1. EMedicine - Anophthalmos : Article By Nick Mamalis, MD anophthalmos True or primary anophthalmos is very rare. Only when there is complete anophthalmos. Last Updated April 18, 2001, http://www.emedicine.com/oph/topic572.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Ophthalmology Globe Anophthalmos Last Updated: April 18, 2001 Rate this Article Email to a Colleague AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Nick Mamalis, MD , Director of Ophthalmic Pathology, Director of Intermountain Ocular Research Center, Professor, Department of Ophthalmology, University of Utah School of Medicine Nick Mamalis, MD, is a member of the following medical societies: American Academy of Ophthalmology American Medical Association American Society of Cataract and Refractive Surgery , and Association for Research in Vision and Ophthalmology Editor(s): Ron W Pelton, MD, PhD , Consulting Staff, Department of Surgery, Memorial Hospital; Donald S Fong, MD, MPH , Assistant Clinical Professor of Ophthalmology, UCLA School of Medicine; Consulting Physician, Department of Ophthalmology, Southern California Permamente Medical Group; Mark T Duffy, MD, PhD

2. EMedicine - Anophthalmos : Article Excerpt By: Nick Mamalis, MD anophthalmos True or primary anophthalmos is very rare. (advertisement). Excerpt from anophthalmos. Please click here to view the full topic text anophthalmos. http://www.emedicine.com/oph/byname/anophthalmos.htm

(advertisement) Excerpt from Anophthalmos Please click here to view the full topic text: Anophthalmos Background: True or primary anophthalmos is very rare. Only when there is complete absence of the ocular tissue within the orbit can the diagnosis of true anophthalmos be made. Extreme microphthalmos is seen more commonly. In this condition, a very small globe is present within the orbital soft tissue, which is not visible on initial examination. Anophthalmia and microphthalmia may occur secondary to the arrest of development of the eye at various stages of growth of the optic vesicle. It is important to recognize microphthalmia because the development of the orbital region, as well as the lids and fornices, is dependent on the presence of a normal-sized eye in utero. Anophthalmia may lead to serious problems in a child, not only due to the absence of a seeing eye, but also due to the secondary disfigurement of the orbit, lids, and eye socket. Early treatment with various expanders or surgery, when necessary, will help decrease the orbital asymmetry and cosmetic deformities in these children. Pathophysiology: Anophthalmia occurs when the neuroectoderm of the primary optic vesicle fails to develop properly from the anterior neural plate of the neural tube during embryological development. The more commonly seen microphthalmia can result from a problem in development of the globe at any stage of growth of the optic vesicle.

3. Anophthalmos And Orbital Implants anophthalmos And Orbital Implants While it is rare for a person to be born without an eye, it is unfortunately an all too frequent occurrence for patients to http://www.asoprs.org/Pages/anophthalmos.html

The American Society of Ophthalmic Plastic and Reconstructive Surgery Anophthalmos And Orbital Implants While it is rare for a person to be born without an eye, it is unfortunately an all too frequent occurrence for patients to experience loss of an eye due to trauma, infection or an underlying disease state. The first reported surgical removal of an eye (enucleation) was performed over four centuries ago. It is however, in the last century that the greatest strides have been made in perfecting this surgical procedure. Once an eye is removed it is important that the loss in orbital soft tissue be replaced with a suitable implant to provide normal cosmesis. The search for a well-tolerated orbital implant which gives an excellent appearance as well as good motility has covered the gamut of autogenous and alloplastic materials and implant designs. Almost every conceivable material known to man has been used as an orbital implant including: Magnets, gold, silver, glass, silicone, cartilage, bone, fat, cork, titanium mesh, acrylics, wool, rubber, catgut, peat, agar, asbestos, ivory, cellulose, paraffin, sponge, polyethylene and hydroxyapatite. In addition, a wide variety of implant shapes has been implanted in order to achieve an acceptable cosmetic result including: sphere, sphere with a truncated surface, sphere with a truncated surface and small "knobs projecting from the surface, etc. The most frequent complication associated with the majority of the "older" implants was extrusion of the implant. Other common complications included infection, migration, poor motility, contracted lid fornices and enophthalmos (sunken in appearance). In 1985, hydroxyapatite corraline sphere shaped implants were introduced. Hydroxyapatite is an inert, biocompatible and nontoxic material that has been in use in the medical field for over 15 years. Hydroxyapatite is a calcium phosphate hydroxide compound made up of multiple interconnecting pores. Because this is an inert porous substance, once implanted into the orbit it becomes vascularized and hence an integral part of the orbit. In recent years, porous polyethylene implants have been utilized in a similar fashion

4. 1914: Anophthalmos-microphthalmos Spectrum: Characterization Of Ophthalmic, Syst Program Nr 1914. anophthalmosmicrophthalmos spectrum characterization of ophthalmic, systemic and genetic features in a large series.N.K. Ragge, A.J. Vivian, R.B. Jones, J.R. Collin. Moorfields Eye Hospital, London, England. anophthalmos (absence of eye) is an extremely rare congenital anomaly http://www.faseb.org/genetics/ashg99/f1914.htm

Program Nr: 1914 Anophthalmos-microphthalmos spectrum: characterization of ophthalmic, systemic and genetic features in a large series. N.K. Ragge, A.J. Vivian, R.B. Jones, J.R. Collin. Moorfields Eye Hospital, London, England. Anophthalmos (absence of eye) is an extremely rare congenital anomaly occurring in 0.3-0.6/10,000 births. We reviewed 83 cases of anophthalmos (or extreme microphthalmic remnant), characterising the ocular, systemic and genetic features. Systemic findings included: cleft lip and palate, preauricular skin tags, facial clefting, dysplastic kidneys, corpus callosal dysgenesis, Delleman's syndrome, CHARGE, skin loss over chest wall, and branchio-oculo-facial syndrome. Possible etiologies included gestational exposure to varicella, carbamazepine and i.v. drug abuse. Autosomal recessive inheritance was implied in five cases which were the product of consanguinous marriages. One case had a strong family history of Waardenburg's syndrome. Seven cases had a family history of developmental eye anomalies or early onset blindness and 13 cases had a family history of relevant systemic features, such as deafness or cleft palate. The case with brachio-oculo-facial syndrome had an affected sibling and a cousin with 'cat-eye' phenotype. Only one case was known to have a chromosome anomaly - a Turner's mosaic. Seven families had a history of miscarriage. This series adds significantly to the world literature on anophthalmos and further clinical and genetic analysis may provide clues to the developmental ocular genetic process.

5. Anophthalmia (anophthalmos) Is A Condition That Means One, Or Both Eyes Didn’t Thanks to the gracious contribution from MACS (our sister support group in the United Kingdom), I now have a comprehensive definition leaflet about Anophthalmia, Microphthalmia, and Coloboma for you . http://www.angelfire.com/mi/microphthalmia/MACSmicroLeaflet.html

Thanks to the gracious contribution from MACS (our sister support group in the United Kingdom), I now have a comprehensive definition leaflet about Anophthalmia, Microphthalmia, and Coloboma for you. THANK YOU MACS! var cm_role = "live" var cm_host = "angelfire.lycos.com" var cm_taxid = "/memberembedded" A nophthalmia P rimary anophthalmia is a complete absence of eye tissue due to a failure of the part of the brain that forms the eye. I n secondary anophthalmia the eye starts to develop and for some reason stops, leaving the infant with only residual eye tissue or extremely tiny eyes which can only be seen under close examination. I n degenerative anophthalmia the eye started to form and, for some reason, degenerated. One reason for this occurring could be a lack of blood supply to the eye. T reatment T here is no cure for this condition. Sometimes the child may have other conditions or complications that may require monitoring. Prosthetic eyes can be fitted to the empty eye sockets which can sometimes involve surgery for reasons such as putting implants into the socket to make it easier to fit the prostheses. Prostheses are not just for cosmetic purposes but also help to promote the growth of the eye socket. Conformers, which are a bit like balloons that can be expanded inside the socket, are sometimes used to further encourage the growth of the socket. M icrophthalmia (microphthalmos) is a condition that means the eye(s) started to form during pregnancy but for some reason stopped, leaving the infant with small eyes. The size of the eye can vary from child to child. If very mild, It can almost go unnoticed but is usually

6. Anophthalmia And Microphthalmia Resource Guide [NEI] Publication about anophthalmia and microphthalmia (small eye syndrome). The ocularists' management of congenital microphthalmos and anophthalmos. Dootz GL stimulation is crucial for management of congenital anophthalmos and microphthalmos among infants http://www.nei.nih.gov/health/anoph

Health Funding News Laboratories ... Health Information Anophthalmia and Microphthalmia On this page: Other Names What are anophthalmia and microphthalmia? What causes anophthalmia and microphthalmia? Can anophthalmia and microphthalmia be treated? ... Medical Literature Related Topics: Diagram of the Eye Vision-Related TermsSelected Online Sources Finding an Eye Care Professional Talking to Your Doctor ... Eye Health Organizations Database New! The information provided in this Resource Guide was developed by the National Eye Institute to help patients and their families in searching for general information about anophthalmia and microphthalmia . An eye care professional who has examined the patient's eyes and is familiar with his or her medical history is the best person to answer specific questions. Other Names Anophthalmos and microphthalmos, small eye syndrome. What are anophthalmia and microphthalmia? Anophthalmia and microphthalmia are often used interchangeably. Microphthalmia is a disorder in which one or both eyes are abnormally small, while anophthalmia is the absence of one or both eyes. These rare disorders develop during pregnancy and can be associated with other birth defects. What causes anophthalmia and microphthalmia?

7. Anophthalmos Information Diseases Database anophthalmos Cryptophthalmia Cryptophthalmos Agenesis of eye Anophthalmia, Disease Database Information http://www.diseasesdatabase.com/sieve/item1.asp?glngUserChoice=29617

8. Eyeatlas - Online Atlas Of Ophthalmology Eyeatlas. The online Atlas of Ophthalmology. anophthalmos. © Copyright Oculisti OnLine. http://www.eyeatlas.com/box/04.htm

Eyeatlas The online Atlas of Ophthalmology Anophthalmos Oculisti OnLine

9. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies: Resources Help What's New About. Browse By Condition By Disease Heading Diseases and Abnormalities at or before Birth anophthalmos. Include trials that are no longer recruiting patients. 1 study was found. Molecular Analysis of Microphthalmia/Anophthalmia. Condition anophthalmos. U.S. National Library of http://clinicaltrials.gov/ct/screen/BrowseAny?path=/browse/by-condition/hier/BC1

10. Eyeatlas - Online Atlas Of Ophthalmology SLA Tilt Tilt Vertical dissociated deviation. GLOBE. anophthalmos anophthalmos. GLAUCOMA. Angle recession Glaucoma, Acute Glaucoma, Closure http://www.eyeatlas.com/contents.htm

ANATOMY Eye anatomy ANTERIOR CHAMBER Angle, Closure Angle, Pigmentation Anterior chamber IOL Atalamia ... Synchysis scintillans CHOROID Angioid Streaks CONJUNCTIVA Allergic conjunctivitis, Giant papillae Allergic conjunctivitis, Giant papillae Allergic conjunctivitis, Giant papillae Amyloidosis ... Vernal conjunctivitis CORNEA Abrasion Abrasion Abrasion Alkali burn ... Wilson's disease EXTRAOCULAR MUSCLES Accomodative strabismus Accomodative strabismus Brown's syndrome Duane's syndrome ... Vertical dissociated deviation GLOBE Anophthalmos Anophthalmos GLAUCOMA Angle recession Glaucoma, Acute Glaucoma, Closure angle Glaucoma, Closure angle ... Trabeculectomy, Bleb INTRAOCULAR PRESSURE Bleb after trabeculectomy Glaucoma cupping Neovascular glaucoma Pseudoexfoliatio IRIS AND CILIARY BODY Aniridia Anisocoria Ciliary body adenoma Coloboma ... Wilson's disease LACRIMAL SYSTEM Canaliculitis Canaliculitis Dacryoadenitis Dacryocele ... Pseudocanaliculitis LENS Aphakia, Surgical Capsular fibrosis Capsular fibrosis Capsule rupture ... Pseudoexfoliatio lentis LID Allergy, Atropine

11. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies: By Disease Heading Eye Diseases anophthalmos. Include trials that are no longer Molecular Analysis of Microphthalmia/Anophthalmia. Condition anophthalmos. U.S. National Library of http://clinicaltrials.gov/ct/screen/BrowseAny?path=/browse/by-condition/hier/BC1

12. Anophthalmos Information Diseases Database anophthalmos,Cryptophthalmia,Cryptophthalmos,Agenesis of eye,Anophthalmia, Disease Database Information. Medical information linksanophthalmos specific sites. http://www.diseasesdatabase.com/ddb29617.htm

Diseases Database Index Sponsors Contact ... Previous Page Anophthalmos Information Search 5 synonyms or equivalents were found. Anophthalmos aka/or Cryptophthalmia aka/or Cryptophthalmos aka/or Agenesis of eye aka/or Anophthalmia may be caused by or feature of (Follow link for list) may cause or feature (Follow link for list) belong(s) to the category of (Follow link for list) see also (Follow link for list) Anophthalmos: Definition(s) via UMLS Code translations and terms via UMLS Anophthalmos: specific sites Send Anophthalmos to medical search engines (JavaScript enabled browsers only) If your browser has no JavaScript you can still use these: Search using Internet medical databases Search using Internet search engines (non-specialist) We subscribe to the HONcode principles of the Health On the Net Foundation i-medicine.info - the evidence based medicine, informatics and audit portal Valid XHTML 1.0 Served 2004-06-02 08:45:34 Metadata Updated 2004-05-22

13. Eye Plastics Anophthalmos: Overview Page -Loss Of An Eye- Enclucleation, Eviscer anophthalmos, enucleation, porex, medpor, bioeye, bioeye, evisceration, eye trauma, anopthalmos, EyePlastics (Oculoplastics) Ophthalmic Plastic and http://www.eyeplastics.com/topics/anophthalmos/anophthalmos.htm

document.write(''+''); Alcon Allergan FCI-Ophthalmics IOP INC ... Stryker Leibinger document.write(''+''); Back to top Mark Scott Brown, M. D 702.973.7564 (fax) mark@eyeplastics.com (email) We subscribe to the HONcode principles of the Health On the Net Foundation The HIPAA Policy is available at any MD's Office Back to top Back to top Back to top Back to top ... Back to top Anophthalmos Overview Anatomy Before Surgery Guidelines After Surgery Guidelines ... Price Overview Definitions Etiology Goals in Surgery Movies ... Bottom of Page Definitions Anophthalmia is a medical term used to describe the absence of the globe and ocular tissue from the orbit. This was first reported more than 400 years ago, yet it is only recently that significant reconstructive options became available. There are many reasons why one might lose an eye. Surgeries which result in anophthalmos: Enucleation The entire eye iris, lens, vitreous, retina, and choroid) AND SCLERA are removed Muscles are detached from the sclera and may be re-attached to the implant The implant may be made of MEDPOR®,

14. Anophthalmia/Anophthalmos sonar" information. anophthalmosmicrophthalmos spectrum characterization of ophthalmic, systemic a tethered spinal cord. anophthalmos, clinical. anophthalmos, clinical. Nanophthalmia http://www.bdid.com/micropht.htm

15. ORPHANET® : Anophthalmos, Clinical Orphanet database access. anophthalmos, clinical. Summary True or primary anophthalmos is always associated with major brain defects incompatible with life. http://www.orpha.net/static/GB/anophthalmos.html

Orphanet database access Anophthalmos, clinical Direct access to data Summary Clinical signs Anophthalmos Autosomal recessive inheritance Blepharophimosis/short palp. fissures Microphthalmos Update : 01/06/2004 Orphanet database access

16. ORPHANET - Rare Diseases - Orphan Drugs Printing version, DISEASE anophthalmos, clinical, True or primary anophthalmos is always associated with major brain defects incompatible with life. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=1098

17. ANOPHTHALMOS Terms of Use. anophthalmos. Specialty Definition anophthalmos. Domain, Definition. Health. Congenital absence of the eye or eyes. Top. Usage Frequency anophthalmos. http://www.websters-online-dictionary.org/definition/english/An/Anophthalmos.htm

Philip M. Parker, INSEAD. ANOPHTHALMOS Specialty Definition: ANOPHTHALMOS Domain Definition Health Congenital absence of the eye or eyes. ( references Source: compiled by the editor from various references ; see credits. Top Usage Frequency: ANOPHTHALMOS ANOPHTHALMOS " is generally used as a noun (plural) approximately 100.00% of the time. " ANOPHTHALMOS " is used about 2 times out of a sample of 100 million words spoken or written in English. Its rank is based on over 700,000 words used in the English language. Some parts-of-speech are not covered due to the samples used by the British National Corpus. (note: percents less than one-hundredth of one percent have been omitted) Parts of Speech Percent Usage per 100 Million Words Rank in English Noun (plural) Source: compiled by the editor from several corpora ; see credits. Top Modern Translation: ANOPHTHALMOS Language Translations for "ANOPHTHALMOS"; alternative meanings/domain in parentheses. Danish anophtalmi (anophthalmia, anophthalmus). ( various references Dutch anophthalmos (anophthalmia, anophthalmus)

18. LookSmart - Directory - Micropthalmos Micropthalmia Anophthalmia & Anophthalmos Micropthalmos Micropthalmia Anophthalmia anophthalmos Learn about cause, symptoms, diagnosis, treatment, personal support of this small or missing eye http://search.looksmart.com/p/browse/us1/us317837/us317920/us53948/us71238/us274

@import url(/css/us/style.css); @import url(/css/us/searchResult1.css); Home IN the directory this category YOU ARE HERE Home Personal Health Eye Conditions Directory Listings About International Children's Anophthalmia Network - ican Nonprofit group provides support for families of children born without eyes. Includes a bulletin board and newsletter. MACS Presented by the Micro and Anophthalmic Children's Society, this site provides a general medical overview, and links to other resources. Support group for children suffering from this group of congenital eye defects. Offers a newsletter and discussion forum. National Eye Institute - Anophthalmia and Microphthalmia Provides patient information about this rare disorder, including causes, treatment, and additional resources. Microphthalmia-A Singular View Created by a mother whose son has been diagnosed with microphthalmos, this site includes links to other informative resources. We're always looking for ways to improve your search experience. Tell us how we're doing. Join the Zeal community and help IN the directory this category About Us Advertise with Us Advertiser Log-in Terms of Service

19. Anophthalmia/Anophthalmos Anophthalmia/anophthalmos. anophthalmos, clinical; anophthalmos, clinical; Nanophthalmia; Anophthalmia and microphthalmia the search for an answer; http://www.bdid.com/anophthalmia.htm

HOME Anophthalmia/Anophthalmos ANOPHTHALMOS, TRUE OR PRIMARY International Children's Anophthalmia Network Clinical (Microphthalmia/Microphthalmos/Nanophthalmia/Nanophthalmos, Autosomal Recessive) Microphthalmia, Anophthalmia and other related eye disorders Steven has microphthalmia (small eye), partial aniridia (absence of iris) and retinal coloboma (closure defects) No Title Available - "sonar" information Status of Pesticides in Registration, Reregistration... - "sonar" information Anophthalmos-microphthalmos spectrum: characterization of ophthalmic, systemic and genetic features in a large series Microphthalmos Franchesca has anophthalmia Microphthalmia and Anophthalmia - this has a message board for other parents. here is the real important information on the site re: environmental pollutants - at the bottom of the page there are some links to pesticide information Anophthalmia/Microphthalmia - chat site for parents and people with these conditions International Children's Anophthalmia Network A public forum for questions - about microphthalmia and other optic conditions PubMed medline query - this is a page which has some links to environmental effects/microphthalmos, but you have to pay for the reports...

20. X-LINKED ANOPHTHALMOS Features Listed For XLINKED anophthalmos. McKusick 301590. Anophthalmia; Auricular tags; Microphthalmia; Synechiae/fused eyelids/ankyloblepharon. http://www.hgmp.mrc.ac.uk/dhmhd-bin/hum-look-up?2144

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