1. NINDS Soto's Syndrome Information Page Also known as cerebral gigantism, an information sheet compiled by NINDS. http://www.ninds.nih.gov/health_and_medical/disorders/sotos.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about Soto's Syndrome Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health NINDS Soto's Syndrome Information Page Synonym(s): Cerebral Gigantism Reviewed 07-01-2001 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Soto's Syndrome? Is there any treatment? What is the prognosis? What research is being done? ... Organizations What is Soto's Syndrome? Soto's syndrome is a rare genetic disorder characterized by excessive physical growth during the first 2 to 3 years of life. The disorder may be accompanied by mild mental retardation, delayed motor, cognitive, and social development, hypotonia (low muscle tone), and speech impairments. Children with Soto's syndrome tend to be large at birth and are often taller, heavier, and have larger heads (macrocrania) than is normal for their age. Symptoms of the disorder, which vary among individuals, include a disportionately large and long head with a slightly protrusive forehead, large hands and feet, hypertelorism (an abnormally increased distance between the eyes), and downslanting eyes. Clumsiness, an awkward gait, and unusual aggressiveness or irritability may also occur. Although most cases of Soto's syndrome occur sporadically, familial cases have also been reported.

2. Sotos' Syndrome (www.whonamedit.com) Sotos' syndrome A syndrome of excessive growth during the first 4 to 5 years of life, cerebral gigantism, acromegalic features, and mild mental retardation and defective coordination. Also known http://www.whonamedit.com/synd.cfm/2464.html

Home List categories Eponyms A-Z Biographies by country ... Contact Whonamedit.com does not give medical advice. This survey of medical eponyms and the persons behind them is meant as a general interest site only. No information found here must under any circumstances be used for medical purposes, diagnostically, therapeutically or otherwise. If you, or anybody close to you, is affected, or believe to be affected, by any condition mentioned here: see a doctor. Sotos' syndrome Also known as: Nevo's syndrome Sotos' sequence Synonyms: Cerebral gigantism, cerebral gigantism in childhood, constitutional gigantism, gigantismus cerebralis, gigantismus constitutionalis, gigantismus idiopathicus, hypothalamic gigantism, macrostomia-mental retardation syndrome, mental retardation-overgrowth sequence, pituitary gigantism, prenatal gigantism with macrocephaly. Associated persons: S. Nevo Juan Fernandez Sotos Description: A syndrome of excessive growth during the first 4 to 5 years of life, with cerebral gigantism and generalised large muscles in childhood, acromegalic features, and a nonprogressive cerebral disorder with nonprogressive mild mental retardation and defective coordination. After early childhood growth seems to approach normal, remaining, however, two standard deviations above means for chronological age. Birth weight and length greater than normal. Other principal features are dolicocephaly, macrocrania, hypertelorism, antimongoloid palpebral slant, high-arched palate, frontal bossing, mandibular prognathism, and precocious dentition. Occasionally, obesity, convulsions, abnormal dermatoglyphic pattern. Both sexes. Most cases are sporadic but some are transmitted as an autosomal dominant trait.

3. Neuroguide.com - Human Neurological Diseases Cerebral Palsy. Cerebral Palsy Information and Resource Links Cephalic Disorders. Cerebral Aneurysm. Cerebral Arteriosclerosis. Cerebral Atrophy. cerebral gigantism. Cerebral Palsy http://www.neuroguide.com/cgi-bin/pdistoc.pl?file=cerebral_palsy

4. Healthfinder® - Cerebral Gigantism Carefully selected government and nonprofit health information on cerebral gigantism. healthfinder® home page, healthfinder® — your http://www.healthfinder.gov/Scripts/SearchContext.asp?topic=146

5. Healthfinder® - Cerebral Gigantism Carefully selected government and nonprofit health information on cerebral gigantism. home health library all topics C cerebral gigantism. http://www.healthfinder.gov/Scripts/SearchContext.asp?topic=146&refine=1

6. Cerebral Gigantism cerebral gigantism Page, Growth Index. http://www.fpnotebook.com/END48.htm

Home About Links Index ... Editor's Choice document.write(code); Advertisement Endocrinology Growth Assorted Pages Delayed Growth Calculation of Growth Delay Growth Delay Onset Determination Achondroplasia ... Risser Sign Cerebral Gigantism Soto Syndrome Book Home Page Cardiovascular Medicine Dentistry Dermatology Emergency Medicine Endocrinology Gastroenterology General Medicine Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Endocrinology Index Adrenal Disease General Dermatology Diabetes Mellitus Examination Ophthalmology Geriatric Medicine Growth Hematology and Oncology Hypoglycemia Laboratory Metabolism Neonatology Obesity Obstetrics Parathyroid Disease Pediatrics Pharmacology Pituitary Disease Prevention Radiology Nephrology Sex Sports Medicine Surgery Symptom Evaluation Thyroid Disease Page Growth Index Short Short Calculation Short Onset Short Achondroplasia Short Constitutional Short Familial Tall Tall Cerebral Gigantism Signs Tall Stature Prominent forehead Hypertelorism High arched palate Large irregular head Antimongoloid slant of palpebral fissures Mental retardation Advanced bone age Labs See Tall Stature Lab results are normal in this condition Search other websites for this topic Search National Library of Medicine PubMed for related articles Search Google for related images or topics Advertisement Please see the

7. Gigantism gigantism ( The Mosby Medical Encyclopedia)gigantism gigantism ( AAP General News (Australia))cerebral gigantism ( The Mosby Medical Encyclopedia)exophthalmosmacroglossia- gigantism http://www.infoplease.com/ce6/sci/A0820796.html

HOTWORDS CITE PRINT EMAIL in All Infoplease Almanacs Biographies Dictionary Encyclopedia Home Almanacs Atlas Dictionary ... D-Day Infoplease Tools Periodic Table Conversion Tool Perpetual Calendar Year by Year ... Site Map Also from Infoplease Search Infoplease Info search tips Search Biographies Bio search tips Encyclopedia gigantism gigantism, acromegaly results. Giants appear in the legends and folklore of many cultures. The Columbia Electronic Encyclopedia, Gifu Gigli, Beniamino Related content from HighBeam Research on: gigantism gigantism (The Mosby Medical Encyclopedia) NSW: New discovery could lead to cure for dwarfism, gigantism (AAP General News (Australia)) ENVIRONMENT: NEW BUTTER FACES FEARS OF CANCER, GIGANTISM (Inter Press Service English News Wire) COMPARED TO ATLANTA, AUSSIES HAVE ADVANTAGE IN SECURITY ORGANIZERS OF 2000 OLYMPICS TRY TO AVOID TRAFFIC CONGESTION, GIGANTISM, COMMERICALISM OF `ENORMOUS' 1996 GAMES (Denver Rocky Mountain News) gigantism (The Hutchinson Dictionary of Science) cerebral gigantism (The Mosby Medical Encyclopedia) exophthalmos-macroglossia-gigantism syndrome (The Mosby Medical Encyclopedia) GRASS ROOTS FIGHT MEDIA GIGANTISM.(Editorial)(Column)

8. SOTOS SYNDROME (CEREBRAL GIGANTISM) Features Listed For SOTOS SYNDROME (cerebral gigantism). McKusick 117550. Advanced bone age/large epiphyses; Advanced tooth eruption http://www.hgmp.mrc.ac.uk/dhmhd-bin/hum-look-up?1613

9. Gigantism gigantism ( The Mosby Medical Encyclopedia)gigantism gigantism ( AAP General News (Australia))cerebral gigantism ( The Mosby Medical Encyclopedia)exophthalmosmacroglossia- gigantism http://www.infoplease.com/ce5/CE020807.html

HOTWORDS CITE PRINT EMAIL in All Infoplease Almanacs Biographies Dictionary Encyclopedia Home Almanacs Atlas Dictionary ... D-Day Infoplease Tools Periodic Table Conversion Tool Perpetual Calendar Year by Year ... Site Map Also from Infoplease Search Infoplease Info search tips Search Biographies Bio search tips Encyclopedia gigantism gigantism, acromegaly results. Giants appear in the legends and folklore of many cultures. The Columbia Electronic Encyclopedia, Gifu Gigli, Beniamino Related content from HighBeam Research on: gigantism gigantism (The Mosby Medical Encyclopedia) NSW: New discovery could lead to cure for dwarfism, gigantism (AAP General News (Australia)) ENVIRONMENT: NEW BUTTER FACES FEARS OF CANCER, GIGANTISM (Inter Press Service English News Wire) COMPARED TO ATLANTA, AUSSIES HAVE ADVANTAGE IN SECURITY ORGANIZERS OF 2000 OLYMPICS TRY TO AVOID TRAFFIC CONGESTION, GIGANTISM, COMMERICALISM OF `ENORMOUS' 1996 GAMES (Denver Rocky Mountain News) gigantism (The Hutchinson Dictionary of Science) cerebral gigantism (The Mosby Medical Encyclopedia) exophthalmos-macroglossia-gigantism syndrome (The Mosby Medical Encyclopedia) GRASS ROOTS FIGHT MEDIA GIGANTISM.(Editorial)(Column)

10. NINDS - Neurological Disorder Information Degeneration Cerebellar Hypoplasia Cerebral Aneurysm Cerebral Arteriosclerosis Cerebral Atrophy Cerebral Beriberi cerebral gigantism Cerebral Hypoxia Cerebral http://www.ninds.nih.gov/health_and_medical/disorder_index.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about a disorder Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health Browse All Disorders (includes synonyms and research topics) Request mailed brochures Publicaciones en español Select a letter to jump to the disorder... or return to top of page A B C D ... Z A ADHD AIDS - Neurological Complications Absence of the Septum Pellucidum Acquired Epileptiform Aphasia ... Autonomic Dysfunction Select a letter to jump to the disorder... or return to top of page A B C D ... Z B Back Pain Barth Syndrome Batten Disease Behcet's Disease ... Bulbospinal Muscular Atrophy Select a letter to jump to the disorder... or return to top of page A B C D ... Z C Canavan Disease Carpal Tunnel Syndrome Causalgia Cavernomas ... Cytomegalovirus Infection Select a letter to jump to the disorder... or return to top of page A B C D ... Z D Dancing Eyes-Dancing Feet Syndrome Dandy-Walker Syndrome Dawson Disease De Morsier's Syndrome ... Dystonias Select a letter to jump to the disorder... or return to

11. Healthfinder® — Cerebral Palsy Among Children This online brochure presents a synopsis of CPrelated surveillance and research activities. The brochure provides statistics on incidence and prevalence and discusses secondary conditions and help about healthfinder®. Cerebral Palsy Among Children Birth Defect. cerebral gigantism. Cerebral Palsy. Neuromuscular Diseases http://www.healthfinder.gov/docs/doc04850.htm

health library just for you health care organizations search: help Cerebral Palsy Among Children internet URL http://www.cdc.gov/ncbddd/factsheets/cp.pdf sponsoring agency National Center on Birth Defects and Developmental Disabilities description This online brochure presents a synopsis of CP-related surveillance and research activities. The brochure provides statistics on incidence and prevalence and discusses secondary conditions and resource materials. related topics Birth Defect Cerebral Gigantism Cerebral Palsy Neuromuscular Diseases Research Surveillance and Data Systems review date accessibility freedom of information act privacy contact us ... U.S. Department of Health and Human Services

12. Cerebral Gigantism - General Practice Notebook cerebral gigantism. Sotos syndrome presents in childhood with developmental delay, high forehead, large hands and feet and tall for age. http://www.gpnotebook.co.uk/cache/349175833.htm

cerebral gigantism Sotos' syndrome presents in childhood with developmental delay, high forehead, large hands and feet and tall for age. Click here for more information...

13. Cerebral Gigantism - General Practice Notebook cerebral gigantism. Medical search. Sotos syndrome presents in childhood with developmental delay, high forehead, large hands and feet and tall for age. http://www.gpnotebook.co.uk/medwebpage.cfm?ID=349175833

14. EMedicine - Gigantism And Acromegaly : Article By Melanie Shim, MD Other Problems to be Considered Familial tall stature Exogenous obesity cerebral gigantism (Sotos syndrome) Weaver syndrome. http://www.emedicine.com/ped/topic2634.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Pediatrics Endocrinology Gigantism and Acromegaly Last Updated: March 18, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: growth hormone excess, GH excess, giantism, gigantosoma, giant, hypersomia, somatomegaly, acromegalia, endocrine system, pituitary gland, abnormal growth AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Melanie Shim, MD , Clinical Instructor, Department of Pediatrics, Division of Pediatric Endocrinology, Mattel Children's Hospital and University of California at Los Angeles Coauthor(s): Pinchas Cohen, MD , Director of Research and Training, Professor, Department of Pediatrics, Division of Endocrinology, Mattel Children's Hospital, University of California at Los Angeles Melanie Shim, MD, is a member of the following medical societies: American Diabetes Association , and Endocrine Society Editor(s): Phyllis Speiser, MD

15. Endotext.com - Pediatric Endocrinology, Gigantism Contributors. Search. Gigantism refers to a condition characterized by extreme physical size and stature. By definition, this originates during infancy, childhood or adolescence, while epiphyseal growth plates remain open. Sotos syndrome, also known as cerebral gigantism, was first described in 196493 http://www.endotext.com/pediatrics/pediatrics1b/pediatrics1b.htm

GIGANTISM Chapter 1B - Erica A. Eugster and Ora H. Pescovitz May 19, 2004 Index Contributors Search I. INTRODUCTION Gigantism refers to a condition characterized by extreme physical size and stature. By definition, this originates during infancy, childhood or adolescence, while epiphyseal growth plates remain open. Although often used to specifically denote growth hormone excess, the term gigantism is also applied to a number of non-hormonally mediated overgrowth conditions in children. All forms of gigantism are extremely rare, and have in common a complex pathophysiologic origin and extraordinary clinical manifestations. Although many aspects of overgrowth disorders remain to be elucidated, insights into the molecular genetic basis of several forms of gigantism have contributed greatly to our understanding of specific mediators of growth and cellular function. Both growth hormone hypersecretion and overgrowth syndromes will be reviewed in this chapter. II. GROWTH HORMONE EXCESS . The major difference between these two conditions is that gigantism results from excessive GH production during the period of active growth, and acromegaly results from GH excess ensuing after epiphyseal fusion has occurred. A further distinction relates to the overall incidence of these disorders. While acromegaly is uncommon, occurring at an estimated worldwide annual rate of 2.8-4 cases per million

16. Sotos Syndrome,Cerebral Gigantism,Sotos Syndrome,Cerebral Gigantism,Sotos Syndro Sotos Syndrome,cerebral gigantism,Sotos Syndrome,cerebral gigantism,Sotos Syndrome,cerebral gigantism. Sotos Syndrome also known as cerebral gigantism http://www.icomm.ca/geneinfo/sotos.htm

Sotos Syndrome,Cerebral Gigantism,Sotos Syndrome,Cerebral Gigantism,Sotos Syndrome,Cerebral Gigantism For Information on Workshops and Seminars for Special Needs Children click here The GAPS INDEX to Information on the Internet about Genetic Disorders and Birth Defects Genetic Information and Patient Services, Inc. (GAPS) HOME DISORDERS GLOSSARY Sotos Syndrome also known as: Cerebral Gigantism (as defined by the National Organization for Rare Disorders Sotos Syndrome is a rare genetic disorder characterized by excessive growth that occurs prior to and after birth (prenatally and postnatally). At birth, affected infants have unusually increased body length that is abnormal in proportion to weight, which may also be above average; in addition, newborns typically demonstrate advanced bone growth, abnormally large hands and/or feet, and characteristic facial features. Abnormally rapid growth continues after birth until approximately four or five years of age, at which time growth may slow to a normal rate. Adult height usually exceeds the 50th percentile. Some affected individuals may reach excessive adult heights; males of 193 cm to 203 cm (6 feet 4 inches to 6 feet 8 inches) and females up to 188 cm (6 feet 2 inches) have been described.

17. Soto's Syndrome - Information / Diagnosis / Treatment / Prevention the prognosis. ? Soto s Syndrome Also known as cerebral gigantism, an information sheet compiled by NINDS. ? Sotos Syndrome http://www.healthcyclopedia.com/genetic-disorders/soto's-syndrome.html

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... genetic disorders > soto's syndrome Soto's Syndrome Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Health News Web Directory: Health News: Search millions of published articles for news on Soto's Syndrome Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: About com Guide Laura L. Jelliffe, Ph.D. Symptoms, diagnosis, and treatment of Soto's syndrome. Information on research, community outreach and support. MCW Healthlink An article about soto's syndrome with an explanation of what it is, the features, symptoms and the prognosis. Soto's Syndrome Also known as cerebral gigantism, an information sheet compiled by NINDS. Sotos Syndrome Support Association Online community for education of professionals and families and to exchange ideas, gather research, and help one another cope. Quarterly newsletters, reference library, annual meetings, and conferences are available to members and professionals.

18. Sotos Syndrome subdivision(s) covered by this report. Synonyms cerebral gigantism. Disorder Subdivisions None. General Discussion Sotos Syndrome is a rare http://my.webmd.com/hw/health_guide_atoz/nord271.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Quizzes, Calculators Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report Sotos Syndrome Important It is possible that the main title of the report Sotos Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Cerebral Gigantism Disorder Subdivisions None General Discussion Resources March of Dimes Birth Defects Foundation 1275 Mamaroneck Avenue White Plains, NY 10605 Tel: (914)428-7100 Fax: (914)997-4763 Tel: (888)663-4637 TDD: (914)997-4764 Email: Askus@marchofdimes.com Internet: http://www.marchofdimes.com The Arc (a national organization on mental retardation) 1010 Wayne Ave Suite 650 Silver Spring, MD 20910

19. Index Disorder IV Familial Cerebellopontine Angle Tumor Cerebelloretinal Hemangioblastomatosis Cerebral Arachnoiditis cerebral gigantism Cerebral Malformations http://my.webmd.com/hw/index/index-topics-C.asp

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20. Database Search Results Department of Health and Human Services.. Searched keywords for cerebral gigantism. Sotos Syndrome Support Association. NHIC Home Page http://www.health.gov/nhic/NHICScripts/Hitlist.cfm?Keyword=Cerebral Gigantism

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