1. Alpha-1 Information about this non profit organization as well as the disorder, research, membership and contact details. http://www.alpha1.org

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2. Understanding Alpha-1 Antitrypsin Deficiency Information on signs and symptoms of this disorder, as well as risk factors and treatment. http://www.nhlbi.nih.gov/health/public/lung/other/antitryp.htm

Understanding Alpha-1 Antitrypsin Deficiency Table of Contents: Introduction What is alpha-1 antitrypsin deficiency? How do normal lungs work? What happens if there isn't enough alpha-1 antitrypsin? ... Can the disorder be treated? Home Page Lung Information for the General Public Introduction Your health care team has made this web page to answer your questions about alpha-1 antitrypsin deficiency. It contains information on signs and symptoms of the disorder as well as risk factors and treatment. When you understand more about alpha-1 antitrypsin deficiency, you will be able to play a more active role in your care. [Return to the Table of Contents] What is alpha-1 antitrypsin deficiency? Alpha-1 antitrypsin is a protein that is made in the liver. The liver releases this protein into the bloodstream. Alpha-1 antitrypsin protects the lungs so they can work normally. Without enough alpha-1 antitrypsin, the lungs can be damaged, and this damage may make breathing difficult. Alpha-1 antitrypsin deficiency is an inherited (passed down from parents) disorder that causes low levels of, or no alpha-1 antitrypsin in the blood. [Return to the Table of Contents] How do normal lungs work?

3. Alpha-1-Antitrypsin Deficiency Alpha1-Antitrypsin Deficiency. Alpha 1 National Association International Lay Advocacy Groups. Understanding alpha-1 antitrypsin deficiency, National Heart, Lung, and Blood http://www.kumc.edu/gec/support/alpha1.html

Alpha-1-Antitrypsin Deficiency Alpha 1 National Association 8120 Penn Avenue S., Suite 549 Minneapolis, MN 55431 Phone: (800) 521-3025 or 612-703-9979 Fax: 612-885-0133 Web site: http://www.alpha1.org/ E-mail: julie@alpha1.org Understanding pulmonary function testing (PFT) Respiratory System Liver Support Alphabeaters support group (Colorado) Alpha One Foundation 2937 SW 27th Avenue Suite 302 Miami, Florida 33133 Phone: (305) 567-9888 or toll free: 877-2 CURE A1 (877 228-7321) Fax: (305) 567-1317 Web site: http://www.alphaone.org/main.htm E-mail: mserven@alphaone.org International Sites Spanish Asociación Española para el Déficit de Alfa 1-Antitripsina Apartado de Correos 96 47320 Tudela de Duero (Valladolid - España) UE Telephone/Fax: 983.682043 Web Page: http://www.alfa1.org United Kingdom Alpha-1 Support UK Alpha-1-antitrypsin deficiency British Liver Trust Information Service Also See: National and International Lay Advocacy Groups Understanding Alpha-1 Antitrypsin Deficiency , National Heart, Lung, and Blood Institute (NHLBI), NIH Liver conditions web sites Lung conditions web sites Liver and Billary Disease American Association for Study of Liver Diseases ... Alpha-1 Antitrypsin Deficiency Children's Liver Disease Foundation Lab tests of Liver Diseases Second Wind Lung Transplant Association American Lung Association Alpha-1 Antitrypsin , American Liver Foundation Chronic Pulmonary Disease United Network for Organ Sharing (UNOS) Transplant Recipient's International Org. Inc.- TRIO

4. MedlinePlus Medical Encyclopedia: Alpha-1 Antitrypsin Deficiency alpha1 antitrypsin deficiency is a lack of a liver protein that blocks the destructive effects of certain Return to top. alpha-1 antitrypsin deficiency results from a genetic defect http://www.nlm.nih.gov/medlineplus/ency/article/000120.htm

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Alpha-1 antitrypsin deficiency Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Calling your health care provider Illustrations Lungs Liver anatomy Alternative names Return to top AAT deficiency Definition Return to top Alpha-1 antitrypsin deficiency is a lack of a liver protein that blocks the destructive effects of certain enzymes. The condition may lead to emphysema and liver disease Causes, incidence, and risk factors Return to top Alpha-1 antitrypsin deficiency results from a genetic defect. The mechanism that causes associated liver disease and emphysema in some people with this deficiency is not known, however some evidence suggests that it may be related to inflammation. Approximately 75% of adults with severe deficiency will develop emphysema, which often begins before 40 years of age. Smoking can increase risk. Symptoms Return to top Shortness of breath with and without exertion Unintentional weight loss Wheezing Additional symptoms that may be associated with emphysema or cirrhosis include the following: Abnormal breathing pattern (exhalation takes more than twice as long as inspiration) Agitation Ankle, feet, and leg swelling

5. HealthlinkUSA Alpha-1 Antitrypsin Deficiency Links Finding alpha1 antitrypsin deficiency is a Click Away at 2020Search.com what you re looking for on%3A alpha-1 antitrypsin deficiency%3F 2020Search will instantly provide you with http://www.healthlinkusa.com/10ent.htm

6. Alpha One Foundation The Alpha1 Foundation is dedicated to providing the leadership and resources a cure for alpha-1 antitrypsin deficiency (Alpha-1). Alpha-1 is a genetic disorder http://www.alpha1foundation.org/

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7. Alpha-1 Antitrypsin Deficiency - Learn More From MedlinePlus Find the latest news stories, overviews, research and more on alpha1 antitrypsin deficiency from MedlinePlus, the National Library of Medicine's consumer health site. http://rdre1.inktomi.com/click?u=http://www.nlm.nih.gov/medlineplus/alpha1antitr

8. Alpha-1 Antitrypsin Deficiency alpha1 antitrypsin deficiency. alpha-1 antitrypsin deficiency is the most common genetic cause of liver disease children and of emphysema in adults. http://www.childliverdisease.org/aatd.html

Colin Buchanan appeal video Alpha-1 Antitrypsin Deficiency 30 years since recognition that it could cause liver disease in children The link between alpha-1 antitrypsin deficiency (AATD) and liver disease in children was first described 30 years ago by Dr E F Freier. Alpha-1 antitrypsin deficiency is the most common genetic cause of liver disease children and of emphysema in adults. It is also the most common genetic disease for which liver transplantation is undertaken in children. What is it? Alpha-1 antitrypsin is a protease (a digestive enzyme that causes the breakdown of protein) inhibitor (PI), genotype MM, which protects tissues from the effects of neutrophil (a type of white blood cell which can ingest and kill bacteria. It is mainly produced in the liver. Work carried out at University College London Medical School and funded by CLDF found that alpha-1 antitrypsin played a role in tissue repair by stimulating fibroblast proliferation and procollagen production. Following tissue injury and inflammation levels of alpha-1 antitrypsin rise sharply three or four fold. (Dickson and Alper 1994) In AATD an abnormal protein is made by the body, genotype ZZ. Studies have suggested that accumulation of this abnormal protein in the liver cell causes inflammation and damage. This is associated with polymerisation, ie where a large number of abnormal alpha-1 antitrypsin molecules become linked together.

9. Health And Medical Information: Diseases And Conditions, Medical Dictionary, Pro An alpha1 antitrypsin deficiency article with details such as what it is, normal lungs and how they work, smoking, risk factors, how it is inherited, signs, symptoms and treatment. http://www.medicinenet.com/Script/Main/Art.asp?li=MNI&ArticleKey=278

10. Alpha-1 Antitrypsin Deficiency organization, dedicated to improving the lives of individuals and their families affected by alpha1 antitrypsin deficiency. Alpha1 Canadian Registry. http://www.lung.ca/diseases/alph1.html

What is Alpha-1 Antitrypsin Deficiency? Alpha-1 Antitrypsin deficiency is an inherited disorder that may cause lung or liver disease. Normally, the protein alpha-1 antitrysin, is released into the bloodstream and travels to the lung where it protects the lungs from the destructive actions of common illnesses and exposures, particularly tobacco smoke. People with a deficiency of this protective protein often suffer from progressive lung damage known as emphysema. Unlike the common form of emphysema seen in otherwise healthy individuals who have smoked for many years, this alpha antitrypsin deficiency form of emphysema may occur at an unusually young age and after minimal exposure to tobacco smoke. Visit the Alpha 1 Association web site. They are a non-profit, membership organization, dedicated to improving the lives of individuals and their families affected by alpha-1 antitrypsin deficiency. Alpha1 Canadian Registry This is the Canadian site for the International Alpha1 Registry. The International Registry has been set up with approximately 3500 participants. There are several goals of this registry. Initially, the registry will gather existing medical information about people who are deficient in the protein to understand better why some people remain healthy and free of lung disease and why some people develop emphysema. In the longer term, people who are participants in the registry may be asked if they are willing to participate in research trials that might improve our diagnoses, assessment or management of the disease. By coordinating research efforts at this international level, the registry scientists hope to make more rapid progress than individual scientists could achieve working in isolation.

11. Alpha-1 Antitrypsin Deficiency - Patient UK A list of resources and support for persons living in the UK who are interested in alpha1 antitrypsin deficiency. http://www.patient.co.uk/showdoc.asp?doc=90

12. Alpha-1 Antitrypsin Deficiency / Family Village Library Alpha1 Lungs and Life The Alpha1 Lungs Life Support E Mail It is a powerful tool for support and education concerning alpha-1 antitrypsin deficiency Disorder http://www.familyvillage.wisc.edu/lib_alph.htm

Alpha-1 Antitrypsin Deficiency Who to Contact Where to Go to Chat with Others Learn More About It Web Sites ... Search Google for "Alpha-1 Antitrypsin Deficiency" Who to Contact Alpha-1 Association 1225 Eye Street NW, Suite 1225 Washington, DC 20005-5918 Phone: (202) 887-1900 Toll-Free: (800) 521-3025 Fax (202) 887-1964 E-mail: info@alpha1.org Website: http://www.alpha1.org The mission of this association is to improve, through support, education, and research, the quality of life of those affected by alpha1-antitrypsin deficiency. Available services include: offering support and education to patients with A1AD, the general public, and the medical community; acting as a clearinghouse of information to assist healthcare professionals and individuals with A1AD; acting as an advocate for people with A1AD; and aiding in support of research of A1AD. Where to Go to Chat with Others Alpha1 Lungs and Life Learn More About It Alpha-1-antitrypsin Deficiency - A Simplified Description From the Alpha-1 Association Understanding Alpha-1 Antitrypsin Deficiency From the National Heart, Lung, and Blood Institute (NHLBI)

13. Alpha-1 Antitrypsin Deficiency - Liver Health Information - The American Liver F alpha1 antitrypsin deficiency, Alpha-1 - antitrypsin deficiency is a hereditary disease that may lead to hepatitis and cirrhosis. http://www.liverfoundation.org/db/articles/1044

Liver Health Articles Liver Health Links Patient Stories PDF Newsletter ... Publications Alpha-1 Antitrypsin Deficiency Alpha-1 - antitrypsin deficiency is a hereditary disease that may lead to hepatitis and cirrhosis. It is the most common genetic cause of liver disease in children. Adults are also affected and may have lung involvement with emphysema as well as liver disease. The protein alpha-1 - antitrypsin is a substance made in the liver. It plays an important role preventing the breakdown of enzymes in various organs of the body. A child must inherit the tendency from both parents to develop the disease, alpha-1 -antitrypsin deficiency. The incidence of the disease in the United States is approximately 1:2000 live births. Fortunately, for reasons that are not understood, only 10-20% of the babies born with the deficiency will have liver disease. Decreased levels of the serum protein, alpha-1 - antitrypsin, lead to liver damage with scarring and abnormal liver function. The disease most often appears in the newborn period with jaundice, swelling of the abdomen, and poor feeding. It may also appear in late childhood or adulthood and be detected because of fatigue, poor appetite, swelling of the abdomen and legs or abnormal liver tests. The diagnosis is made by blood tests when the serum level of alpha-1 - antitrypsin is low and standard liver function tests are abnormal. Other tests such as urine collection, ultrasound examination, or tests using specialized X-ray techniques may be necessary. A biopsy of the liver (sampling liver tissue with a needle or by operation) is usually performed to look for liver injury. Relatives who are carriers but do not have the disease can also be diagnosed by blood tests.

14. MedlinePlus: Alpha-1 Antitrypsin Deficiency Topics. alpha1 antitrypsin deficiency. Printer Encyclopedia. Search MEDLINE for recent research articles on • alpha-1 antitrypsin deficiency. You http://www.nlm.nih.gov/medlineplus/alpha1antitrypsindeficiency.html

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Other health topics: A B C D ... List of All Topics Alpha-1 Antitrypsin Deficiency Contents of this page: From the NIH General/Overviews Coping Diagnosis/Symptoms ... Information from the Medical Encyclopedia Search MEDLINE for recent research articles on Alpha-1 Antitrypsin Deficiency You may also be interested in these MedlinePlus related pages: COPD (Chronic Obstructive Pulmonary Disease) Genetics/Birth Defects Lungs and Breathing From the National Institutes of Health Understanding Alpha-1 Antitrypsin Deficiency (National Heart, Lung, and Blood Institute) General/Overviews Alpha-1 Antitrypsin Deficiency: Frequently Asked Questions (Alpha 1 Association) Guide for the Recently Diagnosed Individual: Alpha-1 Antitrypsin Deficiency (Alpha One Foundation) - Links to PDF File Also available in: Spanish Clinical Trials ClinicalTrials.gov: alpha 1-Antitrypsin Deficiency (National Institutes of Health) Coping Work Simplification and Energy Conservation (Alpha 1 Association) Diagnosis/Symptoms Gene Testing (Dept. of Energy, Human Genome Project)

15. EMedicine - Alpha1-Antitrypsin Deficiency : Article By Paul Fairman, MD Synonyms and related keywords alpha1 antiprotease deficiency, alpha1 antiprotease deficiency, alpha-1 antitrypsin deficiency, AAT, early-onset panacinar http://www.emedicine.com/med/topic108.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Pulmonology Alpha1-Antitrypsin Deficiency Last Updated: March 7, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: alpha-1 antiprotease deficiency, alpha1 antiprotease deficiency, alpha-1 antitrypsin deficiency, AAT, early-onset panacinar emphysema, hepatic cirrhosis AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Paul Fairman, MD , Medical Director of Lung Transplant Service, Professor, Department of Internal Medicine, Divisions of Pulmonary and Critical Care Medicine, Medical College of Virginia Paul Fairman, MD, is a member of the following medical societies: American College of Chest Physicians American College of Physicians American Thoracic Society , and International Society for Heart and Lung Transplantation Editor(s): Ryland P Byrd, Jr, MD

16. EMedicine - Alpha1-Antitrypsin Deficiency : Article Excerpt By: Paul Fairman, MD Synonyms, Key Words, and Related Terms alpha1 antiprotease deficiency, alpha1 antiprotease deficiency, alpha-1 antitrypsin deficiency, AAT, early-onset http://www.emedicine.com/med/byname/alpha1-antitrypsin-deficiency.htm

(advertisement) Excerpt from Alpha1-Antitrypsin Deficiency Synonyms, Key Words, and Related Terms: alpha-1 antiprotease deficiency, alpha1 antiprotease deficiency, alpha-1 antitrypsin deficiency, AAT, early-onset panacinar emphysema, hepatic cirrhosis Please click here to view the full topic text: Alpha1-Antitrypsin Deficiency Background: Alpha1-antitrypsin (AAT) deficiency is one of the most common inherited disorders among whites. Its primary manifestation is early-onset panacinar emphysema. A minority of patients develops hepatic cirrhosis. Slowly progressive dyspnea is the primary symptom, although many patients initially have symptoms of cough, sputum production, or wheezing. Pathophysiology: The genetic defect in AAT deficiency results in a molecule that cannot be released from its production site in hepatocytes. Low serum levels of the protein result in low alveolar concentrations, where the AAT molecule normally would serve as protection against antiproteases. The resulting protease excess destroys alveolar walls and causes emphysema. Frequency: In the US: This genetic defect affects 1 per 3000-5000 individuals. AAT is 1 of the 3 most common lethal genetic diseases among whites. The other 2 common fatal genetic defects are cystic fibrosis and Down syndrome.

17. Alpha-1-Antitrypsin Deficiency & Lung Disease alpha1 antitrypsin deficiency LUNG DISEASE. Alpha-1-antitrypsin deficiency What is alpha-1-antitrypsin deficiency? Alpha-1-antitrypsin deficiency http://www.nevdgp.org.au/geninf/lung_f/alpha-1-health.html

Alpha-1-antitrypsin deficiency is an inherited disorder which usually affects the lungs. The information presented here is intended to answer your questions and provide you with a better understanding of this rare condition. What is alpha-1-antitrypsin? Alpha-1-antitrypsin is a protein which is produced by the liver and enters the blood stream. Its main role is to protect the lungs from destruction by other proteins called enzymes. Enzymes are found in all parts of the body and are needed for digestion to ensure that chemical reactions in the body proceed normally. Enzymes are also involved in areas of inflammation and tissue injury where they occur as a result of cell damage. What is alpha-1-antitrypsin deficiency? Alpha-1-antitrypsin deficiency is present when there is less than the normal amount of this protein in the blood. It becomes important only when the concentration in the blood is less than 20% to 30% of what we would normally expect. When this deficiency occurs, the lung is poorly protected from destructive enzymes and loss of lung tissue occurs, leading to a condition called emphysema. Once in every 2500 people in Australia has severe alpha-1-antitrypsin deficiency (levels below 20% of normal). This translates to nearly 7000 Australians with alpha-1-antitrypsin deficiency.

18. Alpha-1 Antitrypsin Deficiency - Information / Diagnosis / Treatment / Preventio Understanding alpha1 antitrypsin deficiency Information on Laboratory in Cambridge, UK, researching the cause and treatment of alpha1-antitrypsin deficiency. http://www.healthcyclopedia.com/genetic-disorders/alpha-1-antitrypsin-deficiency

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... genetic disorders > alpha-1 antitrypsin deficiency Alpha-1 Antitrypsin Deficiency Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Medical Definition Health News Web Directory: Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "alpha-1 antitrypsin deficiency" Health News: Search millions of published articles for news on Alpha-1 Antitrypsin Deficiency Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: Alpha 1 Awareness Alliance A site where members of the medical professions and the public can find information about alpha 1-antitrypsin- deficiency. Includes news, reports and links. Alpha One Foundation Information about the organization, research, and news as well as alpha 1-antitrypsin deficiency.

19. Alpha-1 Antitrypsin Deficiency - Causes, Symptoms & Treatment alpha1 antitrypsin deficiency Fact Book. What is alpha-1 antitrypsin deficiency? Alpha-1 antitrypsin is a protein that is made in the liver. http://www.healthnewsflash.com/conditions/alpha_1_antitrypsin_deficiency.php

Search our Archive for the Latest News on Alpha-1 Antitrypsin Deficiency Browse By Category Browse Alphabetically Search Health Conditions Alpha-1 Antitrypsin Deficiency Fact Book Table of Contents What is alpha-1 antitrypsin deficiency? How do normal lungs work? What happens if there isn't enough alpha-1 antitrypsin? How does smoking worsen lung damage caused by the disorder? ... Keeping on top of Your Condition What is alpha-1 antitrypsin deficiency? Alpha-1 antitrypsin is a protein that is made in the liver. The liver releases this protein into the bloodstream. Alpha-1 antitrypsin protects the lungs so they can work normally. Without enough alpha-1 antitrypsin, the lungs can be damaged, and this damage may make breathing difficult. Alpha-1 antitrypsin deficiency is an inherited (passed down from parents) disorder that causes low levels of, or no alpha-1 antitrypsin in the blood. Back to Top Click Here for the Latest News on Alpha-1 Antitrypsin Deficiency Back to Top How do normal lungs work? Air usually enters the nose and mouth and goes down the air tube (trachea) to two main air passages (bronchi). These passages allow air to go into the right and left lung.

20. Alpha-1 Antitrypsin Deficiency alpha1 antitrypsin deficiency. Written by Dr David Maxton, gastroenterologist. What is alpha-1 antitrypsin deficiency? http://www.netdoctor.co.uk/diseases/facts/alpha1def.htm

NetDoctor.co.uk Home News and features News Newsletter Features Encyclopaedia Diseases Examinations Medicines Premium services SMS services StayQuit thediet Health centres Allergy and asthma Children's health Depression Eczema ... All health centres Discussion and support Discussion forums Support groups Services Ask the doctor Find a hospital Search Medline Test yourself Information About NetDoctor Commercial opportunities NetDoctor.com Alpha-1 antitrypsin deficiency Dr David Maxton , gastroenterologist What is alpha-1 antitrypsin deficiency? Alpha-1 antitrypsin deficiency is a disease caused by reduced or abnormal production in the body of the enzyme inhibitor alpha-1 antitrypsin. Body tissues and blood normally contain powerful enzymes - known as proteases - that can attack foreign substances within the body that may be harmful, such as tobacco smoke. However, these protease enzymes must be carefully regulated as they could attack and damage normal tissues rather than the intended target resulting in local tissue damage. Blood and tissues have a protease inhibitor that binds the enzyme to prevent unrestricted and potentially harmful protease activity. The commonest protease inhibitor in the blood is alpha-1 antitrypsin and its role is to protect the tissues from protease attack.

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