21. Environ Health Perspect 102-6-7, 1994: Beryllium: A Chronic Problem Article by Leslie Lang, published in Environmental Health Perspectives in 1994. Discusses uses of this metal in industry, chronic beryllium disease, the possibility of genetic testing for CBD, and the incidence of the disease in the workforce. http://ehpnet1.niehs.nih.gov/docs/1994/102-6-7/focus.html

Advanced Search Become a Print Subscriber Subscribe online today! Subscriber Services Buy EHP Publications View Shopping Cart Advertising Information ... Purchase This Issue Beryllium: A Chronic Problem Principal uses of beryllium stem from the discovery in the 1920s that an addition of only 2% beryllium to copper results in an alloy six times stronger than copper. beryllium-copper alloys withstand high temperatures, are extraordinarily hard, resistant to corrosion, do not spark, and are nonmagnetic. These alloys are used in many critical moving parts of aircraft engines, in key components of precision instruments, electrical relays, and switches. Beryllium-copper hammers, wrenches, and other nonsparking tools are used in the petroleum industry where sparks from steel might cause explosions. In the electronics industry, including personal computers, Beryllium-copper alloys are found in integrated circuit sockets and electronic connectors. An alloy of 25% beryllium has some limited use in camera shutters. Beryllium-copper alloys are also used in golf clubs, springs, pivots, wheels, pinions, submarine cable housings, and dental prostheses. Because of its low atomic number, beryllium is very permeable to X-rays. Its low neutron absorptance and high scattering cross-section make it a suitable moderator and reflector in structural materials within nuclear facilities. Beryllium metal can be used as structural material in space technology, in special windows for X-ray tubes, in gyroscopes, computer parts, and missle inertial guidance systems, as an additive in solid propellant rocket fuels, heat-sink material in high performance aircraft brakes, mirror components in satellite optical systems, and development of brass alloys.

22. Chronic Beryllium Disease And Cancer Risk Estimates With Uncertainty For Berylli Chronic beryllium disease and Cancer Risk Estimates with Uncertainty for Beryllium Released to the Air from the Rocky Flats Plant, atmospheric transport modeling, beryllium, chronic beryllium cancer risks and risks of chronic beryllium disease to hypothetical receptors http://ehis.niehs.nih.gov/docs/1999/107p731-744mcgavran/abstract.html

Advanced Search Become a Print Subscriber Subscribe online today! Subscriber Services Buy EHP Publications View Shopping Cart Advertising Information ... Purchase This Issue Chronic Beryllium Disease and Cancer Risk Estimates with Uncertainty for Beryllium Released to the Air from the Rocky Flats Plant Patricia D. McGavran, Arthur S. Rood, and John E. Till Environmental Risk Assessment, Inc., Boise, Idaho, USA K-Spar, Inc., Rigby, Idaho, USA Risk Assessments Corporation, Neeses, South Carolina, USA Abstract . Predicted air concentrations were well below the current reference concentration derived by the EPA for beryllium sensitization. Key words : atmospheric transport modeling, beryllium, chronic beryllium disease, exposure assessment, lung cancer, uncertainty. Environ Health Perspect 107:731-744 (1999). [Online 3 August 1999] http://ehpnet1.niehs.nih.gov/docs/1999/107p731-744mcgavran/ abstract.html Address correspondence to P.D. McGavran, 841 Harcourt Road, Boise, ID 83702-1817. Telephone: (208) 336-5617. Fax: (208) 336-0045. E-mail: mcgavran@micron.net

23. THE MERCK MANUALSECOND HOME EDITION, Beryllium Disease In Ch. 49 beryllium disease. beryllium disease (sometimes called berylliosis) is a lung inflammation caused by inhaling dust or fumes that contain beryllium. http://www.merck.com/mrkshared/mmanual_home2/sec04/ch049/ch049e.jsp

24. Beryllium Support Group Large collection of information maintained by Denverarea support group for people with chronic beryllium disease. http://www.beryllium.org/

B eryllium S upport G roup Home Overview Contact Announcements ... Search Overview This web site was formally launched on March 12, 1996 by Michael Jackson a member of the Beryllium Support Group which meets monthly at the National Jewish Medical and Research Center in Denver, Colorado. The intent is to provide a platform where any other Beryllium Support Group regardless of affiliation or location can freely participate in the presentation of or transfer of information relating to this incurable disease. Some of the goals of this site is to provide a means: To provide a forum where anyone around the country or the world can obtain information or provide information they have experienced as a result of this disease. To provide current and historical information on studies and papers relating to this disease. To provide current and historical information relating to the health risks of using beryllium. To provide current and historical information relating to regulations governing the use and control of beryllium. To provide current and historical information of the nature of this disease and its effects on the human body.

25. What Is Chronic Beryllium Disease? Chronic beryllium disease, or CBD, is an inflammation in the lungs that can occur when a person is exposed to respirable beryllium fumes, dusts or powder, and http://www.befacts.com/cbd/

Chronic beryllium disease, or CBD, is an inflammation in the lungs that can occur when a person is exposed to respirable beryllium fumes, dusts or powder, and subsequently demonstrates an allergic reaction to beryllium. CBD is an occupational disease that may occur in the manufacture of metallic beryllium, beryllium oxide ceramic, or alloys containing beryllium. It was first identified more than 50 years ago. Not everyone who is exposed to beryllium fumes, dusts or powder will develop CBD; most people do not . Researchers now believe that the tendency to develop CBD is genetically determined and results from an allergic sensitivity. Some individuals develop an allergy to beryllium upon exposure and are, therefore, more likely to develop CBD. Some people who are diagnosed with CBD do not develop clinical symptoms at all. In others, the disease can lead to clinical symptoms that include scarring and damage of lung tissue, causing shortness of breath, wheezing and/or coughing. Extreme cases of CBD can cause disability or death. The course of the disease can range from a few years to decades. Home What is Beryllium?

26. Beryllium Facts: Bibliography Brush Wellman, Code of Safe Work Practices 78, 1972. Brush Wellman, Statement of Current Knowledge on Chronic beryllium disease, Aug. 1995. http://www.befacts.com/biblio.html

Bibliography 38 Federal Register 66, April 6, 1973. 53 Federal Register 20960, 1988. 54 Fed. Reg. 2331, corrected at 54 Fed. Reg. 2331, 1989. 58 Fed. Register 35512, 35515-24, July 1, 1993. Toxicological Profile for Beryllium American Industrial Hygiene Association, Beryllium and Compounds, American National Standards Institute, Acceptable Concentrations of Beryllium and Beryllium Compounds, Brush Wellman, Air Sampling Program , May 18, 1950. Brush Wellman, Code of Safe Work Practices Brush Wellman, Statement of Current Knowledge on Chronic Beryllium Disease, Aug. 1995. Chemical Substance TLV Committee, American Conference of Governmental Industrial Hygienists, Beryllium and Compounds The Committee on Technologies for Preparing Beryllium Metal, National Materials Advisory Board, NMAB-452, Beryllium Metal Supply Options, Deodhar, Sharad D. , et al. "A Study of the Immunologic Aspects of Chronic Berylliosis," 63

27. OSH Answers: Beryllium Disease What is beryllium disease? What is acute beryllium disease? What is chronic beryllium disease? beryllium disease. What is beryllium disease? http://www.ccohs.ca/oshanswers/diseases/beryllium.html

Canadian Centre for Occupational Health and Safety Contact Us Help Canada Site Web Info Service ... Shop@CCOHS Beryllium Disease What is beryllium disease? What is acute beryllium disease? What is chronic beryllium disease? What are the industrial uses of beryllium? ... How can we prevent beryllium disease? OSH Answers Feedback Printer Friendly Layout Inquiries Service The Inquiries Service at CCOHS answers questions on the health or safety concerns people have about the work they do. More on Inquiries Service Printer Friendly Layout Beryllium Disease What is beryllium disease? Beryllium disease is the term used to describe various conditions resulting from exposure to beryllium and its compounds or alloys. These conditions can be grouped into acute beryllium disease and chronic beryllium disease Depending on how workers are exposed, the diseases can affect different tissues and organs. Breathing in fumes or dusts of beryllium compounds may injure the lungs. Direct contact with beryllium fumes or dusts may injure the exposed areas of the body, such as the eyes or the skin. Beryllium may also affect such organs as the liver, kidneys, heart, nervous system, and the lymphatic system, which carries water, white blood cells and proteins to the blood. What is acute beryllium disease?

28. Chronic Beryllium Disease And Other Beryllium-Related Diseases And Medical Issue Describes Berylliumrelated diseases and other Beryllium-related medical issues, including chronic beryllium disease or berylliosis. http://www.chronicberylliumdisease.com/medical/med_bediseases.htm

Chronic beryllium disease (CBD or berylliosis) The Department of Health and Human Services Environmental Protection Agency CBD Symptoms: Cough Shortness of breath Fever Fatigue Night sweats Loss of appetite Skin rash (sometimes) Chronic beryllium disease (berylliosis or CBD) Diseases Due to Inorganic Dusts The average time from first beryllium exposure to the development of CBD symptoms (the latency period) can be a few months or as long as forty years ( Medfacts Testing treated Acute beryllium disease Acute beryllium disease (ABD) is caused by breathing in relatively high concentrations of beryllium in dust and metal fumes ( Medfacts Skin Irritation Printer friendly version home beryllium defined exposure ... about us This web site is sponsored by the law firm of for educational purposes. Please see our

29. Chronic Beryllium Disease Diagnosis Doctors sometimes find it difficult to distinguish chronic beryllium disease from sarcoidosis. Is It Chronic beryllium disease or Sarcoidosis? http://www.chronicberylliumdisease.com/news/nw_031204_sarcoidosis.htm

Is It Chronic Beryllium Disease or Sarcoidosis? March 12, 2004 Sarcoidosis is a chronic disease of unknown cause marked by the formation of abnormal nodes in the lungs, lymph glands and other areas. Chronic beryllium disease Determining whether a patient has chronic beryllium disease or sarcoidosis is helpful because the course of each disease may be different. Sarcoidosis is often mild, without lasting lung damage. Many patients with sarcoidosis have granulomas that disappear without treatment. More serious cases require the use of corticosteroids such as prednisone. On the other hand, chronic beryllium disease is incurable. Severe cases involve lung scarring and even strain on the right side of the heart due to increased pressure in the pulmonary artery from lung damage (cor pulmonale). Prednisone may also be used in treat chronic beryllium disease. ). Both HRCT scans and pulmonary function tests can show the presence and severity of respiratory disease, but they are not useful in distinguishing chronic beryllium disease from sarcoidosis. Brayton Purcell is dedicated to upholding the legal rights of those with chronic beryllium disease. Since the late 1980s, we have represented beryllium workers as well as those who have come into contact with beryllium through others. Please feel free to

30. Chronic Beryllium Disease: Diagnosis And Management Chronic beryllium disease Diagnosis and Management, beryllium, granuloma, restrictive lung disease, occupational lung disease, immunology, cellmediated http://ehpnet1.niehs.nih.gov/docs/1996/Suppl-5/rossmanabs.html

Advanced Search Become a Print Subscriber Subscribe online today! Subscriber Services Buy EHP Publications View Shopping Cart Advertising Information ... Purchase This Issue Chronic Beryllium Disease: Diagnosis and Management Milton D. Rossman Pulmonary and Critical Care Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania Abstract Chronic beryllium disease is predominantly a pulmonary granulomatosis that was originally described in 1946. Symptoms usually include dyspnea and cough. Fever, anorexia, and weight loss are common. Skin lesions are the most common extrathoracic manifestation. Granulomatous hepatitis, hypercalcemia, and kidney stones can also occur. Radiographic and physiologic abnormalities are similar to those in sarcoidosis. While traditionally the pathologic changes included granulomas and cellular interstitial changes, the hallmark of the disease today is the well-formed granuloma. Immunologic studies have demonstrated a cell-mediated response to beryllium that is due to an accumulation of CD4 T cells at the site of disease activity. Diagnosis depends on the demonstration of pathologic changes (i.e., granuloma) and evidence that the granuloma was caused by a hypersensitivity to beryllium (i.e., positive lung proliferative response to beryllium). Using these criteria, the diagnosis of chronic beryllium disease can now be made before the onset of clinical symptoms. Whether, with early diagnosis, the natural course of this condition will be the same as when it was traditionally diagnosed is not known. Currently, corticosteroids are used to treat patients with significant symptoms or evidence of progressive disease.

31. Chronic Beryllium Disease: Uncommon Disease, Less Common Diagnosis Chronic beryllium disease Uncommon Disease, Less Common Diagnosis, berylliosis, beryllium, granulomatous, hypersensitive, lymphocyte, pulmonary, sarcoidosis http://ehpnet1.niehs.nih.gov/members/1998/106p765-767middleton/middleton-full.ht

Advanced Search Become a Print Subscriber Subscribe online today! Subscriber Services Buy EHP Publications View Shopping Cart Advertising Information ... December 1998 Commentary Acute Beryllium Disease Chronic Beryllium Disease Differential Diagnosis of CBD Summary ... Purchase This Issue Chronic Beryllium Disease: Uncommon Disease, Less Common Diagnosis Dannie C. Middleton Health Investigations Branch, Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30333 USA Abstract Key words : berylliosis, beryllium, granulomatous, hypersensitive, lymphocyte, pulmonary, sarcoidosis. Environ Health Perspect 106:765-767 (1998). [Online 2 November 1998] http://ehpnet1.niehs.nih.gov/docs/1998/106p765-767middleton/ abstract.html Address correspondence to D.C. Middleton, Health Investigations Branch, Division of Health Studies, Agency for Toxic Substances and Disease Registry, 1600 Clifton Road MS E31, Atlanta, GA 30333 USA. I thank Mary C. White and Myron G. Schultz for advice and encouragement during the preparation of this manuscript. Received 15 May 1998; accepted 16 July 1998.

32. HLA-DPB1*E69 And Chronic Beryllium Disease:  HuGE Factsheet fact sheet HLADPB1 *E69 and Chronic beryllium disease Ainsley Weston, Kathleen Kreiss, Michael Andrew, Erin McCanlies. HuGE Review Published April 10, 2003. http://www.cdc.gov/genomics/hugenet/factsheets/FS_Beryllium.htm

Your browser does not support script fact sheet HLA-DPB1 and Chronic Beryllium Disease Ainsley Weston , Kathleen Kreiss, Michael Andrew, Erin McCanlies. HuGE Review Published April 10, 2003 Gene HLA-DPB1 These molecules are responsible for initiation of the immune response through antigen presentation to T cells. Prevalence of Gene Variants There are 103 known variants of HLA-DPB1 Table 1 The supratypic marker HLA-DPB1 , coding for glutamic acid at the 69 th residue of the mature protein, is found in 34 of those variants. The allelic frequency of the supratypic marker HLA-DPB1 Frequencies are typically based on studies of 20-150 individuals ( Disease Burden Chronic Beryllium Disease (CBD) is caused by exposure to beryllium (Be), in the form of particles of BeO, BeF, other Be-salts, Be-metal, or Be-alloy. It has been estimated that approximately 1-12% of workers in the primary industry are immunologically sensitized to beryllium. Of those, 36-100% develop CBD (

33. Beryllium Disease Among Workers In A Spacecraft- Manufacturing Plan beryllium disease among Workers in a Spacecraft Manufacturing Plant California. Epidemic chronic beryllium disease among scrap metal refiners. http://www.cdc.gov/epo/mmwr/preview/mmwrhtml/00000125.htm

August 19, 1983 / 32(32);419-20,425 Beryllium Disease among Workers in a Spacecraft- Manufacturing Plant California From 1977 to 1981, three cases of beryllium disease (berylliosis) among workers in a large spacecraft-manufacturing plant in California, were reported to the Beryllium Case Registry (BCR) of the National Institute for Occupational Safety and Health (NIOSH). All three patients were machinists who had worked with beryllium metal from the late 1950s to the mid-1970s, fabricating special parts for missile guidance systems. Laboratory tests in January 1980 showed a hemoglobin level of 16.1 g. White blood cell count was 6,100, with a normal differential. Sputum tests were negative for fungi and acid-fast bacilli. Measurements of arterial blood gases showed a pH of 7.42, PCO((2)) of 36 mm Hg, PO((2)) of 69, and oxygen saturation of 93%. Pulmonary function tests showed moderate reduction of vital capacity and total lung capacity and marked reduction of forced expiratory volume and diffusing capacity. Pathologic examination of biopsied mediastinal lymph nodes revealed non-caseating granuloma and chronic interstitial pneumonitis. A lymphoblast transformation test (LTT) conducted in 1981 was positive. The patient was first employed in 1956 as a milling machinist. He worked with beryllium metal and alloys from 1960 through the mid-1970s at three different plants of this company, two of which have been closed. According to the industrial protocol, such machining was to be done wet or under high-efficiency, local-exhaust ventilation. However, the patient stated that at times there was sufficient spillage of dusts to require vacuuming. He did not use a respirator.

34. Beryllium Central Jon Gelman Attorney 1-888-696-7900 beryllium disease benefits for energy workers and their families, bystanders and household contact. Beryllium Central beryllium disease Resouces. http://www.berylliumcentral.com/

Beryllium Central Beryllium Disease Resouces What Is The Federal Cold War Compensation Act Medical Resources for Beryllium Related Disease Who Was Exposed Where Beryllium Was Used ... What's New Beryllium Beryllium Central Cold War Compensation Medical Resources Who Is At Risk ... Reading Room Jon Gelman, who practices in Wayne, NJ , wrote Workers' Compensation Law, 3rd ed. (West Group). He can be reached electronically at: jon@gelmans.com . Internet: www.gelmans.com ; 1450 Valley Road, PO Box 934, Wayne, NJ 07474-0934, Toll Free: (888) 696-7900, Tel: (973) 696-7900; Fax: (973) 696-7988. For additional information call Toll Free 1(888) 696-7900 Subscribe to Beryllium Central news Powered by groups.yahoo.com

35. Beryllium Disease beryllium disease. NJMRC Facts About beryllium disease - Learn about the symptoms and treatments of berylliosis, a disease that affects the lungs. http://www.health-nexus.com/beryllium_disease.htm

Health-Nexus.Net Health-Nexus.Org The #1 Health information site Home ... Up Search Health-Nexus for: Match ALL words Match ANY word Email this page to a friend ! Post a question or comment on our Message Board Home Page Health Specialties Health News ... Alternative Health Options Substance Abuse Animal Health Search: Books Magazines Video Keywords: Find it Here Beryllium Disease NJMRC - Facts About Beryllium Disease Learn about the symptoms and treatments of berylliosis, a disease that affects the lungs. From the National Jewish Medical and Research Center. ... FACTS ABOUT BERYLLIUM DISEASE. What is Natural History of Beryllium Sensitization and Chronic Beryllium Disease A medical article about the early detection of beryllium sensitization and chronic beryllium disease. Includes recent studies .... Beryllium Support Group ... can also develop Chronic Beryllium Disease, or CBD. Recent studies indicate ... Occupations which are at risk for beryllium disease include beryllium metal and ... Colorado, Ohio and Tennessee Beryllium Disease Support Groups. NABER does ... National Beryllium Support Group Provides fact sheets and articles about the incurable disease, plus details about government regulations regarding exposure to beryllium. ... evident among workers, who when exposed to beryllium fumes and dust, can also develop Chronic Beryllium Disease, or CBD. ...

36. Clinical-Laboratory-Testing.com - Beryllium Disease Cholesterol Testing Betaine Offers clinical laboratory testing for beryllium disease, LDL cholesterol, heavy metal, osteoporosis risk, and diabetes. beryllium disease cholesterol testing. http://www.clinical-laboratory-testing.com/lung-disease.html

ENTER beryllium disease cholesterol testing beryllium disease cholesterol testing betaine homocysteine calcium osteoporosis betaine homocysteine calcium osteoporosis

37. Clinical-Laboratory-Testing.com - Ldl Cholesterol Test Chronic Beryllium Disease Offers clinical laboratory testing for beryllium disease, LDL cholesterol, heavy metal, osteoporosis risk, and diabetes. ENTER. ldl cholesterol test. http://www.clinical-laboratory-testing.com/bnp.html

ENTER ldl cholesterol test ldl cholesterol test chronic beryllium disease blood test for diabetes chronic beryllium disease blood test for diabetes

38. Hazardous Substances - Beryllium information. ? beryllium disease Prevention Program Resources, program information and FAQs from Lawrence Livermore National Laboratory. http://www.healthcyclopedia.com/occupational-health-and-safety/hazardous-substan

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... hazardous substances > beryllium Hazardous Substances - Beryllium Health Information External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Related Topics Health News Web Directory: Related Topics: Open Directory: Science/Chemistry/Elements/Beryllium Health News: Search millions of published articles for news on Hazardous Substances - Beryllium Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: Preventing Adverse Health Effects From Exposure to Beryllium on the Job US OSHA Hazard Information Bulletin on this substance. Beryllium at Hanford Information about beryllium as it pertains to the DOE Hanford Site, in Washington State. Contains health issues, questions and answers and links. Beryllium Compounds U.S. Environmental Protection Agency fact sheet on this metal and its hazards, with links to related toxicological information.

39. Berylliosis this report. Synonyms Acute beryllium disease; Beryllium Granulomatosis; Beryllium Pneumonosis; Beryllium Poisoning. Disorder Subdivisions http://my.webmd.com/hw/health_guide_atoz/nord481.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Quizzes, Calculators Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report Berylliosis Important It is possible that the main title of the report Berylliosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Acute Beryllium Disease Beryllium Granulomatosis Beryllium Pneumonosis Beryllium Poisoning Disorder Subdivisions Acute Berylliosis (Acute Beryllium Disease) Chronic Berylliosis (Chronic Beryllium Disease [CBD]) General Discussion Berylliosis is a form of metal poisoning caused by inhalation of beryllium dusts, vapors, or its compounds or implantation of the substance in the skin. The toxic effects of beryllium most commonly occur due to occupational exposure. Beryllium is a metallic element used in many industries, including electronics, high-technology ceramics, metals extraction, and dental alloy preparation. Resources American Lung Association 61 Broadway, 6th Floor

40. Unmasking The Mysteries Of Chronic Beryllium Disease Unmasking the mysteries of chronic beryllium disease. New tests identify sensitivity, genetic susceptibility. Beryllium is a unique http://www.eurekalert.org/features/doe/2001-06/danl-utm061302.php

Text-Only Privacy Policy Site Map Unmasking the mysteries of chronic beryllium disease New tests identify sensitivity, genetic susceptibility Beryllium is a unique lightweight metal used in nuclear weapons and, in the commercial sector, for telescope mirrors, golf clubs and a variety of other applications. While solid beryllium and beryllium alloys are safe, fine particulate beryllium is hazardous if inhaled. In certain individuals, breathing microscopic beryllium particles can lead to Chronic Beryllium Disease (CBD), sometimes called berylliosis. CBD is a long-duration, allergic-type lung response that can make the sufferer abnormally weak and is sometimes fatal. Research into beryllium health effects in the Bioscience Division at Los Alamos National Laboratory center on identifying worker sensitivity and increased risk caused by genetic factors. Only a small percentage of people exposed to beryllium become sensitized to it, meaning they experience an immune-system reaction to exposure. In addition, it appears that not everyone who is sensitized develops CBD. A team led by Bioscience Division researcher Babs Marrone has devised an improved Lymphocyte Proliferation Test, or LPT, a blood test that can identify sensitized individuals. The researchers also have found genetic markers that indicate increased susceptibility.

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