41. Blackwell Synergy - Cookie Absent 04024.x. Congenital Bicuspid aortic valve disease with an Aneurysm of the Ascending Aorta in Adults Vertical Reduction Aortoplasty http://www.blackwell-synergy.com/links/doi/10.1111/j.0886-0440.2004.04024.x/abs/

Home An Error Occurred Setting Your User Cookie A cookie is a small amount of information that a web site copies onto your hard drive. Synergy uses cookies to improve performance by remembering that you are logged in when you go from page to page. If the cookie cannot be set correctly, then Synergy cannot determine whether you are logged in and a new session will be created for each page you visit. This slows the system down. Therefore, you must accept the Synergy cookie to use the system. What Gets Stored in a Cookie? Synergy only stores a session ID in the cookie, no other information is captured. In general, only the information that you provide, or the choices you make while visiting a web site, can be stored in a cookie. For example, the site cannot determine your email name unless you choose to type it. Allowing a web site to create a cookie does not give that or any other site access to the rest of your computer, and only the site that created the cookie can read it. Please read our for more information about data collected on this site.

42. ResearchChannel: Programs Valve Replacement aortic valve disease. The University of Washington Regional Heart Center presents patient case studies focusing on valve replacement. http://www.researchchannel.org/program/displayevent.asp?rid=1288

43. CHANGING OUTCOME OF AORTIC VALVE DISEASE IN PATIENTS WITH SUBAORTIC STENOSIS 366, Return to Table of Contents. CHANGING OUTCOME OF aortic valve disease IN PATIENTS WITH SUBAORTIC STENOSIS. Z Laksman, C Silversides http://www.ccs.ca/society/congress2002/abstracts/abs/a366.htm

Return to Table of Contents CHANGING OUTCOME OF AORTIC VALVE DISEASE IN PATIENTS WITH SUBAORTIC STENOSIS Z Laksman, C Silversides, M Hart, WG Williams, G Webb, P Liu Toronto Adult Congenital Cardiology Clinic, University of Toronto OBJECTIVE: In patients with congenital subaortic stenosis (SAS), aortic regurgitation due to a subaortic jet is generally seen as the common sequel. We have re-examined the aortic complications in adult patients with SAS. METHODS: Consecutive patients with isolated subaortic stenosis presenting to the Toronto Adult Congenital Cardiology Clinic were reviewed (n=53). Patients with the following associated anomalies were excluded: septal defects, transposition, double outlet RV, hypertrophic cardiomyopathy, and univentricular connections. RESULTS: There were 28 males, and the mean age was 36.8±1.8 (mSD) years at current follow up. The common associated anomalies included 17 aortic stenosis, 13 aortic regurgitation, 14 bicuspid aortic valves (BAV), 5 supravalvular aortic stenosis, 9 coarctation, 4 mitral stenosis, and 5 PDAs. All 53 patients had undergone at least one surgical resection of their subaortic membrane at a median age for the first resection at 10 (range 1,67 years), with an average LV outflow gradient of 74.5±5.2 mmHg. Of the 53 pts, 28% (15/53) required subsequent aortic valve surgery, including 10 valvotomies and 9 AV replacements at a median age of 21 years (14,27). At the time of surgery, 47% had BAVs and 53% had tricuspid AVs, all with valvular aortic stenosis. Of those requiring aortic valve replacements, 67% also required reoperation for recurring subaortic stenosis.

44. BICUSPID AORTIC VALVE DISEASE IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION 414. BICUSPID aortic valve disease IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION. K Al Faraidy, L Shewchuk, YH Sun, A Maitland, TJ Anderson, S Verma. http://www.pulsus.com/ccc2003/abs/a414.htm

Return to Table of Contents BICUSPID AORTIC VALVE DISEASE IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION K Al Faraidy, L Shewchuk, YH Sun, A Maitland, TJ Anderson, S Verma Calgary, Alberta BACKGROUND: Bicuspid aortic valve disease is the most common congenital cardiac abnormality and is associated with a high rate of aortic stenosis, aortic dilatation, coarctation and atherosclerosis. Recent evidence, from gene knock out studies, suggest that deficiency in nitric oxide (NO) production may be linked to the development of bicuspid aortic valve disease. In the present study, we hypothesized that patients with bicuspid aortic valves would exhibit impaired endothelium-dependent vasodilatation when compared to case-matched patients with tricuspid aortic valves. METHODS AND RESULTS: CONCLUSION: We uncover, for the first time, an important association between bicuspid aortic valves and endothelial dysfunction, in otherwise healthy, asymptomatic patients without heart failure or coronary artery disease. These data may provide new insight into the development of atherosclerosis in patients with this common congenital cardiac abnormality.

45. FIBRILLIN-1 IS SYSTEMICALLY DEFICIENT IN BICUSPID AORTIC VALVE DISEASE 785. FIBRILLIN1 IS SYSTEMICALLY DEFICIENT IN BICUSPID aortic valve disease. P Fedak, PWM Fedak, MPL de Sa, S Verma, J Butany, RD Weisel, TE David. http://www.pulsus.com/ccc2003/abs/a785.htm

Return to Table of Contents FIBRILLIN-1 IS SYSTEMICALLY DEFICIENT IN BICUSPID AORTIC VALVE DISEASE P Fedak, PWM Fedak, MPL de Sa, S Verma, J Butany, RD Weisel, TE David Toronto, Ontario INTRODUCTION: We previously determined that fibrillin-1 is deficient in the aortic media of patients with bicuspid aortic valve malformations (BAV) and may contribute to aortic disruption or dilatation. This study was designed to determine the expression of fibrillin-1 and matrix metalloproteinases (MMPs) in vasculature remote from the diseased aorta. METHODS AND RESULTS: CONCLUSIONS: These data support both a systemic deficiency of fibrillin-1 in subsets of patients with BAV and a role for aberrant fibrillin-1 processing and elevated MMP activity in the aortic complications characteristic of this common congenital malformation. Notably, the devastating vascular manifestations of BAV disease may be a consequence of fibrillin-1 gene dysregulation. DNC NEXT

46. Welcome To Enh.org - Heart aortic valve disease may also cause dizziness, lightheadedness or even fainting spells. The decision to proceed with surgery should http://www.enh.org/heart/procedures.asp?gpid=41&pid=42&id=198<ype=C

47. Numerical Simulations In Studying Combined Aortic Valve Disease - SLEZAK/Tau Numerical Simulations in Studying Combined aortic valve disease. Dr. Moshe Rosenfield Fleischman Faculty of Engineering, Tel Aviv University Prof. http://www.tau.ac.il/institutes/slezak/reports/reports97-5.html

Numerical Simulations in Studying Combined Aortic Valve Disease Dr. Moshe Rosenfield Fleischman Faculty of Engineering , Tel Aviv University Prof. Gad Keren Sackler Faculty of Medicine , Tel Aviv University The aim of the present study is to investigate combined aortic stenosis and regurgitation of varying severity using numerical simulations. The numerical simulations will provide detailed data on the time dependent flow field. Moreover, the numerical simulations can be effectively utilized to isolate the governing factors and to develop (together with other tools of investigation) more reliable methodologies in the assessment of the severity of aortic stenosis and regurgitation. Usually the simplified Bernoulli equation is used to calculate the pressure drop across heart valves. However, since the flow is viscous (rotational) and time dependent, this equation may not be valid or yield accurate results. This is especially true in the present case of stenotic lesions in combined aortic stenosis and regurgitation, where strong interaction and the vortical flow invalidates the underlying assumptions. Furthermore, the effect of stenosis severity on the color Doppler assessment of the regurgitant jet in these lesions was never studied in a controlled manner. Therefore it is of utmost importance to comprehend the resulting flow field and consequently to develop improved and simplified relationships (or correlations) for estimating more accurately the pressure drops in the case of combined aortic stenosis and regurgitation.

48. Kardiologia Polska AWA TRACZ, PIOTR PODOLEC MARTA HLAWATY, MIECZYS£AW PASOWICZ aortic valve disease HEMODYNAMIC CHANGES in PREGNANT WOMEN with aortic valve disease Department of http://www.ptkardio.pl/kardio/wydania/kp99/kp9_99_2-e.html

Polish Heart Journal, September 1999, Vol. L, Nr 3 Contents ORIGINAL CONTRIBUTIONS D. Zy¶ko, M. Negrusz-Kawecka, J. Gajek REACTIVITY of the AUTONOMIC NERVOUS SYSTEM in PATIENTS with PAROXYSMAL ATRIAL FIBRILLATION and CORONARY HEART DISEASE. Evaluation by means of heart rate variability analysis - page 189 A. Le¶niak, W. Tracz, P. Podolec, M. Hlawaty, M. Pasowicz AORTIC VALVE DISEASE HEMODYNAMIC CHANGES in PREGNANT WOMEN with AORTIC VALVE DISEASE - page 201 J. Korewicki, T. Zieliñski, P. Leszek, M. Kabat, K. Mazurek, E. £astowiecka, B. Ku¶mierczyk HEART FAILURE. Comparison of the effects of trandolapril and captopril on 24-hour blood pressure profile - page 214 CASE REPORTS R. Krynicki, H. Koniecko, I. Szantula ACUTE TYPE A AORTIC DISSECTION COMPLICATED with HAEMOPERICARDIUM and CARDIOGENIC SHOCK - A CASE REPORT - page 227 L. Bryniarski, J. Dragan, A. Klecha, K. Kawecka-Jaszcz, K. ¯mudka TOTAL OCCLUSION of the LEFT MAIN CORONARY ARTERY RECOGNIZED DURING LIFE - A CASE REPORT - page 232 J. Ju¶ciñski, D. Tomaszewski, W. Jusza, R. Lango, L. Anisimowicz, K. Roszak, W. Pawliszak, M. Narkiewicz CONCOMITANT MID CABG and LEFT LOWER LOBECTOMY - A CASE REPORT - page 236 AGATA LE¦NIAK, WIES£AWA TRACZ, PIOTR PODOLEC MARTA HLAWATY, MIECZYS£AW PASOWICZ

49. ACE Linked To Calcium Growth On Aortic Valve and in the bloodstream, raising the possibility that LDL carries the ACE into lesions, where the ACE then contributes to aortic valve disease development. http://www.washington.edu/newsroom/news/2002archive/10-02archive/k102202.html

Search Directories Reference Tools UW Home ... News and Events FOR IMMEDIATE RELEASE FROM: Walter Neary wneary@u.washington.edu DATE: Oct. 22, 2002 ACE linked to calcium growth on aortic valve Future studies may find that ACE inhibitors, a class of drugs now taken by people with high blood pressure, could slow down or prevent the development of aortic valve calcium, say University of Washington researchers. Currently, the only treatment for severe calcium in the aortic valve is surgical replacement. "Since we already know that ACE inhibition has benefit in a similar disease, atherosclerosis, further study of this therapy in calcific aortic valvular disease makes a lot of sense," says the lead author, Dr. Kevin O’Brien, an associate professor of medicine in the UW School of Medicine’s Division of Cardiology. In the study, published in the Oct. 22 issue of Circulation, O’Brien and colleagues analyzed 21 human aortic valves, either from autopsy or from people who were having their valves replaced. Angiotensin-converting enzyme, or ACE, was not detected in normal aortic valves, but was present in all valves with lesions. ACE was found in association with LDL cholesterol, both in lesions and in the bloodstream, raising the possibility that LDL carries the ACE into lesions, where the ACE then contributes to aortic valve disease development. The findings also raise the possibility that the association of ACE with LDL particles may be relevant to a number of diseases in which LDL accumulates, such as atherosclerosis and some renal diseases.

50. Statins May Help Aortic Valve Disease-KPRC-TV Health Center Statins may help aortic valve disease. By Amanda Gardner HealthScoutNews Reporter. In aortic valve disease, the valve doesn t open or shut properly. http://kprc-tvhealth.ip2m.com/index.cfm?pt=itemDetail&item_id=65498&site_cat_id=

51. Valve Surgery In Young Adult: Repair, Replacement, Ross Many times, patients with congenital or bicuspid aortic valve disease do not require aortic valve surgery until they are adults. http://www.clevelandclinic.org/heartcenter/pub/guide/disease/valve/youngvalve.ht

Heart Guide Vascular Guide History of Innovations About Us ... Dictionary Treating the Heart, Blood Vessels and Circulation Aortic Valve Surgery in the Young Adult Patient Repair, Replacement, and Ross Procedure written with Gosta Pettersson, M.D. Cleveland Clinic Heart Center Normal aortic valve Bicuspid aortic valve Bicuspid aortic valve is the most common type of aortic valve abnormality occurring in about two percent of the population. Instead of the normal three leaflets or cusps, the bicuspid aortic valve has only two. Without the third leaflet, the valve may be: well functioning (2/3 of bicuspid valves function well for life) stenotic - stiff valves that can not open or close properly leaky - not able close tightly (also called regurgitation) Other aortic valve abnormalities, congenital as well as aquired (for example rheumatic, infection radiation), occur but are less common. Many times, patients with congenital or bicuspid aortic valve disease do not require aortic valve surgery until they are adults. Most young patients are concerned about valve surgery because they want to: maintain an active, normal lifestyle, including sports, travel, pregnancy, etc.;

52. Aortic Valve Disease Subject aortic valve disease Topic Area Heart Disease Forum The Heart Forum Question Posted By Susan on Monday, September 21, 1998 http://www.medhelp.org/forums/cardio/archive/4000.html

Questions in The Heart Forum are being answered by doctors from The Cleveland Clinic Heart Center, consistently ranked the #1 Heart Center in America. Subject: Aortic Valve Disease Topic Area: Heart Disease Forum: The Heart Forum Question Posted By: Susan on Monday, September 21, 1998 Thank you for your time. I realize your answers will be somewhat general since you've not seen the patient. Dear Susan, I apologize greatly for the delay in answering your question, actually it was a technical problem- the comment section of the web site was minute-tiny and just for your qwestion only, and of course this precluded me being able to submit the answer until today when I just happened to check the site and it was all fixed! So here is your answer Susan and Good Luck. There are quite a few issues regarding your father's case which place him at much greater risk for major events while undergoing surgery (major risk factors for any cardiothoracic surgery are heart attack, stroke, and death.) For someone who simply needs an aortic vavle replacement and is otherwise healthy and fairly young the risk of these major events is around 5%- This #is variable from institution to institution and a little even from surgeon to surgeon.

53. High Cholesterol And Calcification Are To Blame For Aortic Valve Disease High cholesterol and calcification are to blame for aortic valve disease. No medical therapy has been proven to alter the progression of aortic valve disease. http://www.globaltechnoscan.com/12thJune-18thJune02/cholesterol.htm

Please register here to Search or Submit B usiness O pportunities REGISTER HERE LOGIN High cholesterol and calcification are to blame for aortic valve disease High cholesterol levels can lead to fatty deposits in the aortic valve. These deposits may induce undifferentiated cells to transform to bone-forming cells that calcify and narrow the aortic valve, according to researchers. Narrowing of the aortic valve is a common condition that causes the heart to have to squeeze harder to support normal blood flow, causing the heart muscle to enlarge and eventually fail. A study published today in Circulation authored by researchers at Northwestern and the Mayo Clinic is the first to explain the mechanism responsible for this process. Contact: Amanda Widtfeldt awidtfel@nmh.org Northwestern Memorial Hospital Home Technology transfer opportunities ... Contact

54. Valve Surgery At The Turn Of The Millennium|KLUWER Academic Publishers Does the postoperative echo make a difference? Section III Pre And PeriOperative Evaluation Of aortic valve disease. aortic valve disease. http://www.wkap.nl/prod/b/1-4020-7834-X?a=1

55. PillSupplier.com - Conditions And Diseases/Cardiovascular Disorders/Heart Diseas Category aortic valve disease. Conditions and Diseases/Cardiovascular Disorders/Heart Disease/Valvular/aortic valve disease. Links http://www.pillsupplier.com/dir/656/

Category: Aortic Valve Disease HOME ABOUT US ORDER STATUS BMI CALCULATOR ... CONTACT US Prescription Drugs Diet Pills Adipex Bontril Didrex ... Login Conditions and Diseases/Cardiovascular Disorders/Heart Disease/Valvular/Aortic Valve Disease Links: Adam.com: An Overview [rate it] [review it] A look at aortic insufficiency and its alternative names, causes, incidence and risk factors. American Heart Association [rate it] [review it] Defines aortic regurgitation and looks at the causes and what should be done. Aortic Stenosis - Overview [rate it] [review it] Adam.com looks at this disorder and its causes, risk factors and incidence. Aortic Valve Disease [rate it] [review it] A look at stenosis and regurgitation of this valve. Cardiothoracic Surgery Notes [rate it] [review it] A look at the types of disease of the aortic valve, incompetence, symptoms, diagnosis, natural history of stenosis and regurgitation. Facts about replacement surgery, the survival statistics and risk factors post operation. Heart Matters [rate it] [review it] A look at the symptoms, diagnosis and etiology of both stenosis and regurgitation of the aortic valve. Heart Surgery To Swimathon In Five Month [rate it] [review it] Personal story, support and fund-raising for cardiac patients.

56. Aortic Stenosis The procedure first involves determining the severity of the aortic valve disease and identification of the coronary artery anatomy. http://www.westsubcardiology.com/pages/cases/Aorticvalve/aorticstenosis.htm

West Suburban Cardiologists New: Indications for Endocarditis Prophylaxis Aortic Stenosis C alcific Aortic Stenosis is often a disease seen in the elderly. Symptomatic patients may report chest pain (angina), loss of consciousness (syncope), or shortness of breath (congestive heart failure). When severe or critical aortic stenosis is present and the patient has one of the symptoms mentioned above, surgery to replace the aortic valve is best course of action. H owever, many patients have other illnesses or problems that impose a high risk for major complications from cardiac surgery. Others have one of more contraindications for valve replacment. For these carefully selected patients, palliative (symptom relieving) Balloon Aortic Valvuloplasty can be offered. This procedure is not as durable as surgery nor does it offer the same benefits in terms of altering the natural history of the disease as is found with aortic valve replacement. Nevertheless, it is a resonable procedure for carefully selected patients who are otherwise unacceptable surgical candidates. The balloon procedure usually results in symptom improvement and increased functional capacity for the next 6-18 months. While re-narrowing of the valve is not uncommon, the procedure can be repeated safely and effectively if necessary. B alloon Aortic Valvuloplasty is performed in the cardiac catheterization lab in a manner similar to other types of cardiac catheterization including coronary angioplasty. An overnight hospital stay is almost always required. Most patients can be discharged within 24-48 hours after the procedure.

57. Aortic Valve Disease ....... aortic valve disease Definition. aortic valve disease entails damage to, and dysfunction of, the aortic valve, one of the four valves in the heart. http://ww3.komotv.com/global/story.asp?s=1230770&ClientType=Printable

58. Mitral And Aortic Valve Disease - General Practice Notebook mitral and aortic valve disease. Combined aortic and valve disease may be due to rheumatic fever; coexistent different degenerative http://www.gpnotebook.co.uk/cache/1550516261.htm

mitral and aortic valve disease Combined aortic and valve disease may be due to: rheumatic fever co-existent different degenerative pathologies, for example, floppy mitral valve and calcific aortic stenosis Click here for more information...

59. Gulfcoast Ultrasound Institute - Videotapes 4 aortic valve disease VWC1 (1998, 53 minutes) 2 AMA Cat.1 CME* * With additional $25.00 processing fee at time of CME test (also meets requirements for ARDMS http://www.gcus.com/video4.htm

The Cardiac Video Interpretation Workshop Series The VideoInterpretation Workshop Series is designed for the medical professional with a minimum of six months experience performing and/or interpreting ultrasound examinations. The videotape series features several case studies illustrating various types of pathology. Initially the clinical history is provided and the case is viewed. The ultrasound case is then reviewed a second time along with a narrated discussion of the actual ultrasound findings. After completing each video workshop, a series of written questions can be completed and returned to obtain CME credit. The objective of The Video Workshop Series is to enhance the physician and sonographer's ability to recognize and identify disease. The workshops are also an excellence source for registry preparation in conjunction with the P.A.S.S. Audiocassettes and Workbooks. $75.00 each

60. 6.5 Aortic Valve Disease 6.5 aortic valve disease Small nodules and fenestrations of the aortic valve cusps are common findings in normal horses. Fenestrations http://www.provet.co.uk/equinecardiology/5a66442.htm

6.5 Aortic valve disease Small nodules and fenestrations of the aortic valve cusps are common findings in normal horses. Fenestrations are usually found on the leading edge of the valve and may even be found in the fetus. Small nodules are more often found in older animals and become most common in horses over approximately seven years of age. These nodules are due to degenerative change, but frequently appear to have no effect on valve function. In some animals band-type lesions are found, and these are more often associated with signs of abnormal valve function. Nodules and bands are most frequently found on the right coronary cusp of the valve, although the left coronary cusp and the non-coronary cusp are also affected. Lesions, particularly those of a band-type, may result in valvular incompetence; however, there is no evidence that they ever result in sufficient obstruction to outflow to merit the term 'stenosis' (see section 6.5.4 ). Aortic regurgitation (AR) is quite common in older horses, but is occasionally found in younger animals. Topics 6.5.1 Auscultation

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