81. NodeWorks - Rare Disorders: Alstrom Syndrome thumbnail, 1. alstrom syndrome Clinical features, literature and research. 4. NORD - alstrom syndrome - Sample report, plus links to organisations. http://dir.nodeworks.com/Health/Conditions_and_Diseases/Rare_Disorders/Alstrom_S

in entire NodeWorks Directory in Health in Rare Disorders in ++ Alstrom Syndrome Top Health Rare Disorders Alstrom Syndrome A rare disorder inherited as an autosomal recessive genetic trait. Characteristic features of this disorder include progressive loss of vision and hearing beginning in early childhood, diabetes mellitus, and obesity. Alstrom Syndrome Clinical features, literature and research. Includes guidelines for health care professionals. Alstrom Syndrome of Canada Includes information about the condition, and the organisation. Alstrom Syndrome UK Support Group Information centre and discussion forum for anyone with an interest in this disorder. NORD - Alstrom Syndrome Sample report, plus links to organisations. [Fee required for full report] Smart Groups: Alström Families Mailing list, pictures, links and files. NodeWorks boosts web surfing! Page Returned in seconds - HTML Compressed Help build the largest human-edited directory on the web. Submit a Site Update a Site Open Directory Project Become an Editor

82. Rare Disorders - 115 Of The Best Sites Selected By Humans Pemphigus Pemphigus Hub -Pemphigus -Pemphigus Vulgaris -Pemphigus -International Pemphigus Foundation Alstrom_Syndrome -NORD - alstrom syndrome -Smart Groups http://www.cbel.com/rare_disorders/?order=alpha

83. Rare Disorders - 115 Of The Best Sites Selected By Humans Hub 1 Pemphigus 1 -Pemphigus Vulgaris 0 -Pemphigus 0 -International Pemphigus Foundation 0 Alstrom_Syndrome 2 -NORD - alstrom syndrome 2 -Smart http://www.cbel.com/rare_disorders/?order=pop

84. FORMULAIRE INSCRIPTION RECHERCHE WWW.LACHAINETTE.COM Contacts Rare disease selected alstrom syndrome Id, First name, Country, Web. 882, Jan Marshall, FRANCE, http://www.lachainette.com/US/ContactsPathologie.php?Action=contacter&Id=956

85. References For Alstrom Syndrome With The MeSH Term Blindness References for alstrom syndrome with the MeSH term Blindness, G2D Home. PMID and date. Follow the link to see the corresponding entry by PubMed http://www.bork.embl-heidelberg.de/g2d/exam_mesh_disease.pl?Blindness:U7840:Alst

86. References For Alstrom Syndrome With The MeSH Term Acanthosis References for alstrom syndrome with the MeSH term Acanthosis Nigricans, G2D Home. PMID and date. Follow the link to see the corresponding entry by PubMed http://www.bork.embl-heidelberg.de/g2d/exam_mesh_disease.pl?Acanthosis_Nigricans

87. GeneCard For ALMS1 Approved UCL/HGNC/HUGO Human Gene Nomenclature database symbol ALMS1 (alstrom syndrome 1). mouse (MGD), Alms1, 6, alstrom syndrome 1 homolog (human), http://bioinfo.cnio.es/cgi-bin/db/genecards/carddisp?ALMS1

88. Hum. Mol. Genet. -- Abstracts: Collin Et Al. 6 (2): 213 Human Molecular Genetics, Vol 6, 213219, Copyright © 1997 by Oxford University Press. ARTICLES. Homozygosity mapping at alstrom syndrome to chromosome 2p. http://hmg.oupjournals.org/cgi/content/abstract/6/2/213

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: Full Text of this Article PDF Version of this Article Email this article to a friend Similar articles found in: Hum. Mol. Genet. Online PubMed PubMed Citation This Article has been cited by: other online articles Search PubMed for articles by: Collin, G. B. Nishina, P. M. Alert me when: new articles cite this article Download to Citation Manager ARTICLES Homozygosity mapping at Alstrom syndrome to chromosome 2p GB Collin, JD Marshall, LR Cardon and PM Nishina Jackson Laboratory, Bar Harbor, ME 04609-1500, USA. Alstrom syndrome is a rare autosomal recessive disorder characterized by pigmentary retinal degeneration, sensorineural hearing loss, childhood obesity, non-insulin-dependent diabetes mellitus, hyperlipidemia and chronic nephropathy. Features occasionally observed include acanthosis nigricans, hypogonadism, hypothyroidism, alopecia, short stature and cardiomyopathy. We report here the results of a linkage study in a large French Acadian kindred, as a first step in identifying the molecular basis

89. GeneCard For ALMS1 Approved UCL/HGNC/HUGO Human Gene Nomenclature database symbol ALMS1 (alstrom syndrome 1). mouse (MGD), Alms1, , alstrom syndrome 1 homolog (human), , . http://www6.unito.it/cgi-bin/cards/carddisp?ALMS1

90. CMGS-Wolfram Syndrome/11.2.99 The association of DM and optic atrophy also occurs in Friedrich s ataxia,Refsum disease, alstrom syndrome, Lawrence Moon syndrome, Kearn- Sayre syndrome and http://www.ich.ucl.ac.uk/cmgs/wolfram.htm

Wolfram Syndrome Wolfram syndrome is an autosomal recessive disorder characterised by juvenile-onset diabetes mellitus and optic atrophy. The acronym DIDMOAD is used to describe the syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness). The median age of death is 30 years (range 25-49 years). Psychiatric disorders have also been associated with Wolfram syndrome. In a study of 68 patients, 60% were reported to have episodes of severe depression, organic psychosis or organic brain syndrome. Presumed carriers may be predisposed to psychiatric illness. Differential diagnosis includes congenital rubella syndrome, Leber's hereditary optic atrophy and thiamine responsive anaemia with DM and deafness. The association of DM and optic atrophy also occurs in Friedrich's ataxia,Refsum disease, Alstrom syndrome, Lawrence- Moon syndrome, Kearn- Sayre syndrome and deafness and diabetes in the 3243 mitochondrial DNA mutation. The estimated prevalence in the U.K. is 1/770,000 with a carrier frequency of 1/354 (lower than the 1/100,00 in the U.S. population but this is probably due to methodological differences) Mapping of the gene Positional cloning was used Using microsatellite repeat polymorphisms reported in the Genethon map of the human genome, the Wolfram gene had been found to be linked to markers on the short arm of chromosome 4 with a maximum LOD score between D4S431-D4S394.

91. Pro-inflammatory Cytokine Cascade In Human Plucked Hair. Homozygosity Mapping At Genet. 1997 Feb;6(2)2139. Homozygosity mapping at alstrom syndrome to chromosome 2p. Collin GB, Marshall JD, Cardon LR, Nishina PM. http://hairmillion.com/ref-alopecia/alopecia-research-abs3.8.html

alopecia areata. References: Hair growth and hair loss Skin Pharmacol. 1996;9(6):366-75. Pro-inflammatory cytokine cascade in human plucked hair. Mahe YF, Buan B, Billoni N, Loussouarn G, Michelet JF, Gautier B, Bernard BA. L'Oreal Hair Biology Research Group, Centre de Recherche C. Zviak, Clichy, France. alopecia androgenetica, hair growth might be negatively influenced by IL-1, directly produced by the outer root sheath keratinocytes. Consequently, identifying the "inflammatory alopecic individual' might be of clinical interest to discriminate among individuals for whom anti-IL-1 strategies might be of therapeutic relevance. Hum Mol Genet. 1997 Feb;6(2):213-9. Homozygosity mapping at Alstrom syndrome to chromosome 2p. Collin GB, Marshall JD, Cardon LR, Nishina PM. Jackson Laboratory, Bar Harbor, ME 04609-1500, USA. Alstrom syndrome is a rare autosomal recessive disorder characterized by pigmentary retinal degeneration, sensorineural hearing loss, childhood obesity, non-insulin-dependent diabetes mellitus, hyperlipidemia and chronic nephropathy. Features occasionally observed include acanthosis nigricans, hypogonadism, hypothyroidism, alopecia , short stature and cardiomyopathy. We report here the results of a linkage study in a large French Acadian kindred, as a first step in identifying the molecular basis of Alstrom syndrome. Evidence of a founder effect made if feasible to use a homozygosity mapping strategy to identify the chromosomal location of the Alstrom gene. In a genome-wide screen, haplotype sharing for a region on chromosome 2 was observed in all affected individuals. Two point linkage analysis resulted in a maximum lod score of 3.84 (theta = 0.00) for marker D2S292. By testing additional markers, the disease gene was localized to a 14.9 cM region on chromosome 2p.

92. Dictionary Definition Of ALSTROM'S SYNDROME Dictionary definition of alstrom S syndrome. Medical dictionary. Browse Dictionary by alphabet. 0 1 2 3 4 5 6 7 8 9 A B C D E F G H http://www.dictionarybarn.com/ALSTROMS-SYNDROME.php

Dictionary definition of ALSTROM'S SYNDROME Browse Dictionary by alphabet A B C D ... Z Top Words Al al-phitomancy ala auris ala central lobule ... albuminocytologic dissociation Please select first two letters of word you are looking for AA AB AC AD ... AZ fiSearchFormMaxSetId='AX006027'; Top Words albuminogenous albuminoid albuminoidal albuminolysis ... Home Sponsored By: Oklahoma Car Rentals Oregon Car Rentals Pennsylvania Car Rentals

93. Electricbrain Home: Index: Health: Conditions And Diseases: Rare Disorders: Alst Health Conditions and Diseases Rare Disorders alstrom syndrome News at 0933 on May 17, 2004 Random quote It s grad exam time http://www.electricbrain.com/index/Health/Conditions_and_Diseases/Rare_Disorders

electricbrain Index Health Conditions and Diseases ... Rare Disorders : Alstrom Syndrome home index write privacy ... cache Quote of the Minute... Your computer account is overdrawn. Please see Big Brother. Find someone: Old Friends New Friends Lost Love New Love ... privacy

94. DBI - Alström Syndrome Kay Parkinson Alström syndrome UK 49 Southfield Avenue Paignton South Devon England, UK. TQ3 1LH alstrom@syndromeUK.freeserve.co.uk. http://www.deafblindinternational.org/review/alstrom.html

DbI Homepage Site Map What's New? Who is DbI? ... President's Letter Conditions and syndromes that can result in deafblindness Introduction Diagnosis In clinical medicine, diagnosis is made when four out of five principal features of AS are present. These are degeneration of the retina (retinopathy) at an early age i.e. under 1 year, which is usually first noticed as involuntary eye movements (nystagmus) and/or light sensitivity (photophobia). In addition, infantile obesity, cardiomyopathy (infantile or adolescent), mild to moderate sensorineual hearing loss may also be observed in early childhood, and type 2 diabetes mellitus or high levels of insulin in the blood (hyperinsulinemia) usually begin in adolescence. Presentation of features Pattern of inheritance Prognosis International Contacts Jan Marshall The Jackson Laboratory 600 Main Street Bar Harbor Maine 04609 - 1500 USA jdm@jax.org International SASF 14 Whitney Farm Road Mount Desert, Maine 04660 USA Kay Parkinson 49 Southfield Avenue Paignton South Devon England, UK. TQ3 1LH

95. MedlinePlus Medical Encyclopedia: Alström Syndrome Alström syndrome. Treatment. There is no specific treatment for this syndrome. Diabetes can be treated with oral medications, insulin, or a combination of both. http://www.nlm.nih.gov/medlineplus/ency/article/001665.htm

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Alstr¶m syndrome Contents of this page: Definition Causes, incidence, and risk factors Symptoms Signs and tests ... Calling your health care provider Definition Alstr¶m syndrome is an inherited disease characterized by progressive blindness deafness , early-onset type 2 diabetes mellitus , and obesity . Intelligence is not affected. Causes, incidence, and risk factors Alstr¶m syndrome is an autosomal recessive inherited disorder, which means that a person must inherit a copy of the defective gene from both parents in order to be affected. It is extremely rare, but is more common in Holland and Sweden than in the United States. The mutated gene, , was recently identified, but it is not yet known how this gene causes the disorder. Symptoms Blindness or severe vision impairment in infancy Symptoms of childhood onset of type 2 diabetes Obesity Deafness Dark patches of skin (acanthosis nigricans) Growth retardation Impaired heart function ( cardiomyopathy ), which may lead to heart failure

96. FORMULAIRE INSCRIPTION RECHERCHE WWW.LACHAINETTE.COM http://www.lachainette.com/ContactsPathologie.php?Action=contacter&Id=956

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