1. ALS Association Information about this nonprofit health organization that is dedicated solely to the fight against amyotrophic lateral sclerosis, Lou Gehrigs Disease. http://www.alsa.org/

Continental Crusade to Benefit ALSA From the Dedication of Children Former Newscaster's Trip to Washington Symbolizes ALSA Advocacy Fenton Art Glass Company Partners with ALSA ... Help Us Help You The ALS Association National Office: 27001 Agoura Road, Suite 150, Calabasas Hills, CA 91301, Tel: (818) 880-9007 The information contained on this web site may not be published, broadcast or otherwise distributed without the prior written authorization of The ALS Association. ALSA Webmaster

2. NINDS Amyotrophic Lateral Sclerosis Information Page ALS or Lou Gehrig's disease information sheet compiled by NINDS, the National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/health_and_medical/disorders/amyotrophiclateralsclerosi

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about Amyotrophic Lateral Sclerosis Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health NINDS Amyotrophic Lateral Sclerosis Information Page Synonym(s): Lou Gehrig's Disease Reviewed 07-01-2001 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Amyotrophic Lateral Sclerosis? Is there any treatment? What is the prognosis? What research is being done? ... Additional resources from MEDLINEplus What is Amyotrophic Lateral Sclerosis? Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease, is a progressive, fatal neurological disease affecting as many as 20,000 Americans with 5,000 new cases occurring in the United States each year. The disorder belongs to a class of disorders known as motor neuron diseases. ALS occurs when specific nerve cells in the brain and spinal cord that control voluntary movement gradually degenerate. The loss of these motor neurons causes the muscles under their control to weaken and waste away, leading to paralysis. ALS manifests itself in different ways, depending on which muscles weaken first. Symptoms may include tripping and falling, loss of motor control in hands and arms, difficulty speaking, swallowing and/or breathing, persistent fatigue, and twitching and cramping, sometimes quite severely. ALS strikes in mid-life. Men are about one-and-a-half times more likely to have the disease as women.

3. World Federation Of Neurology Amyotrophic Lateral Sclerosis This website is sponsored by the World Federation of Neurology to link researchers and clinicians worldwide with the goal of finding effective treatment and a cure for ALS. http://www.wfnals.org/

World Federation of Neurology Amyotrophic Lateral Sclerosis This web site is sponsored by the World Federation of Neurology Research Group on Motor Neuron Diseases to link researchers and clinicians worldwide with the goal of finding effective treatment and a cure for ALS. What's New Clinics (posted 31 May 2004) - Two new clinics have been added from Australia. For Your Information Information is available about the WFN Research Group on Motor Neuron Diseases including membership and the journal. The Website Management Committee oversees this website. Please note the Committee cannot respond to individual medical inquiries. Recent version browsers, such as Internet Explorer 5+/, or Opera 5+, are required to properly view this website. The Latest Research News Alzheimer Research Forum News The Alzheimer Research Forum's editorial staff researches and reports on the most recent advances of relevance to neurodegenerative disease research, and they are generously sharing this information on the WFN ALS website because of our common research interests. The news items will be updated continously and clicking on the story's title will take you to the Alzforum website for the full story: Courtesy of: This site was generously initiated by the Henry M. Unger Family Foundation

4. Amyotrophic Lateral Sclerosis Fact Sheet A fact sheet about symptoms, diagnosis, treatment, and research on ALS, Motor Neuron Disease, or Lou Gehrig's Disease from the National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/health_and_medical/pubs/als.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about a disorder Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health Amyotrophic Lateral Sclerosis Fact Sheet Get Web page suited for printing Email this to a friend or colleague Request free mailed brochure Table of Contents What is amyotrophic lateral sclerosis? Who gets ALS? What are the symptoms? How is ALS diagnosed? ... Where can I find more information? What is amyotrophic lateral sclerosis? Amyotrophic lateral sclerosis (ALS), sometimes called Lou Gehrig's disease, is a rapidly progressive, invariably fatal neurological disease that attacks the nerve cells (neurons) responsible for controlling voluntary muscles. The disease belongs to a group of disorders known as motor neuron diseases

5. Amyotrophic Lateral Sclerosis: Lou Gehrig's Disease - March 15, 1999 - American amyotrophic lateral sclerosis Lou Gehrig's Disease. ANNE D. WALLING, M.D. University of Kansas School of Medicine. Wichita, Kansas amyotrophic lateral sclerosis (ALS), commonly called Lou Gehrig's disease, is a progressive neuromuscular http://www.aafp.org/afp/990315ap/1489.html

Advanced Search Amyotrophic Lateral Sclerosis: Lou Gehrig's Disease ANNE D. WALLING, M.D. University of Kansas School of Medicine Wichita, Kansas A myotrophic lateral sclerosis (ALS) was first described in 1869. It is frequently referred to as "Lou Gehrig's disease" in memory of the famous baseball player who died of ALS in 1941. ALS is defined as adult-onset, idiopathic, progressive degeneration of anterior horn cells and upper and lower motor neurons resulting in progressive muscle weakness, wasting and fasciculations. The clinical picture varies, depending on the location and progression of the pathologic changes. Diagnostic criteria of the World Federation of Neurology (the "El Escorial criteria") can help define and classify ALS ( Table 1 Illustrative Case 1 Bulbar Form Relatives of a 61-year-old woman reported that she appeared to have difficulty concentrating during long discussions. Apart from longstanding thyroid and estrogen supplementation, her medical history was unremarkable. Review of systems, a mental status examination and a physical assessment were normal. The patient was a psychologist who usually read several books a week and had an active social life, including competitive bridge and vigorous daily exercise. She had no symptoms of depression, or mental or intellectual difficulties, and denied alcohol or substance abuse. She believed her family's concerns were unwarranted but eventually conceded that her voice "just wore out" during prolonged conversations.

6. ALS Survival Guide - Amyotrophic Lateral Sclerosis - Lou Gehrig's Disease Information and hope to those with ALS or Lou Gehrig's Disease news, research, treatments, adaptive equipment, advocacy, discussion group, more. to people with Amyotrophic. Lateral Sclerosis http://www.lougehrigsdisease.net/

Offering hope to people with Amyotrophic Lateral Sclerosis [ Home ] What is ALS? ALS News Causes of ALS Vital Stats ... www.alssurvivalguide.com and www.lougehrigsdisease.net ALS can conquer the body but not the mind and the spirit! Stay strong in your hearts dear PALS. This website is dedicated to the loving memory of Douglas Edwin Eshleman, who lost his battle with ALS on Wednesday, November 28, 2001. Thank you for all your thoughts and prayers during this difficult time. The Discuss ALS Forum has been graciously continued by PALS Patrick Madigan. Click here to go to DiscussALS.com What is New? 3rd Annual Walk to d'feet ALS will be held in Cincinnati, Ohio on Sunday, September 21, 2003 and in Columbus, Ohio on Sunday, September 28, 2003. See the Support Group page for more information. 11-25-01 Doug's last Journal entry.

7. MedlinePlus: Amyotrophic Lateral Sclerosis N O P Q R S T U V W XYZ List of All Topics. amyotrophic lateral sclerosis amyotrophic lateral sclerosis. You may also be interested in these MedlinePlus related http://www.nlm.nih.gov/medlineplus/amyotrophiclateralsclerosis.html

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Other health topics: A B C D ... List of All Topics Amyotrophic Lateral Sclerosis Contents of this page: News From the NIH General/Overviews Coping ... Children Search MEDLINE for recent research articles on Amyotrophic Lateral Sclerosis You may also be interested in these MedlinePlus related pages: Brain and Nervous System Latest News Gene Therapy Improves Survival of Mice with ALS (05/26/2004, Reuters Health) From the National Institutes of Health Amyotrophic Lateral Sclerosis (ALS) (National Institute of Neurological Disorders and Stroke) Also available in: Spanish General/Overviews Amyotrophic Lateral Sclerosis (Patient Education Institute) - - requires Flash plug-in Also available in: Spanish Amyotrophic Lateral Sclerosis (ALS) (Muscular Dystrophy Association) Clinical Trials ClinicalTrials.gov: Amyotrophic Lateral Sclerosis (National Institutes of Health) Coping ALS Association's Patient Bill of Rights for People Living with ALS (ALS Association) For Caregivers (ALS Association) Reasons for Living with ALS (ALS Association) When a Loved One Has ALS: A Caregiver's Guide (Muscular Dystrophy Association) Diagnosis/Symptoms Creatine Kinase Test (Muscular Dystrophy Association) Electromyography and Nerve Conduction Velocities (Muscular Dystrophy Association) Disease Management Rehabilitation Approach to Adaptive Devices and Equipment and Techniques (ALS Association) Talking with Technology (Muscular Dystrophy Association) Research

8. A Taylor & Francis Health Sciences Journal: Amyotrophic Lateral Sclerosis And Ot Official journal of the World Federation of Neurology Research Group on Motor Neuron Disease publishes clinical and experimental reasearch on motor neuron disorders. Published 4 times a year by Taylor Francis Health Sciences. http://www.tandf.co.uk/journals/titles/14660822.asp

Contact Us Members of the Group All Products Books Journal Article eBooks Alphabetical Listing Journals by Subject Advertising Customer Services ... eBooks Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders The official publication of the World Federation of Neurology Research Group on Motor Neuron Disease Editor: Michael Swash , London, UK Editorial Information Publication Details: Volume 5, 2004, Quarterly ISSN Print 1466-0822 ISSN Online 1471-180X 2004 Subscription Rates Subscribe Online! Institutional: US$410/£248 Individual: US$156/£95 of CrossRef SARA (Free contents alerting service) Online Sample Copy Visit the Health Sciences Website Instructions for Authors Table of Contents (Available Online from Volume 1) Aims and Scope: Amyotrophic Lateral Sclerosis provides outstanding coverage of research in a wide range of issues related to motor neuron diseases, especially ALS (Lou Gehrig's disease) and spinal muscular atrophies. The journal also covers related disorders of the motor system, when relevant to these core diseases. Amyotrophic Lateral Sclerosis aims to disseminate information on new developments in the pathogenesis and management of motor neuron disease, and enhance awareness of these devastating and often under-recognised disorders.

9. Les Turner ALS Foundation- Fighting Lou Gehrig's Disease The nation's largest, independent amyotrophic lateral sclerosis (ALS) organization devoted to raising money for research, patient services and educational materials and to maintaining quality of life for every person with Lou Gehrig's disease. http://www.lesturnerals.org/

The Les Turner ALS Foundation is the only independent publicly supported non-profit organization in the Chicago-area devoted solely to the treatment and elimination of amyotrophic lateral sclerosis (ALS), better known as Lou Gehrig's disease. What's New! The Foundation is affiliated with Northwestern University's Feinberg School of Medicine, Community Health Charities of Illinois and the International Alliance of ALS/MND Associations. Contact Us Site Map Join Our Mailing List Les Turner ALS Foundation 8142 North Lawndale Avenue, Skokie, IL 60076-3322 var MenuLinkedBy='AllWebMenus [2]', awmBN='502'; awmAltUrl='';

10. Amyotrophic Lateral Sclerosis - General Practice Notebook Clinicallyoriented information. http://www.gpnotebook.co.uk/simplepage.cfm?ID=-268042240

11. Amyotrophic Lateral Sclerosis Alzheimer disease. amyotrophic lateral sclerosis. Angelman syndrome amyotrophic lateral sclerosis. amyotrophic lateral sclerosis (ALS) is a neurological disorder characterized by http://www.ncbi.nlm.nih.gov/disease/ALS.html

This Genes and Disease page has been moved to: Please update your bookmarks. If you are not automatically transported to the new page after 15 seconds, click on this link Genome View on chromosome 21 Databases PubMed the literature LocusLink collection of gene-related information OMIM catalog of human genes and disorders Protein structure the molecule in 3D Information The ALS Association research and patient support ALS Fact sheet from the National Institute of Neurological Disorders and Stroke MEDLINE plus links on ALS compiled by the National Library of Medicine AMYOTROPHIC LATERAL SCLEROSIS (ALS) is a neurological disorder characterized by progressive degeneration of motor neuron cells in the spinal cord and brain, which ultimately results in paralysis and death. The disease takes its less-scientific name from Lou Gehrig, a baseball player with the New York Yankees in the late 1920s and 1930s, who was forced to retire in 1939 as a result of the loss of motor control caused by the disease. In 1991, a team of researchers linked familial ALS to chromosome 21. Two years later, the SOD1 gene was identified as being associated with many cases of familial ALS. The enzyme coded for by SOD1 carries out a very important function in cells: it removes dangerous superoxide radicals by converting them into non-harmful substances. Defects in the action of this enzyme mean that the superoxide radicals attack cells from the inside, causing their death. Several different mutations in this enzyme all result in ALS, making the exact molecular cause of the disease difficult to ascertain.

12. Boulianne Lab. The Hospital For Sick Children. Toronto, Ontario, Canada. Her laboratory has been using genetic techniques available in Drosophila to study the development and the function of the nervous system. They have developed models of aging and human neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Alzheimer's Disease (AD). From the University of Toronto (Canada). http://www.utoronto.ca/gboullab/

Program in Developmental Biology Hospital for Sick Children Gabrielle Boulianne Staff Alumni Research ... Links University of Toronto Mail comments, questions and suggestions to jamie.hughes@utoronto.ca Last updated January 6, 2003 Hospital for Sick Children

13. Mycoplasma Information on the role of mycoplasma infections within amyotrophic lateral sclerosis. http://www.goulburn.net.au/~shack/mycoplasma.htm

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14. What Is ALS? Back to Top. What do the letters ALS stand for? ALS stands for amyotrophic lateral sclerosis. Like many medical terms it comes from Greek words. http://www.lougehrigsdisease.net/als_what_is_als.htm

Offering hope to people with Amyotrophic Lateral Sclerosis Home [ What is ALS? ] ALS News Causes of ALS Vital Stats Treatments ... Doug's Journal What is ALS? and 44 other frequently asked questions about the disease. What is ALS? What do the letters ALS stand for? When was ALS first discovered? Are there are other names for ALS? ... Is there anything I can do to help find a cure for ALS? What is ALS? ALS is a fatal neuromuscular disease characterized by progressive muscle weakness resulting in paralysis. Back to Top What do the letters ALS stand for? ALS stands for Amyotrophic Lateral Sclerosis. Like many medical terms it comes from Greek words. A—without Myo—muscle Trophic—nourishment Lateral—side (of the spinal cord) Sclerosis—hardening or scarring For more definitions of ALS related terms, please go to the Dictionary page. Back to Top When was ALS first discovered? ALS was first described in scientific literature in 1869 by the French neurologist Jean-Martin Charcot.

15. Welcome To TriOne Held in Alameda in the San Francisco Bay area in August. TriOne is a nonprofit triathlon with all proceeds directly benefiting ALS (amyotrophic lateral sclerosis) research. ALS is more commonly known as Lou Gehrig's Disease. http://www.trione.org/

16. ALS MA Chapter Statewide amyotrophic lateral sclerosis group; information on disease, services, and newsletter. http://www.als-ma.org/

The ALS Massachusetts Chapter is a multi-faceted grass-roots organization that carries out ALSA's mission and strategic goals at the community level. The chapter - with supporting services from the National Office - actively pursues The Association's goals. Primarily, ALS MA Chapter exist to serve people with ALS, their families and caregivers. The ALS MA chapter offers the following programs: Educational Support groups Telephone information Equipment loan programs Respite programs Referrals programs Research programs STRIKE OUTS WINS 105.7 WROR TEAMS UP WITH CURT SCHILLING . . . VIEW DETAILS Clinical Update From ALSA’s National Office . . . VIEW DETAILS ... VIEW DETAILS 75 McNeil Way, 201 - Dedham, MA 02026 - Dedham Office: 888-CURE ALS 7 Lincoln Street - Wakefield, MA 01880 - Wakefield Office: 781-245-2133 Patient Line: 800-258-3323 Powered By ContentPlus - WebAxis, Inc.

17. Amyotrophic Lateral Sclerosis Neuroland. Search NeuroLand. Neuro diseaseNotes. Practice Hints. Relax page. Search for medical info. Neuro Med. amyotrophic lateral sclerosis( ALS) Overview. Also known as Motor neuron disease, Lou http://www.neuroland.com/deg/als.htm

Neuroland Neurology information Click on the brain to index page Search NeuroLand Neuro disease Notes ... Neuro Med Amyotrophic Lateral Sclerosis (ALS) Overview Also known as: Motor neuron disease, Lou Gehrig's disease a number of overlapping syndromes such as pseudobulbar palsy, progressive bulbar palsy, progressive muscular atrophy and primary lateral sclerosis. Annual incidence is approximately 1/100,000 population Pockets of high incidence in Guam (ALS-Parkinson-dementia complex), the Kii peninsula of Japan, and western New Guinea. 95% of cases in the US are of the sporadic variety, but a few families have several members with the typical clinical picture of sporadic ALS arising in an autosomal dominant pattern. Onset of the disease can be as early as the third decade of life, most cases begin after age 40, and the incidence increases into the eighth decade. Etiology: unknown Male = Female Symptoms Slowly progressive muscle weakness involving the limbs, trunk, respiratory muscles, throat, and tongue. Onset is insidious, and initial symptoms may be confined to a single limb, especially the distal muscles.

18. MedlinePlus Medical Encyclopedia: Amyotrophic Lateral Sclerosis amyotrophic lateral sclerosis. amyotrophic lateral sclerosis is caused by progressive loss of motor nerves in the spinal cord and brain. http://www.nlm.nih.gov/medlineplus/ency/article/000688.htm

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Amyotrophic lateral sclerosis Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Central nervous system Alternative names Return to top Lou Gehrig's disease; ALS Definition Return to top A disease of the motor nerve cells in the brain and spinal cord, causing progressive loss of motor control. Causes, incidence, and risk factors Return to top Amyotrophic Lateral Sclerosis is caused by progressive loss of motor nerves in the spinal cord and brain. In about 10% of cases, ALS is caused by a genetic defect. In other cases, the cause of the nerve deterioration is unknown. ALS affects approximately 1 out of 100,000 people. Except for having a family member affected with the hereditary form of the disease, there are no known risk factors. Symptoms Return to top Symptoms usually do not develop until until after age 50. Progressive loss of muscle strength and coordination eventually interfere with the ability to perform routine activities, such as going up steps, getting out of a chair, or swallowing. Occasionally, breathing or swallowing muscles may be the first to be affected. As the disease progresses, more muscle groups are affected and patients become progressively incapacitated. There is no effect on the ability to think or reason.

19. Home Of The ALSA North Texas Chapter improving the quality of life for those living with amyotrophic lateral sclerosis (ALS), both patients and caregivers, and to support research to find a cure. http://www.alsanorthtexas.org/

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20. Amyotrophic Lateral Sclerosis (ALS) (aka Lou Gehrig's Disease) | MDA Receive email news, tips and updates from MDA or ask us a quick question. amyotrophic lateral sclerosis (ALS) http://www.mdausa.org/disease/als.html

Amyotrophic Lateral Sclerosis (ALS) (Also known as Lou Gehrig's Disease) Click for and MDAchats Receive e-mail news, tips and updates from MDA or ask us a quick question. Quick Definition: Adulthood. Generalized weakness and muscle wasting with cramps and muscle twitches common. ALS first affects legs, arms and/or throat muscles. Usually progresses rapidly with 3 to 5 year average survival. Autosomal dominant, autosomal recessive. Find Your Local MDA Do you need to find MDA in your city? Enter your Zip code here for where to turn for clinics and medical services; support groups; summer camp; local events and volunteer and fund-raising opportunities close to home. For more articles and references, please use the search feature Basic References Special ALS Materials FAQ's and Simply Stated Articles ... News Releases Basic References Facts About ALS "Ask the Experts" Responses about ALS: Diagnosis, Symptoms and Treatments Diseases Related or Often Confused With ALS General Neuromuscular Questions Genetics and Neuromuscular Diseases ... General Interest Publications Special ALS Materials ‘How the MDA Clinic can make a difference’ ALS Fall Conference with Dr. Bradley - Part 1

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