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  1. Thiamine Deficiency and Associated Clinical Disorders (Contemporary Clinical Neuroscience) by David W. McCandless, 2009-09-15

61. Arquivos De Neuro-Psiquiatria -
Translate this page ABSTRACT - central pontine myelinolysis (CPM) and extra-pontine myelinolysis (EPM) are different presentations of a demyelinating disorder of the brain more
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2002000600028&l

62. Central Pontine Myelinolysis A Complication Of Hyponatremia Or Of Therapeutic In
Pages 444451 Author(s) Haibach H, Ansbacher LE, Dix JD Title central pontine myelinolysis A Complication of Hyponatremia or of Therapeutic Intervention?
http://journalsip.astm.org/jofs/PAGES/837.htm
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Haibach H, Ansbacher LE, Dix JD
Title: Central Pontine Myelinolysis A Complication of Hyponatremia or of Therapeutic Intervention?
Keywords: alcoholism, central pontine myelinolysis, forensic science, hypernatremia, hyponatremia, hypothermia, malnutrition, pathology and biology, saline infusion
Abstract: We report four cases of central pontine myelinolysis (CPM) that illustrate important features of the disorder. The condition is described mainly in the neurological literature and, to our knowledge, is not discussed in the forensic science journals. This disorder must be recognized and understood by the forensic science expert who addresses issues of liability. In cases of multiple motor deficits and death with a history of hyponatremia, CPM must be included in the differential diagnosis. Careful examination of the pons and adjoining structures must be performed. Myelin stains are advisable. The association of CPM with major illnesses, hyponatremia and the correction of hyponatremia by intravenous saline infusions is discussed. Return to Search Page

63. ► Central Pontine Myelinolysis
Home Medical Reference Encyclopedia (English) Toggle English / Spanish central pontine myelinolysis.
http://www.umm.edu/ency/article/000775sym.htm
Disease Nutrition Surgery Symptoms Injury ... Encyclopedia (English)
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Central pontine myelinolysis
Overview Symptoms Treatment Prevention Alternative Names: CPM
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64. Resource Library Find Information On Central Pontine Myelinolysis
Find information on central pontine myelinolysis at MerckSource. Learn more central pontine myelinolysis. Definition Central pontine
http://www.mercksource.com/pp/us/cns/cns_hc_women_content_adam.jspzQzpgzEzzSzppd

65. Central Pontine Myelinolysis : An Iatrogenic Sequelae Of Hyponatraemia Managemen
central pontine myelinolysis an iatrogenic sequelae of hyponatraemia management ? The Indian Practitioner. 1997 Jan; 50(1) 617.
http://medind.nic.in/imvw/imvw10815.html
Extracted from IndMED Joshi SR; Deshpande AK; Shah SC. Central pontine myelinolysis : an iatrogenic sequelae of hyponatraemia management ? The Indian Practitioner. 1997 Jan; 50(1): 61-7 ABSTRACT: A 45 year old male alcoholic in an unconscious state with abnormal posture had hyperreflexia with extensor plantars. His hyponatraemia was corrected, yet he deteriorated and died. C T showed pontine and extrapontine myelinolysis which was confirmed on autopsy. This highlights the need for careful management of severe hyponatraemia and the role of gradual correction for the same. (The Ind. Pract. 1997; 50(1): 61-67). KEYWORDS: Myelinolysis, Central Pontine/DI; Hyponatremia/DT; Adrenal Cortex Hormones/DE; Data Interpretation, Statistical; Human; Male; Middle Age; Case Report References: 19 Record Identifier: NI203551

66. Central Pontine Myelinolysis In Chronic Renal Failure : A Case Report.
400026. central pontine myelinolysis in chronic renal failure a case report. Indian Journal of Nephrology. 1992 JanMar; 2(1) 19-20.
http://medind.nic.in/imvw/imvw17595.html
Extracted from IndMED Bhowmik DM; Dandi BG; Kale SA; Wadia NH; Bulchand S Laslok Hospital and Research Centre, 15, Dr. G Deshmukh Marg, Bombay 400026 Central pontine myelinolysis in chronic renal failure : a case report. Indian Journal of Nephrology. 1992 Jan-Mar; 2(1): 19-20 ABSTRACT: We report a patient with renal failure, altered sensorium, bilateral cerebellar ataxia and pathological laughter. MRI showed demyelination of the pons and midbrain. He showed a complete recovery from the neurological deficit and successful renal transplantation was later carried out. KEYWORDS: Myelinolysis, Central Pontine/ET; Myelinolysis, Central Pontine/PA; Kidney Failure, Chronic/CO; Case REport; Human; Male; Adolescence References: 5 Record Identifier: NI002453

67. Disease - Central Pontine Myelinolysis - Detroit, Michigan
Disease central pontine myelinolysis - courtesy of Henry Ford Health System of Detroit, Michigan. Disease - central pontine myelinolysis.
http://www.henryfordhealth.org/15368.cfm
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Disease - Central pontine myelinolysis
Central nervous system Definition: Central pontine myelinolysis is a condition characterized by nerve damage caused by the destruction of the covering layer ( myelin sheath) of nerve cells in the brainstem (pons). Alternative Names: CPM Causes And Risk: The destruction of the myelin sheath that coats nerves inhibits impulse conduction within the cell and thus decreases its ability to communicate with other cells. The most common cause of central pontine myelinolysis is a rapid, drastic change in sodium levels in the body. Most commonly, this occurs when someone is being treated for low levels of sodium ( hyponatremia ) and the levels rise too fast, but it can occasionally occur when high levels of sodium in the body (hypernatremia) are corrected too quickly. This condition does not occur spontaneously; it is a complication of either treatment for other conditions or the other conditions themselves. Risks include hyponatremia from any cause.

68. PharmGKB: Myelinolysis, Central Pontine
Alternate Names Central Pontine Myelinoclasis; central pontine myelinolysis; Extrapontine Myelinoclases; Extrapontine Myelinoclasis; Extrapontine Myelinolyses
http://www.pharmgkb.org/do/serve?objId=PA446520&objCls=Disease

69. Health Encyclopedia
central pontine myelinolysis is a condition characterized by nerve damage caused by the destruction of the covering layer ( myelin sheath) of nerve cells in
http://healthcontent.baptistnortheast.com/adamcontent/ency/article/000775.asp
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Central pontine myelinolysis
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Alternate Names
CPM
Definition
Central pontine myelinolysis is a condition characterized by nerve damage caused by the destruction of the covering layer ( myelin sheath) of nerve cells in the brainstem (pons).
Causes and Risk
The destruction of the myelin sheath that coats nerves inhibits impulse conduction within the cell and thus decreases its ability to communicate with other cells. The most common cause of central pontine myelinolysis is a rapid, drastic change in sodium levels in the body. Most commonly, this occurs when someone is being treated for low levels of sodium ( hyponatremia ) and the levels rise too fast, but it can occasionally occur when high levels of sodium in the body (hypernatremia) are corrected too quickly. This condition does not occur spontaneously; it is a complication of either treatment for other conditions or the other conditions themselves.

70. Disease - Central Pontine Myelinolysis, North Carolina
Disease central pontine myelinolysis, Online Medical Encyclopedia courtesy of University Health Systems of Eastern Carolina serving 29 counties in eastern
http://www.uhseast.com/17636.cfm

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Disease - Central pontine myelinolysis
Central nervous system Definition: Central pontine myelinolysis is a condition characterized by nerve damage caused by the destruction of the covering layer ( myelin sheath) of nerve cells in the brainstem (pons). Alternative Names: CPM Causes And Risk: The destruction of the myelin sheath that coats nerves inhibits impulse conduction within the cell and thus decreases its ability to communicate with other cells. The most common cause of central pontine myelinolysis is a rapid, drastic change in sodium levels in the body. Most commonly, this occurs when someone is being treated for low levels of sodium ( hyponatremia ) and the levels rise too fast, but it can occasionally occur when high levels of sodium in the body (hypernatremia) are corrected too quickly. This condition does not occur spontaneously; it is a complication of either treatment for other conditions or the other conditions themselves. Risks include hyponatremia from any cause.

71. P991029c - Hyponatremia - Central Pontine Myelinosis
Initially named central pontine myelinolysis, this disease is now known to also affect extrapontine brain areas. Manifestations
http://www.emory.edu/WHSCL/grady/amreport/litsrch99/p991029c.html
Hyponatremia - Central Pontine Myelinosis 10/29/99 (Walker) Question: What are the best ways to avoid central pontine myelinosis as a consequence of therapy for hyponatremia? Link Directly to Fulltext article in Ovid Unique Identifier: 97127952 Authors: Laureno R. Karp BI. Institution: Washington Hospital Center, Washington, D.C., USA. Title: Myelinolysis after correction of hyponatremia [see comments]. [Review] [49 refs] Source: Annals of Internal Medicine. 126(1):57-62, 1997 Jan 1. Fulltext Available in EBSCO using HEALTH SOURCE PLUS and the search term: Hyponatremia: focus on therapy Unique Identifier: 95064213 Authors: Oster JR. Singer I. Institution: Department of Veterans Affairs Medical Center, Miami, Fla. Title: Hyponatremia: focus on therapy [see comments] [published erratum appears in South Med J 1995 Sep;88(9):927]. [Review] [51 refs] Source: Southern Medical Journal. 87(12):1195-202, 1994 Dec. Morning Report Emory University School of Medicine 1999 Edition Participating Faculty: Daniel Stephens MD / Donald Brady MD dbrady@emory.edu

72. Central Pontine Myelinolysis
central pontine myelinolysis. Definition The most common cause of central pontine myelinolysis is a rapid, drastic change in sodium levels in the body.
http://www.shands.org/health/information/article/000775.htm
Disease Injury Nutrition Poison ... Central nervous system
Central pontine myelinolysis
Definition: Central pontine myelinolysis is a condition characterized by nerve damage caused by the destruction of the covering layer ( myelin sheath) of nerve cells in the brainstem (pons).
Alternative Names: CPM
Causes, incidence, and risk factors: The destruction of the myelin sheath that coats nerves inhibits impulse conduction within the cell and thus decreases its ability to communicate with other cells. The most common cause of central pontine myelinolysis is a rapid, drastic change in sodium levels in the body. Most commonly, this occurs when someone is being treated for low levels of sodium ( hyponatremia ) and the levels rise too fast, but it can occasionally occur when high levels of sodium in the body (hypernatremia) are corrected too quickly. This condition does not occur spontaneously; it is a complication of either treatment for other conditions or the other conditions themselves. Risks include hyponatremia from any cause. Alcoholism Wernicke-Korsakoff syndrome , and general ill health and malnutrition associated with serious illnesses (cachexia) increase the risk of central pontine myelinolysis.

73. Welcome To AJC!
Ency. home Disease C central pontine myelinolysis. central pontine myelinolysis. Ency. home Disease C central pontine myelinolysis.
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ajc store Gifts Photos/pages Browser tip  Make ajc.com  your homepage: ajc guides Schools Visitors Illustrated Health Encyclopedia Important notice Ency. home Disease C Central pontine myelinolysis Overview Symptoms Treatment Prevention Definition: Central pontine myelinolysis is a condition characterized by neurologic damage caused by the destruction of the covering layer ( myelin sheath) of nerve cells in the brainstem (pons). Causes and Risks The destruction of the myelin sheath inhibits impulse conduction along the nerve cell. The most common cause of this condition is rapid correction of low sodium levels in the body (hyponatremia). Less commonly, this also occurs from rapid correction of high levels of sodium in the body (hypernatremia). Risks include hyponatremia from any cause.

74. AIC News Release
ADVANCED IMAGING CENTER PHYSICIAN NEWS, August 28, 2000. INTERESTING CASE PRESENTATION central pontine myelinolysis (CPM) Fig. 1, Fig. 2, Fig. 3, Fig. 4.
http://www.aiclancaster.com/nl/nl_0027.htm
ADVANCED IMAGING CENTER
PHYSICIAN NEWS

August 28, 2000 INTERESTING CASE PRESENTATION:
Central Pontine Myelinolysis (CPM)

Fig. 1
Fig. 2
Fig. 3
Fig. 4 CLINICAL PRESENTATION: This 50-year-old male patient presented to the office of Dr. Jensen with numbness in the left aspect of the body. A brain MRI was ordered by Dr. David Jensen and Dr. Janumpally . Further history from the patient revealed history of chronic alcohol use. MRI FINDINGS: A brain MRI with and without gadolinium contrast was performed on AIC's high-field 1.5 Tesla Siemens Symphony scanner. Fig. 1 shows a midline sagittal T1 weighted image. Fig. 2-4 show the axial T1 weighted, turbo T2 weighted, and turbo FLAIR images, respectively, through the pons. There is a 2 x 2.5 cm abnormality occupying the majority of the pons characterized by low T1 and high T2 and FLAIR signal intensity. The pons is not enlarged. There is no mass effect on the 4th ventricle and no midline shift. No abnormal enhancement was observed on post-contrast images (not shown). MR diffusion and perfusion studies (not shown) were also negative for any acute infarct.

75. SearchBug Directory: Health: Conditions_and_Diseases: Neurological_Disorders: Br
Search the Web Web. Open Directory. Search central pontine myelinolysis,
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Web Pages - ranked by popularity E-Medicine http://www.emedicine.com/neuro/topic50.htm Central Pontine Myelinolysis: An introduction, clinical features, differencials, work up, treatment and follow up. Drkoop: Medical Encyclopedia: Central Pontine Myelinolysis http://www.drkoop.com/ency/article/000775.htm A definition of central pontine myelinolysis, including the causes, risks, prevention, symptoms, diagnosis, treatment, prognosis and complications. Pediatric Database http://www.icondata.com/health/pedbase/files/CENTRALP.HTM A definition of central pontine myelinolysis, the epidemiology, pathogenesis, clinical features, investigations and management.
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76. Penn State Faculty Research Expertise Database (FRED)
Faculty Research Expertise Database. Myelinolysis, Central Pontine. Related Terms, central pontine myelinolysis, Extrapontine Myelinolysis.
http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D017590

77. Entrez PubMed
central pontine myelinolysis induced by hyperemesis gravidarum Article in Spanish Tonelli J, Zurru MC, Castillo J, Casado P, Di Prizito C, Gutfraind E
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

78. Entrez PubMed
Wernicke s encephalopathy and central pontine myelinolysis induced by hyperemesis gravidarum. Peeters A, Van de Wyngaert F, Van
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8

79. Abstract
In 1959 year Adams, Victor and Mancella described central pontine myelinolysis (CPM) as a disease of fulminant course and fatal prognosis.
http://www.ia.pw.edu.pl/~wujek/neurol/str/3-98-e17.html
In 1959 year Adams, Victor and Mancella described central pontine myelinolysis (CPM) as a disease of fulminant course and fatal prognosis. In the typical cases progressive tetraparesis with bulbar signs results in severe crippledom or death. The disease was diagnosed before only by autopsy, as soon as the modern radiological technics i.e. CT and MRI were developed it is sometimes successfully diagnosed with patients alive. The authors present the case of 62-year old woman suffering from slight hemiparesis which made us to perform the CT examination. It showed central pontine lesion which was confirmed by MRI examination. The authors suggest that there are not only typical cases of CPM but also the asymptomatic ones as presented above. In 1959 year Adams, Victor and Mancella described central pontine myelinolysis (CPM) as a disease of fulminant course and fatal prognosis. In the typical cases progressive tetraparesis with bulbar signs results in severe crippledom or death. The disease was diagnosed before only by autopsy, as soon as the modern radiological technics i.e. CT and MRI were developed it is sometimes successfully diagnosed with patients alive. The authors present the case of 62-year old woman suffering from slight hemiparesis which made us to perform the CT examination. It showed central pontine lesion which was confirmed by MRI examination. The authors suggest that there are not only typical cases of CPM but also the asymptomatic ones as presented above.

80. Central Pontine Myelinolysis In A Patient With AIDS [letter]
Click here to return to AIDSLINE main menu DonateNow. central pontine myelinolysis in a patient with AIDS letter J Neurol Neurosurg Psychiatry.
http://www.aegis.com/aidsline/1992/nov/M92B0785.html
Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.
Central pontine myelinolysis in a patient with AIDS [letter] J Neurol Neurosurg Psychiatry. 1992 Jul;55(7):631-2. Unique Identifier : AIDSLINE MED/92349099
Holmes AH; Esiri M; Morris CS; Edwards A Keywords: AIDS Dementia Complex/*PATHOLOGY Case Report Demyelinating Diseases/*PATHOLOGY Human Male Middle Age Myelin Sheath/PATHOLOGY Pons/*PATHOLOGY Water-Electrolyte Balance/PHYSIOLOGY LETTER JOURNAL ARTICLE
National Library of Medicine
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