81. Beryllium Sensitization Progresses To Chronic Beryllium Disease 4285.0 Tuesday, November 14, 2000 522 PM. Abstract 17077. Beryllium Sensitization Progresses to Chronic beryllium disease. Lee http://apha.confex.com/apha/128am/techprogram/paper_17077.htm

4285.0: Tuesday, November 14, 2000 - 5:22 PM Abstract #17077 Beryllium Sensitization Progresses to Chronic Beryllium Disease Lee S Newman, MD, MA , Margaret M Mroz, MSPH, Elaine M Daniloff, MSPH, Lisa A Maier, MD, MSPH, and Ronald Balkissoon, MD, DIH. Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, 303-388-4461, newmanl@njc.org Background: Medical screening and surveillance with the blood beryllium lymphocyte proliferation test (BeLPT) results in the identification of both beryllium sensitization (BeS) and chronic beryllium disease (CBD). BeS has been shown to precede CBD, but the frequency and rate of progression from sensitization to disease is unknown. Methods: Between 1987 and 1997 we have identified 75 individuals with BeS who, at the time of their initial assessment, had repeatedly abnormal blood BeLPTs without demonstrable CBD. We follow this cohort of patients every two years with clinical evaluation including transbronchial lung biopsy. Results: Of our 75 patients, 46 (61.3%) have been reevaluated, ten more than once. Eleven of the 46 patients (23.9%) have developed CBD demonstrated by granulomas on biopsy. The follow-up period from BeS to disease development was 2.6 years (1.0 - 9.5 years) resulting in a conversion rate of 9.2% per year. Follow-up time for the other 35 patients was 2.9 years (0.6 - 7.3 years). If we conservatively assume that none of the 29 other subjects progress, the frequency of progression is 14.7%; 5.6% per year. However, not all BeS patients may develop granulomatous lung disease.

82. Your Health - Berylliosis Berylliosis. (beryllium disease). by Rick Alan. Definition. Berylliosis is an occupational lung disease. It occurs in people who work with beryllium. http://www.aurorahealthcare.org/yourhealth/healthgate/getcontent.asp?URLhealthga

83. Airborne Particulate Matter Research Projects Project Title beryllium disease Surveillance/Research. Grant/Contract Keyword(s) beryllium, respiratory disease, genetic susceptibility, workers. http://www.pmra.org/pmra/PM.nsf/WebProj/0A675BA9E5C4CB0B852568D3001E8A60

Airborne Particulate Matter Research Projects Date entered: 05/02/2000 01:33 AM Document last updated: 06/02/2000 09:28:57 AM Project Title: Beryllium Disease Surveillance/Research Grant/Contract #: Principal Investigator(s): Kreiss Kathleen Principal Investigator(s) E-Mail: KKreiss@cdc.gov Research Organization: NIOSH City: Morgantown State: WV Country: USA Sponsoring Organization: NIOSH Sponsoring Org. Contact Person: Kreiss Kathleen Contact Person E-mail: KKreiss@cdc.gov Year Began: Year Ending : Funding Per Year: Total (Multiyear) Funding: Status: ongoing NRC Priority Number(s): Not Categorized Research Category: Epidemiology Location of Study: Keyword(s): beryllium, respiratory disease, genetic susceptibility, workers Abstract: This research extends a well-characterized beryllium-exposed cohort for cumulative incidence of beryllium disease, genetic and other risk factors, and exposure-response relations using new measurement techniques. The Division of Respiratory Disease Studies conducts exposure assessment and analyzes questionnaire interviews, screening blood tests for beryllium allergy, and clinical diagnostic information from a beryllium company, with genetic analyses from the Health Effects Laboratory Division and exposure reconstruction from the Division of Surveillance, Hazard Evaluations, and Field Studies. Understanding the level of beryllium exposure that results in disease among workers with increased genetic susceptibility can guide prevention efforts, affect rulemaking now underway at the Department of Energy, and inform efforts to prevent occupational asthma, a more common lung disease with both genetic and exposure components.

84. Beryllium And What You Need To Kown Total Sensitized 14. Chronic beryllium disease 7. KCP Former workers and Subcontractors as of 8/31/02. What is beryllium disease (Berylliosis)? http://www.lodge778.org/beryllium.htm

The intention of this page is to provide information about Beryllium Disease. In time you will find links (blue colored) to other web site that contain information about Beryllium or the laws that concern beryllium and its diseases. This page will continue to change visit often. Present employees: as of 3/15/2003 Total enrolled in Beryllium surveillance 1,136 Current Associates: Physical examination 1,130 Initial LPT (blood test performed) 1,130 Total Sensitized: 14 Chronic Beryllium Disease: 7 KCP Former workers and Subcontractors: as of 8/31/02 Former workers enrolled 4072 Former Workers what have received initial screening 2651 Subcontractors enrolled 129 Subcontractors what have received initial screening 127 Diagnosed Sensitized: Former Workers 47 Subcontractors 1 Diagnosed CBD: Former Workers 3 Subcontractors Medical Surveillance Enrollment Process Current Workers Forms Available that Medical Care Services Former Workers Contact Bill Stange, PhD (ORISE) 1-800-269-0157 ext. 8

85. Beryllium Disease Expert To Lecture In Mid-Columbia beryllium disease expert to lecture in MidColumbia. Mid-Columbia doctors should be better prepared to treat chronic beryllium disease after this week. http://www.tri-cityherald.com/news/2001/0115/Story5.html

Front page Sports Business Contact the Herald ... Circulation Tri-City Herald Online exclusive: Sign up to receive the Tri-City Herald Recipe of the Week via email. Search the Tri-City Herald Death notices Job openings at the Herald Special reports Hanford Reach National Monument Snake dams Kennewick Man Hydroplanes Beryllium disease expert to lecture in Mid-Columbia This story was published 1/15/2001 By Annette Cary Herald staff writer Mid-Columbia doctors should be better prepared to treat chronic beryllium disease after this week. It's a respiratory illness caused by exposure to the exotic metal beryllium making nuclear sites such as Hanford one of the relatively few places in the world where it's seen. Consequently, few doctors know much about the disease. However, the Hanford Environmental Health Foundation is bringing the doctor who has written much of the medical literature on the disease to the Tri-Cities this week. "Our goal is to provide as much current information as possible and to establish resources for the local providers," said Dr. William Brady, Hanford medical director. Dr. Lee Newman of Denver will meet with the Benton-Franklin County Medical Society, other health groups, Hanford management, Hanford's Beryllium Awareness Group and concerned Hanford workers and their families Tuesday through Friday. He'll be discussing detection, diagnosis and prevention.

86. HLA-DPB1 And Chronic Beryllium Disease HLADPB1 and chronic beryllium disease. HLA-DPB1 and Chronic beryllium disease is one in a series of reviews available from the Human http://bioresearch.ac.uk/cgi/fullRecord.cgi?key=20056610&gateway=bioresearch

87. HLA-DPB1*E69 And Chronic Beryllium Disease HLADPB1*E69 and chronic beryllium disease. HLA-DPB1*E69 and Chronic beryllium disease is one in a series of fact sheets available http://bioresearch.ac.uk/cgi/fullRecord.cgi?key=20056572&gateway=bioresearch

88. Policy Analysis And Clinical Research On Occupational Beryllium Exposure At DOE Adoption of this standard has effectively eliminated the presence of acute beryllium disease. Laboratory Research on Chronic beryllium disease. http://www.cresp.org/dcwrkshp/posters/be/be.html

Consortium for Risk Evaluation with Stakeholder Participation Policy Analysis and Clinical Research on Occupational Beryllium Exposure at DOE Sites R A Ponce T K Takaro S M Bartell A J Jabbour K Ertell J Abbotts S Barnhart and E M Faustman Worker Safety and CRESP and School of Public Health and Community Medicine, University of Washington, Seattle, WA This research supported in part by CRESP through the Department of Energy Cooperative Agreement #DE-FC01-95EW55084. This support does not constitute endorsement of views expressed. Introduction The US Department of Energy has used beryllium in nuclear materials production, reactor rod fabrication, nuclear vessel cladding and many other uses since the 1940s. The industrial use of beryllium was found to result in an acute respiratory disease, acute beryllium disease, leading the Atomic Energy Commission to establish an airborne concentration standard of 2 µg/m3 for the workplace based on then accepted standards for other metals. Adoption of this standard has effectively eliminated the presence of acute beryllium disease. However, epidemiologic studies carried out during the 1980-90s has revealed the presence of another form of lung disease, chronic beryllium disease (CBD), among workers at US DOE sites. In 1997, the Consortium for Risk Evaluation with Stakeholder Participation (CRESP) began a series of research efforts to investigate the prevalence of CBD among former beryllium workers at Hanford, evaluation of alternatives to the current screening tools for identifying pre-clinical disease, and policy implications of alternative occupational health program designs to reduce disease incidence among future beryllium workers, such as those involved in decontamination and decommissioning former beryllium facilities.

89. Consortium For Risk Evaluation With Stakeholder Participation - CRESP Update: Ha Winter 1999. Worker Health and Safety. Hanford Workers Studied For beryllium disease. by Deirdre Grace*. Dr. Timothy Takaro, Technical http://www.cresp.org/update/hanwin99.html

Winter 1999 Worker Health and Safety Hanford Workers Studied For Beryllium Disease by Deirdre Grace* Dr. Timothy Takaro, Technical Director of CRESP-UW's Worker Health and Safety Task Group, and colleagues have determined that workers at the Hanford Nuclear Reservation may be at risk from exposure to beryllium used to seal fuel rods for the reactors that produced plutonium. Beryllium is a strong, lightweight metallic element used not only in connection with weaponry, but also in the aerospace industry and, increasingly, in the manufacture of consumer goods like golf clubs and bicycles. Dr. Takaro emphasizes the complexity of studying occupational diseases. "It's critical that the first case - or 'sentinel event' - is diagnosed correctly with a disease like CBD," he stated in a recent interview. "Once CBD has been correctly identified, our challenge becomes looking at the surrounding occupational population and figuring out whether other people have been exposed and what kind of risks they may face." Although in rare, extreme cases, CBD can kill within a few years, most people respond well to treatment once diagnosed and continue to live for decades with the help of medication. Increasing the urgency of this research is the discovery that a small number of people appear to be genetically predisposed to develop a sensitivity to beryllium even if exposed to extremely low quantities of the substance, such as a single, low-dose event. To gain a greater understanding of who might be at risk for this condition, CRESP-UW Worker Health and Safety and Human Health Identification task groups have been researching genetic biomarkers for information on genetic differences across populations. One biomarker, Glu-69, has shown a high correlation with CBD development, but other genetic factors yet to be studied are involved as well.

90. Seminar At WVU To Focus On Chronic Beryllium Disease Friday August 30, 2002. Seminar at WVU to focus on Chronic beryllium disease. CONTACT Ainsley Weston, NIOSH CDC, 304285-6221. A toxicologist http://www.nis.wvu.edu/2002_Releases/BeryilliumDisease.htm

News and Information Services News Release Back to Newsroom Friday August 30, 2002 Seminar at WVU to focus on Chronic Beryllium Disease CONTACT: Ainsley Weston , NIOSH CDC, 304-285-6221 A toxicologist from the National Institute for Occupational Safety and Health (NIOSH) Centers for Disease Control and Prevention will speak on "Genetic Factors in Chronic Beryllium Disease" at 3:30 p.m. Tuesday, Sept. 3, in Room 2001 of the Agricultural Sciences Building, Evansdale Campus. Ainsely Weston will give the next presentation in a seminar series organized by West Virginia University’s interdisciplinary program in Genetics and Developmental Biology. A strong, lightweight, alkaline earth element with a high melting point, beryllium has been used most successfully in components of nuclear reactors‚ nuclear weapons, aircraft and spacecraft. Beryllium compounds are used in ceramics for electronics, in dental bridges and in some sports equipment. Exposure to beryllium in the workplace may lead to various diseases including chronic beryllium disease, which causes a painful scarring of the lung tissue. Workers in certain occupations and industries are most likely to develop the disease. However‚ even a family member can develop chronic beryllium disease from exposure to dust on the worker’s clothing‚ hair or body.

91. Chronic Beryllium Disease Prevention Program-Provides Information And Resources Chronic beryllium disease Prevention Program Provides information and resources on the health and safety aspects of beryllium More information is available at http://www.scitechresources.gov/Results/show_result.php?rec=1280

92. Chronic Beryllium Disease And Cancer Risk Estimates With Uncertainty For Berylli Chronic beryllium disease and Cancer Risk Estimates with Uncertainty for Beryllium Released to the Air from the Rocky Flats Plant, atmospheric transport http://ehp.niehs.nih.gov/docs/1999/107p731-744mcgavran/abstract.html

Advanced Search Become a Print Subscriber Subscribe online today! Subscriber Services Buy EHP Publications View Shopping Cart Advertising Information ... Purchase This Issue Chronic Beryllium Disease and Cancer Risk Estimates with Uncertainty for Beryllium Released to the Air from the Rocky Flats Plant Patricia D. McGavran, Arthur S. Rood, and John E. Till Environmental Risk Assessment, Inc., Boise, Idaho, USA K-Spar, Inc., Rigby, Idaho, USA Risk Assessments Corporation, Neeses, South Carolina, USA Abstract . Predicted air concentrations were well below the current reference concentration derived by the EPA for beryllium sensitization. Key words : atmospheric transport modeling, beryllium, chronic beryllium disease, exposure assessment, lung cancer, uncertainty. Environ Health Perspect 107:731-744 (1999). [Online 3 August 1999] http://ehpnet1.niehs.nih.gov/docs/1999/107p731-744mcgavran/ abstract.html Address correspondence to P.D. McGavran, 841 Harcourt Road, Boise, ID 83702-1817. Telephone: (208) 336-5617. Fax: (208) 336-0045. E-mail: mcgavran@micron.net

93. Rates Of Beryllium Disease On The Rise beryllium disease slowly destroys the lungs after the dust is inhaled. Newspaper Article Source Toledo Blade. Beryllium dangers were kept secret. http://www.biomed.lib.umn.edu/hmed/1999/03/19990329_ber.html

HMED Home About HMED Meeting Abstracts Comments Form ... Technical Notes View abstracts from: Search all years Health and Medicine in the News Headline: Beryllium dangers were kept secret Newspaper Article Synopsis: A recent investigation into the safety practices at a beryllium plant in Ohio has found that federal officials knew of the risks to workers but did little rectify the situation. Beryllium disease slowly destroys the lungs after the dust is inhaled. Newspaper Article Source: Toledo Blade. Beryllium dangers were kept secret. Star Tribune, 1999 March 29: A4(col. 1-4). Journal Article Citation: Kreiss K., et al. Risks of beryllium disease related to work processes at a metal alloy and oxide production plant. Occupational and Environmental Medicine 1997 Aug; 54. lam /03/30/1999 MNCAT BioMedSearch MEDLINE Library Instruction ... BIS Bio-Medical Library Diehl Hall University of Minnesota Minneapolis, MN 55455-0334 Twin Cities Telephone:(612)626-5653 FAX: (612)626-2454 Email: medref@umn.edu University of Minnesota University Libraries Last revised: Aug 21, 2003 URL of this page: http://www.biomed.lib.umn.edu/hmed/1999/03/19990329_ber.html

94. Blackwell Synergy - Cookie Absent Chronic beryllium disease immunemediated destruction with implications for organ-specific autoimmunity. AP Fontenot 1 + , BL Kotzin 1. beryllium disease. http://www.blackwell-synergy.com/links/doi/10.1046/j.1399-0039.2003.00160.x/full

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95. Beryllium Disease, "A Disaster Waiting To Happen," Chicago Tribune Investigation smallRW.gif (2706 bytes), beryllium disease, A Disaster Waiting To Happen, Chicago Tribune Investigation. CHICAGO, July 28 /PRNewswire http://www.riskworld.com/PressRel/2001/01q3/PR01a008.htm

Beryllium Disease, "A Disaster Waiting To Happen," Chicago Tribune Investigation CHICAGO, July 28 / PRNewswire A Chicago Tribune investigation has found that thousands of Americans are at risk for developing a chronic, potentially fatal lung disease because companies have exposed them to the highly toxic metal beryllium without adequate safeguards or warnings. The story by reporter Sam Roe is published in the Sunday, July 29, Chicago Tribune The Tribune investigation, based on thousands of court, industry and government documents and dozens of interviews with health officials and business owners, found: Many businesses are not taking basic precautions, such as air monitoring. In a spot check of 30 businesses across the country working with beryllium, the Tribune found that none were following the safeguards recommended by the Occupational Safety and Health Administration (OSHA). Warnings from beryllium manufacturers and distributors are often inaccurate, misleading and incomplete. Of 10 warnings reviewed by the Tribune, nine failed to abide by OSHA rules and four failed to even mention beryllium disease. OSHA rarely inspects companies that handle beryllium. Several Chicago-area businesses working with the metal have not been inspected in 10 years.

96. Berylliosis Lawsuit Overview - Find Trial Lawyers And Attorneys With Experience Berylliosis, also known as chronic beryllium disease (CBD), can occur after long term exposure to the metal beryllium. Berylliosis http://www.injuryboard.com/view.cfm/Topic=286

June 2, 2004 Dietary supplements containing the herbal stimulant ephedra were banned from sale in the United States by the FDA in 2004. Vioxx / Rofecoxib Tractor-Trailer Accidents Serzone / Nefazodone Hydrochloride Tort Reform ... Injuries Berylliosis: Overview If you or a family member has been injured, contact a personal injury attorney today. Just fill out InjuryBoard.com's on-line questionnaire and have a personal injury lawyer review your potential personal injury claim - free of charge. Ask an Attorney Berylliosis, also known as chronic beryllium disease (CBD), can occur after long term exposure to the metal beryllium . Berylliosis causes noncancerous lesions to form in the lungs . Symptoms associated with berylliosis include irritation of the mucous membranes, reduced lung capacity shortness of breath fatigue , anorexia, dyspnea, malaise, heart failure , and weight loss. Berylliosis may cause death Would you like to use this material on your law firm web site? What do I do Now? As with many personal injury claims, time is critical.

97. EPA: Federal Register: Chronic Beryllium Disease Prevention Programs; Worker Saf Chronic beryllium disease Prevention Programs; Worker Safety and Health , Federal Register document. http://www.epa.gov/fedrgstr/EPA-IMPACT/2003/December/Day-08/i30287.htm

Federal Register Environmental Documents Recent Additions Contact Us Print Version Search: EPA Home Federal Register FR Years FR Months ... and Regulations Chronic Beryllium Disease Prevention Programs; Worker Safety and Health rule851.comments@hq.doe.gov noting ``Worker Safety and Health Rule Comments'' in the subject line. Where possible, commenters should identify the specific section to which they are responding. Copies of the public hearing transcripts, written comments received, and any other docket material may be reviewed on the Web site specially established for this proceeding. The Internet Web site is http://www.eh.doe.gov/whs/rulemaking The public hearings for this rulemaking will be held at the following addresses: Arlington, VA (Washington, DC): Marriott Crystal City Hotel, 1999 Jefferson Davis Highway, Arlington, VA 22202. Golden, CO (Denver): DOE National Renewable Energy Laboratory, Visitor Center, Auditorium, 15013 Denver West Parkway, Golden, CO 80401 (I-70, Exit 263, right at top of exit ramp if coming from Denver, left at stop sign, building on right). For more information concerning public participation in this rulemaking proceeding, see section IV of this notice of proposed rulemaking (Public Comment Procedures). FOR FURTHER INFORMATION CONTACT: Jacqueline D. Rogers, U.S. Department of Energy, 1000 Independence Avenue SW., Washington, DC 20585-0270, 301-903-5684, e-mail:

98. Am. J. Epidemiol. -- Abstracts: McCanlies Et Al. 157 (5): 388 of Public Health HUMAN GENOME EPIDEMIOLOGY (HuGE) REVIEW. HLADPB1 and Chronic beryllium disease A HuGE Review. Erin C. McCanlies http://aje.oupjournals.org/cgi/content/abstract/157/5/388

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: Full Text of this Article PDF Version of this Article Email this article to a friend Similar articles found in: Am. J. Epidemiol. Online PubMed PubMed Citation This Article has been cited by: other online articles Search PubMed for articles by: McCanlies, E. C. Weston, A. Alert me when: new articles cite this article Download to Citation Manager Am J Epidemiol Johns Hopkins Bloomberg School of Public Health HUMAN GENOME EPIDEMIOLOGY (HuGE) REVIEW HLA-DPB1 and Chronic Beryllium Disease: A HuGE Review Erin C. McCanlies Kathleen Kreiss Michael Andrew and Ainsley Weston Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV. Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV. Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV. The human leukocyte antigen (HLA) complex is a series of genes located on chromosome 6 that are important in normal immune function. Susceptibility to chronic beryllium disease, a granulomatous

99. Ingenta: Article Summary -- HLA-DPB1 And Chronic Beryllium Disease: A HuGE Revie Article HLADPB1 and Chronic beryllium disease A HuGE Review American Journal of Epidemiology 1 March 2003, vol. 157, no. 5, pp. http://www.ingenta.com/isis/searching/ExpandTOC/ingenta?issue=pubinfobike://oup/

100. Groups Warn Of Beryllium Lung Disease CNN http://cnn.com/2001/HEALTH/conditions/09/03/health.metal.reut/index.html

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