21. Atlas Of Pathology Picture of the heart affected by amyloidosis by the Urbana Atlas of Pathology. http://www.med.uiuc.edu/PathAtlasf/Atlas69.html

Back to Previous Image URBANA ATLAS OF PATHOLOGY Image Number 69 - Heart, amyloidosis Arrow 1 depicts the peripherally located nuclei in the cross section of cardiac muscle . Notice the wide spacing between the cardiac muscle cells. This is due to the deposition of amyloid seen for example at arrow 2. This is being viewed with non-polarized light. With this stain the amyloid is a light salmon pink. Click for image To Next Image To Table of Contents To Alphabetical Index To Start

22. Amyloidosis a CHORUS notecard document about amyloidosis Disclaimer. Feedback. Search. amyloidosis. rare, usually systemic disease Related documents amyloidosis gastrointestinal manifestations. phakomatoses. BeckwithWiedemann syndrome http://chorus.rad.mcw.edu/doc/01141.html

CHORUS Collaborative Hypertext of Radiology Multisystem entities Feedback Search amyloidosis rare, usually systemic disease extracellular deposition of insoluble B-pleated sheet configured protein that stains with Congo red systemic (80-90%) primary often presents with renal insufficiency or CHF secondary multiple myeloma rheumatoid arthritis familial Mediterranean fever chronic infection (TB, syphillis) localized (10-20%) manifestations chest tracheal nodules/narrowing pulmonary nodules diffuse parenchymal pattern heart: enlargement (Tc-99m pyrophosphate positive) kidneys large kidneys small kidneys focal masses calcifications bladder/ureters: focal or diffuse infiltration bones: pain/weakness associated with lytic lesions +/- calcium joints (shoulder, elbow, wrist, hip) ST enlargement subchondral cysts gastrointestinal tract Brian Funaki, MD - 14 February 1995 Last updated 26 May 2004 Medical College of Wisconsin

23. Amyloidosis Support Network - What Is Amyloidosis? What Is amyloidosis? amyloidosis is a group of diseases in which one or more organ systems in the body accumulate deposits of abnormal proteins. http://amyloidosis.org/whatisit.asp

Search ASN About Us Site Map Email a Friend Previous Browse Please help... Your donation will go for research to help find a cure... learn more! What Is Amyloidosis? Amyloidosis is a group of diseases in which one or more organ systems in the body accumulate deposits of abnormal proteins. The name "amyloidosis" was first used more than 100 years ago but cases were described over 300 years ago. However, only within the past 20 years have physicians understood the specific make-up and structure of amyloid protein. Although amyloidosis is not cancer, it is very serious. It may be disabling or life threatening. However, growing awareness of the condition seems to be leading to substantial new research and treatment alternatives. There are three major types of amyloidosis that are all very different from each other: 1. PRIMARY AMYLOIDOSIS is a plasma cell disorder which originates in the bone marrow and is usually treated with chemotherapy. It is the most common type of amyloidosis in the United States, with estimates of up to 2000 cases diagnosed each year, and occasionally occurs with multiple myeloma. The deposits in this type of the disease are made up of immunoglobulin light chain proteins which may be deposited in any bodily tissues or organs. The disease results when enough amyloid protein builds up in one or more organs to cause the organ(s) to malfunction. The heart, kidneys, nervous system and gastrointestinal tract are most often affected.

24. Amyloidosis amyloidosis. An Article by Linda Tintle, DVM Published in the July/August 1993 issue of The Barker What is amyloidosis? A http://home.olemiss.edu/~lwaej/sharamli.html

AMYLOIDOSIS An Article by Linda Tintle, DVM Published in the July/August 1993 issue of The Barker What is Amyloidosis? A generic term for a collection of diseases that result in the abnormal deposition of amyloid protein throughout the body. How is Amyloid Made? When inflammation occurs, certain chemicals are produced and released into the blood. These chemicals of inflammation are called the Acute Phase Reactant Proteins (APP). After the inflammation has gone away, the APP are broken down by the body and excreted. Dogs (or people) with amyloidosis can't break these APP down into excretable form and instead turn it into Amyloid AA and dump it outside the cells but still within the body. Why does the Amyloid make them sick? Amyloid is constantly deposited outside the cells. It builds up like a garbage heap in an alley vay until it starts to squeeze the adjacent cell walls. The compressed cells can't work properly. The damage or disease that results depends on what kinds of body cells are most severely damaged or killed. Kidncys can't heal themselves by growing new kidney cells. If a kidney cell dies, it is gone for good and can't be replaced. This is why the amyloid protein usually causes kidney failure first.

25. AL Primary Cutaneous Amyloidosis A case study. Some very explicit pictures. http://matrix.ucdavis.edu/DOJvol1num2/amyloidosis/amyloidosis.html

(6) Long-term AL primary amyloidosis. A case report by Vera A. Chotzen M.D. Regina Gandour-Edwards M.D. Michael K. Zang M.D. Phil Vogt M.D. Dermatology Online Journal, December 1995 Volume 1, Number 2 ABSTRACT This is a case report of AL primary amyloidosis with involvement limited to the skin for more than twenty years before the development of internal organ involvement. The clinical features suggested the systemic form of amyloidosis, rather than that found with nodular cutaneous amyloidosis. Introduction Longstanding lesions of nodular amyloidosis even in the face of a negative workup for internal involvement, can be consistent with systemic disease. This is an example of a patient who had extensive cutaneous amyloidosis for twenty years before developing cardiac involvement which then lead to her death. Patients who present with cutaneous features of amyloidosis usually undergo an evaluation to categorize the disease. Skin biopsy with ultrastructural immunohistochemical stains can help confirm the presence and subtype of amyloid. Once a patient has been found to have cutaneous amyloidosis, an extensive workup must be done to evaluate patients for the possibility of systemic involvement. Workup for systemic disease includes: serum and urine immunoelectrophoresis, rectal mucosal or abdominal fat biopsy, bone marrow biopsy, CBC, chemistry panel, and skull and spine X-rays. The origin of the amyloid and the extent of internal involvement are used to determine the approach to treatment.

26. Treatment Of Amyloidosis, Mayo Clinic In Rochester, Minn. Treatment of amyloidosis at Mayo Clinic in Rochester. Amyloid serious. It may be disabling or lifethreatening. How is amyloidosis diagnosed? http://www.mayoclinic.org/amyloidosis-rst/

Home About Mayo Clinic Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Amyloidosis Amyloidosis Treatment Disease Characteristics Lifestyle Management Appointments ... Medical Services Treatment of Amyloidosis at Mayo Clinic in Rochester Amyloid (pronounced am'-i-loyd) is an abnormal protein that may be deposited in your body's tissues or organs. This abnormal protein comes from cells in your bone marrow. Amyloidosis (pronounced am-i-loy-do'-sis) results when enough amyloid protein builds up in one or more organs to cause the organ(s) to malfunction. The heart, kidneys, nervous system, and gastrointestinal tract are most often affected. Amyloidosis is a disease of the bone marrow. Your bone marrow makes protective antibodies. Antibodies are proteins that protect you against infection and disease. After they have served their function, these antibodies are broken down and recycled by your body. In amyloidosis, cells in the bone marrow produce antibodies that cannot be broken down. These antibodies then begin to build up in the bloodstream. Ultimately, they leave the bloodstream and can deposit in your tissues as amyloid. Cases of amyloidosis were described 350 years ago. The name "amyloidosis" was first used more than 100 years ago. Only within the past 20 years have physicians understood the specific makeup and structure of amyloid protein. Active research on amyloidosis is under way at Mayo Clinic.

27. Atlas Of Pathology A gross specimen of a liver by Urbana Atlas of Pathology. http://www.med.uiuc.edu/PathAtlasf/Atlas67.html

Back to Previous Image URBANA ATLAS OF PATHOLOGY Image Number 67 - Liver, amyloidosis This is a gross specimen of a liver. In comparison to a normal liver, this one has a gray-red and glassy appearance. This is especially noticeable in the areas to the right and left of the "6" mark on the ruler. Had this liver been stained with Lugol's solution, (an iodine containing solution) the amyloid would have stained a mahogany brown. Click for image To Next Image To Table of Contents To Alphabetical Index To Start

28. AL Primary Cutaneous Amyloidosis (6) Longterm AL primary amyloidosis. Patients who present with cutaneous features of amyloidosis usually undergo an evaluation to categorize the disease. http://dermatology.cdlib.org/DOJvol1num2/amyloidosis/amyloidosis.html

(6) Long-term AL primary amyloidosis. A case report by Vera A. Chotzen M.D. Regina Gandour-Edwards M.D. Michael K. Zang M.D. Phil Vogt M.D. Dermatology Online Journal, December 1995 Volume 1, Number 2 ABSTRACT This is a case report of AL primary amyloidosis with involvement limited to the skin for more than twenty years before the development of internal organ involvement. The clinical features suggested the systemic form of amyloidosis, rather than that found with nodular cutaneous amyloidosis. Introduction Longstanding lesions of nodular amyloidosis even in the face of a negative workup for internal involvement, can be consistent with systemic disease. This is an example of a patient who had extensive cutaneous amyloidosis for twenty years before developing cardiac involvement which then lead to her death. Patients who present with cutaneous features of amyloidosis usually undergo an evaluation to categorize the disease. Skin biopsy with ultrastructural immunohistochemical stains can help confirm the presence and subtype of amyloid. Once a patient has been found to have cutaneous amyloidosis, an extensive workup must be done to evaluate patients for the possibility of systemic involvement. Workup for systemic disease includes: serum and urine immunoelectrophoresis, rectal mucosal or abdominal fat biopsy, bone marrow biopsy, CBC, chemistry panel, and skull and spine X-rays. The origin of the amyloid and the extent of internal involvement are used to determine the approach to treatment.

29. Atlas Of Pathology URBANA ATLAS OF PATHOLOGY. Image Number 69 Heart, amyloidosis. Arrow 1 depicts the peripherally located nuclei in the cross section of cardiac muscle . http://www.med.uiuc.edu/pathatlasf/Atlas69.html

Back to Previous Image URBANA ATLAS OF PATHOLOGY Image Number 69 - Heart, amyloidosis Arrow 1 depicts the peripherally located nuclei in the cross section of cardiac muscle . Notice the wide spacing between the cardiac muscle cells. This is due to the deposition of amyloid seen for example at arrow 2. This is being viewed with non-polarized light. With this stain the amyloid is a light salmon pink. Click for image To Next Image To Table of Contents To Alphabetical Index To Start

30. Atlas Of Pathology URBANA ATLAS OF PATHOLOGY. Cardiovascular Volume. Image Number 020 amyloidosis, blood vessel. Amyloid is a group of proteins arranged in a B-pleated sheet. http://www.med.uiuc.edu/pathatlasf/CVAtlas020.html

Back to Previous Image URBANA ATLAS OF PATHOLOGY Cardiovascular Volume Image Number 020 - Amyloidosis, blood vessel Click for image Go to next image in this volume Back to Master Atlas contents

31. Amyloid Research Group Of Indiana University, Indianapolis This site defines amyloidosis and describes current research as well as treatment options. It also introduces the personnel and facilities of the center. http://www.iupui.edu/~amyloid

Amyloid Research Group Indiana University School of Medicine What is Amyloidosis? Meet the department Publications You are the person to visit our web page since January 2003 Indianapolis Time and Date Created by Kamran on January 10, 2000 Last update on January 17, 2003 URL: http://www.iupui.edu/~amyloid email: khamidi@iupui.edu

32. Amyloid amyloidosis. forms. ACQUIRED amyloidosis Protein AL Immunoglobulin light chains; ? or ?. Clinical Most common in middle aged males; http://www.neuro.wustl.edu/neuromuscular/nother/amyloid.htm

Front Search Index Links ... Patient Info AMYLOIDOSIS General clinical features Acquired PNS amyloidosis: AL CNS Amyloidosis Hereditary PNS amyloidosis ... Pathology GENERAL CLINICAL FEATURES Polyneuropathy Small fiber sensory loss Carpal tunnel syndrome Autonomic neuropathy Systemic manifestations Myopathy Myelopathy Cardiomyopathy Ophthalmologic Renal failure Amyloidoma Electrophysiology Axonal, sensory, small fiber neuropathy Carpal tunnel syndrome Associated serum antibody: ? Serum M-Protein : Common in acquired disorders Pathology Congo red positive deposits: Red-Green birefringent with polarized light Located in connective tissue and vessel walls Treatment Liver transplantation in hereditary forms ? Immunosuppression in acquired forms ACQUIRED AMYLOIDOSIS Protein Clinical Most common in middle aged males Associated disorders Paraproteinemia ( M-protein) Most common in nephrotic syndrome Least common in polyneuropathy Light chain in 1/3 Intact immunoglobulin in 2/3 Multiple myeloma : May present 10-81 months after diagnosis of AL Polyneuropathy: Occurs in 20% of patients with light chain amyloid Distal; Symmetric

33. Amyloidosis - Rheumatoid Arthritis: Health And Medical Information About Rheumat What is amyloidosis? This option requires that an accurate diagnosis of the specific protein that causes this disease. amyloidosis At A Glance. http://www.medicinenet.com/Amyloidosis/article.htm

MedicineNet Home Rheumatoid Arthritis Home > Amyloidosis Advanced Search Printer-Friendly Format Add to Favorites Email to a Friend ... Next page Amyloidosis What is amyloidosis? What are symptoms of amyloidosis? How is amyloidosis diagnosed? How is amyloidosis treated? ... Amyloidosis At A Glance What is amyloidosis? Amyloidosis is a group of diseases that result from the abnormal deposition of a particular protein, called amyloid, in various tissues of the body. Amyloid protein can be deposited in a localized area, and may not be harmful or only affect a single tissue of the body. This form of amyloidosis is called localized amyloidosis. Amyloidosis that affects tissues throughout the body is referred to as systemic amyloidosis. Systemic amyloidosis can cause serious changes in virtually any organ of the body. Amyloidosis can occur as its own entity or "secondarily" as a result of another illness, including multiple myeloma , chronic infections (such as tuberculosis or osteomyelitis), or chronic inflammatory diseases (such as rheumatoid arthritis and ankylosing spondylitis ). Amyloidosis can also be localized to a specific body area from aging. This localized form of amyloidosis does not have systemic implications for the rest of the body. The protein that deposits in the brain of patients with

34. MayoClinic.com - Amyloidosis amyloidosis causes an abnormal protein buildup in various organs, possibly including your heart and kidneys, that can permanently damage them and disrupt their http://www.mayoclinic.com/invoke.cfm?id=DS00431

35. Amyloidosis amyloidosis Important It is possible that the main title of the report amyloidosis is not the name you expected. Please check the http://my.webmd.com/hw/health_guide_atoz/nord22.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Quizzes, Calculators Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report Amyloidosis Important It is possible that the main title of the report Amyloidosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Secondary Amyloidosis Transthyretin Methionine-30 Amyloidosis (Type I) Indiana Type Amyloidosis (Type II) Danish Cardiac Type Amyloidosis (Type III) Iowa Type Amyloidosis (Type IV) Finnish Type Amyloidosis (Type V) Icelandic Type Amyloidosis (Type VI) Ohio Type Amyloidosis (Type VII) Familial Visceral Amyloidosis (Type VIII) Familial Lichen Amyloidosis (Type IX) Appalachian Type Amyloidosis Analine 60 Amyloidosis Ashkenazi Type Amyloidosis Isoleucine 33 Amyloidosis Corneal Amyloidosis Amyloid Corneal Dystrophy Familial Cutaneous Amyloidosis Hemodialysis-Related Amyloidosis A Beta-2-Microglobulin Amyloidosis Amyloid Arthropathy of Chronic Hemodialysis Amyloidosis Illinois Type Amyloidosis Prealbumin Tyr-77 Amyloidosis Amyloidosis of Familial Mediterranean Fever Atypical Amyloidosis Cardiopathic Amyloidosis

36. Amyloidosis amyloidosis The FAMYL Organization Online. Interactive amyloidosis Network International, Inc. International Network. Information http://my.webmd.com/hw/health_guide_atoz/shc29amy.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Quizzes, Calculators Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... Amyloidosis Network International, Inc. Amyloidosis The FAMYL Organization Online. Interactive support group for persons affected by familial amyloidosis polyneuropathy disease, a liver protein disorder, Local meeting in Indiana. CALL: 219-436-5476 E-MAIL: EKoeinig@peoplepc.com WEBSITE: http://www.famy.com VERIFIED: 4/21/2003 Amyloidosis Network International, Inc. International Network. Information and support for persons affected by amyloidosis, an accumulation of abnormal proteins. Networks individuals together for support. Provides education to the public and professionals about the disease. WRITE: Amyloidosis Network Int'l, Inc.

37. Dr. Vidt's Web Site -- Health Section Printer Friendly Version amyloidosis amyloidosis is the deposition of an abnormal substance called amyloid in the tissues of the body. http://www.drjwv.com/article.php?view=0001.php

38. EMedicine - Amyloidosis, Overview : Article By Daniel R Jacobson, MD amyloidosis, Overview Amyloid diseases are secondary protein structure diseases in which insoluble protein fibrils accumulate extracellularly. A amyloidosis. http://www.emedicine.com/med/topic3377.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Rheumatology Amyloidosis, Overview Last Updated: May 28, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: amyloid diseases, primary amyloidosis, secondary amyloidosis, myeloma-associated amyloidosis, familial amyloidosis, localized amyloidosis, senile amyloidosis, senile cardiac amyloidosis, light chain amyloidosis, AL, familial amyloid polyneuropathy, transport protein transthyretin, TTR, ATTR, systemic amyloidosis, A amyloidosis, AA, heavy chain amyloidosis, AH, beta -microglobulin amyloidosis, A b M, familial renal amyloidosis, apolipoprotein AI amyloidosis, AapoAI, fibrinogen amyloidosis, AFib, lysozyme amyloidosis, ALys, apolipoprotein AII amyloidosis, AapoAII, beta protein amyloid, A b , prion protein amyloidosis, APrP, cystatin C amyloidosis, ACys, gelsolin amyloidosis, AGel, atrial natriuretic factor amyloidosis, AANF, keratoepithelin amyloidosis, AKE, lactoferrin amyloidosis, ALac, calcitonin amyloidosis, ACal, islet amyloid polypeptide amyloidosis, AIAPP, prolactin amyloid, Apro, keratin amyloid, Aker AUTHOR INFORMATION Section 1 of 11 Author Information Definition Of Amyloidosis Systemic Amyloidoses Hereditary Renal Amyloidoses ... Bibliography Author: Daniel R Jacobson, MD

39. EMedicine - Amyloidosis, Transthyretin-Related : Article By Daniel R Jacobson, M amyloidosis, TransthyretinRelated - The amyloidoses are diseases of secondary protein structure, in which a normally soluble protein forms insoluble http://www.emedicine.com/med/topic3365.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Rheumatology Amyloidosis, Transthyretin-Related Last Updated: November 10, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: senile cardiac amyloidosis, senile systemic amyloidosis, familial amyloidotic polyneuropathy, transthyretin-type familial amyloid cardiomyopathy AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Daniel R Jacobson, MD , Associate Professor, Department of Medicine, Division of Hematology, New York University School of Medicine Editor(s): Robert E Wolf, MD, PhD , Chief, Professor, Department of Internal Medicine, Section of Rheumatology, Louisiana State University Health Sciences Center; Francisco Talavera, PharmD, PhD , Senior Pharmacy Editor, Pharmacy, eMedicine; Lawrence H Brent, MD , Chair, Program Director, Associate Professor, Department of Medicine, Division of Rheumatology, Albert Einstein Medical Center, Thomas Jefferson University;

40. Dermatlas: Online Dermatology Image Library Dermatology Image,lichen Amyloidosis Next Result Set. Dermatlas LEG lichen amyloidosis © 2001-04, Dermatlas, Image Name Lichen_amyloidosis_1_040329, File Type jpg. http://dermatlas.med.jhmi.edu/derm/result.cfm?Diagnosis=1836304652

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