISORDER/charcot/charcot.htm Charcot-Marie-Tooth disease (hereditary) Disease progressive neuropathic muscular atrophy; hereditary peroneal nerve dysfunction; neuropathy - peroneal A slowly progressive, inherited disorder characterized by of tissue in the feet and ... http://www.healthanswers.com/database/ami/converted/000727.html

66. Closing In On Treatment For Charcot-Marie-Tooth Disease? Closing in on treatment for charcotmarie-tooth disease? 08 May 2004 http://www.medicalnewstoday.com/index.php?newsid=8068

67. NetDoctor.co.uk - Smoking - Ask The Expert charcotmarie-tooth disease and smoking 28-11-2002. Question. Does having charcot-marie-tooth disease give me more than most a reason to give up smoking? http://community.netdoktor.com/ccs/uk/smoking/coping/expert/article.jsp?articleI

68. Epilepsy, Charcot Marie Tooth Disease By NYERRN Epilepsy and Charcot Marie Tooth Disease. Charcot Marie Tooth Disease. CharcotMarie-Tooth Association. Family Village on charcot-marie-tooth disease. http://www.nyerrn.com/neuro/3.htm

Epilepsy and Charcot Marie Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Association CMTnet - CMTnet provides information for both the medical and non-medical communities on Charcot-Marie-Tooth (CMT). CMT International - (Charcot-Marie-Tooth Disease) Formally known as Charcot-Marie-Tooth Disease/Peroneal Muscular Atrophy International Association, Inc. This site includes information about hereditary neuropathy with liability to pressure palsies (HNPP). Family Village on Charcot-Marie-Tooth Disease Muscular Dystrophy Association - Facts About Charcot-Marie-Tooth Disease (CMT) National Alliance OF The Disabled (NAOTD) CMT - Charcot Marie Tooth Disease National Center for Biotechnology Information National Institute of Neurological Disorders and Stroke - Charcot-Marie-Tooth Disorder National Organization for Rare Disorders (NORD) - Charcot Marie Tooth Disease Summary Neurology Channel -Charcot-Marie-Tooth Disease Return to the Index of Neurology Topics Epilepsy American Epilepsy Society - A professional organization of clinicians and researchers. Epilepsy Canada Epilepsy Contact Database Epilepsy Education Association Epilepsy Foundation of America - Includes FAQs and a "News Desk"

69. Genetics Research: Charcot Marie Tooth charcotmarie-tooth disease Type 1A. Principal Investigator Pragna I. Patel, Ph.D. Autosomal dominant inheritance pattern; Frequency http://www.bcm.tmc.edu/neurol/research/genes/genes3.html

Charcot-Marie-Tooth Disease Type 1A Principal Investigator: Pragna I. Patel, Ph.D. Autosomal dominant inheritance pattern Frequency: ~ 1 in 2,500 (most common inherited peripheral neuropathy) Signs/symptoms include: distal muscle atrophy, decreased nerve conduction velocity, absent deep tendon reflexes, pes cavus, pes planus Our recent discoveries include: CMT1A associated in >70% of patients with a 1.5 million base pair DNA duplication on chromosome 17 Peripheral myelin protein 22 (PMP22) gene mapped within the duplication Point mutations in PMP22 also associated with CMT1A Current efforts include studying the regulation of the PMP22 gene and using triplex oligonucleotides as a possible approach for modulating PMP22 expression. Selected References: Patel, P.I., and Lupski, J.R. Charcot-Marie-Tooth disease: A new paradigm for the mechanism of inherited disease. Trends. Genet., 10:128-133, 1994. Patel, P.I., Roa, B., Welcher, A., Schoener-Scott, R., Trask, B.J., Pentao, L., Snipes, G.J., Garcia, C.A., Francke, U., Shooter, E., Lupski, J.R., and Suter, U. The gene for the peripheral myelin protein PMP-22 gene is a candidate for Charcot-Marie-Tooth disease type 1A. Nature Genetics, 1:159-165, 1992. Lupski, J.R., Montes de Oca-Luna, R., Slaugenhaupt, S., Pentao, L., Guzzetta, V., Trask, B.J., Saucedo-Cardenas, O., Barker, D.F., Killian, J.M., Garcia, C.A., Chakravarti, A., and Patel, P.I. DNA duplication associated with Charcot- Marie-Tooth disease type 1A. Cell, 66:219-232, 1991.

70. Short Description Of Cell Lines. Pathology: Charcot-Marie-Tooth Disease #118200 Version 4.200205, Short description of cell lines. Pathology charcotmarie-tooth disease 118200 OMIM record. - By selecting the http://www.biotech.ist.unige.it/cldb/pat56.html

Version Short description of cell lines. Pathology: Charcot-Marie-Tooth disease OMIM record By selecting the cell line name , you will receive the detailed description of the cell line By selecting one of the terms between parentheses, you will receive the list of all relevant cell lines You can search any term of the list by using the 'Find' utility of your browser human, Caucasian skin, fibroblast GEIMM human, Caucasian ... By Beatrice...

71. CHARCOT-MARIE-TOOTH DISEASE charcotmarie-tooth disease. Cie Cie Glencross. charcot-marie-tooth disease presents in a variety of clinical forms and presents at different ages. http://podiatry.curtin.edu.au/encyclopedia/ciecle/

CHARCOT-MARIE-TOOTH DISEASE Cie Cie Glencross Figure 1: Charcot-Marie-Tooth typical cavus foot type and inverted champagne bottle leg Introduction Overview Specifics Summary ... References Back to Encyclopedia Index INTRODUCTION Scope of the Report Aims of the Report The report will cover the following areas: Mode of Inheritance Types of Charcot-Marie-Tooth disease Pathogenesis of Charcot-Marie-Tooth disease Pathology of Charcot-Marie-Tooth disease Clinical Features Diagnosis of Charcot-Marie-Tooth disease Conservative and Surgical Treatment of Charcot-Marie-Tooth disease. Back to Contents OVERVIEW: Prevalence Mode of Inheritance Types Back to Contents SPECIFICS: PATHOLOGENESIS Neural Pathogenesis Muscular Pathogenesis 1. The muscles supplied by the longest axon of the Sciatic nerve are affected first. 2. The muscles showing the least bulk are foremost in showing wasting. 3. Muscles above the knee are not affected. Downey et al (1992) and Mann and Missirian (1983; 1986) support this theory in explaining the pattern of muscle wasting and dysfunction. The intrinsic muscles of the foot are the first to atrophy as a result of their size and innervation by the medial and lateral plantar nerves. The anterior muscles of the leg are next to atrophy presumably as a result of their innervation be the smaller branch of the Sciatic nerve. As a result of the lack of muscle bulk, Peroneus Brevis and Peroneus Tertius atrophy before their counterpart Peroneus Longus. As Charcot-Marie-Tooth disease is progressive, the posterior leg muscle group and the triceps surae may be involved. However, because of the greatest muscle bulk, they are typically the last to atrophy (Downey, 1992).

72. Muscular Dystrophy Campaign Hereditary Motor And Sensory Neuropathies (HMSN) Hereditary Motor and Sensory Neuropathies (HMSN). (Sometimes known as charcotmarie-tooth disease or Peroneal muscular atrophy). December 2000. http://www.muscular-dystrophy.org/information/keyfacts/hmsn.html

@import "../../css/cssstyle.css"; Receive copies of Target MD Get your message to over 30,000 readers by advertising in Target MD magazine. Call for details: David N Russell Hereditary Motor and Sensory Neuropathies (HMSN) (Sometimes known as Charcot-Marie-Tooth Disease or Peroneal muscular atrophy) December 2000 From an original written by the late Prof Anita Harding MD, FRCP and revised by Dr D.Hilton-Jones MD, FRCP, for the Muscular Dystrophy Campaign. What are hereditary motor and sensory neuropathies? The term hereditary and sensory neuropathy (HMSN) is used to describe a group of conditions that give rise to weakness and wasting of the muscles below the knees and often those of the hands. Many affected people also have a loss of feeling in the hands and feet, and this is the ‘sensory’ component. The term neuropathy refers to the fact that it is the peripheral nerves (which connect the spinal cord to the muscles, joints and skin, carrying messages in both directions), which do not function normally. As the name implies, these are inherited disorders. Many different names have been used to describe HMSN in the past, and this is rather confusing. They are often referred to as peroneal muscular atrophy, because the peroneal muscle on the outside of the calves are particularly affected. Another commonly used name is Charcot-Marie-Tooth disease, after the three neurologists who first described the condition in 1886. Other names include Dejerine-Sottas disease and hereditary hypertrophic neuropathy. HMSN is now the preferred term, largely because Charcot-Marie-Tooth disease and peroneal muscular atrophy are more general terms used to describe a wider group of conditions including one form of spinal muscular atrophy.

73. MEDLINE Abstracts Charcot-Marie-Tooth Disease Preliminary Study of Large and Small Peripheral Nerve Fibers in charcotmarie-tooth disease, Type I. Hanson P, Deltombe T Am J Phys Med Rehabil 1998; 77(1)45-8 http://www.medscape.com/viewarticle/431507

74. Database Search Results does not imply endorsement by the US Department of Health and Human Services.. Searched keywords for charcotmarie-tooth disease. http://www.health.gov/NHIC/NHICScripts/Hitlist.cfm?Keyword=Charcot-Marie-Tooth D

75. Health Information Resource Database: CMT International (Charcot-Marie-Tooth Dis CMT International (charcotmarie-tooth disease/Peroneal Muscular Atrophy International Association, Inc.). Contact Information. 1 Springback Drive St. http://www.health.gov/nhic/NHICScripts/Entry.cfm?HRCode=HR2300

76. Charcot-Marie-Tooth Disease charcotmarie-tooth disease. charcot-marie-tooth disease is an inherited disorder of nerves (neuropathy) that is characterized by http://www.sciencedaily.com/encyclopedia/charcot_marie_tooth_disease

Match: sort by: relevance date Free Services Subscribe by email RSS newsfeeds PDA-friendly format loc="/images/" A A A Find Jobs In: Healthcare Engineering Accounting College Contract / Freelance Customer Service Diversity Engineering Executive Healthcare Hospitality Human Resources Information Tech International Manufacturing Nonprofit Retail All Jobs by Job Type All Jobs by Industry Relocating? Visit: Moving Resources Moving Companies Mortgage Information Mortgage Calculator Real Estate Lookup Front Page Today's Digest Week in Review Email Updates ... Outdoor Living Encyclopedia Main Page See live article Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease is an inherited disorder of nerves (neuropathy) that is characterized by loss of muscle tissue and touch sensation, predominantly in the feet and legs but also in the hands and arms in the advanced stages of disease. The disorder is caused by the absence of molecules that are essential for normal function of the nerves due to deficiencies in the structure of the genes coding these molecules. The absence of these chemical substances gives rise to dysfunction either in the axon or the myelin sheath of the nerve cell. Symptoms usually begin in late-childhood or early adulthood. Usually, the initial symptom is foot drop due to involvement of the peroneal nerve, which is responsible from raising the feet, early in the course of the disease. Wasting of muscle tissue of the lower parts of the legs may give rise to "stork leg" appearance. The diagnosis is established by electromyography examination (which shows that the velocity of nerve impulse conduction is decreased and the time required to charge the nerve is increased) and nerve biopsy. There is no treatment to replace the missing chemicals. The disease is named for those who classically described it: Jean-Martin Charcot (1825-1893) and his pupil Pierre Marie (1853-1940) (

77. BioMed Central PDF Charcot-Marie-Tooth Disease To obtain access to IDrugs through your institution use the options below. If you would like information about a personal subscription http://www.biomedcentral.com/content/pdf/cd-522764.pdf

78. Neurological Disorders, Peripheral Nervous System, Charcot-Marie-Tooth Disease More charcotmarie-tooth disease Categories » Submit Your Site to the charcot-marie-tooth disease category. Sponsored charcot-marie-tooth disease Sites. http://www.iseekhealth.com/charcot-marie-tooth_disease-2108.php

Home About Us Contact Submit Your Site Search : Home Health Conditions and Diseases Neurological Disorders ... Charcot-Marie-Tooth Disease More Charcot-Marie-Tooth Disease Categories: Submit Your Site to the Charcot-Marie-Tooth Disease category Sponsored Charcot-Marie-Tooth Disease Sites Epilepsy Book Store At WellnessBooks.com Comprehensive source to books on Epilepsy. Includes community boards and chat, book reviews and online ordering. Neurological Disorders Due To An Imbalance? Do you have a neurological disorder? This may be due to an imbalance. Check the balance of your system and get natural recommendations for restoring balance. Charcot-Marie-Tooth Association - Includes information about the organization, its goals, research, news and further resources. Also offers suggestions on ways to help. Charcot-Marie-Tooth Disorder - Information page compiled by National Institute of Neurological Disorders and Stroke. Charcot-Marie-Tooth Syndrome - Information on this disease: peroneal muscular atrophy or CMT. General Practice Notebook - Charcot-Marie-Tooth disease - Clinically-oriented information.

79. Charcot-Marie-Tooth Disease (C) Channel AZ, charcotmarie-tooth disease, CMT UK is the national support group for people affected by charcot-marie-tooth disease (CMT) and their families and carers. http://www.aditus.nhs.uk/Aditus/Patients and Public/A-Z/C/Charcot-Marie-Tooth Di

Home Patients and Public Staff and Students Resources ... Help Not logged in... Login: Register: Forgotten password Search: home patients and public staff and students resources ... help A-Z Charcot-Marie-Tooth Disease Charcot-Marie-Tooth Disease is also referred to as Hereditary Motor and Sensory Neuropathy (HMSN) and Peroneal Muscular Atrophy. For more general information on neurological conditions, please visit the neurological disorders homepage Useful Links CMT UK CMT UK is the national support group for people affected by Charcot-Marie-Tooth Disease (CMT) and their families and carers. The website includes: What is CMT Living with CMT A child's guide. Documents and Reports There are no Documents or Reports currently defined for this topic. Journals and Databases There are no Journals or Databases currently defined for this topic. Support Groups There are no support groups currently defined for this topic. Events There are no events currently defined for this topic. Select a Subject A B C D ... Z Aditus is provided by the North West Health Care Libraries Unit Health Care Libraries Unit, Ground Floor, Brew House, Wilderspool Park

80. Foot Problems In Charcot-Marie-Tooth Disease - CMTworld.org Article charcotmarie-tooth disease web site - Kids! Children! Click here! CMT Symptoms Foot Problems in charcot-marie-tooth disease By Dr. Jay Kumar Issue date Mar. http://www.cmtworld.org/epublisher/publish/article_0090.php

HOME FORUMS ABOUT US DONATE! ... CONTACT US "Courage and perseverance have a magical talisman, before which difficulties disappear and obstacles vanish into air." John Quincy Adams (1767 - 1848) Join our Mailing List! Welcome! What is CMT? Rx - Medications Alert For kids only! ... Articles ARTICLE CATEGORIES Personal Profiles Research Reports Products Reviews Understanding CMT ... Lighten up! Search Articles All Categories Personal Profiles Research Reports Products Reviews Understanding CMT CMT Symptoms CMT Treatment Medications Lighten up! Advanced Search TECH TIP How about opening the desktop in its own window! Click the Start button, select Run, type a dot (.) and press Enter. Voila! For more tips click here June 2, 2004, 5:35 am You can help! Donate Online now! CMT Symptoms Foot Problems in Charcot-Marie-Tooth Disease By Dr. Jay Kumar Issue date: Mar. 19/04 Email this article Printer friendly page One of the common problems seen in children and adolescents who have CMT in the 10 to 16-year-old age group, and in young adults, is a cavo-varus foot where there is a high arch and patients walk on the outer border of the foot. All of the pressure goes through the heel and the outer side of the foot, resulting in calluses on the outer border and heel. With time, the big toe on the inner side drops down creating a lot of pressure on the ball of the foot. As the people we see become older, the toes tend to claw resulting in calluses on the knuckles of the toes. Patients present with the following problems:

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