41. Charcot-Marie-Tooth Disease charcotmarie-tooth disease. Definition charcot-marie-tooth disease (CMT) is the name for a group of inherited disorders of nerve http://www.chclibrary.org/micromed/00042210.html

Main Search Index Definition Description Causes ... Resources Charcot-Marie-Tooth disease Definition Charcot-Marie-Tooth disease (CMT) is the name for a group of inherited disorders of nerve conduction causing weakness and mild loss of sensation in the limbs. Description CMT affects the peripheral nerves, those groups of nerve cells carrying information to and from the spinal cord. CMT decreases the ability of these nerves to carry motor commands to muscles, especially those furthest from the spinal cord in the feet and hands. As a result, these muscles are weakened. CMT also causes mild sensory loss. CMT is named for the three neurologists who first described it, and does not involve the teeth in any way. It is also known as hereditary motor and sensory neuropathy, and is also sometimes called peroneal muscular atrophy, referring to the muscles in the leg affected early on in the disease. Causes The symptoms grouped together under the name CMT can be caused by any of at least six different genetic defects. Most of the defects, identified as of early 1998, affect myelin, the coating that insulates nerve cells to promote efficient conduction. Myelin defects cause either a reduction in nerve conduction velocities, or a diminished nerve signal. CMT is currently subdivided into type 1A, type 1B, type 2, and type X, based on the particular genetic defect involved. All but type X exhibit the inheritance pattern known as autosomal dominant. In this pattern, only one defective gene copy is needed to develop the disease, which may be inherited from either parent (who will also have the disease). A person with CMT of this type has a 50% chance of passing the gene along to each offspring. CMT type X is inherited as an X-linked trait, meaning the gene is carried on the X chromosome. Women carry two X chromosomes, while men carry only one. Without a "backup" copy of the normal gene, a man with the CMT type X gene is more likely to be seriously affected than is a woman. Expression of the gene does occur in women to a lesser extent, leading to disease of variable severity. Affected men may pass the gene on to their daughters, but not to their sons.

42. SupportPath.com: Charcot-Marie-Tooth Disease SupportPath.com, charcotmarie-tooth disease. Also called CMT, Charcot-Marie Disease. Clinical Trials Research on charcot-marie-tooth disease None Listed. http://www.supportpath.com/sl_c/charcot_marie_tooth_disease.htm

Charcot-Marie-Tooth Disease Also called: CMT, Charcot-Marie Disease Other topics of interest on SupportPath.com: disABILITIES About Us Add-A-Link Email ... here Online Communities / Message Boards... Braintalk Communities: Charcot Marie Tooth Website: Description: A part of the BrainTalk Communities website. Registration is required to post to this message board. Date Added: 06/06/2002 Online Chats... Note: Regularly scheduled chats are listed on our NEW Online Events Calendar Links in this section are primarily to chat rooms open 24/7 which may or may not be moderated. None Listed Usenet Groups... Note: Your browser must be properly configured to access Usenet groups from this site. None Listed Mailing Lists... None Listed National / International Organizations... Charcot-Marie-Tooth Association (CMTA) Note: Groups are listed alphabetically by U.S. state and then country. None Listed None Listed Professional Organizations of Interest... None Listed None Listed Miscellaneous Links... None Listed Books about Charcot-Marie-Tooth Disease and Related Topics... None Listed (The following search link is offered in association with Amazon.com

43. AllRefer Health - Charcot-Marie-Tooth Disease (Hereditary) (Hereditary Motor And charcotmarie-tooth disease (Hereditary). charcot-marie-tooth disease causes destruction of the myelin sheath in some people. In http://health.allrefer.com/health/charcot-marie-tooth-disease-hereditary-info.ht

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia You are here : AllRefer.com Health Charcot-Marie-Tooth Disease (Hereditary) Charcot-Marie-Tooth Disease (Hereditary) Definition Prevention Treatment Expectations or Prognosis ... Go To Main Page Alternate Names : Hereditary Motor and Sensory Neuropathy, Hereditary Peroneal Nerve Dysfunction, Neuropathy - Peroneal (Hereditary), Progressive Neuropathic (Peroneal) Muscular Atrophy Definition Charcot-Marie-Tooth disease defines a group of inherited, slowly progressive disorders that result from progressive damage to nerves. Symptoms include numbness and wasting of muscle tissue, first in the feet and legs, then in the hands and arms.

44. AllRefer Health - Charcot-Marie-Tooth Disease (Hereditary): Diagnosis & Tests (H charcotmarie-tooth disease (Hereditary). Main Page of charcot-marie-tooth disease (Hereditary). From Our Sponsors ADAM. ADAM, Inc. http://health.allrefer.com/health/charcot-marie-tooth-disease-hereditary-diagnos

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia You are here : AllRefer.com Health Charcot-Marie-Tooth Disease (Hereditary) Charcot-Marie-Tooth Disease (Hereditary) Definition Prevention Treatment Expectations or Prognosis ... Go To Main Page Alternate Names : Hereditary Motor and Sensory Neuropathy, Hereditary Peroneal Nerve Dysfunction, Neuropathy - Peroneal (Hereditary), Progressive Neuropathic (Peroneal) Muscular Atrophy An examination by touch may reveal thickened nerve bundles under the skin of the legs in the demyelinating form of Charcot-Marie-Tooth disease. The stretch reflexes in the legs are absent. There is loss of muscle control and atrophy in the foot or leg. There is difficulty with lifting up the foot (dorsiflexion) and with toe-out movements (eversion).

45. The Physician And Sportsmedicine: Charcot-Marie-Tooth Disease In A High School T charcotmarie-tooth disease in a High School Tennis Player. 3. TABLE 1. Drugs That May Be Toxic to Patients Who Have charcot-marie-tooth disease. http://www.physsportsmed.com/issues/2002/10_02/stadler.htm

Charcot-Marie-Tooth Disease in a High School Tennis Player Teresa S. Stadler, MD David Ross, MD THE PHYSICIAN AND SPORTSMEDICINE - VOL 30 - NO. 10 - OCTOBER 2002 In Brief: A high school tennis player had recurrent ankle sprains that were initially attributed to incomplete rehabilitation. A closer look revealed subtle symptoms of Charcot-Marie-Tooth disease (CMT), a common, inherited neuromuscular disorder. This case underscores the importance of a wide differential diagnosis when encountering recurrent conditions. Early diagnosis of CMT is imperative so that appropriate injury-prevention measures can be taken. T he underlying cause of recurrent ankle sprains may be improper rehabilitation; however, other, less apparent, conditions may be the source. A comprehensive history and physical examination may lead to the diagnosis of Charcot-Marie-Tooth (CMT) disease, as in the following case. Awareness of this fairly common condition may lead to early diagnosis and prevent recurrent ankle injuries in an otherwise healthy patient. Case Report A 16-year-old male varsity tennis player came to our sports medicine clinic with persistent right ankle pain 2 days after he had an inversion injury while sidestepping in a tennis match. He was able to walk off the court but was not able to continue playing that day. The ankle did not swell.

46. Pediatrics: Charcot-Marie - Tooth Disease charcotmarie-tooth disease Henry Boucher, MD. Paul D. Sponseller, MD Professor and Head of the Division of Pediatric Orthopedics http://www.ortho.hyperguides.com/Tutorials/pediatric_ort/charcot-marie/default.a

window.location="http://www.ortho.hyperguides.com/"; Charcot-Marie-Tooth Disease Henry Boucher, MD Paul D. Sponseller, MD Professor and Head of the Division of Pediatric Orthopedics The Johns Hopkins Hospital Baltimore, Maryland

47. Charcot-Marie-Tooth Syndrome charcotmarie-tooth disease (CMT) disease is named after its three discoverers, who first noted the disease around the turn of the century. http://www.ncbi.nlm.nih.gov/disease/Charcot.html

This Genes and Disease page has been moved to: Please update your bookmarks. If you are not automatically transported to the new page after 15 seconds, click on this link Genome View on chromosome 17 Databases PubMed the literature LocusLink collection of gene-related information OMIM catalog of human genes and disorders Information Charcot-Marie-Tooth Association patient support, education and research Charcot-Marie-Tooth International run by and for people who have CMT disease GeneClinics a medical genetics resource CHARCOT-MARIE-TOOTH disease (CMT) disease is named after its three discoverers, who first noted the disease around the turn of the century. It is the most common inherited peripheral neuropathy in the world, characterized by a slowly progressive degeneration of the muscles in the foot, lower leg, hand and forearm, and a mild loss of sensation in the limbs, fingers and toes. Full expression of CMT's clinical symptoms generally occurs by age 30. CMT is not a fatal disease, however, and the disorder does not affect normal life expectancy. CMT is a genetically heterogeneous disorder, in which mutations in different genes can produce the same clinical symptoms. In CMT, there are not only different genes but different patterns of inheritance. One of the most common forms of CMT is Type 1A. The gene for Type 1A CMT maps to chromosome 17 and is thought to code for a protein (PMP22) involved in coating peripheral nerves with myelin, a fatty sheath that is important for their conductance. Other types of CMT include Type 1B, autosomal-recessive and X-linked.

48. Charcot-Marie-Tooth Disease - Tutorial The first cases of charcotmarie-tooth disease (CMT) were reported in 1855 by Aran and Virchow. Sabir M, Lyttle D. Pathogenesis of charcot-marie-tooth disease. http://www.ortho.hyperguides.com/Tutorials/pediatric_ort/charcot-marie/tutorial.

window.location="http://www.ortho.hyperguides.com/"; Charcot-Marie-Tooth Disease Henry Boucher, MD History Classification Genetics Clinical Features ... References History The first cases of Charcot-Marie-Tooth disease (CMT) were reported in 1855 by Aran and Virchow. They described patients with lower extremity weakness followed by upper extremity involvement. In 1886, Charcot and Marie, simultaneously with Tooth, published on the disease bearing their names. Classification CMT is the prototype disease of the numerous hereditary motor sensory neuropathies (HMSN). The HMSNs are classified into 7 types, with I, II, and III particular to pediatric orthopedics. The other types of HMSNs occur later in life. Type Classification I The hypertrophic form of CMT, also known as Roussy-Levy disease. It has autosomal dominant inheritance. Clinically, it is a demyelinating disease with distal extremity weakness, no DTR, and slow motor NCV. II The neuronal form of CMT. This type has a variable inheritance. Clinically, this form is less severe than type I and displays a mild decrease in NCVs and present DTRs. The onset of disease is later than type I. III IV Known as Refsum's disease, this type is characterized by excessive phytanic acid (a fatty acid).

49. Charcot Marie Tooth Disease Charcot Marie Tooth Disease. Symptoms. Symptoms of charcotmarie-tooth disease usually begin gradually sometime between middle childhood and age 30. http://www.bchealthguide.org/kbase/nord/nord261.htm

document.write(''); var hwPrint=1; var hwDocHWID="nord261"; var hwDocTitle="Charcot Marie Tooth Disease"; var hwRank="1"; var hwSectionHWID="nord261"; var hwSectionTitle=""; var hwSource="cn6.0"; var hwProdCfgSerNo="wsh_html_031_s"; var hwDocType="NORD"; National Organization for Rare Disorders, Inc. Charcot Marie Tooth Disease Important It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms CMT Hereditary Sensory Motor Neuropathy HSMN Peroneal Muscular Atrophy Disorder Subdivisions None Related Disorders List Information on the following diseases can be found in the Related Disorders section of this report: Dejerine-Sottas Disease Hereditary Sensory Radicular Neuropathy Refsum Syndrome Familial Amyloid Neuropathy Hereditary Neuropathy with Liability to Pressure Palsy (HNPP) General Discussion Charcot-Marie-Tooth disease is a hereditary neurological disorder characterized by muscle weakness and atrophy, primarily in the legs. Disappearance of the protective fatty layers surrounding the nerves (segmental demyelination) of peripheral nervous system and associated degeneration of part of the nerve cells (axons) characterize this disorder. Symptoms Symptoms of Charcot-Marie-Tooth disease usually begin gradually sometime between middle childhood and age 30. Muscle atrophy and weakness are most prominent in the legs and the small muscles of the hands. The most incapacitating symptom of CMT is "foot drop", producing a slapping gait. Pain and unusual sensations (paresthesias) may be present in the affected limbs. A decrease in vibration, pain and thermal sensation in the hand, foot and lower part of the leg (glove and stocking pattern) is common. Stretch reflexes are usually absent. The disease is slowly progressive, but may arrest spontaneously. Patients may remain active for years and live a normal life span.

50. Charcot-Marie-Tooth Disease charcotmarie-tooth disease, adolescence. The neuronal form of charcot-marie-tooth disease normally appears after the age of 20. There http://www.kron4.com/global/story.asp?s=1230787

51. Charcot-Marie-Tooth Disease Fact Sheet What is charcotmarie-tooth disease? What are the symptoms of charcot-marie-tooth disease? The neuropathy of CMT affects both motor and sensory nerves. http://www.ninds.nih.gov/health_and_medical/pubs/CMT.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about a disorder Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health Charcot-Marie-Tooth Disease Fact Sheet Get Web page suited for printing Email this to a friend or colleague Request free mailed brochure Table of Contents What is Charcot-Marie-Tooth disease? What are the symptoms of Charcot-Marie-Tooth disease? What are the types of Charcot-Marie-Tooth disease? What causes Charcot-Marie-Tooth disease? ... Where can I get more information? What is Charcot-Marie-Tooth disease? Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States. The disease is named for the three physicians who first identified it in 1886 - Jean-Martin Charcot and Pierre Marie in Paris, France, and Howard Henry Tooth in Cambridge, England. CMT, also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy, comprises a group of disorders that affect peripheral nerves. The peripheral nerves lie outside the brain and spinal cord and supply the muscles and sensory organs in the limbs. Disorders that affect the peripheral nerves are called peripheral neuropathies.

52. Yahoo! Search Results charcotmarie-tooth disease. CMT International UK - Support group for people with charcot-marie-tooth disease. Ask Noah About charcot-marie-tooth disease. http://www.ability.org.uk/Charcot_Marie_Tooth_Disease.html

Our Aims Services Stats ... Z Charcot-Marie-Tooth Disease CMT International UK - Support group for people with Charcot Marie Tooth disease Ask Noah About: Charcot-Marie-Tooth Disease Charcot-Marie-Tooth Disease ... Information Exchange - a hereditary progressive neuromuscular disorder that primarily effects the feet, legs and hands. Charcot-Marie-Tooth International - self-help, consumer run organization providing information for people with CMT around the world. Charcot-Marie-Tooth Association Webmaster . Site Design by Ability "see the ability, not the disability" Acknowledgments

53. ANNALS ONLINE -- Collected Resources : Charcot-Marie-Tooth Disease charcotmarie-tooth disease. Part I. Clinical and Pathological Review of What Constitutes CMT Overview of charcot-marie-tooth disease Type 1A PK THOMAS Ann. http://www.annalsnyas.org/cgi/collection/charcot

HOME HELP FEEDBACK SUBSCRIPTIONS ... SEARCH COLLECTIONS EMAIL ALERTS SEARCH RESULT Charcot-Marie-Tooth Disease Citations 1-10 of 43 total displayed. Most recent content (14 Sep 1999): Part I. Clinical and Pathological Review of What Constitutes CMT Overview of Charcot-Marie-Tooth Disease Type 1A P. K. THOMAS Ann. N.Y. Acad. Sci. 1999; 883: 1-5. [Abstract] [Full text] Part I. Clinical and Pathological Review of What Constitutes CMT Historical Perspective of Defining Charcot-Marie-Tooth Type 1B THOMAS D. BIRD Ann. N.Y. Acad. Sci. 1999; 883: 6-13. [Abstract] [Full text] Part I. Clinical and Pathological Review of What Constitutes CMT Overview of Hereditary Neuropathy with Liability to Pressure Palsies PHILIP F. CHANCE Ann. N.Y. Acad. Sci. 1999; 883: 14-21. [Abstract] [Full text] Part I. Clinical and Pathological Review of What Constitutes CMT Molecular Mechanisms for CMT1A Duplication and HNPP Deletion C. F. BOERKOEL, K. INOUE, L. T. REITER, L. E. WARNER, and J. R. LUPSKI Ann. N.Y. Acad. Sci. 1999; 883: 22-35.

54. ANNALS ONLINE -- Collected Resources : Charcot-Marie-Tooth Disease FAQ. charcotmarie-tooth disease. Citations 31-40 of 43 total displayed. Most recent content (14 Sep 1999) Part II. Pathogenesis http://www.annalsnyas.org/cgi/collection/charcot?page=4

55. Charcot-Marie-Tooth Disease charcotmarie-tooth disease. Definition. charcot-marie-tooth disease (CMT) is a group of genetic disorders that affects movement and sensation in the limbs. http://www.somersetmedicalcenter.com/1290.cfm

Community Advisor Search Send to a friend Home  Diseases, Conditions and Injuries Charcot-Marie-Tooth Disease (Hereditary Motor and Sensory Neuropathies [HMSNs], Dejerine-Sottas Disease) by Michelle Badash, MS Definition Causes Risk Factors ... Organizations Definition Charcot-Marie-Tooth disease (CMT) is a group of genetic disorders that affects movement and sensation in the limbs. The disease progresses slowly and causes damage to the nerves that control muscles. Causes CMT is caused by defects in specific genes (genetic mutations) usually inherited in an autosomal dominant pattern. This means that if one parent has CMT, each child has a 50% chance of inheriting the gene and the disease. There are three types of CMT: Type I – This type affects the coating of the nerve called the myelin sheath, causing nerve impulses to travel more slowly. It usually occurs in childhood or adolescence, and is the most common type of CMT. Type II – This type affects the nerve fibers, called axons. Although the speed is normal, the size or amount of impulses is less than normal. This type of CMT is less common, and occurs after adolescence. Type III – This is a more rare, severe form of CMT. It is also called Dejerine-Sottas disease. Symptoms may include:

56. EPodiatry charcotmarie-tooth disease. Comments charcot-marie-tooth disease. URL http//www ciecle/. Comments charcot-marie-tooth disease. URL http http://www.epodiatry.com/education_sub3.asp?topic=Pediatrics&sub1=Learning resou

57. Your Health - Charcot-Marie-Tooth Disease charcotmarie-tooth disease. Definition. charcot-marie-tooth disease (CMT) is a group of genetic disorders that affects movement and sensation in the limbs. http://www.aurorahealthcare.org/yourhealth/healthgate/getcontent.asp?URLhealthga

58. Charcot-Marie-Tooth Disease charcotmarie-tooth disease. GeneReviews Charcot Marie Tooth hereditary neuropathies. Notes registration. charcot-marie-tooth disease / genetics;. http://omni.ac.uk/browse/mesh/C0007959L0007960.html

low graphics Charcot-Marie-Tooth Disease GeneReviews : Charcot Marie Tooth hereditary neuropathies Notes for physicians on Charcot Marie Tooth hereditary neuropathies (synonyms: CMT, hereditary motor and sensory neuropathies (HMSN), Dejerine-Sottas disease and peroneal muscular atrophy). This document includes diagnosis, a clinical description, incidence, molecular genetics and genetic counselling and testing. This resource forms part of GeneReviews (formerly GeneClinics profile), a peer-reviewed clinical genetic information resource that is funded by the US National Institutes of Health (NIH) and produced by the University of Washington, Seattle. This resource contains a summary and bibliographical references of the review, free access to the full- text version of the review requires brief registration. Charcot-Marie-Tooth Disease / genetics Last modified: 27 May 2004

59. Roussy-Levy Syndrome,Charcot-Marie-Tooth Disease Variant,Charcot-Marie-Tooth-Rou also known as charcotmarie-tooth disease (Variant) Charcot-Marie-Tooth-Roussy-Levy Disease Hereditary Areflexic Dystasia Hereditary Motor Sensory Neuropathy http://www.icomm.ca/geneinfo/roussy.htm

Roussy-Levy Syndrome,Charcot-Marie-Tooth Disease Variant,Charcot-Marie-Tooth-Roussy-Levy Disease,Hereditary Areflexic Dystasia,Hereditary Motor Sensory Neuropathy,Hereditary Motor Sensory Neuropathy I,HMSN I,Roussy-Levy Syndrome,Charcot-Marie-Tooth Disease Variant,Charcot-Marie-Tooth-Roussy-Levy Disease,Hereditary Areflexic Dystasia,Hereditary Motor Sensory Neuropathy,Hereditary Motor Sensory Neuropathy I,HMSN I For Information on Workshops and Seminars for Special Needs Children click here The GAPS INDEX to Information on the Internet about Genetic Disorders and Birth Defects Genetic Information and Patient Services, Inc. (GAPS) HOME DISORDERS GLOSSARY Roussy-Levy Syndrome also known as: Charcot-Marie-Tooth Disease (Variant) Charcot-Marie-Tooth-Roussy-Levy Disease Hereditary Areflexic Dystasia Hereditary Motor Sensory Neuropathy Hereditary Motor Sensory Neuropathy I HMSN I (as defined by the National Organization for Rare Disorders Roussy-Levy Syndrome, also known as hereditary areflexic dystasia, is a rare genetic neuromuscular disorder that typically becomes apparent during early childhood. The disorder is characterized by incoordination, poor judgment of movements (sensory ataxia), and absence of reflexes (areflexia) of the lower legs and, eventually, the hands; weakness and degeneration (atrophy) of muscles of the lower legs; abnormally high arches of the feet with increased extension of the toes (pes cavus or "clawfoot"); and tremors of the hands.

60. Charcot-Marie-Tooth Disease By Anonymous charcotmarie-tooth disease by Anonymous. I am a 40 year old man with charcot-marie-tooth disease, a progressive hereditary neurological disease. http://www.rxmarihuana.com/shared_comments/Charcot-Marie-Tooth3.htm

Charcot-Marie-Tooth Disease by Anonymous As for the benefits of cannabis, these are sustained for several hours following smoking a small marijuana joint over the course of a day. I never use tobacco and alcohol, which are contra-indicated for my disease.. I try not to smoke until late in the day, as I do not want to get too stoned. The effect of being stoned is pleasant, to say the least, but it is not conducive to my daily routine. I never smoke before or during work for that reason. I also feel that it takes some time to 'learn' how cannabis affects each individual and therefore it is not easy to suggest appropriate doses. My muscle cramps are the first thing to disappear, approximately 5-10 minutes after a smoke. Then pain disappears in my legs and hands. I usually will not require a second 'dose' for an hour or two. In CMT balance is affected adversely, and with this in mind I try to avoid getting too stoned if I am up on my feet. But paradoxically, I am a lot more careful and in some ways more spatially aware when I smoke, so it levels out risk and benefit.

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