1. Charcot-Marie-Tooth Disease / Family Village Library charcotmarie-tooth disease. Synonym Peroneal Muscular Atrophy, Hereditary Motor and CMT-Support. Charcot-Marie Tooth Disease (CMT) is the most common neuromuscular disease in the http://www.familyvillage.wisc.edu/lib_cmtd.htm

Charcot-Marie-Tooth Disease Synonym: Peroneal Muscular Atrophy, Hereditary Motor and Sensory Neuropathy Who to Contact Where to Go to Chat with Others Learn More About It Web Sites ... Search Google for "Charcot-Marie-Tooth Disease" Who to Contact Charcot-Marie-Tooth Association 2700 Chestnut Street Chester, PA 19013-4867 1-800-606-CMTA (phone) 1-610-499-9267 (fax) E-mail: CMTAssoc@aol.com Web: http://www.charcot-marie-tooth.org/ Works to educate, fund research, and promote public awareness of CMT, the most commonly inherited peripheral neuropathy. Where to Go to Chat with Others CMT-Support Charcot-Marie Tooth Disease (CMT) is the most common neuromuscular disease in the world. It is sometimes referred to as "Hereditary Motor and Sensory Neuropathy" or HMSN. About one in 2500 people or over 2,000,000 people now have one of the many types of CMT. This group is for sharing feelings as well as life's ups and downs, learning, and mutual support for people with CMT, their friends, families, medical professionals, and anyone that wants to learn about CMT. CMT US CMT US shares resources, positive living strategies, practical suggestions, and new treatment paradigms for Charcot Marie Tooth Disease(CMT), also known as Hereditary Motor and Sensory Neuropathy.

2. Facts About Rare Muscular Dystrophies Facts about charcotmarie-tooth disease. http://www.mdausa.org/publications/fa-cmt.html

Facts About Charcot-Marie-Tooth Disease and Dejerine-Sottas Disease Charcot-Marie-Tooth Disease and Dejerine-Sottas Disease Dear Friends What Is Charcot-Marie-Tooth Disease? What Causes CMT? What Happens to Someone With CMT, and How Is It Treated? ... MDA Is Here to Help You George J. Donahue Dear Friends: I've lived with Charcot-Marie-Tooth disease This pamphlet has been prepared to give you the basic knowledge about CMT and Dejerine-Sottas disease that you'll need, in order to help you prepare for changes that may occur in your future. You'll learn that CMT is usually quite slow in progression and that, while it presents challenges in daily life, there are many techniques and devices to help you adapt to those challenges. You'll read that many different genetic causes of CMT have been found, and cases vary greatly. But CMT is almost never life-threatening, and it seldom affects the heart and breathing functions. Another important extended family in my life is the Muscular Dystrophy Association, which offers a great program of services, leads the world in CMT research and keeps us well informed about the disease. See " MDA Is Here to Help You ," for details of the Association's program.

3. Charcot-Marie-Tooth Disease - General Practice Notebook Clinicallyoriented information. http://www.gpnotebook.co.uk/MedwebPage.cfm?ID=-1241120765

4. Charcot-Marie-Tooth Disease (CMT) (aka HMSN Or Peroneal Muscular Atrophy (PMA)) charcotmarie-tooth disease (CMT)( Also known as Hereditary Motor and Sensory Neuropathy (HMSN) or Peroneal Muscular Atrophy (PMA)) Click for Materials En Español and MDAchats completed 03/02 charcot-marie-tooth disease and Deafness http://www.mdausa.org/disease/cmt.html

Charcot-Marie-Tooth Disease (CMT) (Also known as Hereditary Motor and Sensory Neuropathy (HMSN) or Peroneal Muscular Atrophy (PMA)) Click for and MDAchats Receive e-mail news, tips and updates from MDA or ask us a quick question. Quick Definition: Childhood to young adulthood. Weakness and atrophy of muscles of hands and lower legs, with foot deformities and some loss of sensation in feet. Slow but variable progression among individuals. Normal life span. Autosomal dominant, autosomal recessive, X-linked recessive, X-linked dominant. Find Your Local MDA Do you need to find MDA in your city? Enter your Zip code here for where to turn for clinics and medical services; support groups; summer camp; local events and volunteer and fund-raising opportunities close to home. For more articles and references, please use the search feature Basic References Special CMT Materials FAQ's and Simply Stated Articles ... News Releases Basic References Facts About Charcot-Marie-Tooth Disease "Ask the Experts" Responses about CMT "Ask the Experts" Responses to General Neuromuscular Questions Genetics and Neuromuscular Diseases ... General Interest Publications Special CMT Materials CMT and DS: From Clear-Cut Endings to Complex Beginnings North American Database of People with CMT being Established FAQ's and Simply Stated... Articles

5. NINDS Charcot-Marie-Tooth Disorder Information Page CharcotMarie-Tooth Disorder information page compiled by the National Institute of Neurological Disorders and Stroke (NINDS). charcot-marie-tooth disease Fact Sheet. charcot-marie-tooth disease http://www.ninds.nih.gov/health_and_medical/disorders/charcot_doc.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about Charcot-Marie-Tooth Disorder Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health NINDS Charcot-Marie-Tooth Disorder Information Page Reviewed 07-08-2002 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Charcot-Marie-Tooth Disorder? Is there any treatment? What is the prognosis? What research is being done? ... Additional resources from MEDLINEplus What is Charcot-Marie-Tooth Disorder? Is there any treatment? There is no cure or specific treatment for CMT. Proper foot care including custom-made shoes and leg braces may minimize discomfort and increase function. Physical therapy and moderate activity are often recommended to maintain muscle strength and endurance. For some patients, surgery may be beneficial. What is the prognosis?

6. Charcot-Marie-Tooth Disease - Learn More From MedlinePlus Find the latest news stories, overviews, research and more on charcotmarie-tooth disease from MedlinePlus, the National Library of Medicine's consumer health site. http://rdre1.inktomi.com/click?u=http://www.nlm.nih.gov/medlineplus/charcotmarie

7. MedlinePlus: Charcot-Marie-Tooth Disease Topics. charcotmarie-tooth disease. Printer Organizations. Search MEDLINE for recent research articles on • charcot-marie-tooth disease. You http://www.nlm.nih.gov/medlineplus/charcotmarietoothdisease.html

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Other health topics: A B C D ... List of All Topics Charcot-Marie-Tooth Disease Contents of this page: From the NIH General/Overviews Coping Diagnosis/Symptoms ... Organizations Search MEDLINE for recent research articles on Charcot-Marie-Tooth Disease You may also be interested in these MedlinePlus related pages: Degenerative Nerve Diseases Muscle Disorders Brain and Nervous System Genetics/Birth Defects From the National Institutes of Health Charcot-Marie-Tooth Disease (National Institute of Neurological Disorders and Stroke) Also available in: Spanish Charcot-Marie-Tooth Disorder (National Institute of Neurological Disorders and Stroke) - Short Summary General/Overviews Charcot-Marie-Tooth Disease (CMT) (Muscular Dystrophy Association) Also available in: Spanish Charcot-Marie-Tooth Disease (CMT): Questions and Answers (Muscular Dystrophy Association) Clinical Trials Clinical Trials: Identification of Gene Mutations in Families with Charcot-Marie-Tooth and Deafness (Muscular Dystrophy Association) Coping Bracing Experiences: Correct Braces Can Improve Mobility, Life

8. CMTA: Charcot-Marie-Tooth Association Organization aiming at supporting patient, public education and promotion of research on charcotmarie-tooth disease. http://www.charcot-marie-tooth.org/site/content/

Donate! Site Map Ask the Experts Publications ... Home On February 25, 2004, the CMTA Board of Directors held their quarterly meeting at the Longworth Building directly connected to the Nation's Capitol in Washington, DC. Steve O'Donnell Swims for the Cure Two New Grants Awarded Information on Student IEPs Together, we can educate, fund research, and promote public awareness of CMT, the most commonly inherited peripheral neuropathy. Enter Click here to Sign-Up Receive 6 issues of our newsletter and a discount on merchandise What if? ...up to 26% of each purchase you made went to a worthy cause close to home? Join the iGive.com community and it can. When you shop at GreaterGood.com up to 15% of every purchase automatically goes to Charcot-Marie-Tooth Association at no extra cost to you. CMTAssoc@aol.com Designed and Developed by embarc

9. MedlinePlus Medical Encyclopedia: Charcot-Marie-Tooth Disease (hereditary) charcotmarie-tooth disease (hereditary). charcot-marie-tooth disease causes destruction of the myelin sheath in some people. In http://www.nlm.nih.gov/medlineplus/ency/article/000727.htm

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Charcot-Marie-Tooth disease (hereditary) Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Central nervous system Alternative names Return to top Progressive neuropathic (peroneal) muscular atrophy; Hereditary peroneal nerve dysfunction; Neuropathy - peroneal (hereditary); Hereditary motor and sensory neuropathy Definition Return to top Charcot-Marie-Tooth disease defines a group of inherited, slowly progressive disorders that result from progressive damage to nerves. Symptoms include numbness and wasting of muscle tissue, first in the feet and legs, then in the hands and arms. Causes, incidence, and risk factors Return to top Charcot-Marie-Tooth diseases involve damage to nerves (neuropathy), usually from loss of the electrical insulation ( myelin ) around nerve fibers. All nerves are affected, but motor nerves (the nerves that stimulate movement) are most severely affected. The nerves in the legs are affected first and most severely. Symptoms usually begin between mid-childhood and early adulthood. The disorder is inherited, with

10. Charcot-Marie-Tooth Disease - Genetics Home Reference MarieTooth disease. What is charcot-marie-tooth disease? charcot-marie-tooth disease is a group of The different types of charcot-marie-tooth disease are distinguished by genetic http://ghr.nlm.nih.gov/ghr/disease/charcotmarietoothdisease

A service of the U.S. National Library of Medicine Home Search Conditions Genes ... Help Charcot-Marie-Tooth disease Related Gene(s) Quick links to this topic NIH Publications National Institutes of Health MedlinePlus Health Information Genes and Disease Genetic disorder summaries Educational resources Information pages Patient support For patients and families Gene Reviews Clinical summary Gene Tests DNA test labs PubMed Recent literature OMIM Genetic disorder catalog Charcot-Marie-Tooth disease What is Charcot-Marie-Tooth disease? Charcot-Marie-Tooth disease is a group of progressive disorders affecting peripheral nerves. These nerves connect the brain and spinal cord to muscles as well as sensory cells that detect touch, pain, and temperature. The different types of Charcot-Marie-Tooth disease are distinguished by genetic cause, pattern of inheritance, and nerve abnormality. Genetic factors cause the following types of Charcot-Marie-Tooth disease. Charcot-Marie-Tooth disease, type 1 Charcot-Marie-Tooth disease, type 2 Charcot-Marie-Tooth disease, type 4 Charcot-Marie-Tooth disease, type X The system for categorizing types of Charcot-Marie-Tooth disease is changing. Earlier systems were based largely on the pattern of inheritance and the particular abnormality that disrupts nerve function. With advances in molecular biology, new classification systems that focus on genetic causes are emerging. The genetic-based approach is gaining acceptance and is used here. Because there is not yet a universal system to classify types of Charcot-Marie-Tooth disease, the list of other names used for this disorder, found near the end of this summary, might be helpful.

11. Charcot-Marie-Tooth Disease - Neurologychannel CharcotMarie-Tooth (CMT) disease is an inherited, degenerative peripheral nerve disorder that causes muscle weakness and atrophy in the feet, legs, hands, and forearms.Charcot, Marie, and Tooth http://www.neurologychannel.com/charcot

Home Search SiteMap Ask the Dr. ... Medical Store advertisement CHARCOT-MARIE- TOOTH DISEASE Overview Cause Symptoms Diagnosis ... Find a Neurologist CONDITIONS ADHD ALS Alzheimer's Disease Autism ... Carpal Tunnel Syndrome Cephalic Disorders Cerebral Palsy Charcot-Marie-Tooth Disease Chronic Pain Dementia Encephalitis Epilepsy ... Guillain-Barre Syndrome Headache Huntington's Disease Hydrocephalus Lou Gehrig's Disease ... Traumatic Brain Injury Vertigo TREATMENT OPTIONS Botulinum Toxin Therapy Epidural Injection Trigger Point Injection Vagus Nerve Stimulation RESOURCES neurologychannelMD Clinical Trials Links MDLocator ... What Is a Neurologist? Videos ABOUT US Healthcommunities.com Pressroom Testimonials print this ... email this Overview Charcot-Marie-Tooth (CMT) disease is an inherited, degenerative peripheral nerve disorder that causes muscle weakness and atrophy in the feet, legs, hands, and forearms. It is characterized by progressive loss of use and sensation in the limbs. Charcot, Marie, and Tooth are the names of the physicians who identified the disease and described its symptoms. It is not the same as Charcot's foot disease , a neuropathic joint disease that is a common complication of diabetes mellitus.

12. Welcome To CMT United Kingdom Working to support those who are affected by charcotmarie-tooth disease, also known as Hereditary Motor and Sensory Neuropathy or Peroneal Muscular Atrophy. http://www.cmt.org.uk/

CMT United Kingdom Working to support those who are affected by Charcot-Marie-Tooth Disease, also known as Hereditary Motor and Sensory Neuropathy or Peroneal Muscular Atrophy. Registered Charity No. 327971 Welcome to the website of the support group for people who are affected by Charcot-Marie-Tooth Disease, also known as Hereditary Motor and Sensory Neuropathy or Peroneal Muscular Atrophy. Coping with any medical condition for life is a daunting prospect, but is far more difficult if you can find little information about it or support. This is a problem faced by many people with CMT. Learning to cope with it often means a long search for answers and help. Our website, whilst it will not provide all of the answers, aims to perhaps give you a fresh insight into the condition as well as positive advice about how to live with it. There is also details of the CMT Book which contains a lot more information on CMT. Why not become a member of CMT United Kingdom and enjoy the benefits we are able to offer - ranging from the CMT book 'Charcot-Marie-Tooth Disease - A Practical Guide' through to local support groups, and of course CMT United Kingdom are always there to provide informed personal guidance if you need it.

13. EMedicine - Charcot-Marie-Tooth Disease : Article By Divakara Kedlaya, MBBS charcotmarie-tooth disease. Last Updated March 3, 2004, Background charcot-marie-tooth disease (CMT) is the most common inherited neurologic disorder. http://www.emedicine.com/orthoped/topic43.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Orthopedic Surgery Foot And Ankle Charcot-Marie-Tooth Disease Last Updated: March 3, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: CMT, CMT 1, CMT 2, hereditary motor and sensory neuropathy, HMSN, peroneal muscular atrophy, PMA, peroneal progressive muscular atrophy, peroneal muscular atrophy with thickened nerves, Hoffman disease, Charcot-Marie-Tooth-Hoffman disease AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Divakara Kedlaya, MBBS , Associate Professor, Department of Physical Medicine and Rehabilitation, Loma Linda University Medical Center Divakara Kedlaya, MBBS, is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation American Association of Electrodiagnostic Medicine American Pain Society American Paraplegia Society , and Association of Academic Physiatrists Editor(s): James K DeOrio, MD

14. Charcot-Marie-Tooth Disease Fact Sheet charcotmarie-tooth disease fact sheet developed by CMTTexas.org What is charcot-marie-tooth disease? What are the symptoms of charcot-marie-tooth disease? What are the http://cmttexas.org/aboutcmt.html

About Charcot-Marie-Tooth Disease Facts What is Charcot-Marie-Tooth disease? What are the symptoms of Charcot-Marie-Tooth disease? What are the types of Charcot-Marie-Tooth disease? What causes Charcot-Marie-Tooth disease? ... What research is being done? What is Charcot-Marie-Tooth disease? Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States. The disease is named for the three physicians who first identified it in 1886 - Jean-Marie-Charcot and Pierre Marie in Paris, France, and Howard Henry Tooth in Cambridge, England. CMT, also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy, comprises a group of disorders that affect peripheral nerves. The peripheral nerves lie outside the brain and spinal cord and supply the muscles and sensory organs in the limbs. Disorders that affect the peripheral nerves are called peripheral neuropathies. Back to top What are the symptoms of Charcot-Marie-Tooth disease? The neuropathy of CMT affects both motor and sensory nerves. A typical feature includes weakness of the foot and lower leg muscles, which may result in foot drop and a high-stepped gait with frequent tripping or falls. Foot deformities, such as high arches and hammertoes (a condition in which the middle joint of a toe bends upwards) are also characteristic due to weakness of the small muscles in the feet. In addition, the lower legs may take on an "inverted champagne bottle" appearance due to the loss of muscle bulk. Later in the disease, weakness and muscle atrophy may occur in the hands, resulting in difficulty with fine motor skills. Although sensory nerves are also involved, patients rarely notice significant numbness or pain.

15. EMedicine - Hereditary Neuropathies Of The Charcot-Marie-Tooth Disease Type : Ar Hereditary Neuropathies of the charcotmarie-tooth disease Type. EGR2 is a transcription factor linked to charcot-marie-tooth disease type 1D (CMT1D). http://www.emedicine.com/neuro/topic718.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Neurology Neuromuscular Diseases Hereditary Neuropathies of the Charcot-Marie-Tooth Disease Type Last Updated: September 9, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: hereditary sensorimotor neuropathy, HSMN, peroneal muscular atrophy, Dejerine-Sottas disease, Dejerine-Sottas syndrome, DSS, congenital hypomyelination neuropathy, CHN, hereditary neuropathy with liability to pressure palsy, hereditary neuropathy with predisposition to pressure palsies, HNPP, neuritis with brachial predilection, inherited brachial plexus neuropathy, IBPN, hereditary neuralgic amyotrophy, HNA, Charcot-Marie-Tooth peripheral neuropathies, CMT AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Francisco de Assis Aquino Gondim, MD, MSc, PhD

16. Charcot-Marie-Tooth Disease - Podiatrychannel Incidence and Prevalence Approximately 125,000 people in the United States have charcotmarie-tooth disease. CMT occurs slightly http://www.podiatrychannel.com/charcot/

Home Search SiteMap Ask the Dr. ... Medical Store advertisement CHARCOT-MARIE- TOOTH DISEASE Overview Cause Symptoms Diagnosis ... Treatment CONDITIONS Achilles Tendinitis Allergic Contact Dermatitis Ankle Injuries Athlete's Foot Brachymetatarsia Bunions ... Charcot-Marie-Tooth Disease Claw Toes Complex regional pain syndrome (CRPS) Corns Diabetes Fibromyalgia Gout ... Tarsal Tunnel Syndrome Toe Deformities Xerosis TREATMENT OPTIONS Orthotics RESOURCES Anatomy Clinical Trials Health Quiz Links ... What Is a Podiatrist? Videos ABOUT US Healthcommunities.com Pressroom Testimonials Overview Charcot-Marie-Tooth (CMT) disease is an inherited, degenerative peripheral nerve disorder that causes muscle weakness and atrophy in the feet, legs, hands, and forearms. It is characterized by progressive loss of use and sensation in the limbs. Charcot, Marie, and Tooth are the names of the physicians who identified the disease and described its symptoms. It is not the same as Charcot's foot disease , a neuropathic joint disease that is a common complication of diabetes mellitus. In CMT, the

17. Charcot-Marie-Tooth Disease - Podiatrychannel Signs and Symptoms Symptoms vary from mild to severe, from patient to patient, and even among family members with the disease. Symptoms http://www.podiatrychannel.com/charcot/symptoms.shtml

Home Search SiteMap Ask the Dr. ... Medical Store advertisement CHARCOT-MARIE- TOOTH DISEASE Overview Cause Symptoms Diagnosis ... Treatment CONDITIONS Achilles Tendinitis Allergic Contact Dermatitis Ankle Injuries Athlete's Foot Brachymetatarsia Bunions ... Charcot-Marie-Tooth Disease Claw Toes Complex regional pain syndrome (CRPS) Corns Diabetes Fibromyalgia Gout ... Tarsal Tunnel Syndrome Toe Deformities Xerosis TREATMENT OPTIONS Orthotics RESOURCES Anatomy Clinical Trials Health Quiz Links ... What Is a Podiatrist? Videos ABOUT US Healthcommunities.com Pressroom Testimonials Signs and Symptoms Symptoms vary from mild to severe, from patient to patient, and even among family members with the disease. Symptoms are more severe in cases of early age of onset. The first indications of CMT are mild, usually foot and ankle weakness, and fatigue. If the toes have started to curl into "claw toes," wearing shoes may become painful. Weakness in the hands also may be present. Another sign of CMT is a highly arched foot (cavus arch). When the muscles of the foot weaken, an imbalance develops that typically raises the arch of the foot. This increases tension in the muscles on the bottom of the foot and worsens the curling of the toes. A change in gait is another common sign. When atrophy progresses, the muscle in the front of the leg usually is the first affected. This produces two distinct characteristics in gait:

18. CHARCOT MARIE TOOTH FACT SHEET. CHARCOT MARIE - TOOTH DISEASE. What is Chacot-Marie-Tooth disease? How does a person get charcot-marie-tooth disease? http://www.mda.org.au/specific/mdacmt.html

FACT SHEET CHARCOT - MARIE - TOOTH DISEASE What is Chacot-Marie-Tooth disease? Charcot-Marie-Tooth disease is a hereditary disorder marked by slowly progressive muscle weakness in the feet, lower legs, hands and forearms, and a mild loss of sensation in limbs, fingers, and toes. The weakness results from the degeneration of nerves that stimulate muscle rather than from a degenerative process in the muscle tissue itself. The disorder, named for three physicians who first identified it in 1886, is also known as peroneal muscular atrophy because if primarily affects the peroneal muscles. which are located in the lower leg. There are now thought to be at least two types of the disease - hypertrophic and neuronal - that differ to some degree in severity. How disabling is the disease? In both types of Charcot-Marie-Tooth disease, there is normal life expectancy, limited disability, and very slow progression of the disease. Some patients, however, experience rapid progression and severe disability. What are the early symptoms?

19. Hospital Practice: Charcot-Marie-Tooth Disease charcotmarie-tooth disease A Gene-Dosage Effect Lupski JR et al DNA duplication associated with charcot-marie-tooth disease type 1A. Cell 66219, 1991. http://www.hosppract.com/genetics/9705gen.htm

Molecular Genetics in Clinical Practice Charcot-Marie-Tooth Disease: A Gene-Dosage Effect JAMES R. LUPSKI Baylor College of Medicine A broad spectrum of inherited neuropathy has been traced to three myelin genes, yet in the two most common disorders, there is no mutated gene. Instead, a gene has an extra or missing copy, as part of a 1.5-megabase DNA duplication or deletion. Eventually, duplications may emerge as a large fraction of all mutations. The discoveries have implications even for acquired disordersincluding carpal tunnel syndrome. Dr. Lupski is Cullen Professor of Molecular and Human Genetics, Professor of Pediatrics, and Director, Medical Scientist Training Program, Baylor College of Medicine, Houston. In 1886, the French physicians Jean Martin Charcot and Pierre Marie, and independently the English physician Howard Henry Tooth, described an insidious, slowly progressive atrophy of distal limb muscles that would eventually be recognized as the most common inherited disorder of the peripheral nervous system. It is also among the most common of all genetic disorders, affecting one person in 2,500. Characteristically, the illness becomes evident during the first two decades of life. Often, patients are liable to trip and sprain their ankles, and footdrop forces them to lift the knee, resulting in an equine gait. Eventually, pes cavus appears, and distal muscle atrophy may cause a stork-leg appearance. Weakness of hand muscles usually begins later; in severe cases, claw-like deformity develops.

20. HealthlinkUSA Charcot-marie-tooth Disease Links Find charcotmarie-tooth disease at searchwaves.com. Click here for page 1 of charcot-marie-tooth disease information from the HealthlinkUSA directory. http://www.healthlinkusa.com/67ent.htm

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